Sökning: WFRF:(van de Berg Wilma D J)
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Increased levels of...
Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease
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- Majbour, Nour K (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Hamad Bin Khalifa University
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- Chiasserini, Davide (författare)
- University of Perugia
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- Vaikath, Nishant N. (författare)
- Lund University,Lunds universitet,Neural plasticitet och reparation,Forskargrupper vid Lunds universitet,Neural Plasticity and Repair,Lund University Research Groups,Hamad Bin Khalifa University
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- Eusebi, Paolo (författare)
- University of Perugia
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- Tokuda, Takahiko (författare)
- Kyoto Prefectural University of Medicine
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- van de Berg, Wilma D J (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Parnetti, Lucilla (författare)
- University of Perugia
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- Calabresi, Paolo (författare)
- University of Perugia,IRCCS Fondazione Santa Lucia
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- El-Agnaf, Omar M A (författare)
- Hamad Bin Khalifa University
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(creator_code:org_t)
- 2017-01-10
- 2017
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Several studies reported an association between CSF alpha-synuclein (α-syn) and tau in Alzheimer's disease (AD), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical AD CSF biomarkers. In the current study, we measured CSF levels of different α-syn species in a cohort of AD patients (n = 225) who showed a CSF profile typical of AD at baseline as well as in cognitively intact controls (n = 68). CSF total α-syn (t-α-syn) significantly increased in the AD group (p < 0.0001) compared to controls, while oligomeric- and phosphorylated-Ser129-α-syn did not change significantly. ROC analysis showed a sensitivity of 85% and a specificity of 84% (AUC = 0.88) in distinguishing AD from controls. T-α-syn levels correlated positively with tau species in AD group and negatively with baseline MMSE score. Our data support the added value of measurement of CSF α-syn species for further characterization of the CSF AD profile.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- ref (ämneskategori)
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