| 1. |
- Månsson, Jonas, et al.
(författare)
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COVID-19 Across Professions - Infection, Hospitalisation, and ICU Patterns in a Swedish County
- 2024
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Ingår i: Journal of Occupational and Environmental Medicine. - : Lippincott Williams & Wilkins. - 1076-2752 .- 1536-5948.
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To study infection, hospitalisation, and admission to ICU for COVID-19 in different occupations and pandemic waves in a Swedish county.METHODS: Individual registry data of infection and hospitalisation were merged with occupational data in, this cross-sectional study. Infected, hospital- and ICU-admission were analysed by occupational groups.RESULTS: 22,095 cases of COVID-19 from 21 February 2021 to 31 August 2022 were identified. Healthcare workers and others working in close physical proximity showed a higher rate of confirmed COVID-19 infections in all waves and higher risk for hospital admission early in the pandemic. Exposure to diseases and physical proximity played a decisive role.CONCLUSION: Workers in close-contact occupations experienced a higher rate of confirmed infections throughout the pandemic and higher hospitalisation rates in the first pandemic wave, suggesting a need for more effective initial safety measures in a future pandemic.
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| 2. |
- Andersson, Lena, 1965-, et al.
(författare)
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Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in the Swedish hard metal industry, in particular to cobalt
- 2021
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Ingår i: Biomarkers. - : Taylor & Francis. - 1354-750X .- 1366-5804. ; 26:6, s. 557-569
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To study the relationship between inhalation of airborne particles and cobalt in the Swedish hard metal industry and markers of inflammation and coagulation in blood.Methods: Personal sampling of inhalable cobalt and dust were performed for subjects in two Swedish hard metal plants. Stationary measurements were used to study concentrations of inhalable, respirable, and total dust and cobalt, PM10 and PM2.5, the particle surface area and the particle number concentrations. The inflammatory markers CC16, TNF, IL-6, IL-8, IL-10, SAA and CRP, and the coagulatory markers FVIII, vWF, fibrinogen, PAI-1 and D-dimer were measured. A complete sampling was performed on the second or third day of a working week following a work-free weekend, and additional sampling was taken on the fourth or fifth day. The mixed model analysis was used, including covariates.Results: The average air concentration of inhalable dust and cobalt were 0.11 mg/m3 and 0.003 mg/m3, respectively. For some mass-based exposure measures of cobalt and total dust, statistically significant increased levels of FVIII, vWF and CC16 were found.Conclusions: The observed relationships between particle exposure and coagulatory biomarkers may indicate an increased risk of cardiovascular disease.
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| 3. |
- Andersson, Lena, 1965-, et al.
(författare)
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Respiratory Health and Inflammatory Markers : Exposure to Cobalt in the Swedish Hard Metal Industry
- 2020
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Ingår i: Journal of Occupational and Environmental Medicine. - : Lippincott Williams & Wilkins. - 1076-2752 .- 1536-5948. ; 62:10, s. 820-829
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To study the relationship between inhalable dust and cobalt and respiratory symptoms, lung function, exhaled nitric oxide in expired air and CC16 in the Swedish hard metal industry.METHODS: Personal sampling of inhalable dust and cobalt, medical examination including blood sampling was performed for 72 workers. Exposure-response relationships was determined using logistic, linear and mixed model analysis.RESULTS: The average inhalable dust and cobalt concentrations were 0.079 and 0.0017 mg/m, respectively. Statistically significant increased serum levels of CC16 were determined when the high and low cumulative exposures for cobalt were compared. Non-significant exposure-response relationships was observed between cross-shift inhalable dust or cobalt exposures and asthma, nose dripping and bronchitis.CONCLUSIONS: Our findings suggest an exposure-response relationship between inhalable cumulative cobalt exposure and CC16 levels in blood, which may reflect an injury or a reparation process in the lungs.
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| 4. |
- Andersson, Lena, 1965-, et al.
(författare)
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Silica Exposure and Cardiovascular, Cerebrovascular, and Respiratory Morbidity in a Cohort of Male Swedish Iron Foundry Workers
- 2023
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Ingår i: Journal of Occupational and Environmental Medicine. - : Lippincott Williams & Wilkins. - 1076-2752 .- 1536-5948. ; 65:9, s. 731-739
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we present quantitative exposure-response data on silica exposure in male Swedish iron foundry workers receiving inpatient care for cardiovascular, cerebrovascular, and respiratory morbidity. The study show a significantly increased COPD risk at cumulative silica exposures that correspond to TWA silica below the Swedish OEL of 0.1 mg/m3. ObjectiveWe present quantitative exposure-response data on silica exposure in male Swedish iron foundry workers for cardiovascular, cerebrovascular, and respiratory morbidity.MethodsThis research is a cohort study of 2063 male Swedish iron foundry workers. From the Swedish National Patient Registers, data on morbidity incidence were retrieved. A historical measurement database of 1667 respirable silica exposure measurements from 10 Swedish iron foundries was used to calculate the cumulative exposure dose for each worker.ResultsIncreased morbidity risk for the whole group of foundry workers was determined for ischemic heart disease, cerebrovascular disease, chronic obstructive pulmonary disease (COPD), bronchitis, and pneumonia. In addition, an increased risk for COPD at cumulative silica exposures ranging from 0.11 to 0.84 mg/m3 year is presented.ConclusionsThe study presents a significantly increased COPD risk at cumulative silica exposures below the Swedish occupational exposure limit.
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| 5. |
- Edström, Håkan, et al.
(författare)
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Between the eagle and the bear : Explaining the alignment strategies of the Nordic countries in the 21st century
- 2020
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Ingår i: Comparative Strategy. - : Informa UK Limited. - 0149-5933 .- 1521-0448. ; 39:2, s. 191-208
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Tidskriftsartikel (refereegranskat)abstract
- This article shows that all four Nordic countries, i.e., Denmark, Finland, Norway and Sweden, have adjusted their alignment strategies when responding to the changes in their external environment during the twenty-first century. Furthermore, our findings indicate a great diversity among the four states in their responses. All too often, security policy analyses cluster small states into allies and non-allies, respectively. However, this article suggests that alliance affiliation in isolation is not sufficient for explaining small states’ behavior and adjustments of their strategies. Occasionally, previous experiences of armed conflicts as well as perceptions of strategic exposure provide stronger explanatory power.
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| 6. |
- Edström, Håkan, et al.
(författare)
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Comparative Strategy – A New Framework for Analysis
- 2023
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Ingår i: Comparative Strategy. - : Informa UK Limited. - 0149-5933 .- 1521-0448. ; 42:1, s. 80-102
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Tidskriftsartikel (refereegranskat)abstract
- Scholars of Strategic Studies have seldom problematized the concept of military strategy beyond identifying the three elements constituting the phenomenon, that is ends, means and ways. Moreover, we see a need for contextualizing the presumably universal conceptualization of military strategy. This article contributes to previous research by operationalize each of the three elements one-step further, thereby introducing an analytical framework for systematic comparisons of states’ different priorities regarding military strategy. Additionally, in order to explain these different priorities, the proposed analytical framework introduces tools related to both relative power and position in the international system, and to regional systems and unit-level characteristics. The usefulness of the analytical framework is illustrated by a summary of some of our findings from a research project on comparative strategy including more than 30 states.
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| 7. |
- Edström, Håkan, et al.
(författare)
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Enighetens gränser : Konsensus eller konfrontation vid utformningen av den svenska försvarspolitiken?
- 2023
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Ingår i: Statsvetenskaplig Tidskrift. - 0039-0747. ; 125:3
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Tidskriftsartikel (refereegranskat)abstract
- The limits of unity: Consensus or confrontation in shaping Swedish defence policyHow encompassing is the consensus among the political parties represented in the Swedish parliament when it comes to the military threat from Russia, the relations with NATO and the design of the Swedish Armed Forces? This article aims at answering this question by exploring the Swedish defence policy from the Russian war against Georgia in 2008 to the ongoing war in Ukraine. Our results indicate that the consensus among the parties increases with the escalation of the tensions in the international relations. Hence, we disagree with some results of previous research on Swedish security politics. We conclude that the tipping point regarding the Swedish application for NATO-membership was the existential dimension of the current Russian aggression. When the internal efforts to defend Sweden against a potential Russian attack was perceived not being enough, applying for membership was considered a necessity, not an option, among a majority of the parties.
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| 8. |
- Edström, Håkan, et al.
(författare)
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Military Strategies of the New European Allies : A Comparative Study
- 2022
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Bok (refereegranskat)abstract
- This book analyses how and to what extent ex-communist states have adjusted their defence strategies since joining the EU and NATO, and how differences and similarities between their strategies can be explained.Between 1999 and 2013, four phases of enlargement took place when the European Union (EU) and NATO allowed 11 new former communist states to enter both organisations. These states share some common attributes and experiences related to strategic culture and common experiences during the Cold War era that can potentially explain similarities in behaviour and preferences among them. However, the strategic adjustments among these states are far from uniform. In an effort to explain these differences, the book introduces three intervening variables: (1) differences in relative power and position in the international system, (2) national geographical characteristics; and (3) historical experiences related to formative periods of state-building processes as well as wars and armed conflicts. Empirically, the book strives to present and analyse the defence strategies of each of the new allies by conducting a structured focused comparison of official strategic documents from the twenty-first century for each of the 11 cases. Theoretically and methodologically, it introduces an analytical framework enabling us to explain both similarities and differences in the formulation of the strategies of the 11 states, and to shed light on their external and internal efforts to promote their strategic interest by operationalising the dependent variable - defence strategy. The analytical framework combines elements of structural realism with classical realism, and constructivist research on unit-level characteristics related to relative power and perceptions of strategic exposure.This book will be of much interest to students of strategic studies, European Union policy, NATO and International Relations in general.
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| 9. |
- Edström, Håkan, et al.
(författare)
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Military Strategy of Great Powers : Managing Power Asymmetry and Structural Change in the 21st Century
- 2022
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Bok (refereegranskat)abstract
- This book explores the military strategies of the five system-determining great powers during the twenty-first century.The book’s point of departure is that analyses of countries’ defence strategies should acknowledge that states come in various shapes and sizes and that their strategic choices are affected by their perceptions of their position in the international system and by power asymmetries between more and less resourceful states. This creates diversity in strategies that is often overlooked in theoretically oriented analyses. The book examines how five major powers – the United States, China, the United Kingdom, France and Russia – have adjusted their strategies to improve or maintain their relative position and to manage power asymmetries during the twenty-first century. It also develops and applies an analytical framework for exploring and categorising the strategies pursued by the five major powers which combine elements of structural realism with research on power transition theory and status competition. The concluding chapter addresses questions related to stability and change in the present international system.
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| 10. |
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| 11. |
- Edström, Håkan, et al.
(författare)
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READY OR NOT? Explaining military strategic diversity among NATOs new European allies
- 2023
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Ingår i: The Journal of Slavic Military Studies. - 1351-8046 .- 1556-3006. ; 36:3
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Tidskriftsartikel (refereegranskat)abstract
- This article explores the defense transformation processes during the two initial decades of the twenty-first century among the 11 former communist states that currently are members of both the European Union (EU) and North Atlantic Treaty Organization (NATO). The article introduces an analytical framework for systematic comparisons of states’ priorities regarding military strategy. Moreover, the article evaluates the influence of two intervening variables: (i) differences in relative power between middle powers and small states and (ii) differences in geographical exposure. Our findings suggest that differences related to these intervening variables correlate with differences in prioritized strategic ends, means, and ways.
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| 12. |
- Edström, Håkan, et al.
(författare)
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The alignment strategies of great powers : Managing power asymmetries and structural changes in the international system
- 2022
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Ingår i: Comparative Strategy. - : Informa UK Limited. - 0149-5933 .- 1521-0448. ; 41:1, s. 97-119
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Tidskriftsartikel (refereegranskat)abstract
- AbstractThe article aims to contribute to previous research in two main ways. First, we intervene in the debate on the stability of the present unipolar system by offering an analytical framework and an empirical approach for exploring and categorizing the actual strategies pursued by the major powers in the contemporary international system. In doing so, we present an analysis of how the strategies of the five system-determining states interact and affect the stability of the system. Second, in order to be able to explain why states pursue different strategies, we complement the analytical framework of structural realism with insights from research on Power Transition Theory (PTT). Hereby, we offer a new comprehensive theoretical approach for analyzing how asymmetric power relations affect strategic choices of major powers.
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| 13. |
- Edström, Håkan, et al.
(författare)
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The defense strategies of middle powers : Competing for security, influence and status in an era of unipolar demise
- 2020
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Ingår i: Comparative Strategy. - : Informa UK Limited. - 0149-5933 .- 1521-0448. ; 39:2, s. 171-190
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Tidskriftsartikel (refereegranskat)abstract
- Do middle powers develop similar defense strategies? Is middle powers a useful category for exploring the diversity of strategies among different categories of states? This article presents a great variation of strategies among the selected cases. Concurrently, similarities between middle powers belonging to similar regional security complexes (RSC) are revealed. The higher degree of great power penetration into a RSC, the lesser options for middle powers to develop individual strategies and vice versa. Furthermore, by comparing our findings with the strategies of more and less resourceful states, common elements among middle powers in terms of ends, means and ways, appear.
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| 14. |
- Hedbrant, Alexander, 1987-, et al.
(författare)
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Effects on white blood cell counts and the NLRP3 inflammasome due to dust and cobalt exposure in the hard metal industry
- 2022
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Ingår i: Biomarkers. - : Taylor & Francis. - 1354-750X .- 1366-5804. ; , s. 60-70
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: In light of potential negative health effects of cobalt exposure, a characterization of inflammatory mechanisms in exposed individuals is warranted. The current study investigated cobalt exposure in the Swedish hard metal industry and its relationship to inflammatory markers, including NLRP3 inflammasome activation and white blood cell (WBC) counts.MATERIAL AND METHODS: Inhalable cobalt and dust exposures, and systemic cobalt levels, were determined for 72 workers in the hard metal industry and linear regression models were applied to correlate exposure to markers of inflammasome activation and WBC counts.RESULTS: Mean exposures to inhalable dust (0.11 mg/m3) and cobalt (0.0034 mg/m3) were below the Swedish occupational exposure limits, and these low exposures did not correlate with any investigated outcomes. Instead, cobalt blood levels significantly correlated with a ca 10% decrease in IL-18 plasma levels per 10 nM cobalt increase. Furthermore, pre-shift cobalt blood and/or urine levels significantly correlated with some WBC measures, including decreased neutrophil-to-lymphocyte ratio, increased lymphocyte-to-monocyte ratio, and lymphocyte counts.CONCLUSION: The low inhalable particle exposures had no impact on WBC counts and inflammasome activation. Instead, systemic cobalt levels, which also include skin exposure, demonstrated possible suppressive effects on inflammatory responses in cobalt-exposed individuals in the hard metal industry.
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| 15. |
- Hedbrant, Alexander, Ph.D, 1987-, et al.
(författare)
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Occupational quartz and particle exposure affect systemic levels of inflammatory markers related to inflammasome activation and cardiovascular disease
- 2023
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Ingår i: Environmental Health. - : BioMed Central (BMC). - 1476-069X. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The inflammatory responses are central components of diseases associated with particulate matter (PM) exposure, including systemic diseases such as cardiovascular diseases (CVDs). The aim of this study was to determine if exposure to PM, including respirable dust or quartz in the iron foundry environment mediates systemic inflammatory responses, focusing on the NLRP3 inflammasome and novel or established inflammatory markers of CVDs.METHODS: The exposure to PM, including respirable dust, metals and quartz were determined in 40 foundry workers at two separate occasions per worker. In addition, blood samples were collected both pre-shift and post-shift and quantified for inflammatory markers. The respirable dust and quartz exposures were correlated to levels of inflammatory markers in blood using Pearson, Kendall τ and mixed model statistics. Analyzed inflammatory markers included: 1) general markers of inflammation, including interleukins, chemokines, acute phase proteins, and white blood cell counts, 2) novel or established inflammatory markers of CVD, such as growth/differentiation factor-15 (GDF-15), CD40 ligand, soluble suppressor of tumorigenesis 2 (sST2), intercellular/vascular adhesion molecule-1 (ICAM-1, VCAM-1), and myeloperoxidase (MPO), and 3) NLRP3 inflammasome-related markers, including interleukin (IL)-1β, IL-18, IL-1 receptor antagonist (IL-1Ra), and caspase-1 activity.RESULTS: The average respirator adjusted exposure level to respirable dust and quartz for the 40 foundry workers included in the study was 0.65 and 0.020 mg/m3, respectively. Respirable quartz exposure correlated with several NLRP3 inflammasome-related markers, including plasma levels of IL-1β and IL-18, and several caspase-1 activity measures in monocytes, demonstrating a reverse relationship. Respirable dust exposure mainly correlated with non-inflammasome related markers like CXCL8 and sST2. CONCLUSIONS: The finding that NLRP3 inflammasome-related markers correlated with PM and quartz exposure suggest that this potent inflammatory cellular mechanism indeed is affected even at current exposure levels in Swedish iron foundries. The results highlight concerns regarding the safety of current exposure limits to respirable dust and quartz, and encourage continuous efforts to reduce exposure in dust and quartz exposed industries.
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| 16. |
- Hedbrant, Alexander, 1987-, et al.
(författare)
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Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers
- 2020
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Ingår i: Mediators of Inflammation. - : Hindawi Publishing Corporation. - 0962-9351 .- 1466-1861.
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To study the association between inhalation of particulate matter or quartz in Swedish iron foundries and the effects on NLRP3 inflammasome activation. Methods: Particle exposure measurements were performed during an eight-hour work day for 85 foundry workers at three Swedish iron foundries. Personal sampling was used for measurement of respirable quartz and dust and stationary measurements to obtain exposure measurements for inhalable dust and PM10. The NLRP3 inflammasome markers, interleukin- (IL-) 1β and IL-18, and inhibitors IL-1 receptor antagonist (IL-1Ra) and IL-18 binding protein (IL-18BP) were measured in plasma. Inflammasome activation was measured by caspase-1 enzymatic activity in monocytes in whole blood by flow cytometry, and expression of inflammasome-related genes was quantified using real-time PCR. Multiple linear regression analysis was used to investigate associations between PM exposures and inflammatory markers. Sex, age, smoking, current infection, BMI, and single nucleotide polymorphism in the inflammasome regulating genes CARD8 (C10X) and NLRP3 (Q705K) were included as covariates. Results: The average exposure levels of respirable dust and quartz were 0.85 and 0.052 mg/m3, respectively. A significant exposure-response was found for respirable dust and IL-18 and for inhalable dust and IL-1Ra. Whole blood, drawn from study participants, was stimulated ex vivo with inflammasome priming stimuli LPS or Pam3CSK4, resulting in a 47% and 49% increase in caspase-1 enzymatic activity in monocytes. This increase in caspase-1 activity was significantly attenuated in the higher exposure groups for most PM exposure measures. Conclusions: The results indicate that exposure levels of PM in the iron foundry environment can affect the NLRP3 inflammasome and systemic inflammation.
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| 17. |
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| 18. |
- Klasson, Maria, 1977-
(författare)
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Cobalt in the hard metal production industry : exposure via inhalation and skin and the inflammatory response in human keratinocytes
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Cobalt is a strong sensitizer and can cause contact allergy upon both direct contact or from airborne exposure on the skin. In the skin, keratinocytes are the first cells to come in contact with the metal and will react and respond to the danger by triggering an alarm system resulting in an inflammatory response in the skin. Keratinocytes have been shown to produce IL-1β, which is one of the most potent inflammatory agents in our body and is associated with a variety of diseases.The aims of this thesis was to investigate cobalt air concentrations for different particle fractions for possible use as proxies for other article measures and to examine if cobalt skin and inhalable air exposure contributes to uptake. Also, to investigate the effect of cobalt on cultured human keratinocyte cell viability, pro-inflammatory cytokine/chemokine release and NLRP3 inflammasome activation using cells cultured at low or high calcium (the latter yielding a more differentiated cell type).Air exposure to cobalt was found in all departments and for all work tasks in the hard metal production facility and exposures were in general below the Swedish OEL for inhalable cobalt. The highest exposure levels were found in the powder production department and for laboratory and furnace work. Good correlations for the mass based measures enable us to use the findings for future references. When personal inhalable air levels of cobalt, cobalt skin levels skin and biological monitoring of cobalt in blood were analysed, the skin exposure was determined to be import as a route of uptake. Skin exposure to cobalt in the hard metal industry, could further affect the total uptake in the same order of magnitude as air exposure. In vitro investigations of cobalt using the human keratinocyte cell line HaCaT, showed that CoCl2 triggered an alarm system in cells where the proinflammatory cytokines/chemokines IL-6, CXCL8 and CCL2, known to be involved in skin inflammation, were secreted in a time- and dosedependent manner. Comparing HaCaT cells of high- and low differentiation stages indicated that the effect of cobalt chloride on cell toxicity occurs throughout the living epidermis. CoCl2 exposure also resulted in secretion of the proinflammatory cytokines IL-1β and IL-18, and caspase-1, which indicates activation of the NLRP3 inflammasome in the cells. CoCl2 regulates the inflammasome both as primer and as an activator. Our mRNA results indicates a negative feedback mechanism in the inflamamsome due to the exposure. The inflammatory response in general is more dose than time dependent, which be important for understanding the mechanisms of allergic sensitization.
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| 19. |
- Klasson, Maria, 1977-, et al.
(författare)
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Dermal exposure to cobalt studied in vitro in keratinocytes : effects of cobalt exposure on inflammasome activated cytokines, and mRNA response
- 2021
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Ingår i: Biomarkers. - : Taylor & Francis. - 1354-750X .- 1366-5804. ; 26:8, s. 674-684
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Cobalt is a dermal sensitizer, and keratinocytes respond to cobalt exposure by releasing proinflammatory mediators, regulating the immune response.OBJECTIVE: To determine the effect of cobalt on the inflammasome associated cytokine- and gene expression in cultured human keratinocytes (HaCaT). Cultivation in low- or high calcium conditions model separate differentiation states of keratinocytes in the skin.METHOD: HaCaT cells in two different states of differentiation were exposed to cobalt chloride and caspase-1 activity as well as the production of IL-1 beta, IL-18 and gene expression of IL1B, IL18, NLRP3, CASP1, and PYCARD was quantified. RESULTS: High cobalt chloride exposure mediated significant increase in caspase-1 activity, cytokine levels, and IL1B and NLRP3 expression with a corresponding regulatory decrease for CASP1 and PYCARD expression. No difference between high- and low calcium culturing conditions modelling differentiation states was detected.CONCLUSIONS: Our data suggest that HaCaT cells respond with inflammmasome associated activity upon cobalt exposure in a concentration-dependent manner. These mechanisms could be of importance for the understanding of the pathophysiology behind allergic sensitization to dermal cobalt exposure.
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| 20. |
- Klasson, Maria, 1977-, et al.
(författare)
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Dose- and time-dependent changes in viability and IL-6, CXCL8 and CCL2 production by HaCaT-cells exposed to cobalt : Effects of high and low calcium growth conditions
- 2021
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Ingår i: PLOS ONE. - : PLOS. - 1932-6203. ; 16:6
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Sensitization requires exposure to an allergen with subsequent production of a "danger "signal. In the skin, keratinocytes are the main producers of these signals.OBJECTIVE: To compare dose- and time-effects of cobalt on the viability of and cytokine release from HaCaT cells cultured at low or high calcium.METHOD: To model two separate states of differentiation of keratinocytes, HaCaT cells were cultured under low or high calcium conditions. HaCaT were exposed to different concentrations of cobalt chloride (10 μm to 5 mM) over time (30 minutes- 48 hours). Cell viability was measured with the Cell-Titer Blue Viability assay. Cytokine production was measured using a bead-based immunoassay and flow cytometry. Gene expression was quantified using qPCR. Data was analyzed by ANOVA and linear mixed model.RESULTS: Viability of the cells was dose- and time-dependent. A linear mixed statistical model showed that cobalt exposure induces increase in IL-6, CXCL8 and CCL2 production over time and whereas increase of IL-6 and a decrease of CCL2 was associated with increasing cobalt chloride concentrations. When comparing the cells incubated under high and low calcium conditions, the more differentiated cells in the high concentration were found to exert a stronger response in terms of IL-6 release.CONCLUSIONS: Our data suggest that cobalt chloride triggered an alarm system in HaCaT cells, and proinflammatory cytokines/chemokines were secreted in a dose- and time-dependent manner. When high and low calcium incubations were compared, the difference was seen only for IL-6. These findings indicate that the effect of cobalt chloride on cell toxicity occurs throughout the living epidermis.
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| 21. |
- Larsson, Esbjörn, Professor, 1968-, et al.
(författare)
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Det första valet : Förskolans expansion, marknadisering och ökade betydelse i familjers utbildningsstrategier
- 2022
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Ingår i: Resultatdialog 2022. - Stockholm : Vetenskapsrådet. - 9789188943729 ; , s. 44-48
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Idag gör många familjer sitt första val i utbildningssystemet redan under barnets första levnadsår. Då väljs vanligtvis förskola. Det är ett högst påtagligt val; om du inte aktivt väljer förskola erbjuds du ingen plats. Därmed måste alla familjer som behöver barnomsorg förhålla sig till ett utbildningsrelaterat val mycket tidigt i barnens liv, långt innan barnet själv kan ha åsikt i frågan.Vi har undersökt konsekvenserna av detta val och hur framväxten av en svensk förskolemarknad gick till.
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| 22. |
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| 23. |
- Lenander-Ramirez, Alexander, et al.
(författare)
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Respirable Dust and Silica - Respiratory Diseases Among Swedish Iron Foundry Workers
- 2022
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Ingår i: Journal of Occupational and Environmental Medicine. - : Lippincott Williams & Wilkins. - 1076-2752 .- 1536-5948. ; 64:7, s. 593-598
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The mortality and morbidity pattern for respiratory diseases was determined in a cohort of 1,752 Swedish foundry workers, particularly for respirable silica dust exposure.METHODS: The morbidity follow-up in the Swedish National Non-primary Outpatient Register covered 2001 to 2017 (NPR; specialist not in care patients), the mortality from the National Causes of Death Register covered 2001 to 2017. Cumulative exposures to silica and dust were determined.RESULTS: The morbidity in COPD showed significantly increased risk for all exposure groups, as did silicosis in the high exposure group, these cases corresponded to silica exposure levels below 0.05 mg/m3. The mortality of all causes and respiratory diseases was significantly increased by cumulative silica exposure in the high exposure group.CONCLUSIONS: Significantly increased morbidity for respiratory diseases and COPD was determined at silica exposure levels below the current Swedish OEL.
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| 24. |
- Wahlqvist, Fredrik, et al.
(författare)
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Dermal and inhalable cobalt exposure-Uptake of cobalt for workers at Swedish hard metal plants
- 2020
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Ingår i: PLOS ONE. - : PLOS. - 1932-6203. ; 15:8
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Cobalt exposure is known to cause adverse effects on health. A major use of cobalt is in the manufacture of hard metal. Exposure can lead to asthma, hard metal lung disease, contact allergy and increased risk of cancer. Cobalt is mainly absorbed from the pulmonary tract, however penetration through skin may occur. The relationships between exposure to inhalable cobalt in air and on skin and the uptake in blood and urine will be investigated, as well as the association between dermal symptoms and dermal exposure.METHODS: Cobalt exposure in 71 workers in hard metal production facilities was measured as inhalable cobalt in the breathing zone and cobalt found on skin with acid wash. Uptake of cobalt was determined with concentrations in blood and urine. Correlations between exposure and uptake were analysed.RESULTS: Inhalable cobalt in air and cobalt in blood and urine showed rank correlations with coefficients 0.40 and 0.25. Cobalt on skin and uptake in blood and urine presented correlation coefficients of 0.36 and 0.17. Multiple linear regression of cobalt in air and on skin with cobalt in blood showed regression coefficients with cobalt in blood (β = 203 p < 0.0010, and β = 0.010, p = 0.0040) and with cobalt in urine (β = 5779, p = 0.0010, and β = 0.10, p = 0.60).CONCLUSIONS: Our data presents statistically significant correlations between exposure to cobalt in air with uptake of cobalt in blood and urine. Cobalt on skin was statistically significant with cobalt in blood but not with urine.
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