| 1. |
- Lind, Lars, et al.
(författare)
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Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)
- 2021
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Ingår i: eLife. - : eLife Sciences Publications Ltd. - 2050-084X. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
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| 2. |
- Ahlberg, M., et al.
(författare)
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Time without PSA recurrence after radical prostatectomy as a predictor of prostate cancer death
- 2022
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Ingår i: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560. ; 81:Suppl. 1, s. S286-S286
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Introduction & Objectives: Although surveillance after radical prostatectomy routinely includes repeated Prostate Specific Antigen (PSA)-testing for many years, biochemical recurrence often occurs without further clinical progression. We therefore hypothesised that follow-up can be shortened for many patients without increasing the risk for prostate cancer death. We investigated the long-term probabilities of PSA recurrence, metastases and prostate cancer death in patients without biochemical recurrence 5 and 10 years after radical prostatectomy.Materials & Methods: Between 1989 and 1998, 14 urological centres in Scandinavia randomized patients to the Scandinavian Prostate Cancer Group study number 4 (SPCG-4) trial. Data was collected prospectively. All 306 patients from the SPCG-4 trial who underwent radical prostatectomy within 1 year from inclusion were eligible in our cohort. 4 patients were excluded due to surgery-related death (n=1) or salvage radiotherapy or hormonal treatment within 6 weeks from surgery (n=3). We stratified by Gleason score (≤3+4=7 or ≥4+3=7), pathological tumour stage (pT2 or ≥pT3), and negative or positive surgical margins. We analysed the cumulative incidences and absolute differences in metastatic disease and prostate cancer death.Results: We analysed 302 patients with complete follow-up during a median of 18 years. Median preoperative PSA was 9.8 ng/ml and median age at inclusion was 65 years. For patients without biochemical recurrence 5 years after radical prostatectomy the 20-year probability of biochemical recurrence was 25% among men with Gleason score ≤3+4=7 and 57% among men with Gleason score ≥4+3=7; the probabilities for metastases were 0.8% and 17%; and for prostate cancer death 0.8% and 12% respectively. The long-term probabilities were higher for pT≥3 vs. pT2 and for positive vs. negative surgical margins.Conclusions: Following radical prostatectomy, patients with Gleason score ≤3+4=7 without biochemical recurrence 5 years after radical prostatectomy had low risk of metastases and prostate cancer death independent of pT-stage and surgical margins. The risk of clinical progression decreased drastically the first 3 years after radical prostatectomy and after 10 years without biochemical recurrence, no patient was diagnosed with metastases or died from prostate cancer. Our study indicates that men with favourable histopathology without biochemical recurrence 5 years after radical prostatectomy can stop follow-up earlier than 10 years after radical prostatectomy while men with adverse pathology should continue with at least 10 years follow-up
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| 3. |
- Berggren, Peter, et al.
(författare)
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Coping with large disruptions in the payment system : stakeholder experience from stakeholder workshops and computer based simulation gaming exercises
- 2020
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Ingår i: Proceedings of the 2020 the 3rd International Conference on Computers in Management and Business (ICCMB 2020) Session - Computer and Mobile Technology. - New York : Association for Computing Machinery (ACM). - 9781450376778 ; , s. 141-145, s. 141-145
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Konferensbidrag (refereegranskat)abstract
- In this paper, we describe a work in progress where a mixed methods approach is used to increase insight into what kind of consequences a temporal disruption or total breakdown of the payment system creates for a large variety of societal actors and to increase insight in how their collaborative behaviour can be guided to be more resilient. This approach includes data from different types of data collections; workshop with high-level decisionmakers from involved sectors, interviews with citizens, representatives from the fuel, foods, and finance sectors, as well as experiences from 15 simulation game exercises with stakeholders. The triangulated and aggregated outcomes of the different data collections resulted in a set of recommendations on how to cope with disruptions in the card payment system.
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| 4. |
- Bergsten, Linnea, et al.
(författare)
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Designing engaging computer based simulation games for increasing societal resilience to payment system
- 2020
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Ingår i: Proceedings of the 2020 the 3rd International Conference on Computers in Management and Business (ICCMB 2020) Session - Computer and Mobile Technology. - New York : Association for Computing Machinery (ACM). - 9781450376778 ; , s. 166-172, s. 166-172
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Konferensbidrag (refereegranskat)abstract
- Large or lengthy disruptions to the card payment system are threats that can cause crisis in society, especially in countries where other payment options are scarce. This paper presents a study that provides suggestions on how to improve a simulation game used to increase societal resilience to payment system disruptions. Questionnaires and interviews have been used to investigate how 16 participant in crisis exercises experience realism, relevance and validity in such exercises. Suggestions on how to improve the simulation game are provided, such as improvements to the graphical interface and introducing supporting roles from the exercise management.
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| 5. |
- Blagorodnova, N., et al.
(författare)
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Progenitor, precursor, and evolution of the dusty remnant of the stellar merger M31-LRN-2015
- 2020
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press. - 0035-8711 .- 1365-2966. ; 496:4, s. 5503-5517
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Tidskriftsartikel (refereegranskat)abstract
- M31-LRN-2015 is a likely stellar merger discovered in the Andromeda Galaxy in 2015. We present new optical to mid-infrared photometry and optical spectroscopy for this event. Archival data show that the source started to brighten similar to 2 yr before the nova event. During this precursor phase, the source brightened by similar to 3 mag. The light curve at 6 and 1.5 months before the main outburst may show periodicity, with periods of 16 +/- 0.3 and 28.1 +/- 1.4 d, respectively. This complex emission may be explained by runaway mass-loss from the system after the binary undergoes Roche lobe overflow, leading the system to coalesce in tens of orbital periods. While the progenitor spectral energy distribution shows no evidence of pre-existing warm dust in the system, the remnant forms an optically thick dust shell at approximately four months after the outburst peak. The optical depth of the shell increases dramatically after 1.5 yr, suggesting the existence of shocks that enhance the dust formation process. We propose that the merger remnant is likely an inflated giant obscured by a cooling shell of gas with mass similar to 0.2 M-circle dot ejected at the onset of the common envelope phase.
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| 6. |
- De Costa, A., et al.
(författare)
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Study protocol for WHO and UNICEF estimates of global, regional, and national preterm birth rates for 2010 to 2019
- 2021
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 16:10
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Tidskriftsartikel (refereegranskat)abstract
- Background Preterm birth is a leading cause of death among children under five years. Previous estimates indicated global preterm birth rate of 10.6% (14.8 million neonates) in 2014. We aim to update preterm birth estimates at global, regional, and national levels for the period 2010 to 2019. Methods Preterm birth is defined as a live birth occurring before 37 completed gestational weeks, or <259 days since a woman's last menstrual period. National administrative data sources for WHO Member States with facility birth rates of >= 80% in the most recent year for which data is available will be searched. Administrative data identified for these countries will be considered if >= 80% of UN estimated live births include gestational age information to define preterm birth. For countries without eligible administrative data, a systematic review of studies will be conducted. Research studies will be eligible if the reported outcome is derived from an observational or intervention study conducted at national or sub-national level in population- or facility-based settings. Risk of bias assessments will focus on gestational age measurement method and coverage, and inclusion of special subgroups in published estimates. Covariates for inclusion will be selected a priori based on a conceptual framework of plausible associations with preterm birth, data availability, and quality of covariate data across many countries and years. Global, regional and national preterm birth rates will be estimated using a Bayesian multilevel-mixed regression model. Discussion Accurate measurement of preterm birth is challenging in many countries given incomplete or unavailable data from national administrative sources, compounded by limited gestational age assessment during pregnancy to define preterm birth. Up-to-date modelled estimates will be an important resource to measure the global burden of preterm birth and to inform policies and programs especially in settings with a high burden of neonatal mortality.
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| 7. |
- Hammarbäck, Jimmy, 1977-, et al.
(författare)
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Modelling situated intent for human-autonomy teaming: a human-centric approach
- 2024
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Ingår i: Theoretical Issues in Ergonomics Science. - : TAYLOR & FRANCIS LTD. - 1463-922X .- 1464-536X. ; , s. 1-22
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Tidskriftsartikel (refereegranskat)abstract
- entering an era where humans and synthetic agents are supposed to collaborate and cooperate, adequate models of human intent are cru-cial for coordinated teamwork. Unfortunately, although there is a need for such models, the concept of intent is ambiguous and approaches to model intent from a human-centric perspective are scarce. Building upon theoretical and methodological foundations, this study aims to address these gaps by presenting a conceptualisation of intent along-side an approach. specifically, leveraging the six levels of cognitive control outlined in the Joint control Framework, a provisional model of human intent alongside a defined and operationalised concept is presented. Building on these foundations, a novel approach is pro-posed. Utilising seven scenario-based interviews, the value of these contributions is demonstrated through an example case in the context of Manned-Unmanned teaming. it is concluded that intent should be understood as a multi-faceted concept shaped by situated constraints, where intent is formed through a commitment to choices by context-sit-uation and means-end reasoning. it is also concluded that the approach is useful, particularly since it can glean insights from choices considered and committed, both being essential in the design of synthetic team-mates’ capability to adapt to their human partner’s agency.
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| 8. |
- Johansson, Björn J.E., et al.
(författare)
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A maturity model to guide inter-organisational crisis management and response exercises
- 2024
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Ingår i: International Journal of Disaster Risk Reduction. - : ELSEVIER. - 2212-4209. ; 106
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Tidskriftsartikel (refereegranskat)abstract
- This paper proposes a six-step maturity ladder for inter-organizational collaborative capability in crisis management and response operations. The paper argues that collaborative crisis management and response can be seen as a case of complex adaptive systems, where awareness of the organizational context of crisis response, technical interoperability, and individual relations are drivers that enable rapid and successful mobilization of crisis response. The maturity ladder provides a link between the capabilities necessary for collaboration possessed by individual crisis response entities and the overall system maturity in terms of collaborative crisis management capability. It can inter alia be used as a basis for a discussion when inter-organizational exercises are appropriate and when focus must remain on the development of the capabilities of individual crisis response entities.
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| 9. |
- Johansson, Björn J. E., et al.
(författare)
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Crisis response during payment disruptions – the themes of TRAMS
- 2020
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Ingår i: Proceedings of the 17th ISCRAM Conference. - : Information Systems for Crisis Response and Management (ISCRAM). - 9781949373271 ; , s. 264-275
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Konferensbidrag (refereegranskat)abstract
- A qualitative analysis of observation protocols and audio recordings from 14 crisis response exercises has been conducted revealing eight themes reoccurring in multi-disciplinary team discussions about crisis response to large disruptions to the card payment system. The themes were: Coordinate and collaborate, Payment options, Cash circulation, Fuel and transportation, Security, Inform, communicate and the media, Hoarding and rationing, and Vulnerable groups. The analysis suggest that Swedish society is vulnerable to disruptions in the card payment services, largely due to a low diversity in payment options, the lack of prepared back up solutions for payment, and insufficient cash flows to support a cash only scenario. A longer (several days) disruption in the card payment system will demand coordinating mechanisms for information management, available payment options, and preparedness for rapid establishment of cash flows. Today, these mechanisms do not exist. Simulation exercises with stake-holders are an important mean for increasing awareness about these vulnerabilities and the challenges associated with coping with them. © 2020 Information Systems for Crisis Response and Management, ISCRAM. All rights reserved.
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| 10. |
- Johansson, Cecilia, et al.
(författare)
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Genomic and Phenotypic Characteristics in Geographically Separated Clinical Campylobacter jejuni ST353CC Isolates
- 2021
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Ingår i: Microorganisms. - : MDPI. - 2076-2607. ; 9:12
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Tidskriftsartikel (refereegranskat)abstract
- Campylobacter jejuni fecal isolates of eight international travelers, 5 of which had traveled to Ecuador and 3 to Bangladesh, were characterized, and the possible relationship between bacterial traits and clinical symptoms was further analyzed. All eight isolates belonged to the same Multi-Locus Sequence Type clonal complex (ST353CC). The three isolates from Bangladesh were all of the same sequence type (ST-9438), and when compared to isolates of various other sequence types, they had a larger quantity of unique genetic content, higher expression levels of some putative virulence genes involved in adhesion and invasion (flpA, ciaB and iamA), and showed higher adhesion levels to human HT-29 colon cancer cells in an in vitro infection model. However, in contrast to the seemingly higher pathogenic potential of these bacterial isolates, travelers infected with the ST-9438 isolates had no or only very mild symptoms, whereas the other individuals, whose bacterial isolates seemed to have less pathogenic potential, generally reported severe symptoms. When studying the 16S rRNA gene-based fecal microbiota in samples collected prior to travel, there was an individual variation in the relative abundance of the three major bacterial phyla Actinobacteria, Bacteroidetes and Firmicutes, but there were no associations between composition and diversity of microbiota and development of severe symptoms from the infection. It remains to be confirmed by larger studies whether an individual's characteristics such as gut microbiota, might be related to the severity of symptoms in Campylobacter infections.
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| 11. |
- Johansson, J., et al.
(författare)
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Machinability evaluation of low-lead brass alloys
- 2020
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Ingår i: Procedia Manufacturing. - : Elsevier BV. - 2351-9789. ; 38, s. 1723-1730
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Tidskriftsartikel (refereegranskat)abstract
- The machinability of brass is considered to increase with the addition of lead as an alloying element. Due to both environmental and health reasons, the decrease of lead in brass components is of high importance. Several mechanical and thermal material properties control a materials machinability, in combination with the chosen machining system. To evaluate the difference in machinability between a traditional free-machining leaded alloy and brass alloys with low lead content, material properties influencing the machinability have been measured. Results of machining, such as burr formation and difference in cutting forces and cutting resistance has been studied. The presented results indicates that alloys with lower lead content do not show as good machinability as leaded brass. However, investigations show that the machinability for some of the alloys with low lead content is not considerably worse compared to alloys with a high lead content, making them viable options for a more sustainable production.
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| 12. |
- Johansson, Jonas, et al.
(författare)
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Solar disinfection at low costs: an experimental approach towards up-scaled continuous flow systems
- 2022
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Ingår i: H2open Journal. - : IWA Publishing. - 2616-6518. ; 5:1, s. 153-165
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Tidskriftsartikel (refereegranskat)abstract
- SOlar DISinfection (SODIS) systems have been studied with the aim of maintaining pathogen removal efficiencies and low costs. Such systems are useful for quickly improving the situation of more than 700 million people worldwide that lack access to an improved water source. Currently, SODIS is mainly used with PET-bottles that are exposed to UV-A radiation for 6 h in the sun. Up-scaled continuous flow SODIS systems could instead provide a continuous source of drinking water, whereas the use of plastic tubes, easily available on local markets, ensures a low construction cost of the systems. Such tubes (PVC) were tested and the best option showed a UV-A transparency ratio of similar to 50%, to be compared with similar to 60% for PET-bottles. By using static batches in samples of this tube, the residence time was investigated and the results show that E. coli concentrations of 0 CFU/ml are reached within less than 4 h of exposure to solar radiation, starting from an initial concentration of 10(6) CFU/ml. It can be concluded that cheap, easily available plastic tubes can be used for treating contaminated water with the SODIS technique, which is promising for future investigations towards constructing continuous flow SODIS systems at low costs.
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| 13. |
- Lange, J., et al.
(författare)
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Impact of cancer screening on metastasis: A prostate cancer case study
- 2021
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Ingår i: Journal of Medical Screening. - : SAGE Publications. - 0969-1413 .- 1475-5793. ; 28:4, s. 480-487
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Tidskriftsartikel (refereegranskat)abstract
- Background Trials of cancer screening present results in terms of deaths prevented, but metastasis is also a key endpoint that screening seeks to prevent. We developed a framework for projecting overall (de novo and progressive) metastases prevented in a screening trial using prostate cancer screening as a case study. Methods Mechanistic simulation model in which screening shifts a fraction of cases that would be metastatic at diagnosis to being non-metastatic. This shift increases the incidence of non-overdiagnosed, organ-confined cases. We use estimates of the risk of metastatic progression for these cases to project how many progress to metastasis after diagnosis and tally the projected de novo and progressive metastatic cases with and without screening. We use data on stage shift from the European Randomized Study of Screening for Prostate Cancer (ERSPC) and data on the risk of metastatic progression from the Scandinavian Prostate Cancer Group-4 trial. We estimate the relative risk and absolute risk reductions in metastatic disease at diagnosis and compare these with reductions in overall metastases. Results Assuming no effect of screening beyond initial stage shift at diagnosis, the model projects a 43% reduction in metastasis at diagnosis but a 22% reduction in the cumulative probability of metastasis over 12 years in favor of screening. These results are consistent with the empirical findings from the ERSPC. Conclusion Any reduction in metastatic disease at diagnosis under screening is likely to be an overly optimistic predictor of the impact of screening on overall metastasis and disease-specific mortality.
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| 14. |
- Larsson, Aron, 1976-, et al.
(författare)
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A Simulation-Game for Resilience Assessments in a Payment System Disruption Scenario
- 2022
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Ingår i: International Journal of Knowledge and Systems Science. - : I G I Global. - 1947-8208 .- 1947-8216. ; 13:1, s. 1-25
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a quantitative agent-based simulation model of the everyday payment system used to simulate the business and consumer consequences of loss of functionality, or disruptions of the payment system for the food and fuel retailing markets as well as the bank sector in order to address resilience. The simulation model is used in a gaming simulation approach that couples a role-playing game with the simulation model in order to provide crisis management team-training to decision-makers in a multi-organisational context. Drawing primarily on resilience engineering and crisis response, the concepts of core values, coping strategies, and resilience value networks were used to guide the design of the simulation model. The ultimate aim of this study is to explore the collaborative responses from the key actors during the disruption scenario in order to evoke and facilitate collective resilience.
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| 15. |
- Larsson, Aron, et al.
(författare)
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A Simulation-Game for Resilience Assessments in a Payment System Disruption Scenario
- 2022
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Ingår i: International Journal of Knowledge and Systems Science (IJKSS). - : IGI Global. - 1947-8208 .- 1947-8216. ; 13:1, s. 1-25
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents a quantitative agent-based simulation model of the everyday payment system used to simulate the business and consumer consequences of loss of functionality, or disruptions of the payment system for the food and fuel retailing markets as well as the bank sector in order to address resilience. The simulation model is used in a gaming simulation approach that couples a role-playing game with the simulation model in order to provide crisis management team-training to decision-makers in a multi-organisational context. Drawing primarily on resilience engineering and crisis response, the concepts of core values, coping strategies, and resilience value networks were used to guide the design of the simulation model. The ultimate aim of this study is to explore the collaborative responses from the key actors during the disruption scenario in order to evoke and facilitate collective resilience.
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| 16. |
- Ljungman, S., et al.
(författare)
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Factors associated with time to first dialysis-associated peritonitis episode: Data from the Peritonitis Prevention Study (PEPS)
- 2023
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Ingår i: Peritoneal Dialysis International. - 0896-8608. ; 43:3, s. 241-251
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Peritonitis remains a potentially serious complication of peritoneal dialysis (PD) treatment. It is therefore important to identify risk factors in order to reduce the incidence of peritonitis. The aim of the present analysis was to identify factors associated with time to first peritonitis episode. Methods: Incident PD patients from 57 centres in Europe participated in the prospective randomised controlled Peritonitis Prevention Study (PEPS) from 2010 to 2015. Peritonitis-free, self-care PD patients >= 18 years were randomised to a retraining or a control group and followed for 1-36 months after PD initiation. The association of biochemical, clinical and prescription data with time to first peritonitis episode was studied. Results: A first peritonitis episode was experienced by 33% (223/671) of participants. Univariable Cox proportional hazard regression showed a strong association between the time-updated number of PD bags connected per 24 h (PD bags/24 h) and time to first peritonitis episode (HR 1.35; 95% confidence interval (CI) 1.17-1.57), even after inclusion of PD modalities in the same model. Multivariable Cox regression revealed that the factors independently associated with time to first peritonitis episode included age (HR 1.16 per 10 years; 95% CI 1.05-1.28), PD bags/24 h (HR 1.32; 95% CI 1.13-1.54), serum albumin >35 g/L (HR 1.39; 95% CI 1.06-1.82) and body weight per 10 kg (HR 1.10; 95% CI 1.01-1.19). Conclusion: This study of incident PD patients indicates that older age, greater number of PD bags connected/24 h, higher body weight and hypoalbuminaemia are independently associated with a shorter time to first peritonitis episode.
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| 17. |
- Ljungman, Susanne, 1942, et al.
(författare)
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Retraining for prevention of peritonitis in peritoneal dialysis patients: A randomized controlled trial
- 2020
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Ingår i: Peritoneal Dialysis International. - : SAGE Publications. - 0896-8608 .- 1718-4304. ; 40:2, s. 141-152
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Tidskriftsartikel (refereegranskat)abstract
- Background: Peritonitis is more common in peritoneal dialysis (PD) patients nonadherent to the PD exchange protocol procedures than in compliant patients. We therefore investigated whether regular testing of PD knowledge with focus on infection prophylaxis could increase the time to first peritonitis (primary outcome) and reduce the peritonitis rate in new PD patients. Methods: This physician-initiated, open-label, parallel group trial took place at 57 centers in Sweden, Denmark, Norway, Finland, Estonia, Latvia, the Netherlands, and the United Kingdom from 2010 to 2015. New peritonitis-free PD patients were randomized using computer-generated numbers 1 month after the start of PD either to a control group (n = 331) treated according to center routines or to a retraining group (n = 340), which underwent testing of PD knowledge and skills at 1, 3, 6, 12, 18, 24, 30, and 36 months after PD start, followed by retraining if the goals were not achieved. Results: In all, 74% of the controls and 80% of the retraining patients discontinued the study. The groups did not differ significantly regarding cumulative incidence of first peritonitis adjusted for competing risks (kidney transplantation, transfer to hemodialysis and death; hazard ratio 0.84; 95% confidence interval (CI) 0.65-1.09) nor regarding peritonitis rate per patient year (relative risk 0.93; 95% CI 0.75-1.16). Conclusions: In this randomized controlled trial, we were unable to demonstrate that regular, targeted testing and retraining of new PD patients increased the time to first peritonitis or reduced the rate of peritonitis, as the study comprised patients with a low risk of peritonitis, was underpowered, open to type 1 statistical error, and contamination between groups.
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| 18. |
- Skallsjö, Kristina, 1976, et al.
(författare)
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Oral health in patients scheduled for hematopoietic stem cell transplantation in the Orastem study
- 2023
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Ingår i: Plos One. - 1932-6203. ; 18:5
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Tidskriftsartikel (refereegranskat)abstract
- Despite advances in transplant medicine, prevalence of complications after hematopoietic stem cell transplantation (HSCT) remains high. The impact of pre-HSCT oral health factors on the incidence and severity of complications post-HSCT is poorly understood. The aim of this prospective, observational study was to analyze oral health in patients planned for HSCT. Patients >= 18 years requiring HSCT were included from five sites between 2011-2018. General health, oral findings and patient-reported symptoms were registered in 272 patients. Oral symptoms around disease onset were reported by 43 patients (15.9%) and 153 patients (58.8%) reported oral complications during previous chemotherapy. One third of patients experienced oral symptoms at the oral examination before conditioning regimen and HSCT. In total, 124 (46.1%) patients had dental caries, 63 (29.0%) had >= one tooth with deep periodontal pockets, 147 (75.0%) had >= one tooth with bleeding on probing. Apical periodontitis was observed in almost 1/4 and partially impacted teeth in 17 (6.3%) patients. Oral mucosal lesions were observed in 84 patients (30.9%). A total of 45 (17.4%) of 259 patients had at least one acute issue to be managed prior to HSCT. In conclusion, oral symptoms and manifestations of oral disease were prevalent in patients planned for HSCT. The extent of oral and acute dental diseases calls for general oral screening of patients pre-HSCT.
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| 19. |
- Taylor, Simon J.E., et al.
(författare)
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Using Simulation and Digital Twins to Innovate: Are we Getting Smarter?
- 2021
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Ingår i: Proceedings - Winter Simulation Conference. - 0891-7736. ; 2021-December
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Konferensbidrag (refereegranskat)abstract
- Digital Twins have recently emerged as a major new area of innovation. Digital Twins are often found at the core of 'smart' solutions that have also emerged as major areas of innovation. Modeling and Simulation (MS) approaches create a model of a real-world system that is linked to data sources and is used to simulate and predict the behavior of its real-world counterpart. On the face of it Digital Twins and MS appear to be similar, if not the same. Is this actually the case? Are the two fields really separate or is Digital Twin research re-inventing the 'MS wheel'? To investigate these relationships, in this panel we will explore some contemporary innovations with Digital Twins and discuss whether or not Digital Twins is a contemporary 'refresh' or 'rebranding' of MS or if there are exciting new synergies.
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| 20. |
- Woltjer, Rogier, et al.
(författare)
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Air Transport System Agility: The Agile Response Capability (ARC) Methodology for Crisis Preparedness
- 2022
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Ingår i: Infrastructures. - : MDPI AG. - 2412-3811 .- 2412-3811. ; 7:2, s. 11-11
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Tidskriftsartikel (refereegranskat)abstract
- Aviation is a highly inter-connected system. This means that a problem in one area maycause effects in other countries or parts of the Air Transport System (ATS). Examples range from localair traffic disruptions to the 2010 volcanic ash crisis. Agility, like resilience, refers to the ability to copewith dynamics and complexity in a flexible manner, by adjusting and adapting performance and theorganization of work to fit changing demands. The aim of this work is to help ATS organizationswith increasing their agility in the face of crises and challenges. To this end, this article presents theAgile Response Capability (ARC) guidance material. ARC was developed from a literature study anda number of case studies that combined past event analysis, interviews, focus groups, workshops,questionnaires, and exercise observation methodologies. ARC aims to help aviation organizations toset up, run, and evaluate exercises promoting agility to handle disturbances and crises, and to enablestructured pro-active and retrospective analysis of scenarios and actual events. The elements andsteps of the ARC approach are illustrated and exemplified with data from three case studies. TheARC methodology facilitates more agile and resilient ways of responding to the fundamental andnovel surprises that have become almost commonplace in the past decade, and are likely to continueto do so.
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| 21. |
- Zhao, J. H., et al.
(författare)
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Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
- 2023
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Ingår i: Nature Immunology. - : Springer Nature. - 1529-2908 .- 1529-2916. ; 24:9, s. 1540-1551
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Tidskriftsartikel (refereegranskat)abstract
- Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans). Integration of pQTL data with eQTL and disease genome-wide association studies provided insight into pathogenesis, implicating lymphotoxin-alpha in multiple sclerosis. Using Mendelian randomization (MR) to assess causality in disease etiology, we identified both shared and distinct effects of specific proteins across immune-mediated diseases, including directionally discordant effects of CD40 on risk of rheumatoid arthritis versus multiple sclerosis and inflammatory bowel disease. MR implicated CXCL5 in the etiology of ulcerative colitis (UC) and we show elevated gut CXCL5 transcript expression in patients with UC. These results identify targets of existing drugs and provide a powerful resource to facilitate future drug target prioritization. Here the authors identify genetic effectors of the level of inflammation-related plasma proteins and use Mendelian randomization to identify proteins that contribute to immune-mediated disease risk.
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