| 2. |
- Hao, Wende, et al.
(författare)
-
Vitronectin : a promising breast cancer serum biomarker for early diagnosis of breast cancer in patients
- 2016
-
Ingår i: Tumor Biology. - : Springer. - 1010-4283 .- 1423-0380. ; 37:7, s. 8909-8916
-
Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is the most common cancer in women worldwide, identification of new biomarkers for early diagnosis and detection will improve the clinical outcome of breast cancer patients. In the present study, we determined serum levels of vitronectin (VN) in 93 breast cancer patients, 30 benign breast lesions, 9 precancerous lesions, and 30 healthy individuals by enzyme-linked immunosorbent assays. Serum VN level was significantly higher in patients with stage 0-I primary breast cancer than in healthy individuals, patients with benign breast lesion or precancerous lesions, as well as those with breast cancer of higher stages. Serum VN level was significantly and negatively correlated with tumor size, lymph node status, and clinical stage (p < 0.05 in all cases). In addition, VN displayed higher area under curve (AUC) value (0.73, 95 % confidence interval (CI) [0.62-0.84]) than carcinoembryonic antigen (CEA) (0.64, 95 % CI [0.52-0.77]) and cancer antigen 15-3 (CA 15-3) (0.69, 95 % CI [0.58-0.81]) when used to distinguish stage 0-I cancer and normal control. Importantly, the combined use of three biomarkers yielded an improvement in receiver operating characteristic curve with an AUC of 0.83, 95 % CI [0.74-0.92]. Taken together, our current study showed for the first time that serum VN is a promising biomarker for early diagnosis of breast cancer when combined with CEA and CA15-3.
|
|
| 3. |
- Persson, Inger, et al.
(författare)
-
Confirming the Structure of the Survey of Attitudes Toward Statistics (SATS-36) by Swedish Students
- 2019
-
Ingår i: Statistics Education Research Journal. - : International Association for Statistical Education. - 1570-1824. ; 18:1, s. 83-93
-
Tidskriftsartikel (refereegranskat)abstract
- Research on students’ attitudes toward statistics has attracted many statistics instructors and statistics education researchers. In this study, we use confirmatory factor analysis to analyze data collected from an introductory statistics course using the Survey of Attitudes toward Statistics. Theresults suggest that the items and six factors are conceptually relevant, confirming the six-factor structure of the pretest version of SATS-36 on this sample of Swedish students, with a few suggested modifications of the original model structure. Two items are excluded from the Difficulty component, two items on the Affect component are allowed to correlate, and two items on the Cognitive competence component are also allowed to correlate.
|
|
