| 1. |
- Haiman, Christopher A., et al.
(author)
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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
- 2011
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:12, s. 61-1210
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Journal article (peer-reviewed)abstract
- Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 x 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 x 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 x 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations.
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| 2. |
- Purrington, Kristen S., et al.
(author)
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Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer
- 2014
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In: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 35:5, s. 1012-1019
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Journal article (peer-reviewed)abstract
- In a genome-wide scan, we show that 30 variants in 25 genomic regions are associated with risk of TN breast cancer. Women carrying many of the risk variants may have 4-fold increased risk relative to women with few variants.Triple-negative (TN) breast cancer is an aggressive subtype of breast cancer associated with a unique set of epidemiologic and genetic risk factors. We conducted a two-stage genome-wide association study of TN breast cancer (stage 1: 1529 TN cases, 3399 controls; stage 2: 2148 cases, 1309 controls) to identify loci that influence TN breast cancer risk. Variants in the 19p13.1 and PTHLH loci showed genome-wide significant associations (P < 5 x 10(-) (8)) in stage 1 and 2 combined. Results also suggested a substantial enrichment of significantly associated variants among the single nucleotide polymorphisms (SNPs) analyzed in stage 2. Variants from 25 of 74 known breast cancer susceptibility loci were also associated with risk of TN breast cancer (P < 0.05). Associations with TN breast cancer were confirmed for 10 loci (LGR6, MDM4, CASP8, 2q35, 2p24.1, TERT-rs10069690, ESR1, TOX3, 19p13.1, RALY), and we identified associations with TN breast cancer for 15 additional breast cancer loci (P < 0.05: PEX14, 2q24.1, 2q31.1, ADAM29, EBF1, TCF7L2, 11q13.1, 11q24.3, 12p13.1, PTHLH, NTN4, 12q24, BRCA2, RAD51L1-rs2588809, MKL1). Further, two SNPs independent of previously reported signals in ESR1 [rs12525163 odds ratio (OR) = 1.15, P = 4.9 x 10(-) (4)] and 19p13.1 (rs1864112 OR = 0.84, P = 1.8 x 10(-) (9)) were associated with TN breast cancer. A polygenic risk score (PRS) for TN breast cancer based on known breast cancer risk variants showed a 4-fold difference in risk between the highest and lowest PRS quintiles (OR = 4.03, 95% confidence interval 3.46-4.70, P = 4.8 x 10(-) (69)). This translates to an absolute risk for TN breast cancer ranging from 0.8% to 3.4%, suggesting that genetic variation may be used for TN breast cancer risk prediction.
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| 3. |
- Tapper, Michael
(author)
-
Alfred Hitchcock's America
- 2014
-
In: Historical Journal of Film, Radio & Television. - : Informa UK Limited. - 0143-9685 .- 1465-3451. ; 34:1, s. 178-179
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Review (other academic/artistic)
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| 4. |
- Tapper, Michael
(author)
-
Allegori under ytan
- 2012
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In: Sydsvenska dagbladet. - 1104-0068.
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Journal article (pop. science, debate, etc.)abstract
- Krönika om filmer om Titanic-katastrofen genom historien
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| 5. |
- Tapper, Michael
(author)
-
Bergmans bortglömda primalskrik
- 2011
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In: Sydsvenska dagbladet. - 1104-0068.
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Journal article (pop. science, debate, etc.)abstract
- Krönika om den på dvd nyutgivna filmversionen av Ingmar Bergmans Ansikte mot ansikte
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| 6. |
- Tapper, Michael
(author)
-
Cornell värd mer uppmärksamhet
- 2012
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In: Sydsvenskan. - 1652-814X.
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Journal article (pop. science, debate, etc.)abstract
- Krönika om filmregissören och manusförfattaren Jonas Cornell.
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| 7. |
- Tapper, Michael, et al.
(author)
-
Dirty Harry in the Swedish Welfare State
- 2011
-
In: Scandinavian Crime Fiction. - 9780708323304 ; , s. 21-33
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Book chapter (other academic/artistic)abstract
- Essay on the development of the Gunvald Larsson character in the Beck film series 1997-2010.
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| 8. |
- Tapper, Michael
(author)
-
En hjälte på djupt vatten
- 2011
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In: Sydsvenska dagbladet. - 1104-0068.
-
Journal article (pop. science, debate, etc.)abstract
- Kulturartikel om arvet efte oceanografen och naturfilmaren Jacques-Yves Cousteau med anledning av en rad böcker och blurayutgåvor om och av honom.
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| 9. |
- Tapper, Michael
(author)
-
"En naturkraft mindre"
- 2012
-
In: Sydsvenska dagbladet. - 1104-0068.
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Journal article (pop. science, debate, etc.)abstract
- Artikel om den japanske filmregissören och manusförfattaren Kaneto Shindo.
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| 10. |
- Tapper, Michael
(author)
-
Ett sant ansikte
- 2011
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In: Sydsvenska dagbladet. - 1104-0068.
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Journal article (pop. science, debate, etc.)abstract
- Krönika om Ken Russell med anledning av dennes död.
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| 11. |
- Tapper, Michael
(author)
-
Filmregissör förvandlad till kulturhelgon
- 2011
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In: Dagens Nyheter. - 1101-2447. ; :2011-08-03
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Review (pop. science, debate, etc.)abstract
- Bokrecension i essäform som också handlar om hur stora filmregissörer görs till museala institutioner, deras verk till nationalmonument. En process som förstör filmernas dialog med publiken och gör regissören till en död nationalklenod.
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| 12. |
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| 13. |
- Tapper, Michael
(author)
-
Förstorat reklamblad
- 2012
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In: Sydsvenskan. - 1652-814X.
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Review (pop. science, debate, etc.)abstract
- Recension av Arnold Schwarzeneggers självbiografi Total Recall.
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| 14. |
- Tapper, Michael
(author)
-
Glittrande glad naturkraft
- 2011
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In: Sydsvenska dagbladet. - 1104-0068.
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Journal article (pop. science, debate, etc.)abstract
- Nekrolog över Sickan Carlsson 1915-2011
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| 15. |
- Tapper, Michael
(author)
-
Greenpeace nästa för Bond?
- 2012
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In: Sydsvenskan. - 1652-814X.
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Journal article (pop. science, debate, etc.)abstract
- Krönika om den ideologiska förändringen av filmserien om James Bond.
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| 16. |
- Tapper, Michael
(author)
-
Han åt, drack och andades film
- 2013
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In: Sydsvenska dagbladet. - 1104-0068.
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Journal article (pop. science, debate, etc.)abstract
- Nekrolog över den amerikanske filmkritikern Roger Ebert
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| 17. |
- Tapper, Michael, et al.
(author)
-
Hans kropp – samhället självt: Manliga svenska mordspanare på ålderns höst
- 2010
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In: Den skandinaviske krimi som medieprodukt. - 9789189471924 ; , s. 49-62
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Book chapter (other academic/artistic)abstract
- Diskussion av maskulinitet och mannen som represenation av nationen och dess tillstånd utifrån svenska polisromaner och polisfilmer, bland andra Per Wahlöös romaner om kommissarie Jensen (Mord på 31:a våningen, 1964; Stålsprånget, 1968, Sjöwall-Wahlöös Roman om ett brott-serie och Henning Mankells Wallanderromaner samt romanfilmatiseringarna och de fristående filmserierna Beck och Wallander.
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| 18. |
- Tapper, Michael
(author)
-
I mörkaste Sverige
- 2011
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In: Sydsvenska dagbladet. - 1104-0068.
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Journal article (pop. science, debate, etc.)abstract
- Kulturartikel om rasism i svensk film med anledning av en SVT1-visning av filmen "I mörkaste Småland" (1943). Särskilt stereotypiseringen av tattaren behandlas i texten.
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| 19. |
- Tapper, Michael
(author)
-
Ingenjör i visioner
- 2012
-
In: Sydsvenskan. - 1652-814X.
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Journal article (pop. science, debate, etc.)abstract
- Feature om den grafiske designern och filmskaparen Saul Bass.
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| 20. |
- Tapper, Michael
(author)
-
Mannen som gick upp i rök
- 2011
-
In: Sydsvenska dagbladet. - 1104-0068.
-
Journal article (pop. science, debate, etc.)abstract
- Kulturkrönika om bortglömda filmregissörer och särskilt Vilgot Sjöman, vars politisk-konstnärliga projekt bedöms som lika intressant för högerextremismens 2000-tal som för maoismens 1960-tal.
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| 21. |
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| 22. |
- Tapper, Michael
(author)
-
Mytomspunna smaklösheter
- 2011
-
In: Sydsvenska dagbladet. - 1104-0068.
-
Journal article (pop. science, debate, etc.)abstract
- Krönika om begreppet kultfilm, de ursprungliga filmerna som samlades under begreppet på 1970-talet jämfört med 2000-talets självmedvetna produktioner.
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| 23. |
- Tapper, Michael
(author)
-
Nationens kropp
- 2012
-
In: FLM : en kulturtidskrift om film. - 1654-711X. ; :17/18, s. 99-106
-
Journal article (pop. science, debate, etc.)abstract
- Ideologisk analys av Anders Behring Breiviks föreställningsvärld i ljuset av en populärkulturell tradition av manliga actionhjältar, främst i relation till filmatiseringarna av Jan Guillous Hamiltonromaner.
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| 24. |
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| 25. |
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