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COOL AMI EU pilot t...
COOL AMI EU pilot trial : A multicentre, prospective, randomised controlled trial to assess cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction
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- Noc, Marko (författare)
- University Medical Centre Ljubljana
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- Erlinge, David (författare)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Neskovic, Aleksandar N. (författare)
- University of Belgrade
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- Kafedzic, Srdjan (författare)
- University of Belgrade
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- Merkely, Béla (författare)
- Semmelweis University
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- Zima, Endre (författare)
- Semmelweis University
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- Fister, Misa (författare)
- University Medical Centre Ljubljana
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- Petrović, Milovan (författare)
- University of Novi Sad
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- Čanković, Milenko (författare)
- University of Novi Sad
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- Veress, Gábor (författare)
- State Hospital for Cardiology in Balatonfüred
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- Laanmets, Peep (författare)
- North Estonia Medical Centre
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Pern, Teele (författare)
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- Vukcevic, Vladan (författare)
- Clinical Center of Serbia
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Dedovic, Vladimir (författare)
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- Średniawa, Beata (författare)
- Medical University of Silesia
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- Światkowski, Andrzej (författare)
- Medical University of Silesia
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- Keeble, Thomas R. (författare)
- Anglia Ruskin University
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- Davies, John R. (författare)
- Anglia Ruskin University
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- Warenits, Alexandra Maria (författare)
- Medical University of Vienna
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- Olivecrona, Göran (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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Peruga, Jan Zbigniew (författare)
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Ciszewski, Michal (författare)
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- Horvath, Ivan (författare)
- University of Pécs
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Edes, Istvan (författare)
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Nagy, Gergely Gyorgy (författare)
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Aradi, Daniel (författare)
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- Holzer, Michael (författare)
- Medical University of Vienna
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(creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: EuroIntervention. - 1774-024X. ; 13:5, s. 531-539
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.4...
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Abstract
Ämnesord
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- Aims: We aimed to investigate the rapid induction of therapeutic hypothermia using the ZOLL Proteus Intravascular Temperature Management System in patients with anterior ST-elevation myocardial infarction (STEMI) without cardiac arrest. Methods and results: A total of 50 patients were randomised; 22 patients (88%; 95% confidence interval [CI]: 69-97%) in the hypothermia group and 23 patients (92%; 95% CI: 74-99) in the control group completed cardiac magnetic resonance imaging at four to six days and 30-day follow-up. Intravascular temperature at coronary guidewire crossing after 20.5 minutes of endovascular cooling decreased to 33.6°C (range 31.9-35.5°C). There was a 17-minute (95% CI: 4.6-29.8 min) cooling-related delay to reperfusion. In "per protocol" analysis, median infarct size/left ventricular mass was 16.7% in the hypothermia group versus 23.8% in the control group (absolute reduction 7.1%, relative reduction 30%; p=0.31) and median left ventricular ejection fraction (LVEF) was 42% in the hypothermia group and 40% in the control group (absolute reduction 2.4%, relative reduction 6%; p=0.36). Except for self-terminating paroxysmal atrial fibrillation (32% versus 8%; p=0.074), there was no excess of adverse events in the hypothermia group. Conclusions: We rapidly and safely cooled patients with anterior STEMI to 33.6°C at the time of coronary guidewire crossing. This is ≥1.1°C lower than in previous cooling studies. Except for self-terminating atrial fibrillation, there was no excess of adverse events and no clinically important cooling-related delay to reperfusion. A statistically non-significant numerical 7.1% absolute and 30% relative reduction in infarct size warrants a pivotal trial powered for efficacy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Femoral
- Other technique
- ST-elevation myocardial infarction (STEMI)
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- Av författaren/redakt...
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Noc, Marko
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Erlinge, David
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Neskovic, Aleksa ...
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Kafedzic, Srdjan
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Merkely, Béla
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Zima, Endre
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visa fler...
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Fister, Misa
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Petrović, Milova ...
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Čanković, Milenk ...
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Veress, Gábor
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Laanmets, Peep
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Pern, Teele
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Vukcevic, Vladan
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Dedovic, Vladimi ...
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Średniawa, Beata
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Światkowski, And ...
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Keeble, Thomas R ...
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Davies, John R.
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Warenits, Alexan ...
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Olivecrona, Göra ...
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Peruga, Jan Zbig ...
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Ciszewski, Micha ...
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Horvath, Ivan
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Edes, Istvan
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Nagy, Gergely Gy ...
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Aradi, Daniel
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Holzer, Michael
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och Klinisk medicin
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EuroIntervention
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