| 1. |
- Aaron, F. D., et al.
(author)
-
Events with an isolated lepton and missing transverse momentum and measurement of W production at HERA
- 2010
-
In: Journal of High Energy Physics. - 1029-8479. ; 2010:3, s. 1-19
-
Journal article (peer-reviewed)abstract
- A search for events containing an isolated electron or muon and missing trans verse momentum produced in e(+/-)p collisions is performed with the H1 and ZEUS detectors at HERA. The data were taken in the period 1994-2007 and correspond to an integrated luminosity of 0.98 fb(-1). The observed event yields are in good overall agreement with the Standard Model prediction, which is dominated by single W production. In the e(+)p data, at large hadronic transverse momentum P-T(X) > 25GeV, a total of 23 events are observed compared to a prediction of 14.0 +/- 1.9. The total single W boson production cross section is measured as 1.06 +/- 0.16 (stat.) +/- 0.07 (sys.) pb, in agreement with an Standard Model (SM) expectation of 1.26 +/- 0.19 pb.
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| 2. |
- Aaron, F. D., et al.
(author)
-
Combined measurement and QCD analysis of the inclusive e(+/-)p scattering cross sections at HERA
- 2010
-
In: Journal of High Energy Physics. - 1029-8479. ; :1
-
Journal article (peer-reviewed)abstract
- A combination is presented of the inclusive deep inelastic cross sections measured by the H1 and ZEUS Collaborations in neutral and charged current unpolarised e(+/-)p scattering at HERA during the period 1994-2000. The data span six orders of magnitude in negative four-momentum-transfer squared, Q(2), and in Bjorken x. The combination method used takes the correlations of systematic uncertainties into account, resulting in an improved accuracy. The combined data are the sole input in a NLO QCD analysis which determines a new set of parton distributions, HERAPDF1.0, with small experimental uncertainties. This set includes an estimate of the model and parametrisation uncertainties of the fit result.
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| 3. |
- Aaron, F. D., et al.
(author)
-
Combined inclusive diffractive cross sections measured with forward proton spectrometers in deep inelastic ep scattering at HERA
- 2012
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:10
-
Journal article (peer-reviewed)abstract
- A combination of the inclusive diffractive cross section measurements made by the H1 and ZEUS Collaborations at HERA is presented. The analysis uses samples of diffractive deep inelastic ep scattering data at a centre-of-mass energy root s = 318 GeV where leading protons are detected by dedicated spectrometers. Correlations of systematic uncertainties are taken into account, resulting in an improved precision of the cross section measurement which reaches 6 % for the most precise points. The combined data cover the range 2.5 < Q(2) < 200 GeV2 in photon virtuality, 0.00035 < x(P) < 0.09 in proton fractional momentum loss, 0.09 < vertical bar t vertical bar < 0.55 GeV2 in squared four-momentum transfer at the proton vertex and 0.0018 < beta < 0.816 in beta = x/x(P), where x is the Bjorken scaling variable.
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| 4. |
- Abramowicz, H., et al.
(author)
-
Combination and QCD analysis of charm production cross section measurements in deep-inelastic ep scattering at HERA
- 2013
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 73:2
-
Journal article (peer-reviewed)abstract
- Measurements of open charm production cross sections in deep-inelastic ep scattering at HERA from the H1 and ZEUS Collaborations are combined. Reduced cross sections sigma(c (c) over bar)(red) for charm production are obtained in the kinematic range of photon virtuality 2.5 <= Q(2) <= 2000 GeV2 and Bjorken scaling variable 3 . 10(-5) <= x <= 5 . 10(-2). The combination method accounts for the correlations of the systematic uncertainties among the different data sets. The combined charm data together with the combined inclusive deep-inelastic scattering cross sections from HERA are used as input for a detailed NLO QCD analysis to study the influence of different heavy flavour schemes on the parton distribution functions. The optimal values of the charm mass as a parameter in these different schemes are obtained. The implications on the NLO predictions for W-+/- and Z production cross sections at the LHC are investigated. Using the fixed flavour number scheme, the running mass of the charm quark is determined.
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| 5. |
- Aaron, F. D., et al.
(author)
-
Diffractive electroproduction of rho and phi mesons at HERA
- 2010
-
In: Journal of High Energy Physics. - 1029-8479. ; 2010:5, s. 1-111
-
Journal article (peer-reviewed)abstract
- Diffractive electroproduction of rho and phi mesons is measured at HERA with the H1 detector in the elastic and proton dissociative channels. The data correspond to an integrated luminosity of 51 pb(-1). About 10500 rho and 2000 phi events are analysed in the kinematic range of squared photon virtuality 2.5 <= Q(2) <= 60 GeV2, photon-proton centre of mass energy 35 <= W <= 180 GeV and squared four-momentum transfer to the proton vertical bar t vertical bar <= 3 GeV2. The total, longitudinal and transverse cross sections are measured as a function of Q(2), W and vertical bar t vertical bar. The measurements show a transition to a dominantly "hard" behaviour, typical of high gluon densities and small q (q) over bar dipoles, for Q(2) larger than 10 to 20 GeV2. They support flavour independence of the diffractive exchange, expressed in terms of the scaling variable (Q(2) + M-V(2))/4, and proton vertex factorisation. The spin density matrix elements are measured as a function of kinematic variables. The ratio of the longitudinal to transverse cross sections, the ratio of the helicity amplitudes and their relative phases are extracted. Several of these measurements have not been performed before and bring new information on the dynamics of diffraction in a QCD framework. The measurements are discussed in the context of models using generalised parton distributions or universal dipole cross sections.
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| 6. |
- Aaron, F. D., et al.
(author)
-
Measurement of the charm and beauty structure functions using the H1 vertex detector at HERA
- 2010
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 65:1-2, s. 89-109
-
Journal article (peer-reviewed)abstract
- Inclusive charm and beauty cross sections are measured in e (-) p and e (+) p neutral current collisions at HERA in the kinematic region of photon virtuality 5a parts per thousand currency signQ (2)a parts per thousand currency sign2000 GeV2 and Bjorken scaling variable 0.0002a parts per thousand currency signxa parts per thousand currency sign0.05. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb(-1). The numbers of charm and beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions.
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| 7. |
- Aaron, F. D., et al.
(author)
-
Prompt photons in photoproduction at HERA
- 2010
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 66:1-2, s. 17-33
-
Journal article (peer-reviewed)abstract
- The production of prompt photons is measured in the photoproduction regime of electron-proton scattering at HERA. The analysis is based on a data sample corresponding to a total integrated luminosity of 340 pb(-1) collected by the H1 experiment. Cross sections are measured for photons with transverse momentum and pseudorapidity in the range 6< E-T(gamma) < 15 GeV and -1.0< eta(gamma) < 2.4, respectively. Cross sections for events with an additional jet are measured as a function of the transverse energy and pseudorapidity of the jet, and as a function of the fractional momenta x(gamma) and x(p) carried by the partons entering the hard scattering process. The correlation between the photon and the jet is also studied. The results are compared with QCD predictions based on the collinear and on the k(T) factorization approaches.
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| 8. |
- Aaron, F. D., et al.
(author)
-
Jet production in ep collisions at low Q(2) and determination of alpha(s)
- 2010
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 67:1-2, s. 1-24
-
Journal article (peer-reviewed)abstract
- The production of jets is studied in deep-inelastic e(+) p scattering at low negative four momentum transfer squared 5 < Q(2) < 100 GeV2 and at inelasticity 0.2 < y < 0.7 using data recorded by the H1 detector at HERA in the years 1999 and 2000, corresponding to an integrated luminosity of 43.5 pb(-1). Inclusive jet, 2-jet and 3-jet cross sections as well as the ratio of 3-jet to 2-jet cross sections are measured as a function of Q(2) and jet transverse momentum. The 2-jet cross section is also measured as a function of the proton momentum fraction xi. The measurements are well described by perturbative quantum chromodynamics at next-to-leading order corrected for hadronisation effects and are subsequently used to extract the strong coupling as.
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| 9. |
- Aaron, F. D., et al.
(author)
-
Measurement of the D*(+/-) meson production cross section and F-2(c(c)over-bar) at high Q(2) in ep scattering at HERA
- 2010
-
In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 686:2-3, s. 91-100
-
Journal article (peer-reviewed)abstract
- The inclusive production of D*(+/-)(2010) mesons in deep-inelastic e(+/-)p scattering is measured in the kinematic region of photon virtuality 100 < Q(2) < 1000 GeV2 and inelasticity 002 < y < 0 7 Single and double differential cross sections for inclusive D* meson production are measured in the visible range defined by vertical bar eta(D*)vertical bar < 1 5 and p(gamma)(D*) > 1 5 GeV The data were collected by the H1 experiment during the period from 2004 to 2007 and correspond to an integrated luminosity of 351 pb(-1) The charm contribution. F-2(c (c) over bar), to the proton structure function F-2 is determined. The measurements are compared with QCD predictions. (C) 2010 Elsevier B V All rights reserved
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| 10. |
- Aaron, F. D., et al.
(author)
-
Diffractive dijet photoproduction in ep collisions at HERA
- 2010
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 70:1-2, s. 15-37
-
Journal article (peer-reviewed)abstract
- Measurements are presented of single and double-differential dijet cross sections in diffractive photoproduction based on a data sample with an integrated luminosity of 47 pb(-1). The events are of the type ep -> eXY, where the hadronic system X contains at least two jets and is separated by a large rapidity gap from the system Y, which consists of a leading proton or low-mass proton excitation. The dijet cross sections are compared with QCD calculations at next-to-leading order and with a Monte Carlo model based on leading order matrix elements with parton showers. The measured cross sections are smaller than those obtained from the next-to-leading order calculations by a factor of about 0.6. This suppression factor has no significant dependence on the fraction x (gamma) of the photon four-momentum entering the hard subprocess. Ratios of the diffractive to the inclusive dijet cross sections are measured for the first time and are compared with Monte Carlo models.
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| 11. |
- Aaron, F. D., et al.
(author)
-
Measurement of charm and beauty jets in deep inelastic scattering at HERA
- 2011
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:1
-
Journal article (peer-reviewed)abstract
- Measurements of cross sections for events with charm and beauty jets in deep inelastic scattering at HERA are presented. Events with jets of transverse energy E-T(jet) > 6 GeV and pseudorapidity - 1.0 < eta(jet) < 1.5 in the laboratory frame are selected in the kinematic region of photon virtuality Q(2) > 6 GeV2 and inelasticity variable 0.07 < y < 0.625. Measurements are also made requiring a jet in the Breit frame with E-T(*jet) > 6 GeV. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb(-1). The numbers of charm and beauty jets are determined using variables reconstructed using the H1 vertex detector with which the impact parameters of the tracks to the primary vertex and the position of secondary vertices are measured. The measurements are compared with QCD predictions and with previous measurements where heavy flavours are identified using muons.
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| 12. |
- Aaron, F. D., et al.
(author)
-
Measurement of the cross section for diffractive deep-inelastic scattering with a leading proton at HERA
- 2011
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:3
-
Journal article (peer-reviewed)abstract
- The cross section for the diffractive deep-inelastic scattering process ep -> eXp is measured, with the leading final state proton detected in the H1 Forward Proton Spectrometer. The data sample covers the range x(P) < 0.1 in fractional proton longitudinal momentum loss, 0.1 < vertical bar t vertical bar < 0.7 GeV2 in squared four-momentum transfer at the proton vertex and 4 < Q(2) < 700 GeV2 in photon virtuality. The cross section is measured four-fold differentially in t, x(P), Q2 and beta = x/x(P), where x is the Bjorken scaling variable. The t and x(P) dependences are interpreted in terms of an effective pomeron trajectory and a sub-leading exchange. The data are compared with perturbative QCD predictions at next-to-leading order based on diffractive parton distribution functions previously extracted from complementary measurements of inclusive diffractive deep-inelastic scattering. The ratio of the diffractive to the inclusive ep cross section is studied as a function of Q(2), beta and x(P).
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| 13. |
- Aaron, F. D., et al.
(author)
-
Measurement of the inclusive e(+/-) p scattering cross section at high inelasticity y and of the structure function F-L
- 2011
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:3
-
Journal article (peer-reviewed)abstract
- A measurement is presented of the inclusive neutral current e(+/-) p scattering cross section using data collected by the H1 experiment at HERA during the years 2003 to 2007 with proton beam energies E-p of 920, 575, and 460 GeV. The kinematic range of the measurement covers low absolute four-momentum transfers squared, 1.5 GeV2 < Q(2) < 120 GeV2, small values of Bjorken x, 2.9 . 10(-5) < x < 0.01, and extends to high inelasticity up to y = 0.85. The structure function F-L is measured by combining the new results with previously published H1 data at E-p = 920 GeV and E-p = 820 GeV. The new measurements are used to test several phenomenological and QCD models applicable in this low Q(2) and low x kinematic domain.
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| 14. |
- Aaron, F. D., et al.
(author)
-
Search for squarks in R-parity violating supersymmetry in ep collisions at HERA
- 2011
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:3
-
Journal article (peer-reviewed)abstract
- A search for squarks in R-parity violating super-symmetry is performed in e(+/-)p collisions at HERA using the H1 detector. The full data sample taken at a centre-of-mass energy root s = 319 GeV is used for the analysis, corresponding to an integrated luminosity of 255 pb(-1) of e(+)p and 183 pb(-1) of e(-)p collision data. The resonant production of squarks via a Yukawa coupling. lambda' is considered, taking into account direct and indirect R-parity violating decay modes. Final states with jets and leptons are investigated. No evidence for squark production is found and mass dependent limits on lambda' are obtained in the framework of the Minimal Supersymmetric Standard Model and in the Minimal Super-gravity Model. In the considered part of the parameter space, for a Yukawa coupling of electromagnetic strength lambda' = 0.3, squarks of all flavours are excluded up to masses of 275 GeV at 95% confidence level, with down-type squarks further excluded up to masses of 290 GeV.
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| 15. |
- Aaron, F. D., et al.
(author)
-
Measurement of beauty photoproduction near threshold using di-electron events with the H1 detector at HERA
- 2012
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:10
-
Journal article (peer-reviewed)abstract
- The cross section for ep -> eb (b) over barX in photoproduction is measured with the H1 detector at the ep-collider HERA. The decay channel b (b) over bar -> eeX' is selected by identifying the semi-electronic decays of the b-quarks. The total production cross section is measured in the kinematic range given by the photon virtuality Q(2) <= 1 GeV2, the inelasticity 0.05 <= y <= 0.65 and the pseudorapidity of the b-quarks vertical bar eta(b)vertical bar, vertical bar eta((b) over bar)vertical bar <= 2. The differential production cross section is measured as a function of the average transverse momentum of the beauty quarks < P-T(b)> down to the threshold. The results are compared to next-to-leading-order QCD predictions.
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| 16. |
- Aaron, F. D., et al.
(author)
-
Inclusive deep inelastic scattering at high Q(2) with longitudinally polarised lepton beams at HERA
- 2012
-
In: Journal of High Energy Physics. - 1029-8479. ; :9
-
Journal article (peer-reviewed)abstract
- Inclusive e(+/-)p single and double differential cross sections for neutral and charged current deep inelastic scattering processes are measured with the H1 detector at HERA. The data were taken at a centre-of-mass energy of root s = 319 GeV with a total integrated luminosity of 333.7 pb(-1) shared between two lepton beam charges and two longitudinal lepton polarisation modes. The differential cross sections are measured in the range of negative four-momentum transfer squared, Q(2), between 60 and 50 000GeV(2), and Bjorken x between 0.0008 and 0.65. The measurements are combined with earlier published unpolarised H1 data to improve statistical precision and used to determine the structure function xF(3)(gamma Z). A measurement of the neutral current parity violating structure function F-2(gamma Z) is presented for the first time. The polarisation dependence of the charged current total cross section is also measured. The new measurements are well described by a next-to-leading order QCD fit based on all published H1 inclusive cross section data which are used to extract the parton distribution functions of the proton.
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| 17. |
- Aaron, F. D., et al.
(author)
-
Measurement of D*(+/-) meson production and determination of F-2(c(c)over-bar) at low Q(2) in deep-inelastic scattering at HERA
- 2011
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:10
-
Journal article (peer-reviewed)abstract
- Inclusive production of D* mesons in deep-inelastic ep scattering at HERA is studied in the range 5 < Q(2) < 100 GeV2 of the photon virtuality and 0.02 < y < 0.7 of the inelasticity of the scattering process. The observed phase space for the D* meson is (pT) (D*) > 1.25 GeV and |eta( D*)| < 1.8. The data sample corresponds to an integrated luminosity of 348 pb(-1) collected with the H1 detector. Single and double differential cross sections are measured and the charm contribution F-2(c (c) over bar) to the proton structure function F-2 is determined. The results are compared to perturbative QCD predictions at next-to-leading order implementing different schemes for the charm mass treatment and with Monte Carlo models based on leading order matrix elements with parton showers.
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| 18. |
- Aaron, F. D., et al.
(author)
-
Determination of the integrated luminosity at HERA using elastic QED Compton events
- 2012
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:10
-
Journal article (peer-reviewed)abstract
- A measurement of the integrated luminosity at the ep collider HERA is presented, exploiting the elastic QED Compton process ep -> e gamma p. The electron and the photon are detected in the backward calorimeter of the H1 experiment. The integrated luminosity of the data recorded in 2003 to 2007 is determined with a precision of 2.3%. The measurement is found to be compatible with the corresponding result obtained using the Bethe-Heitler process.
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| 19. |
- Aaron, F. D., et al.
(author)
-
Inclusive measurement of diffractive deep-inelastic scattering at HERA
- 2012
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:7
-
Journal article (peer-reviewed)abstract
- The diffractive process ep -> eXY, where Y denotes a proton or its low mass excitation with M-Y < 1.6 GeV, is studied with the H1 experiment at HERA. The analysis is restricted to the phase space region of the photon virtuality 3 <= Q(2) <= 1600 GeV2, the square of the fourmomentum transfer at the proton vertex vertical bar t vertical bar < 1.0 GeV2 and the longitudinal momentum fraction of the incident proton carried by the colourless exchange x(P) < 0.05. Triple differential cross sections are measured as a function of x(P), Q(2) and beta = x/x(P) where x is the Bjorken scaling variable. These measurements are made after selecting diffractive events by demanding a large empty rapidity interval separating the final state hadronic systems X and Y. High statistics measurements covering the data taking periods 1999-2000 and 2004-2007 are combined with previously published results in order to provide a single set of diffractive cross sections from the H1 experiment using the large rapidity gap selection method. The combined data represent a factor between three and thirty increase in statistics with respect to the previously published results. The measurements are compared with predictions from NLO QCD calculations based on diffractive parton densities and from a dipole model. The proton vertex factorisation hypothesis is tested.
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| 20. |
- Aaron, F. D., et al.
(author)
-
Measurement of dijet production in diffractive deep-inelastic scattering with a leading proton at HERA
- 2012
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:4
-
Journal article (peer-reviewed)abstract
- The cross section of diffractive deep-inelastic scattering ep -> eXp is measured, where the system X contains at least two jets and the leading final state proton is detected in the H1 Forward Proton Spectrometer. The measurement is performed for fractional proton longitudinal momentum loss x(P) < 0.1 and covers the range 0.1 < vertical bar t vertical bar < 0.7 GeV2 in squared four-momentum transfer at the proton vertex and 4 < Q(2) < 110 GeV2 in photon virtuality. The differential cross sections extrapolated to vertical bar t vertical bar < 1 GeV2 are in agreement with next-to-leading order QCD predictions based on diffractive parton distribution functions extracted from measurements of inclusive and dijet cross sections in diffractive deep-inelastic scattering. The data are also compared with leading order Monte Carlo models.
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| 21. |
- Aaron, F. D., et al.
(author)
-
Measurement of inclusive and dijet D* meson cross sections in photoproduction at HERA
- 2012
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:5
-
Journal article (peer-reviewed)abstract
- The inclusive photoproduction of D* mesons and of D*-tagged dijets is investigated with the H1 detector at the ep collider HERA. The kinematic region covers small photon virtualities Q(2) < 2 GeV2 and photon-proton centre-of-mass energies of 100< W-gamma p < 285 GeV. Inclusive D* meson differential cross sections are measured for central rapidities vertical bar eta(D*)vertical bar < 1.5 and transverse momenta p(T) (D*) > 1.8 GeV. The heavy quark production process is further investigated in events with at least two jets with transverse momentum p(T) (jet) > 3.5 GeV each, one containing the D* meson. Differential cross sections for D*-tagged dijet production and for correlations between the jets are measured in the range vertical bar eta(D*)vertical bar < 1.5 and p(T) (D*) > 2.1 GeV. The results are compared with predictions from Monte Carlo simulations and next-to-leading order perturbative QCD calculations.
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| 22. |
- Aaron, F. D., et al.
(author)
-
Measurement of photon production in the very forward direction in deep-inelastic scattering at HERA
- 2011
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:10
-
Journal article (peer-reviewed)abstract
- The production of photons at very small angles with respect to the proton beam direction is studied in deep-inelastic positron-proton scattering at HERA. The data are taken with the H1 detector in the years 2006 and 2007 and correspond to an integrated luminosity of 126 pb(-1). The analysis covers the range of negative four momentum transfer squared at the positron vertex 6 < Q(2) < 100 GeV2 and inelasticity 0.05 < y < 0.6. Cross sections are measured for the most energetic photon with pseudorapidity eta > 7.9 as a function of its transverse momentum p(T)(lead) and longitudinal momentum fraction of the incoming proton x(L)(lead). In addition, the cross sections are studied as a function of the sum of the longitudinal momentum fraction x(L)(sum) L of all photons in the pseudorapidity range. > 7.9. The cross sections are normalised to the inclusive deep-inelastic scattering cross section and compared to the predictions of models of deep-inelastic scattering and models of the hadronic interactions of high energy cosmic rays.
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| 23. |
- Aaron, F. D., et al.
(author)
-
Measurement of the azimuthal correlation between the most forward jet and the scattered positron in deep-inelastic scattering at HERA
- 2012
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:3
-
Journal article (peer-reviewed)abstract
- Deep-inelastic positron-proton scattering events at low photon virtuality, Q(2), with a forward jet, produced at small angles with respect to the proton beam, are measured with the H1 detector at HERA. A subsample of events with an additional jet in the central region is also studied. For both samples, differential cross sections and normalised distributions are measured as a function of the azimuthal angle difference, Delta phi, between the forward jet and the scattered positron in bins of the rapidity distance, Y, between them. The data are compared to predictions of Monte Carlo generators based on different evolution approaches as well as to next-to-leading order calculations in order to test the sensitivity to QCD evolution mechanisms.
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| 24. |
- Aaron, F. D., et al.
(author)
-
Measurement of the diffractive longitudinal structure function F(L)(D) at HERA
- 2011
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:12
-
Journal article (peer-reviewed)abstract
- First measurements are presented of the diffractive cross section sigma(ep) -> eXY at centre-of-mass energies root s of 225 and 252 GeV, together with a precise new measurement at root s of 319 GeV, using data taken with the H1 detector in the years 2006 and 2007. Together with previous H1 data at root s of 301 GeV, the measurements are used to extract the diffractive longitudinal structure function F(L)(D) in the range of photon virtualities 4.0 <= Q(2) <= 44.0 GeV(2) and fractional proton longitudinal momentum loss 5 x 10(-4) <= x(P) <= 3 x 10(-3). The measured F(L)(D) is compared with leading twist predictions based on diffractive parton densities extracted in NLO QCD fits to previous measurements of diffractive Deep-Inelastic Scattering and with a model which additionally includes a higher twist contribution derived from a colour dipole approach. The ratio of the diffractive cross section induced by longitudinally polarised photons to that for transversely polarised photons is extracted and compared with the analogous quantity for inclusive Deep-Inelastic Scattering.
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| 25. |
- Aaron, F. D., et al.
(author)
-
Search for contact interactions in e(+/-)p collisions at HERA H1 Collaboration
- 2011
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In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 705:1-2, s. 52-58
-
Journal article (peer-reviewed)abstract
- A search for physics beyond the Standard Model in neutral current deep inelastic scattering at high negative four-momentum transfer squared Q(2) is performed in e(+/-)p collisions at HERA. The differential cross section d sigma/dQ(2), measured using the full H1 data sample corresponding to an integrated luminosity of 446 pb(-1), is compared to the Standard Model prediction. No significant deviation is observed. Limits on various models predicting new phenomena at high Q(2) are derived. For general four-fermion eeqq contact interaction models, lower limits on the compositeness scale A are set in the range 3.6 TeV to 7.2 TeV. Leptoquarks with masses M-LQ and couplings lambda are constrained to M-LQ/lambda > 0.41-1.86 TeV and limits on squarks in R-parity violating supersymmetric models are derived. A lower limit on the gravitational scale in 4 + n dimensions of M-S > 0.9 TeV is established for low-scale quantum gravity effects in models with large extra dimensions. For the light quark radius an upper bound of R-q < 0.65 . 10(-18) m is determined. (C) 2011 Elsevier B.V. All rights reserved.
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| 26. |
- Aaron, F. D., et al.
(author)
-
Search for first generation leptoquarks in ep collisions at HERA
- 2011
-
In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 704:5, s. 388-396
-
Journal article (peer-reviewed)abstract
- A search for first generation scalar and vector leptoquarks produced in ep collisions is performed by the H1 experiment at HERA. The full H1 data sample is used in the analysis, corresponding to an integrated luminosity of 446 pb(-1). No evidence for the production of leptoquarks is observed in final states with a large transverse momentum electron or with large missing transverse momentum, and constraints on leptoquark models are derived. For leptoquark couplings of electromagnetic strength lambda = 0.3, first generation leptoquarks with masses up to 800 GeV are excluded at 95% confidence level. (C) 2011 Elsevier B.V. All rights reserved.
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| 27. |
- Aaron, F. D., et al.
(author)
-
Search for lepton flavour violation at HERA
- 2011
-
In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 701:1, s. 20-30
-
Journal article (peer-reviewed)abstract
- A search for second and third generation scalar and vector leptoquarks produced in ep collisions via the lepton flavour violating processes ep -> mu X and ep -> tau X is performed by the H1 experiment at HERA. The full data sample taken at a centre-of-mass energy root s = 319 GeV is used for the analysis, corresponding to an integrated luminosity of 245 pb(-1) of e(+)p and 166 pb(-1) of e(-)p collision data. No evidence for the production of such leptoquarks is observed in the H1 data. Leptoquarks produced in e(+/-)p collisions with a coupling strength of lambda = 0.3 and decaying with the same coupling strength to a muon-quark pair or a tau-quark pair are excluded at 95% confidence level up to leptoquark masses of 712 GeV and 479 GeV, respectively. (C) 2011 Elsevier B.V. All rights reserved.
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| 28. |
- Alexa, C., et al.
(author)
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Elastic and proton-dissociative photoproduction of J/psi mesons at HERA
- 2013
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 73:6
-
Journal article (peer-reviewed)abstract
- Cross sections for elastic and proton-dissociative photoproduction of J/psi mesons are measured with the H1 detector in positron-proton collisions at HERA. The data were collected at ep centre-of-mass energies root s approximate to 318 GeV and root s approximate to 225 GeV, corresponding to integrated luminosities of L = 130 pb(-1) and L = 10.8 pb(-1), respectively. The cross sections are measured as a function of the photon-proton centre-of-mass energy in the range 25 < W-gamma p < 110 GeV. Differential cross sections d sigma/dt, where t is the squared four-momentum transfer at the proton vertex, are measured in the range vertical bar t vertical bar < 1.2 GeV2 for the elastic process and vertical bar t vertical bar < 8 GeV2 for proton dissociation. The results are compared to other measurements. The W-gamma p and t-dependences are parametrised using phenomenological fits.
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| 29. |
- Alexa, C., et al.
(author)
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Measurement of charged particle spectra in deep-inelastic ep scattering at HERA
- 2013
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 73:4
-
Journal article (peer-reviewed)abstract
- Charged particle production in deep-inelastic ep scattering is measured with the H1 detector at HERA. The kinematic range of the analysis covers low photon virtualities, 5 < Q(2) < 100 GeV2, and small values of Bjorken-x, 10(-4) < x < 10(-2). The analysis is performed in the hadronic centre-of-mass system. The charged particle densities are measured as a function of pseudorapidity (n(*)) and transverse momentum (p(T)(*)) in the range 0 < n(*) < 5 and 0 < p(T)(*) < 10 GeV in bins of x and Q(2). The data are compared to predictions from different Monte Carlo generators implementing various options for hadronisation and parton evolutions.
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| 30. |
- Barrett, Jennifer H., et al.
(author)
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Genome-wide association study identifies three new melanoma susceptibility loci
- 2011
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:11, s. 1108-1113
-
Journal article (peer-reviewed)abstract
- We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10(-5) and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10(-3): an SNP in ATM (rs1801516, overall P = 3.4 x 10(-9)), an SNP in MX2 (rs45430, P = 2.9 x 10-9) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 x 10(-10)). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 x 10(-7) under a fixed-effects model and P = 1.2 x 10(-3) under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series.
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| 31. |
- Lundgren, Fredrik, et al.
(author)
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PTFE bypass to below-knee arteries : distal vein collar or not? A prospective randomised multicentre study
- 2010
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In: European Journal of Vascular and Endovascular Surgery. - : Elsevier BV. - 1078-5884 .- 1532-2165. ; 39:6, s. 747-754
-
Journal article (peer-reviewed)abstract
- BackgroundPatency and limb salvage after synthetic bypass to the arteries below-knee are inferior to that which can be achieved with autologous vein. Use of a vein collar at the distal anastomosis has been suggested to improve patency and limb salvage, a problem that is analysed in this randomised clinical study.MethodsPatients with critical limb ischaemia undergoing polytetrafluoroethylene (PTFE) bypass to below-knee arteries were randomly either assigned a vein collar or not in two groups – bypass to the popliteal artery below-knee (femoro-popliteal below-knee (FemPopBK)) and more distal bypass (femoro-distal bypass (FemDist)). Follow-up was scheduled until amputation, death or at most 5 years, whichever event occurred first.ResultsIn the FemPopBK and in the FemDist groups, 115/202 and 72/150 were randomised to have a vein collar, respectively. Information was available for 345 of 352 randomised patients (98%).At 3 years, primary patency was 26% (95% confidence interval (CI) 18–38) with a vein collar and 43 (33–58) without a vein collar for femoro-popliteal bypass and 20 (11–38), and 17 (9–33) for femoro-distal bypass, respectively. The corresponding figures for limb salvage were 64 (54–75) and 61 (50–74) for femoro-popliteal bypass, and 59 (46–76) and 44 (32–61) for femoro-distal bypass with and without a vein collar, respectively. Log-rank-test for the whole Kaplan–Meier life table curve showed no statistically significant differences with or without vein collar primary patency: p = 0.0853, p = 0.228; secondary patency: p = 0.317, p = 0.280; limb salvage: p = 0.757, p = 0.187 for FemPopBK and FemDist, respectively. The use of a vein collar did not influence patency or limb salvage.ConclusionThis study failed to show any benefit for vein collar with PTFE bypass to a below-knee artery.
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| 32. |
- Haq, Rizwan, et al.
(author)
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BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition
- 2013
-
In: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 110:11, s. 4321-4326
-
Journal article (peer-reviewed)abstract
- Although targeting oncogenic mutations in the BRAF serine/threonine kinase with small molecule inhibitors can lead to significant clinical responses in melanoma, it fails to eradicate tumors in nearly all patients. Successful therapy will be aided by identification of intrinsic mechanisms that protect tumor cells from death. Here, we used a bioinformatics approach to identify drug-able, "driver" oncogenes restricted to tumor versus normal tissues. Applying this method to 88 short-term melanoma cell cultures, we show that the antiapoptotic BCL2 family member BCL2A1 is recurrently amplified in similar to 30% of melanomas and is necessary for melanoma growth. BCL2A1 overexpression also promotes melanomagenesis of BRAF-immortalized melanocytes. We find that high-level expression of BCL2A1 is restricted to melanoma due to direct transcriptional control by the melanoma oncogene MITF. Although BRAF inhibitors lead to cell cycle arrest and modest apoptosis, we find that apoptosis is significantly enhanced by suppression of BCL2A1 in melanomas with BCL2A1 or MITF amplification. Moreover, we find that BCL2A1 expression is associated with poorer clinical responses to BRAF pathway inhibitors in melanoma patients. Cotreatment of melanomas with BRAF inhibitors and obatoclax, an inhibitor of BCL2A1 and other BCL2 family members, overcomes intrinsic resistance to BRAF inhibitors in BCL2A1-amplified cells in vitro and in vivo. These studies identify MITF-BCL2A1 as a lineage-specific oncogenic pathway in melanoma and underscore its role for improved response to BRAF-directed therapy.
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| 33. |
- Høyer, B B, et al.
(author)
-
Body mass index in young school age children in relation to organochlorine compounds in early life: a prospective study.
- 2014
-
In: International Journal of Obesity. - : Springer Science and Business Media LLC. - 1476-5497 .- 0307-0565. ; 38:7, s. 919-925
-
Journal article (peer-reviewed)abstract
- Objective:To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in five to nine-year-old children.Methods:Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland) and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.Results:No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) kg m(-2), respectively.Conclusions:This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of five to nine years.International Journal of Obesity accepted article peview online, 10 April 2014; doi:10.1038/ijo.2014.58.
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| 34. |
- Nik-Zainal, Serena, et al.
(author)
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Mutational Processes Molding the Genomes of 21 Breast Cancers
- 2012
-
In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 149:5, s. 979-993
-
Journal article (peer-reviewed)abstract
- All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the DNA damage and repair processes to which cancer cells and their precursors have been exposed. To explore these mechanisms further, we generated catalogs of somatic mutation from 21 breast cancers and applied mathematical methods to extract mutational signatures of the underlying processes. Multiple distinct single- and double-nucleotide substitution signatures were discernible. Cancers with BRCA1 or BRCA2 mutations exhibited a characteristic combination of substitution mutation signatures and a distinctive profile of deletions. Complex relationships between somatic mutation prevalence and transcription were detected. A remarkable phenomenon of localized hypermutation, termed "kataegis,'' was observed. Regions of kataegis differed between cancers but usually colocalized with somatic rearrangements. Base substitutions in these regions were almost exclusively of cytosine at TpC dinucleotides. The mechanisms underlying most of these mutational signatures are unknown. However, a role for the APOBEC family of cytidine deaminases is proposed.
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| 35. |
- Andersson, C, et al.
(author)
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The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes
- 2011
-
In: Autoimmunity. - : Taylor & Francis. - 0891-6934 .- 1607-842X. ; 44:5, s. 394-405
-
Journal article (peer-reviewed)abstract
- Aims: We tested whether autoantibodies to all three ZnT8RWQ variants, GAD65, insulinoma-associated protein 2 (IA-2), insulin and autoantibodies to islet cell cytoplasm (ICA) in combination with human leukocyte antigen (HLA) would improve the diagnostic sensitivity of childhood type 1 diabetes by detecting the children who otherwise would have been autoantibody-negative.Methods: A total of 686 patients diagnosed in 1996–2005 in Skåne were analyzed for all the seven autoantibodies [arginin 325 zinc transporter 8 autoantibody (ZnT8RA), tryptophan 325 zinc transporter 8 autoantibody (ZnT8WA), glutamine 325 Zinc transporter 8 autoantibody (ZnT8QA), autoantibodies to glutamic acid decarboxylase (GADA), Autoantibodies to islet-antigen-2 (IA-2A), insulin autoantibodies (IAA) and ICA] in addition to HLA-DQ genotypes.Results: Zinc transporter 8 autoantibody to either one or all three amino acid variants at position 325 (ZnT8RWQA) was found in 65% (449/686) of the patients. The frequency was independent of age at diagnosis. The ZnT8RWQA reduced the frequency of autoantibody-negative patients from 7.5 to 5.4%—a reduction by 28%. Only 2 of 108 (2%) patients who are below 5 years of age had no autoantibody at diagnosis. Diagnosis without any islet autoantibody increased with increasing age at onset. DQA1-B1*X-0604 was associated with both ZnT8RA (p = 0.002) and ZnT8WA (p = 0.01) but not with ZnT8QA (p = 0.07). Kappa agreement analysis showed moderate (>0.40) to fair (>0.20) agreement between pairs of autoantibodies for all combinations of GADA, IA-2A, ZnT8RWQA and ICA but only slight ( < 0.19) agreement for any combination with IAA.Conclusions: This study revealed that (1) the ZnT8RWQA was common, independent of age; (2) multiple autoantibodies were common among the young; (3) DQA1-B1*X-0604 increased the risk for ZnT8RA and ZnT8WA; (4) agreement between autoantibody pairs was common for all combinations except IAA. These results suggest that ZnT8RWQA is a necessary complement to the classification and prediction of childhood type 1 diabetes as well as to randomize the subjects in the prevention and intervention of clinical trials.
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| 36. |
- Arason, Adalgeir, et al.
(author)
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Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families
- 2010
-
In: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 12:4, s. R50-
-
Journal article (peer-reviewed)abstract
- Chromosomes 2p, 6q and 14q are candidate sites for genes contributing together to high breast cancer risk. A polygenic model is supported, suggesting the joint effect of genes in contributing to breast cancer risk to be rather common in non-BRCA1/2 families. For genetic counselling it would seem important to resolve the mode of genetic interaction.
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| 37. |
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| 38. |
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| 39. |
- Jönsson, Göran B, et al.
(author)
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Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics
- 2010
-
In: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 12:3
-
Journal article (peer-reviewed)abstract
- Introduction: Breast cancer is a profoundly heterogeneous disease with respect to biologic and clinical behavior. Gene-expression profiling has been used to dissect this complexity and to stratify tumors into intrinsic gene-expression subtypes, associated with distinct biology, patient outcome, and genomic alterations. Additionally, breast tumors occurring in individuals with germline BRCA1 or BRCA2 mutations typically fall into distinct subtypes. Methods: We applied global DNA copy number and gene-expression profiling in 359 breast tumors. All tumors were classified according to intrinsic gene-expression subtypes and included cases from genetically predisposed women. The Genomic Identification of Significant Targets in Cancer (GISTIC) algorithm was used to identify significant DNA copy-number aberrations and genomic subgroups of breast cancer. Results: We identified 31 genomic regions that were highly amplified in > 1% of the 359 breast tumors. Several amplicons were found to co-occur, the 8p12 and 11q13.3 regions being the most frequent combination besides amplicons on the same chromosomal arm. Unsupervised hierarchical clustering with 133 significant GISTIC regions revealed six genomic subtypes, termed 17q12, basal-complex, luminal-simple, luminal-complex, amplifier, and mixed subtypes. Four of them had striking similarity to intrinsic gene-expression subtypes and showed associations to conventional tumor biomarkers and clinical outcome. However, luminal A-classified tumors were distributed in two main genomic subtypes, luminal-simple and luminal-complex, the former group having a better prognosis, whereas the latter group included also luminal B and the majority of BRCA2-mutated tumors. The basal-complex subtype displayed extensive genomic homogeneity and harbored the majority of BRCA1-mutated tumors. The 17q12 subtype comprised mostly HER2-amplified and HER2-enriched subtype tumors and had the worst prognosis. The amplifier and mixed subtypes contained tumors from all gene-expression subtypes, the former being enriched for 8p12-amplified cases, whereas the mixed subtype included many tumors with predominantly DNA copy-number losses and poor prognosis. Conclusions: Global DNA copy-number analysis integrated with gene-expression data can be used to dissect the complexity of breast cancer. This revealed six genomic subtypes with different clinical behavior and a striking concordance to the intrinsic subtypes. These genomic subtypes may prove useful for understanding the mechanisms of tumor development and for prognostic and treatment prediction purposes.
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| 40. |
- Jønsson, Knud A, et al.
(author)
-
Ecological and evolutionary determinants for the adaptive radiation of the Madagascan vangas.
- 2012
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 109:17, s. 6620-5
-
Journal article (peer-reviewed)abstract
- Adaptive radiation is the rapid diversification of a single lineage into many species that inhabit a variety of environments or use a variety of resources and differ in traits required to exploit these. Why some lineages undergo adaptive radiation is not well-understood, but filling unoccupied ecological space appears to be a common feature. We construct a complete, dated, species-level phylogeny of the endemic Vangidae of Madagascar. This passerine bird radiation represents a classic, but poorly known, avian adaptive radiation. Our results reveal an initial rapid increase in evolutionary lineages and diversification in morphospace after colonizing Madagascar in the late Oligocene some 25 Mya. A subsequent key innovation involving unique bill morphology was associated with a second increase in diversification rates about 10 Mya. The volume of morphospace occupied by contemporary Madagascan vangas is in many aspects as large (shape variation)--or even larger (size variation)--as that of other better-known avian adaptive radiations, including the much younger Galapagos Darwin's finches and Hawaiian honeycreepers. Morphological space bears a close relationship to diet, substrate use, and foraging movements, and thus our results demonstrate the great extent of the evolutionary diversification of the Madagascan vangas.
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| 41. |
- Lyngso, J., et al.
(author)
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Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study
- 2014
-
In: Human Reproduction. - : Oxford University Press (OUP). - 0268-1161 .- 1460-2350. ; 29:2, s. 359-367
-
Journal article (peer-reviewed)abstract
- Does perfluorooctane sulfonate (PFOS) and perfluorooctanate (PFOA) exposure disrupt the menstrual cyclicity? The female reproductive system may be sensitive to PFOA exposure, with longer menstrual cycle length at higher exposure. PFOS and PFOA are persistent man-made chemicals. Experimental animal studies suggest they are reproductive toxicants but epidemiological findings are inconsistent. A cross-sectional study including 1623 pregnant women from the INUENDO cohort enrolled during antenatal care visits between June 2002 and May 2004 in Greenland, Poland and Ukraine. Information on menstrual cycle characteristics was obtained by questionnaires together with a blood sample from each pregnant woman. Serum concentrations of PFOS and PFOA were measured by liquid chromatography tandem mass spectrometry. Multiple imputations were performed to account for missing data. The association between PFOS/PFOA and menstrual cycle length (short cycle: 24 days, long cycle: 32 days) and irregularities (7 days in difference between cycles) was analyzed using logistic regression with tertiles of exposure. Estimates are given as adjusted odds ratios (ORs) with 95 confidence intervals (CIs). Higher exposure levels of PFOA were associated with longer menstrual cycles in pooled estimates of all three countries. Compared with women in the lowest exposure tertile, the adjusted OR of long cycles was 1.8 (95 CI: 1.0; 3.3) among women in the highest tertile of PFOA exposure. No significant associations were observed between PFOS exposure and menstrual cycle characteristics. However, we observed a tendency toward more irregular cycles with higher exposure to PFOS [OR 1.7 (95 CI: 0.8; 3.5)]. The overall response rate was 45.3 with considerable variation between countries (91.3 in Greenland, 69.1 in Poland and 26.3 in Ukraine). Possible limitations in our study include varying participation rates across countries; a selected study group overrepresenting the most fertile part of the population; retrospective information on menstrual cycle characteristics; the determination of cut-points for all three outcome variables; and lacking information on some determinants of menstrual cycle characteristics, such as stress, physical activity, chronic diseases and gynecological disorders, thus confounding cannot be excluded. The generalizability of the study results is restricted to fertile women who manage to conceive and women who do not use oral contraceptives when getting pregnant or within 2 months before getting pregnant. To our knowledge only one previous epidemiological study has addressed the possible association between perfluorinated chemical exposure and menstrual disturbances. Though pointing toward different disturbances in cyclicity, both studies suggest that exposure to PFOA may affect the female reproductive function. This study contributes to the limited knowledge on effects of exposure to PFOA and PFOS on female reproductive function and suggests that the female reproductive system may be affected by environmental exposure to PFOA. Supported by a scholarship from Aarhus University Research Foundation. The collection of questionnaire data and blood samples was part of the INUENDO project supported by The European Commission (Contract no. QLK4-CT-2001-00 202), . The Ukrainian part of the study was possible by a grant from INTAS (project 012 2205). Determination of PFOA and PFOS in serum was part of the CLEAR study () supported by the European Commissions 7th Framework Program (FP7-ENV-2008-1-226217). No conflict of interest declared.
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| 42. |
- Staaf, Johan, et al.
(author)
-
High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer
- 2010
-
In: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 12:3
-
Journal article (peer-reviewed)abstract
- Introduction: HER2 gene amplification and protein overexpression (HER2+) define a clinically challenging subgroup of breast cancer with variable prognosis and response to therapy. Although gene expression profiling has identified an ERBB2 molecular subtype of breast cancer, it is clear that HER2+ tumors reside in all molecular subtypes and represent a genomically and biologically heterogeneous group, needed to be further characterized in large sample sets. Methods: Genome-wide DNA copy number profiling, using bacterial artificial chromosome (BAC) array comparative genomic hybridization (aCGH), and global gene expression profiling were performed on 200 and 87 HER2+ tumors, respectively. Genomic Identification of Significant Targets in Cancer (GISTIC) was used to identify significant copy number alterations (CNAs) in HER2+ tumors, which were related to a set of 554 non-HER2 amplified (HER2-) breast tumors. High-resolution oligonucleotide aCGH was used to delineate the 17q12-q21 region in high detail. Results: The HER2-amplicon was narrowed to an 85.92 kbp region including the TCAP, PNMT, PERLD1, HER2, C17orf37 and GRB7 genes, and higher HER2 copy numbers indicated worse prognosis. In 31% of HER2+ tumors the amplicon extended to TOP2A, defining a subgroup of HER2+ breast cancer associated with estrogen receptor-positive status and with a trend of better survival than HER2+ breast cancers with deleted (18%) or neutral TOP2A (51%). HER2+ tumors were clearly distinguished from HER2-tumors by the presence of recurrent high-level amplifications and firestorm patterns on chromosome 17q. While there was no significant difference between HER2+ and HER2-tumors regarding the incidence of other recurrent high-level amplifications, differences in the co-amplification pattern were observed, as shown by the almost mutually exclusive occurrence of 8p12, 11q13 and 20q13 amplification in HER2+ tumors. GISTIC analysis identified 117 significant CNAs across all autosomes. Supervised analyses revealed: (1) significant CNAs separating HER2+ tumors stratified by clinical variables, and (2) CNAs separating HER2+ from HER2-tumors. Conclusions: We have performed a comprehensive survey of CNAs in HER2+ breast tumors, pinpointing significant genomic alterations including both known and potentially novel therapeutic targets. Our analysis sheds further light on the genomically complex and heterogeneous nature of HER2+ tumors in relation to other subgroups of breast cancer.
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| 43. |
- Staaf, Johan, et al.
(author)
-
Identification of Subtypes in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Reveals a Gene Signature Prognostic of Outcome.
- 2010
-
In: Journal of Clinical Oncology. - 1527-7755. ; 28:11, s. 1813-1820
-
Journal article (peer-reviewed)abstract
- PURPOSE: Human epidermal growth factor receptor 2 (HER2) gene amplification or protein overexpression (HER2 positivity) defines a clinically challenging subgroup of patients with breast cancer (BC) with variable prognosis and response to therapy. We aimed to investigate the heterogeneous biologic appearance and clinical behavior of HER2-positive tumors using molecular profiling. PATIENTS AND METHODS: Hierarchical clustering of gene expression data from 58 HER2-amplified tumors of various stage, histologic grade, and estrogen receptor (ER) status was used to construct a HER2-derived prognostic predictor that was further evaluated in several large independent BC data sets. RESULTS: Unsupervised analysis identified three subtypes of HER2-positive tumors with mixed stage, histologic grade, and ER status. One subtype had a significantly worse clinical outcome. A prognostic predictor was created based on differentially expressed genes between the subtype with worse outcome and the other subtypes. The predictor was able to define patient groups with better and worse outcome in HER2-positive BC across multiple independent BC data sets and identify a sizable HER2-positive group with long disease-free survival and low mortality. Significant correlation to prognosis was also observed in basal-like, ER-negative, lymph node-positive, and high-grade tumors, irrespective of HER2 status. The predictor included genes associated with immune response, tumor invasion, and metastasis. CONCLUSION: The HER2-derived prognostic predictor provides further insight into the heterogeneous biology of HER2-positive tumors and may become useful for improved selection of patients who need additional treatment with new drugs targeting the HER2 pathway.
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| 44. |
- Wittchen, H U, et al.
(author)
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The size and burden of mental disorders and other disorders of the brain in Europe 2010.
- 2011
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In: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. - : Elsevier BV. - 1873-7862 .- 0924-977X. ; 21:9, s. 655-79
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Journal article (peer-reviewed)abstract
- To provide 12-month prevalence and disability burden estimates of a broad range of mental and neurological disorders in the European Union (EU) and to compare these findings to previous estimates. Referring to our previous 2005 review, improved up-to-date data for the enlarged EU on a broader range of disorders than previously covered are needed for basic, clinical and public health research and policy decisions and to inform about the estimated number of persons affected in the EU.
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| 45. |
- Yang, L., et al.
(author)
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Knockdown of peroxisome proliferator-activated receptor-β induces less differentiation and enhances cell-fibronectinadhesion of colon cancer cells
- 2010
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In: Oncogene. - : Nature publishing group. - 0950-9232 .- 1476-5594. ; 29:4, s. 516-526
-
Journal article (peer-reviewed)abstract
- The role of peroxisome proliferator-activated receptor-/ (PPAR-/) in the pathogenesis of colon cancer remains highly controversial. This study specifically silenced the PPAR- expression in three colon cancer cell lines with different metastatic potentials. Although PPAR-knockdown resulted in more malignant morphological changes, bigger colony sizes and lower carcinoembryonic antigen (CEA) secretion, and enhanced the cell-fibronectin adhesion, cell invasion and migration were unaffected. These effects were stronger in poorly metastatic cell lines compared with highly metastatic ones. Simultaneously, PPAR-knockdown decreased the mRNAs encoding adipocyte differentiation-related protein and liver fatty acid binding protein, and increased the mRNA of ILK, whereas the mRNAs encoding integrin-1 and angiopoietin-like 4 were unchanged. Using immunohistochemistry, we determined that the intensity of PPAR- expression was stronger in rectal cancers with better differentiation than in those with poor differentiation, and was stronger in early-stage tumors than in advanced ones. Together, these findings consistently indicate that PPAR- may facilitate differentiation and inhibit the cell-fibronectin adhesion of colon cancer, having a role as an inhibitor in the carcinogenesis and progression of colorectal cancer. Interestingly PPAR- seems to have a more important role in poorly metastatic cells than in highly metastatic ones.
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| 46. |
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| 47. |
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| 48. |
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| 49. |
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| 50. |
- Bornehag, Carl-Gustaf, 1957-, et al.
(author)
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The SELMA study : a birth cohort study in Sweden following more than 2000 mother-child pairs
- 2012
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In: Paediatric and Perinatal Epidemiology. - Hoboken, USA : Wiley-Blackwell. - 0269-5022 .- 1365-3016. ; 26:5, s. 456-467
-
Journal article (peer-reviewed)abstract
- Background: This paper describes the background, aim and study design for the Swedish SELMA study that aimed to investigate the importance of early life exposure during pregnancy and infancy to environmental factors with a major focus on endocrine disrupting chemicals for multiple chronic diseases/disorders in offspring.Methods: The cohort was established by recruiting women in the 10th week of pregnancy. Blood and urine from the pregnant women and the child and air and dust from home environment from pregnancy and infancy period have been collected. Questionnaires were used to collect information on life styles, socio-economic status, living conditions, diet and medical history.Results: Of the 8394 reported pregnant women, 6658 were invited to participate in the study. Among the invited women, 2582 (39%) agreed to participate. Of the 4076 (61%) non-participants, 2091 women were invited to a non-respondent questionnaire in order to examine possible selection bias. We found a self-selection bias in the established cohort when compared with the non-participant group, e.g. participating families did smoke less (14% vs. 19%), had more frequent asthma and allergy symptoms in the family (58% vs. 38%), as well as higher education among the mothers (51% vs. 36%) and more often lived in single-family houses (67% vs. 60%).Conclusions: These findings indicate that the participating families do not fully represent the study population and thus, the exposure in this population. However, there is no obvious reason that this selection bias will have an impact on identification of environmental risk factors.
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