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1.	Abt, I, et al. (författare) Measurement of the b(b)over-bar production cross section in 920 GeV fixed-target proton-nucleus collisions 2003 Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 26:3, s. 345-355 Tidskriftsartikel (refereegranskat)abstract Using the HERA-B detector, the b (b) over bar production cross section has been measured in 920 GeV proton collisions on carbon and titanium targets. The b (b) over bar production was tagged via inclusive bottom quark decays into J/psi by exploiting the longitudinal separation of J/psi --> l(+)l(-) decay vertices from the primary proton-nucleus interaction. Both e(+)e(-) and mu(+)mu(-) channels have been reconstructed and the combined analysis yields the cross section sigma(b (b) over bar) = 32(-12)(+14)(stat) (+6)(-7)(sys) nb/nucleon.
2.	Abt, I, et al. (författare) Inclusive V-0 production cross sections from 920 GeV fixed target proton-nucleus collisions 2003 Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 29:2, s. 181-190 Tidskriftsartikel (refereegranskat)abstract Inclusive differential cross sections dsigma(pA)/dx(F) and dsigma(pA)/dp(t)(2) for the production of K-S(0), Lambda, and (&ULambda;) over bar particles are measured at HERA in proton-induced reactions on C, Al, Ti, and W targets. The incident beam energy is 920 GeV, corresponding to roots = 41.6 GeV in the proton-nucleon system. The ratios of differential cross sections dsigma(pA)(K-S(0))/dsigma(pA)(Lambda) and dsigma(pA)((&ULambda;) over bar)/dsigma(pA) (Lambda) are measured to be 6.2 +/- 0.5 and 0.66 +/- 0.07, respectively, for x(F) approximate to -0.06. No significant dependence upon the target material is observed. Within errors, the slopes of the transverse momentum distributions da,Ald t also show no significant dependence upon the target material. The dependence of the extrapolated total cross sections sigma(pA) on the atomic mass A of the target material is discussed, and the deduced cross sections per nucleon sigma(pN) are compared with results obtained at other energies.
3.	Alcorn, J, et al. (författare) Basic instrumentation for Hall A at Jefferson Lab 2004 Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002. ; 522:3, s. 294-346 Tidskriftsartikel (refereegranskat)abstract The instrumentation in Hall A at the Thomas Jefferson National Accelerator Facility was designed to study electro-and photo-induced reactions at very high luminosity and good momentum and angular resolution for at least one of the reaction products. The central components of Hall A are two identical high resolution spectrometers, which allow the vertical drift chambers in the focal plane to provide a momentum resolution of better than 2 x 10(-4). A variety of Cherenkov counters, scintillators and lead-glass calorimeters provide excellent particle identification. The facility has been operated successfully at a luminosity well in excess of 10(38) CM-2 s(-1). The research program is aimed at a variety of subjects, including nucleon structure functions, nucleon form factors and properties of the nuclear medium. (C) 2003 Elsevier B.V. All rights reserved.
4.	Imanishi, T., et al. (författare) Integrative annotation of 21,037 human genes validated by full-length cDNA clones 2004 Ingår i: PLoS biology. - : Public Library of Science (PLoS). - 1544-9173 .- 1545-7885. ; 2:6, s. 856-875 Tidskriftsartikel (refereegranskat)abstract The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level. Our international collaboration has validated 21,037 human gene candidates by analysis of high-quality full-length cDNA clones through curation using unified criteria. This led to the identification of 5,155 new gene candidates. It also manifested the most reliable way to control the quality of the cDNA clones. We have developed a human gene database, called the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). It provides the following: integrative annotation of human genes, description of gene structures, details of novel alternative splicing isoforms, non-protein-coding RNAs, functional domains, subcellular localizations, metabolic pathways, predictions of protein three-dimensional structure, mapping of known single nucleotide polymorphisms (SNPs), identification of polymorphic microsatellite repeats within human genes, and comparative results with mouse full-length cDNAs. The H-InvDB analysis has shown that up to 4% of the human genome sequence (National Center for Biotechnology Information build 34 assembly) may contain misassembled or missing regions. We found that 6.5% of the human gene candidates (1,377 loci) did not have a good protein-coding open reading frame, of which 296 loci are strong candidates for non-protein-coding RNA genes. In addition, among 72,027 uniquely mapped SNPs and insertions/deletions localized within human genes, 13,215 nonsynonymous SNPs, 315 nonsense SNPs, and 452 indels occurred in coding regions. Together with 25 polymorphic microsatellite repeats present in coding regions, they may alter protein structure, causing phenotypic effects or resulting in disease. The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology.
5.	Andres, E., et al. (författare) Selected recent results from AMANDA 2001 Ingår i: ICHEP 2000. Proceedings of the 30th International Conference on High Energy Physics. - : World Scientific. ; , s. 965-968 Konferensbidrag (refereegranskat)abstract We present a selection of results based on data taken in 1997 with the 302-PMT Antarctic Muon and Neutrino Detector Array-B10 ("AMANDA-B10") array. Atmospheric neutrinos created in the northern hemisphere are observed indirectly through their charged current interactions which produce relativistic, Cherenkov-light-emitting upgoing muons in the South Pole ice cap. The reconstructed angular distribution of these events is in good agreement with expectation and demonstrates the viability of this ice-based device as a neutrino telescope. Studies of nearly vertical upgoing muons limit the available parameter space for WIMP dark matter under the assumption that WIMPS are trapped in the earth's gravitational potential well and annihilate with one another near the earth's center.
6.	Wijesooriya, K, et al. (författare) Polarization measurements in high-energy deuteron photodisintegration 2001 Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 86:14, s. 2975-2979 Tidskriftsartikel (refereegranskat)abstract We present measurements of the recoil proton polarization for the d(γ⃗,p⃗)n reaction at θc.m. = 90° for photon energies up to 2.4 GeV. These are the first data in this reaction for polarization transfer with circularly polarized photons. The induced polarization py vanishes above 1 GeV, contrary to meson-baryon model expectations, in which resonances lead to large polarizations. However, the polarization transfer Cx does not vanish above 1 GeV, inconsistent with hadron helicity conservation. Thus, we show that the scaling behavior observed in the d(γ,p)ncross sections is not a result of perturbative QCD. These data should provide important tests of new nonperturbative calculations in the intermediate energy regime.
7.	Andrés, E., et al. (författare) Observation of high-energy neutrinos using Čerenkov detectors embedded deep in Antarctic ice 2001 Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 410:6827, s. 441-443 Tidskriftsartikel (refereegranskat)abstract Neutrinos are elementary particles that carry no electric charge and have little mass. As they interact only weakly with other particles, they can penetrate enormous amounts of matter, and therefore have the potential to directly convey astrophysical information from the edge of the Universe and from deep inside the most cataclysmic high-energy regions. The neutrino's great penetrating power, however, also makes this particle difficult to detect. Underground detectors have observed low-energy neutrinos from the Sun and a nearby supernova2, as well as neutrinos generated in the Earth's atmosphere. But the very low fluxes of high-energy neutrinos from cosmic sources can be observed only by much larger, expandable detectors in, for example, deep water3,4 or ice5. Here we report the detection of upwardly propagating atmospheric neutrinos by the ice-based Antarctic muon and neutrino detector array (AMANDA). These results establish a technology with which to build a kilometre-scale neutrino observatory necessary for astrophysical observations1.
8.	Andrés, E., et al. (författare) Recent results from AMANDA 2001 Ingår i: International Journal of Modern Physics A. - 0217-751X .- 1793-656X. ; 16:1C, s. 1013-1015 Tidskriftsartikel (refereegranskat)abstract We present results based on data taken in 1997 with the 302-PMT Antarctic Muon and Neutrino Detector Array-B10 ("AMANDA-B10") array. Atmospheric neutrinos created in the northern hemisphere are observed indirectly through their charged current interactions which produce relativistic, Cherenkov-light-emitting upgoing muons in the South Pole ice cap. The reconstructed angular distribution of these events is in good agreement with expectation and demonstrates the viability of this ice-based device as a neutrino telescope.
9.	Karle, A., et al. (författare) Observation of high energy atmospheric neutrinos with AMANDA 2000 Ingår i: AIP Conference Proceedings. - : American Institute of Physics (AIP). ; , s. 823-827 Konferensbidrag (refereegranskat)abstract In 1997 the Antarctic Muon and Neutrino Detector Array (AMANDA) started operating with 10 strings. In an analysis of data taken during the first year of operation 188 atmospheric neutrino candidates were found. Their zenith angle distribution agrees with expectations based on Monte Carlo simulations. A preliminary upper limit is given on a diffuse flux of high energy neutrinos of astrophysical origin.
10.	Schulte, EC, et al. (författare) High energy angular distribution measurements of the exclusive deuteron photodisintegration reaction 2002 Ingår i: Physical Review C (Nuclear Physics). - : American Physical Society. - 0556-2813 .- 1089-490X. ; 66:4 Tidskriftsartikel (refereegranskat)abstract The first complete measurements of the angular distributions of the two-body deuteron photodisintegration differential cross section at photon energies above 1.6 GeV were performed at the Thomas Jefferson National Accelerator Facility. The results show a persistent forward-backward asymmetry up to E-gamma=2.4 GeV, the highest-energy measured in this experiment. The Hard Rescattering and the Quark-Gluon string models are in fair agreement with the results.
11.	Wijesooriya, K, et al. (författare) Polarization measurements in neutral pion photoproduction 2002 Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 66:3 Tidskriftsartikel (refereegranskat)abstract We present measurements of the recoil proton polarization for the H-1((γ) over right arrow,(p) over right arrow)pi(0) reaction for theta(c.m.)(pi) = 60degrees-135degrees and for photon energies up to 4.1 GeV. These are the first data in this reaction for polarization transfer with circularly polarized photons. Various theoretical models are compared with the results. No evidence for hadron helicity conservation is observed. Models that employ factorization are not favored. It appears from the strong angular dependence of the induced polarization at photon energies of 2.5 and 3.1 GeV that a relatively high spin resonance or background amplitude might exist in this energy region.
12.	Ahmed, M., et al. (författare) Search for the lepton-family-number nonconserving decay μ +→e +γ 2002 Ingår i: Physical Review D. - : American Physical Society. - 1550-7998 .- 1550-2368. ; 65:11 Tidskriftsartikel (refereegranskat)abstract The MEGA experiment, which searched for the muon- and electron-number violating decay μ +→e + γ, is described. The spectrometer system, the calibrations, the data taking procedures, the data analysis, and the sensitivity of the experiment are discussed. The most stringent upper limit on the branching ratio, B(μ + →e + γ)<1.2×10 -11 with 90% confidence, is derived from a likelihood analysis.
13.	Ahrens, J., et al. (författare) Search for Extraterrestrial Point Sources of Neutrinos with AMANDA-II 2004 Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 92:7, s. 711021-711025 Tidskriftsartikel (refereegranskat)abstract The results of a search for point sources of high energy neutrinos in the northern hemisphere were presented using AMANDA-II data collected in the year 2000. The results included the flux limits on several active-galactic-nuclei blazars, microquasars, magnetars, and other candidate neutrino sources. A search for excesses above a random background of cosmic ray induced atmospheric neutrinos and misreconstructed downgoing cosmic-rays muons, which revealed no statistically significant neutrino point sources was also presented. It was shown that AMANDA-II had achieved the sensitivity required to probe known TeV γ-ray sources such as the blazar Markarian 501 in its 1997 flaring state at a level where neutrino and γ-ray fluxes were equal.
14.	Gayou, O, et al. (författare) Measurement of G(Ep)/G(Mp) in (e)over-right-arrowp -> e(p)over-right-arrow to Q(2)=5.6 GeV2 2002 Ingår i: Physical Review Letters. - 1079-7114. ; 88:9 Tidskriftsartikel (refereegranskat)abstract The ratio of the electric and magnetic form factors of the proton G(Ep)/G(Mp), which is an image of its charge and magnetization distributions, was measured at the Thomas Jefferson National Accelerator Facility (JLab) using the recoil polarization technique. The ratio of the form factors is directly proportional to the ratio of the transverse to longitudinal components of the polarization of the recoil proton in the elastic (e) over right arrowp --> e (p) over right arrow reaction. The new data presented span the range 3.5 < Q(2) < 5.6 GeV2 and are well described by a linear Q(2) fit. Also, the ratio rootQ(2) F-2p/F-1p reaches a constant value above Q(2) = 2 GeV2.
15.	Heyns, M, et al. (författare) Scaling of high-k dielectrics towards sub-Inm EOT 2003 Ingår i: Proceedings of International Symposium on VLSI Technology, Systems, and Applications. ; , s. 247-250 Konferensbidrag (refereegranskat)
16.	Niessen, Peter, et al. (författare) Recent results from the amanda experiment 2003 Ingår i: Proceedings of 38th Rencontres de Moriond on Electroweak Interactions and Unified Theories 15-22 Mar 2003. Les Arcs, France. Konferensbidrag (refereegranskat)abstract AMANDA (Antarctic Muon And Neutrino Detector Array) is a neutrino telescope built under the southern polar icecap and its scope is to explore the possibility to detect high energy cosmic neutrinos. This should generate insight into the powerful celestial objects where acceleration mechanisms can bring up to 10 20 eV. We describe the achievements and results from the AMANDA-B10 prototype and the preliminary results from the current AMANDA-II detector which show dramatic increase in sensitivity.
17.	Wiebusch, C., et al. (författare) Results from AMANDA 2002 Ingår i: Modern Physics Letters A. - : Institution of Electrical Engineers (IEE). - 0217-7323 .- 1793-6632. ; 17:31, s. 2019-2037 Tidskriftsartikel (refereegranskat)abstract The Antarctic Muon and Neutrino Detector Array (AMANDA) is a high-energy neutrino telescope operating at the geographic South Pole. It is a lattice of photomultiplier tubes buried deep in the polar ice. The primary goal of this detector is to discover astrophysical sources of high energy neutrinos. We describe the detector methods of operation and present results from the AMANDA-B10 prototype. We demonstrate the improved sensitivity of the current AMANDA-II detector. We conclude with an outlook to the envisioned sensitivity of the future IceCube detector.
18.	Ahrens, J., et al. (författare) Observation of high energy atmospheric neutrinos with the Antarctic muon and neutrino detector array 2002 Ingår i: Physical Review D. - : American Physical Society. - 1550-7998 .- 1550-2368. ; 66:1, s. 120051-1200520 Tidskriftsartikel (refereegranskat)abstract The Antarctic muon and neutrino detector array (AMANDA) began collecting data with ten strings in 1997. Results from the first year of operation are presented. Neutrinos coming through the Earth from the Northern Hemisphere are identified by secondary muons moving upward through the array. Cosmic rays in the atmosphere generate a background of downward moving muons, which are about 106 times more abundant than the upward moving muons. Over 130 days of exposure, we observed a total of about 300 neutrino events. In the same period, a background of 1.05 × 109 cosmic ray muon events was recorded. The observed neutrino flux is consistent with atmospheric neutrino predictions. Monte Carlo simulations indicate that 90% of these events lie in the energy range 66 GeV to 3.4 TeV. The observation of atmospheric neutrinos consistent with expectations establishes AMANDA-B10 as a working neutrino telescope.
19.	Ahrens, J., et al. (författare) Results from AMANDA 2001 Ingår i: Proceedings, 9th International Workshop, Venice, Italy, March 6-9, 2001. Vol. 1, 2. ; , s. 569-580 Konferensbidrag (refereegranskat)
20.	Ahrens, J., et al. (författare) Results from the Antarctic muon and nuetrino detector array 2003 Ingår i: Nuclear physics B, Proceedings supplements. - : Elsevier. - 0920-5632 .- 1873-3832. ; 118, s. 371-379 Tidskriftsartikel (refereegranskat)abstract We show new results from both the older and newer incarnations of AMANDA (AMANDA-B10 and AMANDA-II, respectively). These results demonstrate that AMANDA is a functioning, multipurpose detector with significant physics and astrophysics reach. They include a new higher-statistics measurement of the atmospheric muon neutrino flux and preliminary results from searches for a variety of sources of ultrahigh energy neutrinos: generic point sources, gamma-ray bursters and diffuse sources producing muons in the detector, and diffuse sources producing electromagnetic or hadronic showers in or near the detector.
21.	Ahrens, J., et al. (författare) Search for supernova neutrino bursts with the AMANDA detector 2001 Ingår i: Astroparticle physics. - : Elsevier. - 0927-6505 .- 1873-2852. ; 16:4, s. 345-359 Tidskriftsartikel (refereegranskat)abstract The core collapse of a massive star in the Milky Way will produce a neutrino burst, intense enough to be detected by existing underground detectors. The AMANDA neutrino telescope located deep in the South Pole ice can detect MeV neutrinos by a collective rate increase in all photo-multipliers on top of dark noise. The main source of light comes from positrons produced in the CC reaction of anti-electron neutrinos on free protons ve + p → e+ + n. This paper describes the first supernova search performed on the full sets of data taken during 1997 and 1998 (215 days of live time) with 302 of the detector's optical modules. No candidate events resulted from this search. The performance of the detector is calculated, yielding a 70% coverage of the galaxy with one background fake per year with 90% efficiency for the detector configuration under study. An upper limit at the 90% c.l. on the rate of stellar collapses in the Milky Way is derived, yielding 4.3 events per year. A trigger algorithm is presented and its performance estimated. Possible improvements of the detector hardware are reviewed.
22.	Kowalski, Marek, et al. (författare) Physics results from the AMANDA neutrino detector 2001 Ingår i: Proceedings of Science. - 1824-8039. ; HEP2001 Tidskriftsartikel (refereegranskat)abstract In the winter season of 2000, the AMANDA (Antarctic Muon And NeutrinoDetector Array) detector was completed to its nal state. We report on major physicsresults obtained from the AMANDA-B10 detector, as well as initial results of the fullAMANDA-II detector.
23.	Ahrens, J., et al. (författare) Limits to the muon flux from WIMP annihilation in the center of the Earth with the AMANDA detector 2002 Ingår i: Physical Review D. - : American Physical Society. - 1550-7998 .- 1550-2368. ; 66:3, s. 032006- Tidskriftsartikel (refereegranskat)abstract A search for nearly vertical up-going muon-neutrinos from neutralino annihilations in the center of the Earth has been performed with the AMANDA-B10 neutrino detector. The data collected in 130.1 days of live time in 1997, ∼10 9 events, have been analyzed for this search. No excess over the expected atmospheric neutrino background has been observed. An upper limit at 90% confidence level has been obtained on the annihilation rate of neutralinos in the center of the Earth, as well as the corresponding muon flux limit, both as a function of the neutralino mass in the range 100 GeV-5000 GeV. © 2002 The American Physical Society.
24.	Bai, X., et al. (författare) Status of the Neutrino Telescope AMANDA : Monopoles and WIMPS 2001 Ingår i: Dark Matter in Astro- and Particle Physics. - Berlin, Heidelberg : Springer. - 9783642626081 ; , s. 699-706 Konferensbidrag (refereegranskat)abstract The neutrino telescope AMANDA has been set up at the geographical South Pole as first step to a neutrino telescope of the scale of one cubic kilometer, which is the canonical size for a detector sensitive to neutrinos from Active Galactic Nuclei (AGN), Gamma Ray Bursts (GRB) and Topological Defects (TD). The location and depth in which the detector is installed is given by the requirement to detect neutrinos by the Cherenkov light produced by their reaction products and to keep the background due to atmospheric muons as small as possible. However, a detector optimized for this purpose is also capable to detect the bright Cherenkov light from relativistic Monopoles and neutrino signals from regions with high gravitational potential, where WIMPS are accumulated and possibly annihilate. Both hypothetical particles might contribute to the amount of dark matter. Therefore here a report about the status of the experiment (autumn 2000) and about the status of the search for these particles with the AMANDA B10 sub-detector is given.
25.	Edsjö, Joakim, et al. (författare) WIMP searches with AMANDA-B10 2001 Ingår i: The Identification Of Dark Matter. - : World Scientific. - 9789810246020 ; , s. 499-505 Bokkapitel (övrigt vetenskapligt/konstnärligt)
26.	Ahrens, J., et al. (författare) Initial results from AMANDA 2001 Ingår i: 21st Rencontres de Moriond Workshop on Very High-Energy Phenomena in the Universe. Konferensbidrag (refereegranskat)
27.	Ahrens, J., et al. (författare) Search for neutrino-induced cascades with the AMANDA detector 2003 Ingår i: Physical Review D. - : American Physical Society (APS). - 1550-7998 .- 1550-2368. ; 67:1, s. 012003- Tidskriftsartikel (refereegranskat)abstract We report on a search for electromagnetic and/or hadronic showers (cascades) induced by a diffuse flux of neutrinos with energies between 5 TeV and 300 TeV from extraterrestrial sources. Cascades may be produced by matter interactions of all flavors of neutrinos, and contained cascades have better energy resolution and afford better background rejection than throughgoing νμ-induced muons. Data taken in 1997 with the AMANDA detector were searched for events with a high-energy cascadelike signature. The observed events are consistent with expected backgrounds from atmospheric neutrinos and catastrophic energy losses from atmospheric muons. Effective volumes for all flavors of neutrinos, which allow the calculation of limits for any neutrino flux model, are presented. The limit on cascades from a diffuse flux of νe+ νμ + ντ+ ν̄e + ν̄μ+ ν̄τ is E2(dΦ/dE)<9.8×10-6 GeV cm-2 s-1 sr-1, assuming a neutrino flavor flux ratio of 1:1:1 at the detector. The limit on cascades from a diffuse flux of νe+ν̄e is E2(dΦ/dE)<6. 5×10-6 GeV cm-2 s-1 sr-1, independent of the assumed neutrino flavor flux ratio. © 2003 The American Physical Society.
28.	Pickett, J.S., et al. (författare) Waves observed in the auroral zone : The cluster multi-spacecraft perspective 2004 Ingår i: Nonl. Proc. Geophys.. ; 11, s. 183-196 Tidskriftsartikel (refereegranskat)
29.	Giorgi, F., et al. (författare) Chapter 10 of the IPCC TAR (Climate Change 2001: The Scientific Basis) 2001 Ingår i: Chapter 10-Regional Climate Information Evaluation and Projections, Cambridge University Press, Cambridge, UK. ; , s. 584-638 Bokkapitel (övrigt vetenskapligt/konstnärligt)
30.	Hoieggen, A., et al. (författare) The impact of serum uric acid on cardiovascular outcomes in the LIFE study 2004 Ingår i: Kidney Int. - 0085-2538. ; 65:3, s. 1041-9 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study demonstrated the superiority of a losartan-based regimen over atenolol-based regimen for reduction of cardiovascular (CV) morbidity and mortality. It has been suggested that the LIFE study results may be related to the effects of losartan on serum uric acid (SUA). SUA has been proposed as an independent risk factor for CV morbidity and death. METHODS: Cox regression analysis was used to assess relationship of SUA and treatment regimens with the LIFE primary composite outcome (CV death, fatal or nonfatal myocardial infarction, fatal or nonfatal stroke). RESULTS: Baseline SUA was significantly associated with increased CV events [hazard ratio (HR) 1.024 (95% CI 1.017-1.032) per 10 micromol/L, P < 0.0001] in the entire study population. The association was significant in women [HR = 1.025 (1.013-1.037), P < 0.0001], but not in men [HR = 1.009 (0.998-1.019), P= 0.108]. After adjustment for Framingham risk score (FRS), SUA was no longer significant in the entire study population [HR = 1.006 (0.998-1.014), P= 0.122] or in men [HR = 1.006 (0.995-1.017), P= 0.291], but was significant in women [HR = 1.013 (1-1.025), P= 0.0457]. The baseline-to-end-of-study increase in SUA (standard deviation, SD) was greater (P < 0.0001) in atenolol-treated subjects (44.4 +/- 72.5 micromol/L) than in losartan-treated subjects (17.0 +/- 69.8 micromol/L). SUA as a time-varying covariate was strongly associated with events (P < 0.0001) in the entire population. The contribution of SUA to the treatment effect of losartan on the primary composite end point was 29% (14%-107%), P= 0.004. The association between time-varying SUA and increased CV risk tended to be stronger in women (P < 0.0001) than in men (P= 0.0658), although the gender-outcome interaction was not significant (P= 0.079). CONCLUSION: The increase in SUA over 4.8 years in the LIFE study was attenuated by losartan compared with atenolol treatment, appearing to explain 29% of the treatment effect on the primary composite end point. The association between SUA and events was stronger in women than in men with or without adjustment of FRS.
31.	Gonzalez, I, et al. (författare) New nomenclature and DNA testing guidelines for myotonic dystrophy type 1 (DM1). The International Myotonic Dystrophy Consortium (IDMC) 2000 Ingår i: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 54:6, s. 1218-1221 Tidskriftsartikel (refereegranskat)
32.	Beiersdorfer, Peter, et al. (författare) Hyperfine structure of hydrogenlike thallium isotopes 2001 Ingår i: Phys. Rev. A. ; 64, s. 032506- Tidskriftsartikel (refereegranskat)
33.	Beuchat, L. R., et al. (författare) Performance of mycological media in enumerating desiccated food spoilage yeasts : an interlaboratory study 2001 Ingår i: International Journal of Food Microbiology. - : Elsevier. - 0168-1605 .- 1879-3460. ; 70:1-2, s. 89-96 Tidskriftsartikel (refereegranskat)abstract Dichloran 18% glycerol agar (DG18) was originally formulated to enumerate nonfastidious xerophilic moulds in foods containing rapidly growing Eurotium species. Some laboratories are now using DG18 as a general purpose medium for enumerating yeasts and moulds, although its performance in recovering yeasts from dry foods has not been evaluated. An interlaboratory study compared DG18 with dichloran rose bengal chloramphenicol agar (DRBC), plate count agar supplemented with chloramphenicol (PCAC), tryptone glucose yeast extract chloramphenicol agar (TGYC), acidified potato dextrose agar (APDA), and orange serum agar (OSA) for their suitability to enumerate 14 species of lyophilized yeasts. The coefficient of variation for among-laboratories repeatability within yeast was 1.39% and reproducibility of counts among laboratories was 7.1%. The order of performance of media for recovering yeasts was TGYC > PCAC = OSA > APDA > DRBC > DG18. A second study was done to determine the combined effects of storage time and temperature on viability of yeasts and suitability of media for recovery. Higher viability was retained at - 18 degreesC than at 5 degreesC or 25 degreesC for up to 42 weeks, although the difference in mean counts of yeasts stored at - 18 degreesC and 25 degreesC was only 0.78 log(10) cfu/ml of rehydrated suspension. TGYC was equal to PCAC and superior to the other four media in recovering yeasts stored at - 18 degreesC, 5 degreesC, or 25 degreesC for up to 42 weeks. Results from both the interlaboratory study and the storage study support the use of TGYC for enumerating desiccated yeasts. DG18 is not recommended as a general purpose medium for recovering yeasts from a desiccated condition.
34.	Hagell, Peter, et al. (författare) Career opportunities in neuroscience nursing 2001 Ingår i: Journal of Neuroscience Nursing. - 0888-0395. ; 33:2, s. 113-116 Tidskriftsartikel (refereegranskat)
35.	Hedenfalk, I, et al. (författare) Gene-expression profiles in hereditary breast cancer 2001 Ingår i: New England Journal of Medicine. - 0028-4793. ; 344:8, s. 48-539 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Many cases of hereditary breast cancer are due to mutations in either the BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often characteristic of the mutant gene. We hypothesized that the genes expressed by these two types of tumors are also distinctive, perhaps allowing us to identify cases of hereditary breast cancer on the basis of gene-expression profiles.METHODS: RNA from samples of primary tumor from seven carriers of the BRCA1 mutation, seven carriers of the BRCA2 mutation, and seven patients with sporadic cases of breast cancer was compared with a microarray of 6512 complementary DNA clones of 5361 genes. Statistical analyses were used to identify a set of genes that could distinguish the BRCA1 genotype from the BRCA2 genotype.RESULTS: Permutation analysis of multivariate classification functions established that the gene-expression profiles of tumors with BRCA1 mutations, tumors with BRCA2 mutations, and sporadic tumors differed significantly from each other. An analysis of variance between the levels of gene expression and the genotype of the samples identified 176 genes that were differentially expressed in tumors with BRCA1 mutations and tumors with BRCA2 mutations. Given the known properties of some of the genes in this panel, our findings indicate that there are functional differences between breast tumors with BRCA1 mutations and those with BRCA2 mutations.CONCLUSIONS: Significantly different groups of genes are expressed by breast cancers with BRCA1 mutations and breast cancers with BRCA2 mutations. Our results suggest that a heritable mutation influences the gene-expression profile of the cancer.
36.	Salahshor, S, et al. (författare) A germline E-cadherin mutation in a family with gastric and colon cancer. 2001 Ingår i: International Journal of Molecular Medicine. - : Spandidos Publications. - 1107-3756 .- 1791-244X. ; 8, s. 439-443 Tidskriftsartikel (refereegranskat)
37.	Ulmer, PE, et al. (författare) H-2(e,e ' p)n reaction at high recoil momenta 2002 Ingår i: Physical Review Letters. - 1079-7114. ; 89:6 Tidskriftsartikel (refereegranskat)abstract The 2H(e,e(')p)n cross section was measured in Hall A of the Thomas Jefferson National Accelerator Facility near the top of the quasielastic peak (x(Bj)=0.964) at a four-momentum transfer squared, Q(2)=0.665 (GeV/c) (2) (omega=0.368 GeV, W=2.057 GeV), and for recoil momenta up to 550 MeV/c. The measured cross section deviates by 1-2sigma from a state-of-the-art calculation at low recoil momenta. At high recoil momenta the cross section is well described by the same calculation; however, in this region, final-state interactions and interaction currents are predicted to be large, and alternative choices of nucleon-nucleon potential and nucleon current operator may result in significant spread in the calculations.
38.	Andres, E, et al. (författare) Observation of high-energy neutrinos using Cerenkov detectors embedded deep in Antarctic ice 2001 Ingår i: NATURE. - : MACMILLAN PUBLISHERS LTD. - 0028-0836. ; 410:6827, s. 441-443 Tidskriftsartikel (refereegranskat)abstract Neutrinos are elementary particles that carry no electric charge and have little mass. As they interact only weakly with other particles, they can penetrate enormous amounts of matter, and therefore have the potential to directly convey astrophysical info
39.	Carpten, JD, et al. (författare) HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome 2002 Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 32:4, s. 676-680 Tidskriftsartikel (refereegranskat)abstract We report here the identification of a gene associated with the hyperparathyroidism-jaw tumor (HPT-JT) syndrome. A single locus associated with HPT-JT (HRPT2) was previously mapped to chromosomal region 1q25-q32. We refined this region to a critical interval of 12 cM by genotyping in 26 affected kindreds. Using a positional candidate approach, we identified thirteen different heterozygous, germline, inactivating mutations in a single gene in fourteen families with HPT-JT. The proposed role of HRPT2 as a tumor suppressor was supported by mutation screening in 48 parathyroid adenomas with cystic features, which identified three somatic inactivating mutations, all located in exon 1. None of these mutations were detected in normal controls, and all were predicted to cause deficient or impaired protein function. HRPT2 is a ubiquitously expressed, evolutionarily conserved gene encoding a predicted protein of 531 amino acids, for which we propose the name parafibromin. Our findings suggest that HRPT2 is a tumor-suppressor gene, the inactivation of which is directly involved in predisposition to HPT-JT and in development of some sporadic parathyroid tumors.
40.	Coube, O., et al. (författare) Computer simulation of die compaction : guidelines and an example from the European dienet project 2004 Ingår i: Conference proceedings. - Shrewsbury : European powder metallurgy association. - 1899072152 Konferensbidrag (refereegranskat)
41.	Desmyter, L., et al. (författare) Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death 2004 Ingår i: Experimental Gerontology. - : Elsevier BV. - 0531-5565. ; 39:5, s. 707-715 Tidskriftsartikel (refereegranskat)abstract Ferritin is one of the major eukaryotic proteins involved in regulating iron metabolism and maintaining iron homeostasis. However, Saccaromyces cerevisiae is an exception, possessing no ferritin and using other means to store excess iron. The only potential iron storage protein identified in yeast so far is the homologue of human frataxin (YFH1p). In this study, we found that dysfunction of yeast frataxin shortens mean lifespan by 49% compared to the WT control. Interestingly, the human ferritin L gene can, at least partially, complement the function of yeast frataxin, extending lifespan and protecting cells from death induced by oxidative stress or excess iron. Our findings indicate that ferritin L can perform functions in yeast that are similar to its functions in mammals, and suggest that common mechanisms may exist for preventing iron and oxidative damage in single- and multi-cellular eukaryotic organisms. Clearly, elucidation of the function of human ferritin in yeast would help in gaining a better understanding the molecular basis of iron storage diseases
42.	Duffy, SW, et al. (författare) The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish counties. 2002 Ingår i: Cancer. ; 95, s. 458- Tidskriftsartikel (refereegranskat)
43.	Duffy, S.W., et al. (författare) The Swedish two-county trial of mammographic screening : Cluster randomisation and end point evaluation 2003 Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 14:8, s. 1196-1198 Tidskriftsartikel (refereegranskat)abstract Background: The Swedish Two-County Trial has been criticised on the grounds of the cluster randomisation and alleged bias in classification of cause of death. Patients and methods: In the Two-County Trial, 77080 women were randomised to regular invitation to screening (active study population, ASP) and 55985 to no invitation (passive study population, PSP), in 45 geographical clusters. After ~7 years, the PSP was invited to screening and the trial closed. We analysed data using hierarchical statistical models to take account of cluster randomisation, and performed a conservative analysis assuming a systematic difference between ASP and PSP in baseline breast cancer mortality in one of the counties. We also analysed deaths from causes other than breast cancer and from all causes among breast cancer cases diagnosed in the ASP and PSP. Results: Taking account of the cluster randomisation there was a significant 30% reduction in breast cancer mortality in the ASP. Conservatively, assuming a systematic difference between ASP and PSP clusters in baseline breast cancer mortality, there was a significant 27% reduction in mortality in the ASP. Ignoring classification of cause of death, there was a significant 13% reduction in all-cause mortality in breast cancer cases in the ASP. Conclusions: Breast cancer mortality is a valid end point and mammographic screening does indeed reduce mortality from breast cancer. The criticisms of the Swedish Two-County Trial are unfounded.
44.	Gao, Y. L., et al. (författare) Crystal structure and electrochemical behavior of copper complex with 6-hydroxymethyl-substituted tris(2-pyridylmethyl) amine, CuCl(C19H20N4O) ClO4 2004 Ingår i: Chinese journal of structural chemistry. - 0254-5861. ; 23:11, s. 1262-1265 Tidskriftsartikel (refereegranskat)abstract A Cu(II) complex [CuCl(C19H20N40)]ClO4 1 containing hydroxymethyl substituted TPA (TPA = tris(2-pyridylmethyl)amine) was prepared. It crystallizes in monoclinic, space group P2(1)/c with a = 11.7628(2), b = 13.0083(3), c = 15.11280(10) Angstrom, beta = 108.724(2)degrees, V = 2190.09(7) Angstrom(3), M-r = 518.83, Z = 4, T = 293 (2) K, D-c = 1.574 g/cm(3), mu = 1.280 mm(-1), F(000) = 1060 and S = 1.085. The final R = 0.0543 and wR = 0.1433 for 2693 observed reflections with I >2sigma(I). The penta-coordinated copper (H) complex. assumes an approximate square pyramidal geometry. Cyclic voltammetry measurement of the complex showed a quasi-reversible Cu-II/Cu-I redox couple with E-1/2 -0.467 v and DeltaE = 68 mv.
45.	Johansson, L, et al. (författare) Exploiting the 21st amino acid-purifying and labeling proteins by selenolate targeting 2004 Ingår i: Nature methods. - 1548-7091. ; 1:1, s. 61-66 Tidskriftsartikel (refereegranskat)
46.	Nilsson, A B, et al. (författare) IGF-I treatment attenuates renal abnormalities induced by neonatal ACE inhibition. 2000 Ingår i: American journal of physiology. Regulatory, integrative and comparative physiology. - 0363-6119. ; 279:3 Tidskriftsartikel (refereegranskat)abstract An intact renin-angiotensin system (RAS) during nephrogenesis is essential for normal renal development. We have shown previously that neonatal inhibition of the RAS, either with ANG II type 1-receptor blockade or angiotensin-converting enzyme (ACE) inhibition, induces irreversible renal abnormalities. The aim of the present study was to investigate whether an interrupted RAS can be compensated for by exogenous administration of another important renal growth-promoting factor, the insulin-like growth factor-I (IGF-I). Rats were treated daily with either the ACE inhibitor enalapril (10 mg/kg), recombinant human IGF-I (3 mg/kg), or the combination enalapril + IGF-I from perinatal day 3 to 13. Urinary concentrating ability, renal function, and renal morphology were assessed at adult age. The gene expression and localization of IGF-I, its receptor, and the growth hormone receptor (GHR) were investigated during ongoing ACE inhibition. The present study demonstrates normalized renal function and histology in enalapril + IGF-I-treated animals. Ongoing ACE inhibition suppressed the medullary IGF-I mRNA expression and altered the local distribution of both IGF-I and GHR. Thus the present study provides evidence for an interaction between the RAS and GH/IGF-I axis in renal development.
47.	Shepherd, R., Audebert, P., Chen, H-K, Fournier, K.B., Peyreusse, O., Moon, S., Price, D., Klein, L., Gaithier, J.C., Springer, P., Lee, R.W. (författare) Satellite and opacity effects on resonance line shapes produced from short-pulse laser heated foils. 2003 Ingår i: J. Quant. Spectroscopy & Radiative Transfer. ; 81 Annan publikation (övrigt vetenskapligt/konstnärligt)
48.	Tabar, L., et al. (författare) All-cause mortality among breast cancer patients in a screening trial : Support for breast cancer mortality as an end point 2002 Ingår i: Journal of Medical Screening. - : SAGE Publications. - 0969-1413 .- 1475-5793. ; 9:4, s. 159-162 Tidskriftsartikel (refereegranskat)abstract Background: It has recently been suggested that all-cause mortality is a more appropriate end point than disease specific mortality in cancer screening trials, and that disease specific mortality is biased in favour of screening. This suggestion is based partly on supposed inconsistencies between all-cause mortality results and disease specific results in cancer screening trials, and alleged increases in deaths from causes other than breast cancer among breast cancer cases diagnosed among women invited to screening. Methods: We used data from the Swedish Two-County Trial of mammographic screening for breast cancer, in which 77 080 women were randomised to an invitation to screening and 55 985 to no invitation. We estimated relative risks (RRs) (invited v control) of death from breast cancer, death from other causes within the breast cancer cases, and death from all causes within the breast cancer cases. RRs were adjusted for age and took account of the longer follow up of breast cancer cases in the invited group due to lead time. Results: There was a significant 31% reduction in breast cancer mortality in the invited group (RR 0.69, 95% confidence interval (Cl) 0.58-0.80, p
49.	Tabar, L., et al. (författare) Number needed to screen : Lives saved over 20 years of follow-up in mammographic screening 2004 Ingår i: Journal of Medical Screening. - : SAGE Publications. - 0969-1413 .- 1475-5793. ; 11:3, s. 126-129 Tidskriftsartikel (refereegranskat)abstract Objective: To estimate the number needed to screen with mammography to save one life, based on a stated amount of screening activity and long-term follow-up for breast cancer death. Setting: A randomised controlled trial of mammographic screening for breast cancer, with 77,080 women invited to screening and 55,985 not invited. The invited group was offered screening for seven years. Follow-up continued for a total of just over 20 years. Methods: Number needed to screen for seven years to save one life over 20 years was calculated by dividing the number screened (not the number invited) by the total number of lives saved. Similarly, we calculated the number of mammographic examinations required to save one life. Results: We estimate that the number of women needed to screen for seven years to save one life over 20 years is 465 (95% CI 324-819). The number of mammographic examinations needed to save one life was 1499 (95% CI 1046-2642). Conclusions: The number needed to screen to save one life is smaller than has been reported in the past. Mammographic screening is effective in absolute terms as well as relative. Long-term follow-up allowed us to estimate the absolute benefit with greater accuracy.
50.	Yu, S, et al. (författare) Increased susceptibility to experimental autoimmune neuritis after upregulation of the autoreactive T cell response to peripheral myelin antigen in apolipoprotein E-deficient mice 2004 Ingår i: Journal of neuropathology and experimental neurology. - : Oxford University Press (OUP). - 0022-3069 .- 1554-6578. ; 63:2, s. 120-128 Tidskriftsartikel (refereegranskat)

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