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- Strömberg, Ingrid, et al.
(författare)
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c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat.
- 2004
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Ingår i: Brain Research. - : Elsevier BV. - 0006-8993. ; 1000:1-2, s. 192-4
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Tidskriftsartikel (refereegranskat)abstract
- Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.
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