| 1. |
- Lukasik, J., et al.
(författare)
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Discriminant analysis and secondary-beam charge recognition
- 2008
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 587:2-3, s. 413-419
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Tidskriftsartikel (refereegranskat)abstract
- The discriminant-analysis method has been applied to optimize the exotic-beam charge recognition in a projectile fragmentation experiment. The experiment was carried out at the GSI using the fragment separator (FRS) to produce and select the relativistic secondary beams, and the ALADIN setup to measure their fragmentation products following collisions with Sn target nuclei. The beams of neutron poor isotopes around La-124 and Sn-107 were selected to study the isospin dependence of the limiting temperature of heavy nuclei by comparing with results for stable Sn-124 projectiles. A dedicated detector to measure the projectile charge upstream of the reaction target was not used, and alternative methods had to be developed. The presented method, based on the multivariate discriminant analysis, allowed to increase the efficacy of charge recognition up to about 90%, which was about 20% more than achieved with the simple scalar methods.
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| 2. |
- Trautmann, W., et al.
(författare)
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Isotopic dependence of the caloric curve
- 2009
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Ingår i: Progress in Particle and Nuclear Physics. - : Elsevier BV. - 0146-6410. ; 62:2, s. 407-412
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Tidskriftsartikel (refereegranskat)abstract
- Isotopic effects in projectile fragmentation at relativistic energies have been studied with the ALADIN forward spectrometer at SIS. Stable and radioactive Sn and La beams with an incident energy of 600 MeV per nucleon have been used in order to explore a wide range of isotopic compositions. Chemical freeze-out temperatures are found to be nearly invariant with respect to the A/Z ratio of the produced spectator sources, consistent with predictions for expanded systems. Consequences for the proposed interpretation of chemical breakup temperatures as representing the limiting temperatures predicted by microscopic models are discussed. (C) 2009 Elsevier B.V. All rights reserved.
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| 3. |
- Klug, Stefanie J, et al.
(författare)
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TP53 codon 72 polymorphism and cervical cancer : a pooled analysis of individual data from 49 studies
- 2009
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Ingår i: The Lancet Oncology. - 1470-2045 .- 1474-5488. ; 10:8, s. 772-784
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Cervical cancer is caused primarily by human papillomaviruses (HPV). The polymorphism rs1042522 at codon 72 of the TP53 tumour-suppressor gene has been investigated as a genetic cofactor. More than 80 studies were done between 1998 and 2006, after it was initially reported that women who are homozygous for the arginine allele had a risk for cervical cancer seven times higher than women who were heterozygous for the allele. However, results have been inconsistent. Here we analyse pooled data from 49 studies to determine whether there is an association between TP53 codon 72 polymorphism and cervical cancer. METHODS: Individual data on 7946 cases and 7888 controls from 49 different studies worldwide were reanalysed. Odds ratios (OR) were estimated using logistic regression, stratifying by study and ethnic origin. Subgroup analyses were done for infection with HPV, ethnic origin, Hardy-Weinberg equilibrium, study quality, and the material used to determine TP53 genotype. FINDINGS: The pooled estimates (OR) for invasive cervical cancer were 1.22 (95% CI 1.08-1.39) for arginine homozygotes compared with heterozygotes, and 1.13 (0.94-1.35) for arginine homozygotes versus proline homozygotes. Subgroup analyses showed significant excess risks only in studies where controls were not in Hardy-Weinberg equilibrium (1.71 [1.21-2.42] for arginine homozygotes compared with heterozygotes), in non-epidemiological studies (1.35 [1.15-1.58] for arginine homozygotes compared with heterozygotes), and in studies where TP53 genotype was determined from tumour tissue (1.39 [1.13-1.73] for arginine homozygotes compared with heterozygotes). Null results were noted in studies with sound epidemiological design and conduct (1.06 [0.87-1.29] for arginine homozygotes compared with heterozygotes), and studies in which TP53 genotype was determined from white blood cells (1.06 [0.87-1.29] for arginine homozygotes compared with heterozygotes). INTERPRETATION: Subgroup analyses indicated that excess risks were most likely not due to clinical or biological factors, but to errors in study methods. No association was found between cervical cancer and TP53 codon 72 polymorphism when the analysis was restricted to methodologically sound studies.
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| 4. |
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| 5. |
- Fransson, Åsa, 1971, et al.
(författare)
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A new parameter to assess hydromechanical effects in single-hole hydraulic testing and grouting
- 2007
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Ingår i: International Journal of Rock Mechanics and Minings Sciences. - : Elsevier BV. - 1365-1609. ; 44:7, s. 1011-1021
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Tidskriftsartikel (refereegranskat)abstract
- Grouting or filling of the open voids in fractured rock is done by introducing a fluid (grout) through boreholes under pressure. The grout may be either a Newtonian fluid or a Bingham fluid. The penetration of the grout and the resulting pressure profile may give rise to hydromechanical effects, which depend on factors such as the fracture aperture, the pressure at the borehole, and the rheological properties of the grout. In this paper, we postulate that a new parameter, Å, which is the areal integral of the fluid pressure change over the fracture plane, is an appropriate measure to describe the change in fracture aperture volume due to a change in effective stress. In many cases, analytic expressions are available to calculate pressure profiles and the Å parameter. The approach is verified using a fully coupled hydromechanical simulator for the case of a Newtonian fluid. Results of the verification exercise show that the new approach is reasonable and that the Å parameter is a good measure for the fracture volume change: i.e., the larger the Å parameter, the larger the fracture volume change, in an almost linear fashion. To demonstrate the application of the approach, short duration hydraulic tests and constant pressure grouting are studied. It is concluded that using analytic expressions for penetration lengths and pressure profiles to calculate the Å parameter provides a possibility to describe a complex situation and compare, discuss and weigh the impact of hydromechanical couplings for different alternative grouting strategies. Further, the analyses identify an effect of high-pressure grouting, that of uncontrolled grouting of larger fractures and insufficient (or less-than-expected) sealing of finer fractures under certain grouting conditions. © 2007 Elsevier Ltd. All rights reserved.
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| 6. |
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| 7. |
- Min, Ki-Bok, et al.
(författare)
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Thermally induced mechanical and permeability changes around a nuclear waste repository - a far-field study based on equivalent properties determined by a discrete approach
- 2005
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Ingår i: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 42:5-6, s. 765-780
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Tidskriftsartikel (refereegranskat)abstract
- A numerical investigation is conducted on the impacts of the thermal loading history on the evolution of mechanical response and permeability field of a fractured rock mass containing a hypothetical nuclear waste repository. The geological data are extracted from the site investigation results at Sellafield, England. A combined methodology of discrete and continuum approaches is presented. The results of a series of simulations based on the DFN-DEM (discrete fracture network-distinct element method) approach provide the mechanical and hydraulic properties of fractured rock masses, and their stress-dependencies. These properties are calculated on a representative scale that depends on fracture network characteristics and constitutive models of intact rock and fractures. In the present study, data indicate that the large scale domain can be divided into four regions with different property sets corresponding to the depth. The results derived by the DFN-DEM approach are then passed on to a large-scale analysis of the far-field problem for the equivalent continuum analysis. The large-scale far-field analysis is conducted using a FEM code, ROCMAS for coupled thermo-mechanical process. The results show that the thermal stresses of fractured rock masses vary significantly with mechanical properties determined at the representative scale. Vertical heaving and horizontal tensile displacement are observed above the repository. Observed stress and displacement fields also shows significant dependency on how the mechanical properties are characterized. The permeability changes induced by the thermal loading show that it generally decreases close to the repository. However, change of permeability is small, i.e., a factor of two, and thermally induced dilation of fracture was not observed. Note that the repository excavation effects were not considered in the study. The work presented in this paper is the result of efforts on a benchmark test (BMT2) within the international co-operative projects DECOVALEX III and BENCHPAR.
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| 8. |
- Rutqvist, J., et al.
(författare)
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A numerical study of THM effects on the near-field safety of a hypothetical nuclear waste repository - BMT1 of the DECOVALEX III project. Part 3 : Effects of THM coupling in sparsely fractured rocks
- 2005
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Ingår i: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 42:5-6, s. 745-755
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Tidskriftsartikel (refereegranskat)abstract
- As a part of the international DECOVALEX III project, and the European BENCHPAR project, the impact of thermal-hydrological-mechanical (THM) couplings on the performance of a bentonite-back-filled nuclear waste repository in near-field crystalline rocks is evaluated in a Bench-Mark Test problem (BMT1) and the results are presented in a series of three companion papers in this issue. This is the third paper with focuses on the effects of THM processes at a repository located in a sparsely fractured rock. Several independent coupled THM analyses presented in this paper show that THM couplings have the most significant impact on the mechanical stress evolution, which is important for repository design, construction and post-closure monitoring considerations. The results show that the stress evolution in the bentonite-back-filled excavations and the surrounding rock depends on the post-closure evolution of both fields of temperature and fluid pressure. It is further shown that the time required to full resaturation may play an important role for the mechanical integrity of the repository drifts. In this sense, the presence of hydraulically conducting fractures in the near-field rock might actually improve the mechanical performance of the repository. Hydraulically conducting fractures in the near-field rocks enhances the water supply to the buffers/back-fills, which promotes a more timely process of resaturation and development of swelling pressures in the back-fill, thus provides timely confining stress and support to the rock walls. In one particular case simulated in this study, it was shown that failure in the drift walls could be prevented if the compressive stresses in back-fill were fully developed within 50 yr, which is when thermally induced rock strain begins to create high differential (failure-prone) stresses in the near-field rocks. Published by Elsevier Ltd.
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| 9. |
- Tsang, C. F., et al.
(författare)
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The DECOVALEX III project : A summary of activities and lessons learned
- 2005
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Ingår i: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 42:5-6, s. 593-610
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Tidskriftsartikel (refereegranskat)abstract
- Initiated in 1992, the DECOVALEX project is an international collaboration for advancing the understanding and modeling of coupled thermo-hydro-mechanical (THM) processes in geologic systems. The project has made important scientific achievements through three stages and is progressing in its fourth stage. It has played a key role in the development of mathematical modeling and in situ testing of coupled THM processes in fractured rock and buffer/backfill materials, a subject of importance for performance assessment of radioactive waste geologic repositories. This paper summarizes studies under the most recent stage of the project, DECOVALEX III (2000-2003). These studies include those of two major field experiments: (a) the FEBEX experiment at Grimsel, Switzerland, investigating coupled THM processes in a crystalline rock-bentonite system, and (b) the Drift Scale Test (DST) experiment at Yucca Mountain, Nevada, investigating coupled THM processes in unsaturated tuff. These are two of the largest multiyear heater tests undertaken to date for the study of coupled THM processes in geological systems. In addition, three so-called benchmark tests are also studied to evaluate the impact of coupled THM processes under different scenarios and geometries. Within the DECOVALEX project, multiple research teams participated in each of the studies, using different approaches and computer codes. Comparisons of results have provided insight into coupled THM processes, which in turn has stimulated further development of our modeling capabilities. Lessons learned from these studies are discussed. The scientific advances and enhanced insight gained through this kind of international cooperation illustrate the effectiveness of the DECOVALEX project.
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| 10. |
- Tsang, S W Y, et al.
(författare)
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Ten-year fracture probability in Hong Kong Southern Chinese according to age and BMD femoral neck T-scores
- 2009
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Ingår i: Osteoporosis International. - : Springer Science and Business Media LLC. - 0937-941X .- 1433-2965. ; 20:11, s. 1939-45
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Tidskriftsartikel (refereegranskat)abstract
- This study estimated the 10-year probability of osteoporotic fracture in Hong Kong Southern Chinese based on a simplified model of the recently developed WHO fracture risk prediction tool (FRAX). Thus, the data provides further insights into potential development of a population-specific FRAX model for Hong Kong in the future. INTRODUCTION: The purpose of this paper was to estimate the 10-year probability of osteoporotic fracture in Hong Kong (HK) Southern Chinese according to age and bone mineral density (BMD) T-score at the femoral neck based on the methodology of the FRAX risk assessment tool calibrated to the epidemiology of HK. METHODS: Hip fracture data was obtained from the Clinical Data Analysis Reporting System (CDAS) of the Hospital Authority of HK and population size and death rates were taken from the HK Government Census and Statistics Department. Fracture probability was calculated using the cut-off values for T-scores derived from the NHANES III data for Caucasian women aged 20-29 years for BMD at the femoral neck. RESULTS: In this study, the 10-year probability of osteoporotic fracture in HK Southern Chinese increased markedly with increasing age and decreasing femoral neck BMD T-scores in both women and men. Interestingly, at low T-scores, the increase in 10-year probability of osteoporotic fracture in women with age was greater than in men. Fracture probabilities were substantially higher than those from mainland China. CONCLUSIONS: Based on this evidence, and until we have HK Southern Chinese population-specific information, we recommend the application of the Caucasian risk profile to calculate the absolute fracture risk for HK Southern Chinese subjects.
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| 11. |
- Yoo, S. J. B., et al.
(författare)
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Spectral phase encoded time spread optical code division multiple access technology for next generation communication networks Invited
- 2007
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Ingår i: Journal of Optical Networking. - 1536-5379. ; 6:10, s. 1210-1227
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Tidskriftsartikel (refereegranskat)abstract
- We overview and summarize the progress of the spectral phase encoded time spreading (SPECTS) optical code division multiple access (O-CDMA) technology. Recent progress included a demonstration of a 320 Gbit/s (32-user x 10 Gbit/s) all-optical passive optical network testbed based on the SPECTS O-CDMA technology and a theoretical prediction of the spectral efficiency at 100% and above. In particular, InP-based integrated photonics allows implementation of SPECTS O-CDMA transmitters and receivers monolithically integrated on a chip. The integrated InP chip technology not only allows robust and compact configurations for practical and low-cost O-CDMA network deployments but also offers code reconfigurations at rapid rates for secure communication applications.
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