| 1. |
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| 2. |
- Andersson, Catrine
(författare)
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Governing through love : Same-sex cohabitation in Sweden
- 2017
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Ingår i: Sexualities. - : Sage Publications. - 1363-4607 .- 1461-7382. ; 20:5-6, s. 604-621
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Tidskriftsartikel (refereegranskat)abstract
- The concept of love was introduced into a Swedish policy context in the early 1980s as regulations of same-sex cohabitation were proposed. The same-sex cohabitation legislation was presented as a tool in the battle against discrimination of lesbian women and gay men in the government commissioned reports, and offered an inclusion of same-sex couples based on the idea of same-sex love and heterosexual love as fundamentally the same. The article demonstrates how this governing of same-sex relationships rested heavily on authenticity and inclusion/exclusion of wanted/unwanted non-heterosexual subjects. By creating a concept of gay identity based on an essentialist notion of orientation, love was used as a sign of normality indicating authentic homosexual orientation' and restricting this authenticity to individuals in monogamous and stable same-sex relationships. Nevertheless, the act only recognized a selected few and created new lines of division between different non-heterosexual subjectivities.
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| 3. |
- Andersson, Claes, 1973, et al.
(författare)
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Group size and cultural complexity
- 2014
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 511:7507, s. E1-
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Tidskriftsartikel (refereegranskat)abstract
- A decade ago, Henrich1 proposed group size as a driver of cultural complexity. Derex et al now present experimental results they say support this ‘group size hypothesis’ by seemingly showing that larger groups perform better than smaller groups under imitation-based cultural evolution. Our reanalysis of their experimental data, however, shows that larger groups actually perform worse than smaller groups. Thus, contrary to their claim, their data are consistent with empirical evidence discounting the group size hypothesis for non-food producing societies.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
- Andersson, Claes-Henrik, 1980-
(författare)
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Chemistry of Carbon Nanostructures : Functionalization of Carbon Nanotubes and Synthesis of Organometallic Fullerene Derivatives
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis is based on two main parts. The first part concerns purification and functionalization of carbon nanotubes (papers I-III), and the second part is related to the synthesis of organometallic fullerene derivatives (papers IV-VII): Two oxidative methods involving aqueous nitric acid were compared with respect to their capability to introduce carboxylic groups into single walled carbon nanotubes, and several literature methods for esterification and amidation of these groups have been evaluated with focus on efficiency and reproducibility in forming covalently functionalized products soluble in organic media. Amidation proceeding via a SWNT-(COCl)n intermediate yielded the expected covalent product, whereas carboxylate salt formation dominated with other attempted methods. Esterification was achieved via the acyl chloride method and via alkylation of SWNT-(COO–)n, the latter being the more efficient method. A new, reagent-free method for purification of single- and multi walled carbon nanotubes has been developed. Microwave treatment dissociates non-nanotube carbon and disperses it into an organic solvent, resulting in very pure carbon nanotubes within a few minutes of heating, without the involvement of acidic/oxidative reagents. According to thermogravimetric analysis, Raman and IR spectroscopy, as well as SEM, the process yields nanotubes with a low degree of defects. A non-covalent approach has been employed to prepare nanotubes functionalized with glycosides. Derivatives of galactose and lactose were covalently linked to a pyrene moiety and the thus formed pyrene-glycosides were non-covalently attached to single- and multi walled carbon nanotubes by π-π interactions. Fluorescence titrations have been used to quantify the formed supramolecular assemblies, which for SWNTs exhibits increased water solubility. A fulleropyrrolidine-(tricarbonyl)chromium complex was synthesized and fully characterized. IR spectroelectrochemistry was used to probe the redox state of the fullerene and provided evidence for electronic communication between the two electroacive moieties. A C60-ferrocene-C60 triad system was synthesized and characterized. Cyclic voltammetry and fluorescence studies suggested electronic communication between ferrocene and the two fullerenes. Finally, the synthesis and initial characterization of short fullerene-ferrocene oligomers are presented.
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| 8. |
- Andersson, Carl-Håkan, et al.
(författare)
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Fibre Handleability, Damage Formation, Dust Emission and Morphology
- 1994
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Ingår i: Composites Testing and Standardization. - 1855731878 ; , s. 625-632
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Konferensbidrag (refereegranskat)abstract
- The mechanical stress build up in fibre handling, the dynamical frictional phenomena between fibres and curved surfaces and formation of dust have been studied. Typical are stick slip behavior and threshold stress levels for formation of dust. The emission of dust can be limited by electrostatic charging. The measured coefficients of friction of the fibres depend on the mechanical properties, micro structure, morphology and sizing of the fibres, the friction materials, the deformation rates and applied loads.
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| 9. |
- Andersson, Christian H., et al.
(författare)
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Mathematical understanding of training data and AI : a lesson plan for critical thinking and ethical perspectives
- 2024
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Ingår i: Proceedings / Actes CIEAEM 74. - Palermo, Italy. ; , s. 681-685
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Konferensbidrag (refereegranskat)abstract
- AI and machine learning are increasingly being applied to solve complex societal issues. One approach is to train algorithms on training data that describes human behavior. This is not without potential problems though. For example, historical human behavior may contain biases, and then algorithms may reproduce social injustices. This workshop contained lesson elements from a study where pre-service mathematics teachers conducted lessons to first conceptually teach how mathematical modelling based on machine learning works, and then to broaden the scope to consider critical thinking in relation to ethics and democratic values. The participants were invited to test and discuss the lesson elements.
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| 10. |
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| 11. |
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| 12. |
- Blom, Mattias Bolkéus
(författare)
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Vita husets vita lögner
- 2002
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Ingår i: Sydsvenska Dagbladet 2002-06-20. ; :2002-06-20
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 13. |
- Blom, Martin, et al.
(författare)
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Företagets roller i samhället
- 2016. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Varför finns egentligen företag? Vilka roller spelar de i samhället?Vårt svar är att företag samtidigt spelar flera olika roller och i boken presenteras och diskuteras några av dessa.Utgångspunkten är de många offentliga sammanhang där företag och företagande diskuteras och där olika, ibland sinsemellan motstridiga, roller bildar utgångspunkten. Dessa roller har alla sitt stöd i vetenskaplig teori liksom i olika ideologier, något som också tas upp i boken. Splittringen i synen på företag som fenomen och vilka roller de spelar i samhället får också konsekvenser i förhållande till dagsaktuell politisk debatt.Boken riktar sig främst till studenter på universitet och högskola som precis påbörjat sina akademiska studier i företagsekonomi,men också till mer erfarna studenter som börjat reflektera över fenomenet företag. Nyfikna personer inom näringsliv och politik bör också finna boken stimulerande och intressant.Syftet med boken är att ge en tankeväckande introduktion till några av de perspektiv som finns på företag och den mångfald av teorier som betonar och stödjer dessa olika perspektiv.Ambitionen är också att bidra till en mer nyanserad syn på fenomenet företag och vilka roller de spelar och därmed bidra till en mer konstruktiv debatt i de sammanhang där företag och företagande åberopas.
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| 14. |
- Bohlooly-Yeganeh, Mohammad, 1966
(författare)
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Cardiovascular, behavioural and metabolic consequences of growth hormone overexpression in transgenic mice
- 2001
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Growth hormone (GH) exerts major effects on body growth and metabolism. GH is also important in controlling cardiovascular function and behaviour. To study the role of growth hormone in cardiovascular function and regulation of blood pressure, we overexpressed bovine growth hormone regulated by the metallothionein promoter in mice (Mt-bGH). This caused an increase in mean arterial pressure (MAP) which was not salt sensitive and was associated with an increased resistance of the hindquarter vasculature. No difference in the contractile strength of the mesenteric vascular wall or in endothelial function was observed. The Mt-bGH transgenic mice displayed more spontaneous locomotor activity than nontransgenic controls and had an enhanced capacity of brain 5-HT systems and an increased sensitivity to amphetamine. To study the influence of growth hormone action in the CNS on spontaneous locomotor activity and metabolism, we overexpressed bovine growth hormone specifically in the CNS (GFAP-bGH). This model showed that the enhanced spontaneous locomotor activity in Mt-bGH transgenic mice was not due to activation of GHR in the CNS but rather involves some peripheral factor(s). T3 and IGF-I are the two major candidates in enhanced spontaneous locomotor activity in Mt-bGH transgenic mice.At 18 weeks of age, the GFAP-bGH transgenic females were 31% heavier and males were 19% heavier than their littermate controls and also displayed an increased food intake. CT, MRI and organ dissections showed an increase of body fat in the GFAP-bGH transgenic mice. The serum leptin and insulin levels were increased while the glucose level was normal and the pancreas showed an islet hyperplasia in GFAP-bGH transgenic mice. Serum lipid analysis showed a decrease in TG and an increase in serum cholesterol. We observed a decrease in VLDL, an increase in LDL and a slight increase in HDL in GFAP-bGH transgenic mice. AGRP and NPY expression in the hypothalamus increased in GFAP-bGH transgenic mice. The increase in NPY was statistically significant in females only.
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| 15. |
- Böhlmark, Anders, 1973-
(författare)
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School Reform, Educational Achievement and Lifetime Income : Essays in Empirical Labor Economics
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Impact of School Choice on Pupil Achievement, Segregation and Costs: Swedish Evidence. This paper evaluates school choice at the compulsory school level. We estimate the impact of an increased enrolment in private schools on average achievement using within-municipality variation over time. We find positive effects, shown to be the sum of a (small) private school attendance effect and a competition effect. We also find effects on segregation and costs.Age at Immigration and School Performance: A Siblings Analysis Using Swedish Register Data. This paper analyzes the role of age at immigration for the school performance gap between native and immigrant pupils by exploiting within-family variation. The critical age is about nine, above which there is a strong negative impact on performance. The results are similar for boys and girls, but vary by region of origin. A comparison of sibling-difference and cross-sectional estimates reveals striking similarities. Integration of Childhood Immigrants in the Short and in the Long Run: Swedish Evidence. I study childhood immigrants at different stages in life in order to examine the role of age at immigration for educational and labor market outcomes. I find that childhood immigrants tend later to recover strongly in terms of educational achievement. Yet, the same individuals are on average found to be poorly integrated into the labor market. Life-Cycle Variations in the Association between Current and Lifetime Income: Replication and Extension for Sweden. We apply a generalized errors-in-variables model, recently developed by Steven Haider and Gary Solon, in order to produce estimates of the association between current and lifetime income. We find strong life-cycle patterns. This implies that the widespread use of current income as a proxy for lifetime income leads to inconsistent estimates even when the proxy is used as the dependent variable. We find country similarities, but gender and cohort differences.
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| 16. |
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| 17. |
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| 18. |
- Enriquez, Josue, et al.
(författare)
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Influence of Housing Temperature and Genetic Diversity on Allogeneic T Cell-Induced Tissue Damage in Mice
- 2023
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Ingår i: PATHOPHYSIOLOGY. - 0928-4680 .- 1873-149X. ; 30:4, s. 522-547
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study was to determine how housing temperature and genetic diversity affect the onset and severity of allogeneic T cell-induced tissue damage in mice subjected to reduced intensity conditioning (RIC). We found that adoptive transfer of allogeneic CD4+ T cells from inbred donors into sub-lethally irradiated inbred recipients (I -> I) housed at standard housing temperatures (ST; 22-24 degrees C) induced extensive BM and spleen damage in the absence of injury to any other tissue. Although engraftment of T cells in RIC-treated mice housed at their thermo-neutral temperature (TNT; 30-32 degrees C) also developed similar BM and spleen damage, their survival was markedly and significantly increased when compared to their ST counterparts. In contrast, the adoptive transfer of allogeneic T cells into RIC-treated outbred CD1 recipients failed to induce disease in any tissue at ST or TNT. The lack of tissue damage was not due to defects in donor T cell trafficking to BM or spleen but was associated with the presence of large numbers of B cells and myeloid cells within these tissues that are known to contain immunosuppressive regulatory B cells and myeloid-derived suppressor cells. These data demonstrate, for the first time, that housing temperature affects the survival of RIC-treated I -> I mice and that RIC-conditioned outbred mice are resistant to allogeneic T cell-induced BM and spleen damage.
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| 19. |
- Enríquez Pérez, Julio, et al.
(författare)
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Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas
- 2020
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Ingår i: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 20
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM. Systemic delivery of chemotherapeutic drugs is hampered by the difficulty of achieving intratumoral levels as systemic toxicity is a dose-limiting factor. Although some of its effects might be mediated by immune reactivity, systemic chemotherapy can also inhibit induced or spontaneous antitumor immune reactivity. Convection-enhanced delivery of temozolomide (CED-TMZ) can tentatively increase intratumoral drug concentration while reducing systemic side effects. The objective of this study was to evaluate the therapeutic effect of intratumorally delivered temozolomide in combination with immunotherapy and whether such therapy can generate a cellular antitumor immune response. METHODS: Single bolus intratumoral injection and 3-day mini-osmotic pumps (Alzet®) were used to deliver intratumoral TMZ in C57BL6 mice bearing orthotopic gliomas. Immunotherapy consisted of subcutaneous injections of irradiated GL261 or KR158 glioma cells. Tumor size and intratumoral immune cell populations were analyzed by immunohistochemistry. RESULTS: Combined CED-TMZ and immunotherapy had a synergistic antitumor effect in the GL261 model, compared to CED-TMZ or immunotherapy as monotherapies. In the KR158 model, immunization cured a small proportion of the mice whereas addition of CED-TMZ did not have a synergistic effect. However, CED-TMZ as monotherapy prolonged the median survival. Moreover, TMZ bolus injection in the GL261 model induced neurotoxicity and lower cure rate than its equivalent dose delivered by CED. In addition, we found that T-cells were the predominant cells responsible for the TMZ antitumor effect in the GL261 model. Finally, CED-TMZ combined with immunotherapy significantly reduced tumor volume and increased the intratumoral influx of T-cells in both models. CONCLUSIONS: We show that immunotherapy synergized with CED-TMZ in the GL261 model and cured animals in the KR158 model. Single bolus administration of TMZ was effective with a narrower therapeutic window than CED-TMZ. Combined CED-TMZ and immunotherapy led to an increase in the intratumoral influx of T-cells. These results form part of the basis for the translation of the therapy to patients with GBM but the dosing and timing of delivery will have to be explored in depth both experimentally and clinically.
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| 20. |
- Gewert, Berit, 1989-
(författare)
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Chemical Pollutants Released to the Marine Environment by Degradation of Plastic Debris
- 2018
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Since the beginning of the mass production in the 1940s, plastic has been manufactured in quickly increasing amounts. Plastic debris accumulates in the environment and lately much attention has been drawn to the pollution in the world’s oceans. Despite the rapid development and ubiquitous presence of plastic, degradation in the marine environment and potential risks associated with plastic are not fully understood. Thus, these knowledge gaps were addressed in this thesis, which adds information about exposure and hazards of marine plastic debris.Although sampling studies have been conducted all over the world, the concentrations of plastic debris in the Baltic Sea have hardly been investigated. In Paper I, the level and distribution of plastic debris in the Stockholm Archipelago were assessed. Plastic concentrations were higher close to suspected point sources compared to remote areas. Fibers accounted for the most common form and the predominant polymer types were polypropylene (PP) and polyethylene (PE).In Paper II, the literature was critically reviewed for the most important degradation pathways for plastic under environmentally relevant conditions. Ultraviolet (UV) radiation, leading to photo-oxidation, is the most important initiating factor for buoyant plastic. Consequently, a UV lamp was used in Paper III for an artificial weathering setup in the laboratory to degrade pristine plastics and analyze the chemical leachates by liquid chromatography-mass spectrometry (LC-MS) for degradation products using a nontarget approach. Carboxylic acids and dicarboxylic acids of polymer fragments were the most commonly identified degradation products of the plastic polymers, confirming predictions made in Paper II.To evaluate potential hazards posed by leachates from weathering plastic debris to marine organisms, an acute toxicity screening study with Nitocra spinipes was conducted in Paper IV. Field-exposed plastic and the corresponding newly purchased plastic were artificially aged with the same weathering setup as in Paper III. Poly(vinyl chloride) (PVC) and PP leachates were generally most toxic, while leachates from polystyrene (PS) and poly(ethylene terephthalate) (PET) were least toxic among the tested materials. For plastics, which were supposed to contain only few additives, we observed no difference in toxicity between leachates from the field-exposed and the newly purchased plastic. However, the other plastic products exposed to the marine environment were more toxic than their corresponding newly bought products. This indicates that the toxicity of the leachates not only depends on the polymer type, but also on the weathering condition of the plastic.
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| 21. |
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| 22. |
- Nayeri, Niloofar, et al.
(författare)
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Principles to recover copper-conducting CTR proteins for the purpose of structural and functional studies
- 2023
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Ingår i: Protein Expression and Purification. - : Elsevier BV. - 1046-5928. ; 203
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Tidskriftsartikel (refereegranskat)abstract
- Transition metals such as copper and zinc are essential elements required for the survival of most organisms, from bacteria to humans. Yet, elevated levels of these elements are highly toxic. The Copper TRansporter protein family (CTRs) represents the only identified copper uptake proteins in eukaryotes and hence serves as key components for the maintenance of appropriate levels of the metal. Moreover, CTRs have been proposed to serve as an entry point into cells of certain cancer drugs and to constitute attractive drug-targets for novel antifungals. Nevertheless, the structure, function, and regulation of the CTRs remain elusive, limiting valuable information also for applied sciences. To this end, here we report procedures to isolate a range of CTR members using Saccharomyces cerevisiae as a production host, focusing on three homologs, human CTR1, human CTR2, and Candida albicans CTR. Using forms C-terminally-linked to a protease cleavage sequence, Green Fluorescent Protein (GFP), and a His-tag, assessment of the localization, quantification and purification was facilitated. Cellular accumulation of the proteins was investigated via live-cell imaging. Detergents compatible with acceptable solubilization yields were identified and fluorescence-detection size-exclusion-chromatography (F-SEC) revealed preferred membrane extraction conditions for the targets. For purification purposes, the solubilized CTR members were subjected to affinity chromatography and SEC, reaching near homogeneity. The quality and quantity of the CTRs studied will permit downstream efforts to uncover imperative biophysical aspects of these proteins, paving the way for subsequent drug-discovery studies.
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| 23. |
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| 24. |
- Nordlund, Christer
(författare)
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Hormoner och visioner i mellankrigstid : Louis Bermans idéer om möjligheten att förädla mänskligheten
- 2004
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Ingår i: Lychnos. - Uppsala : Lärdomshistoriska samfundet. - 0076-1648. ; , s. 165-206
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Tidskriftsartikel (refereegranskat)abstract
- In the first half of the twentieth century, hormones took pride of place as life’s master molecules, and the endocrinologist took precedence over the geneticist as the scientist offering the means to control life. But, as with genetics and biotechnology today, the status of endocrinology was not only based on contemporary scientific and medical practices but also, to a high degree, on expectations, or visions, about what endocrinologists would be able to do ”in the future”. Inspired by the research field social studies of techno-scientific expectations, the aim of this article is to explore some of the great expectations that were connected to the development of endocrinology in the 1930s. The analysis is based on popular books written by the American endocrinologist Louis Berman, who worked in New York City most of his life, part time at Columbia University. In 1921, Berman reached fame for his book The glands regulating personality, which was a study of the glands of internal secretion in relation to what Berman called the ”types of human nature”. In the journal Science, Berman later named his approach ”psycho-endocrinology”. In the 1930s, Berman not only argued that it was possible to understand human nature through hormone analysis, but that endocrinologists would also be able to control and ”improve” human nature by using hormone therapy. Furthermore, in contrast to most of the eugenics of his time, Berman suggested that the whole population of the world should be improved, not only humans within a specific race or in specific nations. As a political activist of the 1930s, Berman wanted to contribute to the development of new creations in human beings, ”ideal normal persons”, and thereby to reach an ”ideal society”. That such large-scale hormone replacement therapy could involve risks, such as side effects, was something that Berman seems not to have taken into account.
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| 25. |
- Nordlund, Christer
(författare)
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Nonchalans och precision
- 2005
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Ingår i: Västerbottens-Kuriren. ; :2005-11-21
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 26. |
- Nordlund, Christer, 1970-
(författare)
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Praktverk om okänd mark
- 2015
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Ingår i: Västerbottenskuriren. - Umeå : Västerbottens-Kuriren. - 1104-0246.
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 27. |
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| 28. |
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| 29. |
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| 30. |
- Norrback, Johan, 1966
(författare)
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En "passabel och god" temperering
- 2003
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Ingår i: Tidig musik. - 1400-5123. ; :4, s. 27-31
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 31. |
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| 32. |
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