| 1. |
- Andrén, Lennart, 1946, et al.
(författare)
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Circulatory effects of noise.
- 1983
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Ingår i: Acta medica Scandinavica. - : Wiley. - 0001-6101. ; 213:1, s. 31-5
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Tidskriftsartikel (refereegranskat)abstract
- Thirteen patients with mild essential hypertension, mean age 44 years (range 21-59), were studied during "stress" before and after postsynaptic alpha-adrenoceptor blockade and combined postsynaptic alpha- and non-selective beta-adrenoceptor blockade. Loud broad band noise (100 dBA for 10 min) was used as the stress stimulus. Exposure to noise caused a significant increase in systolic (7%, p less than 0.05), diastolic (9%, p less than 0.01) and mean arterial pressure (6%, p less than 0.01). The blood pressure elevation was caused by an increase in total peripheral resistance (12%, p less than 0.05). There was no significant change in heart rate, stroke volume or cardiac output. The blood pressure response during noise stimulation was not affected by postsynaptic alpha-adrenoceptor blockade (prazosin, 2 mg orally). The hemodynamic reaction pattern, however, was totally reversed. Thus, the cardiac output increased significantly (9%, p less than 0.05), while the total peripheral resistance tended to decrease. Combined postsynaptic alpha- and non-selective beta-adrenoceptor blockade (labetalol, 200 mg orally) inhibited the increase in systolic blood pressure caused by noise, while the diastolic and mean arterial pressures still increased significantly (5%, p less than 0.01). Labetalol effectively blocked the stress-induced increase in total peripheral resistance and there was no significant increase in cardiac output after combined alpha- and beta-adrenoceptor blockade. Exposure to noise caused a significant increase in circulating noradrenaline (20%, p less than 0.05). Plasma adrenaline and plasma renin activity were not affected by noise stimulation. These results suggest that blood pressure elevation is essential during "stress" but that the hemodynamic pattern causing blood pressure elevation may vary and may be affected by pharmacological blockade of various parts of the sympathetic nervous system.
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| 2. |
- Bergman, B, et al.
(författare)
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Transfer of terbutaline across the human placenta in late pregnancy.
- 1984
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Ingår i: European journal of respiratory diseases. Supplement. - 0106-4347. ; 134, s. 81-6
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Tidskriftsartikel (refereegranskat)abstract
- Placental transfer of terbutaline was studied in 22 women in late pregnancy who were delivered by elective Caesarian section. A single i.v. dose of terbutaline (0.25 or 0.5 mg) was given at various times (13-295 min) before delivery. Immediately after delivery, one blood sample was drawn from the placental side of the umbilical vein and one from the mother's antecubital vein. By use of gas chromatography plus mass spectrometry terbutaline was assayed in maternal plasma and in plasma and whole blood from the umbilical vein. Plasma concentrations in the mothers (Cmv) were initially 7 micrograms/L, while the highest umbilical venous level ( Cuv ) recorded was 3.5 micrograms/L. The ratio Cuv /Cmv increased continuously during the time interval studied and approached unity after 2-3 h. The blood:plasma concentration ratio in venous umbilical blood was initially low. It reached unity after about 60 min, but increased steadily to about 1.5 during the time of study. Thus there was a continuous uptake of terbutaline from plasma into the erythrocytes. The slow in vivo equilibration of terbutaline between plasma and erythrocytes is probably due to the low lipophilicity of the drug. However, the latter characteristic did not seem to impede its diffusion across the placenta to any great degree.
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| 3. |
- Bergqvist, D, et al.
(författare)
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Abdominal injury from sporting activities
- 1982
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Ingår i: British journal of sports medicine. - : BMJ. - 1473-0480 .- 0306-3674. ; 16:2, s. 76-79
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Tidskriftsartikel (refereegranskat)abstract
- The frequency of abdominal injury is rising. In an analysis of 1,354 cases of closed abdominal trauma sustained during a 30-year period (1950-1979) in Skaraborg County, Sweden, a distinct increase was found in the numbers associated with sporting activities. The severity of the injuries caused by sports likewise showed an increase. The representation of injured organs was of the same order as in the total series of closed abdominal injuries. An analysis of the 136 cases of sports-associated injury is presented with regard to cause and type of the injuries, diagnosis and prognosis.
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| 4. |
- Bergqvist, D, et al.
(författare)
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Abdominal trauma in persons older than 60 years
- 1982
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Ingår i: Acta Chirurgica Scandinavica. - 0001-5482. ; 148:7, s. 569-573
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Tidskriftsartikel (refereegranskat)abstract
- Abdominal trauma occurring in persons older than 60 years over a 30-year period (1950-79) in a well defined region of Sweden was reviewed. The 177 patients comprised 12.5% of the total with abdominal trauma during that period. Road traffic accidents were the main cause of trauma (48% of cases). The incidence of motor-car accidents rose sharply during the first two decades of the study. Injuries to the liver and bile ducts and multiple intra-abdominal injuries were more common in the elderly than in younger patients, but injury to the abdominal wall was less common. A tendency towards more severe injuries and multiple trauma with extra-abdominal involvement emerged during the study period. The mortality rate was 27.6% in the patients older than 60, but 9.1% in the overall patient series with abdominal trauma. One-third of all the deaths among the older patients were directly due to the abdominal trauma. One consequence of the increasing numbers of old people in the general population is probably that more and more cases of abdominal trauma will be seen in the higher age groups.
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| 5. |
- Bergqvist, D, et al.
(författare)
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Blunt renal trauma. Analysis of 417 patients
- 1983
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Ingår i: European Urology. - 1873-7560. ; 9:1, s. 1-5
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Tidskriftsartikel (refereegranskat)abstract
- Case records of 417 patients, from a well-defined area, who were hospitalized because of blunt renal trauma during the period 1950-1979 were analyzed. The incidence increased during the final decade, corresponding to a rising incidence of motor traffic accidents and sports injuries. Young patients, between 10 and 29 years of age, were responsible for the increase and half of all patients were in this age group. Associated injuries were frequent. Emergency urography was rare during the earlier part of the investigation period, but the frequency increased strongly thereafter. Treatment was mainly conservative (nonoperative) except in patients with major renal injuries. Nephrectomy was performed in 22 patients. Reconstructive surgery was performed especially in patients with intermediate renal injuries during the final decade. The total mortality was 6.5%. Only 7 patients (1.7%) died from the renal injury. A dramatic reduction in the hospitalization time was noted.
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| 6. |
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| 7. |
- Bergqvist, D, et al.
(författare)
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Intestinal trauma, Analysis of 101 cases
- 1981
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Ingår i: Acta Chirurgica Scandinavica. - 0001-5482. ; 147:8, s. 629-635
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Tidskriftsartikel (refereegranskat)abstract
- Intestinal injuries sustained by 101 Swedish patients during the period 1950-1979 are reviewed. The abdominal trauma was blunt in 78 cases and penetrating in 23. Small-bowel and mesenteric, but not large-bowel, injuries showed increasing frequency. This was associated with rising numbers of motorcar accidents. Injuries to other abdominal organs were found in 56 of the 101 patients, particularly in those with mesenteric or large-bowel trauma. Clear physical signs of intra-abdominal injury led to rapid surgical exploration in most cases, but some operations were performed after relatively long observation. Most injuries, including those in the colon, were treated with primary repair or resection. Decompressive colostomy or exteriorization were rarely performed. Deaths were mainly caused by other factors than the type of operation. The mortality rate (35%) was constant.
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| 8. |
- Bergqvist, D, et al.
(författare)
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Patients with abdominal trauma and fatal outcome: analysis of a 30-year series
- 1983
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Ingår i: Journal of Trauma. - 0022-5282. ; 23:6, s. 499-502
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Tidskriftsartikel (refereegranskat)abstract
- Patients with blunt abdominal trauma and fatal outcome during 30 years in a well-defined rural Swedish area have been analyzed. There were 127 patients. Several facts indicate that more severe trauma has been appearing more often during this period The mortality rate has, however, been stable, but the patients have become older. More patients die from pulmonary complications than from the trauma itself. One very important development is the significant decrease in mortality among children.
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| 9. |
- Bergqvist, D, et al.
(författare)
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Upper gastrointestinal trauma. Analysis of 45 cases of gastric, duodenal or pancreatic injury
- 1981
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Ingår i: Acta Chirurgica Scandinavica. - 0001-5482. ; 147:8, s. 637-643
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Tidskriftsartikel (refereegranskat)abstract
- Injuries to the upper gastrointestinal tract occurring over a 30-year period in a geographically well defined region were analyzed. The incidence was low in comparison with other abdominal injuries, but duodenal and pancreatic injuries were increasingly common in the study's last decade. The stomach injuries were mainly caused by penetrating trauma. The duodenal and pancreatic injuries most commonly resulted from road-traffic accidents. Two duodenal injuries were overlooked at the initial exploration, in which the duodenum was incompletely exposed. Anastomotic insufficiency occurred in one of the three patients who underwent duodenal resection. Most of the pancreatic injuries were contusions that could be managed with drainage. The pancreas was severely damaged in five patients, all of whom had multiple intra-abdominal injuries. Three of the five patients died before or during operation.
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| 10. |
- Claesson, B, et al.
(författare)
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Biliary microflora in acute cholecystitis and the clinical implications
- 1984
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Ingår i: Acta Chirurgica Scandinavica. - 0001-5482. ; 150:3, s. 229-237
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Tidskriftsartikel (refereegranskat)abstract
- A prospective bacteriologic investigation was made in 43 consecutive patients (mean age 63 years) operated on for acute cholecystitis. Gallbladder bile and wall were cultured, using four methods and with special attention to optimal anaerobic technique. Cultures were positive in 72% of the patients, yielding a wide variety of species (21 species among 48 isolates). Anaerobes constituted 23% of the isolates. Cultures from gallbladder bile and from gallbladder wall gave almost identical results, as did sampling at the beginning and at the end of cholecystectomy. Bactibilia was found in all patients operated on within 48 hours after the onset of symptoms. Bactibilia and postoperative septic complications showed statistically significant correlation with high patient age. Bactibilia and gallbladder gangrene were significantly correlated with preoperative temperature greater than 38.5 degrees C. There was coincidence of strains isolated from local wound sepsis and from peroperatively sampled gallbladder bile. Adequate preoperative or peroperative antibiotic therapy according to susceptibility testing was associated with significantly reduced rate of postoperative septic complications. The study indicates that bacteria are present early in the course of acute cholecystitis and that they are causally important for postoperative morbidity and mortality.
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| 11. |
- Claesson, B E, et al.
(författare)
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Microflora of the gallbladder related to duration of acute cholecystitis
- 1986
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Ingår i: Surgery Gynecology and Obstetrics. - 0039-6087. ; 162:6, s. 531-535
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Tidskriftsartikel (refereegranskat)abstract
- The microflora of the bile and wall of the gallbladder was prospectively investigated in 104 nonselected consecutive patients treated with early cholecystectomy for acute cholecystitis after an average hospital stay of 1.8 days. The chief purpose was to relate the findings of cultures to duration of the illness. Special attention was paid to anaerobic isolation techniques. The cultures yielded 107 strains, representing 36 species, with overall agreement between four different sampling procedures. Aerobic gram-negative rods predominated, followed by streptococci and anaerobes (48, 31 and 15 per cent, respectively). The incidence of positive culture results (always greater than or equal to 10(6) colon forming units per milliliter) was 81 per cent among the patients who underwent operation within two days from the onset of symptoms and 50 to 65 per cent after longer preoperative intervals. The shorter interval was significantly more often associated with growth solely of anaerobes (p = 0.03). Postoperative sepsis was caused by biliary bacteria and not related to preoperative duration of illness. Appropriate perioperative antibiotic coverage significantly reduced sepsis--3 versus 20 per cent (p = 0.05).
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| 12. |
- Claesson, B E, et al.
(författare)
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Selective cefuroxime prophylaxis following colorectal surgery based on intra-operative dipslide culture
- 1986
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Ingår i: British Journal of Surgery. - : Oxford University Press (OUP). - 1365-2168 .- 0007-1323. ; 73:12, s. 953-957
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Tidskriftsartikel (refereegranskat)abstract
- The concept of a very limited effective period for prophylactic antibiotic action was challenged in a prospective, controlled and randomized study featuring a simplified method for assessing the degree of contamination in the operative field during colorectal surgery. The 226 patients were given 1 g metronidazole IV on induction of anaesthesia and 12 h postoperatively. Following standardized saline irrigation of the abdominal cavity, a uriculture dipslide was dipped in the residual fluid just before abdominal closure. The dipslide was incubated for 18 h, and colony counts of coliforms and Staphylococcus aureus were made. The number of colony-forming units (CFU) was classified as 0, 1-4 or greater than or equal to 5 (n = 123, 33 and 70). The patients with CFU greater than or equal to 5 were randomized to receive cefuroxime (1.5 g IV/8 h for 2 days) or no more antibiotics. In the patients given only metronidazole, the incidence of postoperative infections rose with the colony counts (5.7, 9.1 and 41.2 per cent with CFU 0, 1-4 and greater than or equal to 5). Addition of cefuroxime reduced the 41.2 per cent infection rate to 8.3 per cent (P = 0.003). The method thus identified a high-risk group in which a short postoperative course of cefuroxime significantly lowered the rate of sepsis.
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| 13. |
- Dyrberg, Thomas, et al.
(författare)
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Humoral immunity in the spontaneously diabetic BB rat
- 1983
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Ingår i: Metabolism. - 0026-0495. ; 32:7 SUPPL. 1, s. 87-91
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Tidskriftsartikel (refereegranskat)abstract
- Litters of BB rats with an expected high and low incidence of insulin-dependent diabetes were followed from weaning until the age of about 140 days. Islet cell surface antibodies (ICSA) and lymphocyte antibodies (LA) were determined in a radioligand assay with fixed rat insulinoma (RIN 5F) cells, an insulin-secreting cell line, or spleen lymphocytes. In the low-incidence litter, 2 out of 14 rats had ICSA and LA; one showed insulitis at the end of the study. In the high-incidence litter, 3 out of 7 developed diabetes; all 3 showed ICSA at weaning. The remaining 4 showed insulitis. All 7 diabetes-susceptible rats had ICSA and LA at some time during the study. It is concluded that there is a high incidence of circulating ICSA and LA in the spontaneously diabetic BB rat. The antibodies can often be detected before the onset of diabetes, and may be implicated in the beta-cell destructive process and in the lymphocytopenia characteristic of the syndrome.
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| 14. |
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| 15. |
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| 16. |
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| 17. |
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| 18. |
- Larsson, Thomas B.
(författare)
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The Bronze Age metalwork in southern Sweden : aspects of social and spatial organization 1800-500 B.C.
- 1986
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The present work highlights the Bronze Age metalwork in Southern Sweden, deposited c. 1800-500 B.C., found as single finds or in burials and hoards.The main problem (or the questions posed to the metalwork data) has concerned the social context in which the bronze artefacts had their meaning and active function; aspects of social and spatial organization in particular.The metalwork data used for this purpose derive mainly from two sources/publications: Die ältere Metallzeit in Schweden I-II (1974-76) by Andreas Oldeberg and Die regionale und chronologische Einteilung der jüngeren Bronzezeit im Nordischen Kreis (1960) by Evert Baudou.Altogether approximately 5000 bronze artefacts are considered in this study. In order to analyze and interpret structures, patterns and regularities in societal terms in a given set of data, the first necessary procedure has been to define the socio-theoretical position taken. The interpretation of the social contexts in which the metalwork functioned during the Bronze Age is, consequently, a result of data and theory in combination.The analyses carried out by correlation and multivariate techniques indicate significant differences in the distribution of metalwork of various types in different regions in Southern Sweden during the six phases (periods) of the Bronze Age. The large-scale structures identified in this material are discussed in terms of social organization in space, territoriality and systems of exchange. Working with the Montelian six-period system a diachronic perspective on the processes of change and the regional developments is obtained.To study different principles of organization on a smaller geographical scale, three regional studies are also included (South Scania, Kalmar district, Östergötland) in which the metalwork is complemented by other types of archaeological data from the Bronze Age, such as graves, settlements and rock carvings.These case studies show that spatial patterns and principles of social organization can be inferred from archaeological data, in spite of later disturbances and varying degrees of land exploitation.The results also indicate that bronze artefacts like weapons, ornaments and tools had different functions in society, as utilitarian and/or symbolic objects, in the Swedish regions dealt with here, largely depending on the bronze supply situation and local socio-political conditions.At a general level the spatial distribution of hoard finds from the six chronological phases of the Bronze Age indicates changes in consumption rate of prestige goods, together with considerite differences between the regions under study.It appears as if the social conditions were in a state or rapid change during the last centuries of the Bronze Age, particularly in East and Central Sweden; a transformation of society portending the "dark" Pre-Roman Iron Age of Scandinavia.
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| 19. |
- Mätzsch, Thomas, et al.
(författare)
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Heparin-induced osteoporosis in rats
- 1986
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Ingår i: Thrombosis and Haemostasis. - 0340-6245. ; 56:3, s. 293-294
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Tidskriftsartikel (refereegranskat)abstract
- In order to study the effect of heparin in inducing osteoporosis, 30 female rats were divided in two groups and treated with daily injections of 2 IU heparin/g body weight for 33 and 65 days and compared with the same number of rats acting as controls. The mineral bone mass in the femora of the animals was measured quantitatively. A significant (p less than 0.001) reduction in bone mineral mass was found in the heparin-treated animals. This effect was present to the same degree after 33 days as after 65 days of treatment. It is concluded that heparin in this dose causes osteoporosis in rats after 33 days and that the described method can be used as an experimental model for further studies on this topic.
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| 20. |
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| 21. |
- Mätzsch, Thomas, et al.
(författare)
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Moped and motorcycle accidents--similarities and discrepancies
- 1986
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Ingår i: Journal of Trauma. - 0022-5282. ; 26:6, s. 538-543
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Tidskriftsartikel (refereegranskat)abstract
- Injury patterns and epidemiologic data from 211 moped accident victims and 214 motorcycle accident casualties admitted to hospital over a 5-year period (1977-1981) have been analyzed and compared. The number of those injured in motorcycle accidents tripled; the number of moped accident victims slightly decreased in the period studied. Differences in injury pattern, sex ratio, cause of accident, and age distribution were noted. Among mopedists, head injuries were more common but these injuries decreased significantly after the adoption of helmet use laws for mopedists also in 1978. There were more females involved in moped accidents and the mean age was considerably higher among mopedists. Of those injured in moped accidents, 21% were 60 years old or older and accounted for 56% of fatalities in this group. The most frequent cause of moped accidents was collision with a car, and over turning or running off the road in motorcycle accidents. The difference in injury severity was unexpectedly small, although there was a tendency toward more severe injuries in motorcyclists. Moped accidents are so similar to motorcycle accidents that it seems unjustified to regard mopeds as harmless 'bicycles with a helper motor.' The need for formal registration, driving license, and helmet use laws for mopeds is apparent.
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| 22. |
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| 25. |
- Risman, Per O., et al.
(författare)
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PRINCIPLES AND MODELS OF POWER DENSITY DISTRIBUTION IN MICROWAVE OVEN LOADS.
- 1987
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Ingår i: The Journal of microwave power and electromagnetic energy. - 0832-7823. ; 22:4, s. 193-198
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Tidskriftsartikel (refereegranskat)abstract
- Multi-mode cavity resonances are generally considered the most important phenomenon in transferring energy to the load in microwave ovens. There are, however, other important phenomena, caused by scattering and near-fields. This paper deals with the multi-mode resonant and some other important field types. Some main areas where sufficient knowledge is not available are described and main problems in applying simplified models are discussed.
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