| 1. |
- Alfredsson, Emma, et al.
(författare)
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Background - Framework and Content of the ITP programme
- 2016. - 1
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Ingår i: Realising Child Rights in Education : Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management - Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management. - 9789198226164 ; 1, s. 7-27
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
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| 3. |
- Leo, Ulf, et al.
(författare)
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Analysis and Reflections
- 2014
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Ingår i: Enforcing Child Rights Globally. - 9789198053555 ; , s. 141-156
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Bokkapitel (refereegranskat)
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| 4. |
- Leo, Ulf, et al.
(författare)
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Background
- 2014
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Ingår i: Enforcing Child Rights Globally. - 9789198053555 ; , s. 7-13
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Bokkapitel (refereegranskat)
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| 5. |
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| 6. |
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| 7. |
- Leo, Ulf, et al.
(författare)
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The Role of Change Agents
- 2014
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Ingår i: Enforcing Child Rights Globally. - 9789198053555 ; , s. 171-187
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Bokkapitel (refereegranskat)
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| 8. |
- Rasmusson, Bodil, et al.
(författare)
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Looking back and looking forward
- 2016. - 1
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Ingår i: Realising Child Rights in Education : Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management - Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management. - 9789198226164 ; 1, s. 217-225
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Rasmusson, Bodil, et al.
(författare)
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Mentors´Reflections
- 2016. - 1
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Ingår i: Realising Child Rights in Education : Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management - Experience and Reflections from the International Training Programme on Child Rights, Classroom and School Management. - 9789198226164 ; 1, s. 187-217
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Rasmusson, Bodil, et al.
(författare)
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Summing up
- 2015
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Ingår i: Change Projects from the International Training Programme: Child Rights, Classroom and School Management. Final reports. Batch 18.. - 9789198053531 ; Volume 7, s. 197-207
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Bokkapitel (refereegranskat)
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| 11. |
- Wickenberg, Per, et al.
(författare)
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Analysis and reflections
- 2009
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Ingår i: Taking Child Rights Seriously. - 9789197838108 ; , s. 111-127
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 12. |
- Wickenberg, Per, et al.
(författare)
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Children´s participation as one pathway to protection: : Lessons from the Global South
- 2021
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Ingår i: Research Report in Sociology of Law, Lund University. - 9789172674356 - 9789172674370 ; , s. 13-28
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this report book in Sociology of Law, and Child Rights Institute, Lund University, is to gather, sum up and report, in a summarizing overview in three concluding articles, our main experiences as researchers and teachers. This is the second article in this report book.
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| 13. |
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| 14. |
- Wickenberg, Per, et al.
(författare)
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Introduction
- 2021
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Ingår i: Research Report in Sociology of Law. - 1404-1030 .- 1404-1030. - 9789172674356 - 9789172674370 ; :1, s. 7-12
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this report book in Sociology of Law, and Child Rights Institute, LundUniversity, is to sum up and report, in a summarizing overview in the Introduction our main experiences of Children´s Rights in Education during 18 years in the Global South as researchers and teachers.
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| 15. |
- Wickenberg, Per, et al.
(författare)
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Summing up - Batch 20 : Change Projects from the International Training Programme - Batch 20
- 2015
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Ingår i: Child Rights, Classroom and School Management, Batch 20 : Change Projects from the International Training Programme - Change Projects from the International Training Programme. - 9789198226126 ; , s. 225-232
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003. Theprogramme targets those in a position from which they can initiate processesof change in the education sector in their countries. During the programmeall participating teams initiate a change project in their respective countriesaiming at the realization of the intention of the Child Rights Convention inpolicy as well as in practice. This book contains the final reports from Batch20 with change agents from China, Colombia, DPR of Korea, Indonesia, Malawi,Mozambique, Namibia, Sri Lanka, Uganda, Viet Nam, and Zambia.
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| 16. |
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| 17. |
- Wångdahl Flinck, Agneta, et al.
(författare)
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Summing up - Batch 21: Change Projects from the International Training Programme : Child Rights, Classroom and School Management - Batch 21
- 2016
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Ingår i: Child Rights, Classroom and School Management : Batch 21 - Batch 21. - 9789198226157
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003.The programme targets those in a position from which they can initiate processesof change in the education sector in their countries. During the programmeall participating teams initiate a change project in their respectivecountries aiming at the realization of the intention of the Child Rights Conventionin policy as well as in practice. This book contains the final reportsfrom Batch 21 with change agents from Cambodia, China, Egypt, Ethiopia,Malawi, Namibia, South Africa, Tanzania, Viet Nam, and Zambia.
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| 18. |
- Do, Ron, et al.
(författare)
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Common variants associated with plasma triglycerides and risk for coronary artery disease
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1345-
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Tidskriftsartikel (refereegranskat)abstract
- Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
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| 19. |
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| 20. |
- Moayyeri, Alireza, et al.
(författare)
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Genetic determinants of heel bone properties : genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
- 2014
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:11, s. 3054-3068
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Tidskriftsartikel (refereegranskat)abstract
- Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 x 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 x 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 x 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology.
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| 21. |
- Willer, Cristen J., et al.
(författare)
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Discovery and refinement of loci associated with lipid levels
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1274-1283
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Tidskriftsartikel (refereegranskat)abstract
- Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
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| 22. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 23. |
- Ahlström, Björn, 1972-, et al.
(författare)
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School Leadership as (Un)usual : Insights from Principals in Sweden during a Pandemic
- 2020
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Ingår i: International Studies in Educational Administration. - : Commonwealth Council for Educational Administration and Management. - 1324-1702 .- 1839-2768. ; 48:2, s. 35-41
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Tidskriftsartikel (refereegranskat)abstract
- This paper offers insights into educational leadership in relation to the example of Sweden exceptionalism that kept most of its schools open during the COVID-19 pandemic. Informed discussions based on reports from conversations with principals, media and a survey highlight three themes identified as challenges for the principals: dealing with pupils, staff members and parents’ anxiety, a constant state of uncertainty and the ones left behind. These themes ignite discussions of implications for educational leadership in which the elements of trust, the formation of stable organizations and equity are leadership strategies in what we consider leadership as (un)usual.
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| 24. |
- Andersson, Lena, et al.
(författare)
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Child Rights, Classroom and School Management : Change Projects from the International Training Programme Batch 15 - 2011b
- 2013
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Rapport (populärvet., debatt m.m.)abstract
- Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003. The programmetargets those in a position from which they can initiate processes ofchange in the education sector in their countries. During the programme all participating teams initiate a change project in their respective countries aiming atthe realization of the intention of the Child Rights Convention in policy as wellas in practice. This book contains the final reports from Batch 15 with changeagents from Cambodia, Egypt, India, Indonesia, Malawi, Mozambique, SouthAfrica, Tanzania, Uganda and Vietnam.
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| 25. |
- Andersson, Lena, et al.
(författare)
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Child Rights, Classroom and School Management : Change Projects from the International Training Programme Batch 20-2014a
- 2015
-
Rapport (populärvet., debatt m.m.)abstract
- Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003. Theprogramme targets those in a position from which they can initiate processesof change in the education sector in their countries. During the programmeall participating teams initiate a change project in their respective countriesaiming at the realization of the intention of the Child Rights Convention inpolicy as well as in practice. This book contains the final reports from Batch20 with change agents from China, Colombia, DPR of Korea, Indonesia, Malawi,Mozambique, Namibia, Sri Lanka, Uganda, Viet Nam, and Zambia.
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| 26. |
|
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| 27. |
- Arvidsson, Inger, et al.
(författare)
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Burnout among school teachers : quantitative and qualitative results from a follow-up study in southern Sweden
- 2019
-
Ingår i: BMC Public Health. - : BioMed Central. - 1471-2458. ; 19
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Tidskriftsartikel (refereegranskat)abstract
- Background: Teachers are at high risk of stress-related disorders. This longitudinal study aimed to (a) identify which occupational, sociodemographic and life-style factors and self-efficacy at baseline that were of importance for burnout, (b) explore associations between changes in the studied factors versus changes in burnout, and (c) by interviews increase the understanding of perceived job demands among teachers.Methods: A cohort of 310 Swedish teachers in school-years 4–9 responded to a questionnaire of occupational, sociodemographic and life-style factors, self-efficacy and burnout, at baseline and at follow-up (mean 30 months later). A combined measure with four levels of burnout was crafted, based on exhaustion, cynicism and professional efficacy (Maslach Burnout Inventory-General Survey). Quantitative data were analysed with multiple ordinal regression, and qualitative data were analysed with content analysis of interview responses from a subgroup of the teachers (n = 81).Results: The occurrence of high burnout (level 2 and 3 combined) were similar at baseline and follow-up (14% vs. 15%). However, many teachers fluctuated between the levels of burnout (28% increased and 24% decreased). Burnout at baseline was of importance for change of work or being off duty at follow up. In the multi-exposure model, low self-efficacy [OR 0.42; CI 0.26–0.68] and high job demands [OR 1.97; CI 1.02–3.8] were the strongest explanatory variables. Low self-efficacy remained as the strongest explanatory factor after adjustment for burnout at baseline. Increased job demands during follow-up was associated with an increased level of burnout [OR 3.41; CI 1.73–6.69], whereas increased decision latitude was associated with a decreased level of burnout [OR 0.51; CI 0.30–0.87]. Two major categories of demands emerged in the qualitative analysis; i.e. too high workload and a sense of inadequacy.Conclusions: A substantial proportion of teachers showed signs of burnout at both occasions. Low self-efficacy and high job demands was of importance for burnout, and changes in burnout was further associated with changes in decision latitude. The results points to the need of actions on individual, organizational and a societal levels.
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| 28. |
- Arvidsson, Inger, et al.
(författare)
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Should I stay or should I go? Associations between occupational factors, signs of exhaustion and the intention to change workplace among swedish principals
- 2021
-
Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 18:10, s. 1-20
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Tidskriftsartikel (refereegranskat)abstract
- A high turnover among principals may disrupt the continuity of leadership and negatively affect teachers and, by extension, the students. The aim was to investigate to what extent various work environment factors and signs of exhaustion were associated with reported intentions to change workplace among principals working in compulsory schools. A web-based questionnaire was administered twice, in 2018 and in 2019. Part I of the study involved cross-sectional analyses of the associations 2018 (n = 984) and 2019 (n = 884) between occupational factors, signs of exhaustion, and the intention to change workplace, using Generalized Estimating Equations models. Part II involved 631 principals who participated in both surveys. The patterns of intended and actual changes of workplace across two years were described, together with associated changes of occupational factors and signs of exhaustion. Supportive management was associated with an intention to stay, while demanding role conflicts and the feeling of being squeezed between management and co-workers (buffer-function) were associated with the intention to change workplace. The principals who intended to change their workplace reported more signs of exhaustion. To increase retention among principals, systematic efforts are probably needed at the national, municipal, and local level, in order to improve their working conditions.
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| 29. |
- Arvidsson, Inger, et al.
(författare)
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Should I stay or should I go? Associations between occupational factors, signs of exhaustion and the intention to change workplace among swedish principals
- 2021
-
Ingår i: International Journal of Environmental Research and Public Health. - : MDPI Multidisciplinary Digital Publishing Institute. - 1661-7827 .- 1660-4601. ; 18:10, s. 1-20
-
Tidskriftsartikel (refereegranskat)abstract
- A high turnover among principals may disrupt the continuity of leadership and negatively affect teachers and, by extension, the students. The aim was to investigate to what extent various work environment factors and signs of exhaustion were associated with reported intentions to change workplace among principals working in compulsory schools. A web-based questionnaire was administered twice, in 2018 and in 2019. Part I of the study involved cross-sectional analyses of the associations 2018 (n = 984) and 2019 (n = 884) between occupational factors, signs of exhaustion, and the intention to change workplace, using Generalized Estimating Equations models. Part II involved 631 principals who participated in both surveys. The patterns of intended and actual changes of workplace across two years were described, together with associated changes of occupational factors and signs of exhaustion. Supportive management was associated with an intention to stay, while demanding role conflicts and the feeling of being squeezed between management and co-workers (buffer-function) were associated with the intention to change workplace. The principals who intended to change their workplace reported more signs of exhaustion. To increase retention among principals, systematic efforts are probably needed at the national, municipal, and local level, in order to improve their working conditions.
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| 30. |
- Aschard, Hugues, et al.
(författare)
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Evidence for large-scale gene-by-smoking interaction effects on pulmonary function
- 2017
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Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 46:3, s. 894-904
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Smoking is the strongest environmental risk factor for reduced pulmonary function. The genetic component of various pulmonary traits has also been demonstrated, and at least 26 loci have been reproducibly associated with either FEV1 (forced expiratory volume in 1 second) or FEV1/FVC (FEV1/forced vital capacity). Although the main effects of smoking and genetic loci are well established, the question of potential gene-by-smoking interaction effect remains unanswered. The aim of the present study was to assess, using a genetic risk score approach, whether the effect of these 26 loci on pulmonary function is influenced by smoking.METHODS: We evaluated the interaction between smoking exposure, considered as either ever vs never or pack-years, and a 26-single nucleotide polymorphisms (SNPs) genetic risk score in relation to FEV1 or FEV1/FVC in 50 047 participants of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) and SpiroMeta consortia.RESULTS: We identified an interaction (βint = -0.036, 95% confidence interval, -0.040 to -0.032, P = 0.00057) between an unweighted 26 SNP genetic risk score and smoking status (ever/never) on the FEV1/FVC ratio. In interpreting this interaction, we showed that the genetic risk of falling below the FEV 1: /FVC threshold used to diagnose chronic obstructive pulmonary disease is higher among ever smokers than among never smokers. A replication analysis in two independent datasets, although not statistically significant, showed a similar trend in the interaction effect.CONCLUSIONS: This study highlights the benefit of using genetic risk scores for identifying interactions missed when studying individual SNPs and shows, for the first time, that persons with the highest genetic risk for low FEV1/FVC may be more susceptible to the deleterious effects of smoking.
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| 31. |
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| 32. |
- Benjamin, Caroline M., et al.
(författare)
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Educational priorities and current involvement in genetic practice: a survey of midwives in the Netherlands, UK and Sweden
- 2009
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Ingår i: Midwifery. - : Elsevier BV. - 1532-3099 .- 0266-6138. ; 25:5, s. 483-499
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Tidskriftsartikel (refereegranskat)abstract
- Objective: to investigate whether practising midwives are adequately prepared to integrate genetic information into their practice. Design: a cross-sectional, postal, structured questionnaire survey was sent to practising midwives. Setting: practising midwives from the Netherlands (NL), Sweden (SE) and the United Kingdom (UK). Participants: 1021 replies were received, achieving a response rate of 62%. Findings: 79% (799/1015) of midwives reported attending courses with some 'genetic content' during their initial training. Sixty-eight per cent (533/784) judged this to have been useful for clinical practice. Variation was seen between countries in the amount of genetic content in post-registration training (SE 87%, NL 44%, UK 17%) and underpinned by genetic knowledge. For eight of the 12 procedures, fewer than 20% of midwives considered themselves to be confident. Differences were apparent between countries. Midwives identified psychosocial, screening and risk assessment aspects of genetic education as being important to them, rather than technical aspects or genetic science. Conclusions: given the low reported confidence with genetic issues in clinical practice, it is essential that this is addressed in terms of the amount, content and targeting of genetic education. This is especially important to ensure the success of national antenatal and baby screening programmes. The results of this study suggest that midwives would welcome further training in genetics, addressing genetic topics most relevant to their clinical practice. (C) 2007 Elsevier Ltd. All rights reserved.
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| 33. |
- Bielack, Stefan S, et al.
(författare)
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Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial
- 2015
-
Ingår i: Journal of Clinical Oncology. - 1527-7755. ; 33:20, s. 2279-2287
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose EURAMOS-1, an international randomized controlled trial, investigated maintenance therapy with pegylated interferon alfa-2b (IFN-α-2b) in patients whose osteosarcoma showed good histologic response (good response) to induction chemotherapy. Patients and Methods At diagnosis, patients age ≤ 40 years with resectable high-grade osteosarcoma were registered. Eligibility after surgery for good response random assignment included ≥ two cycles of preoperative MAP (methotrexate, doxorubicin, and cisplatin), macroscopically complete surgery of primary tumor, < 10% viable tumor, and no disease progression. These patients were randomly assigned to four additional cycles MAP with or without IFN-α-2b (0.5 to 1.0 μg/kg per week subcutaneously, after chemotherapy until 2 years postregistration). Outcome measures were event-free survival (EFS; primary) and overall survival and toxicity (secondary). Results Good response was reported in 1,041 of 2,260 registered patients; 716 consented to random assignment (MAP, n = 359; MAP plus IFN-α-2b, n = 357), with baseline characteristics balanced by arm. A total of 271 of 357 started IFN-α-2b; 105 stopped early, and 38 continued to receive treatment at data freeze. Refusal and toxicity were the main reasons for never starting IFN-α-2b and for stopping prematurely, respectively. Median IFN-α-2b duration, if started, was 67 weeks. A total of 133 of 268 patients who started IFN-α-2b and provided toxicity information reported grade ≥ 3 toxicity during IFN-α-2b treatment. With median follow-up of 44 months, 3-year EFS for all 716 randomly assigned patients was 76% (95% CI, 72% to 79%); 174 EFS events were reported (MAP, n = 93; MAP plus IFN-α-2b, n = 81). Hazard ratio was 0.83 (95% CI, 0.61 to 1.12; P = .214) from an adjusted Cox model. Conclusion At the preplanned analysis time, MAP plus IFN-α-2b was not statistically different from MAP alone. A considerable proportion of patients never started IFN-α-2b or stopped prematurely. Long-term follow-up for events and survival continues.
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| 34. |
- Blom, Thomas, 1972-
(författare)
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Tid för tillit : Kritiska ögonblick i rektorers vardagsarbete
- 2022
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This study focuses on principals’ leadership in the light of trust as a natural phenomenon. Trust has earlier been seen as a factor in management and organizations to create results. However, what leadership actions that principals and teachers perceive contribute to this trust has not been studied in a Swedish school context. The purpose is to contribute to a deepened knowledge of what in everyday situations that are perceived to contribute to trust between principals and teachers. Taking the theoretical framework from Løgstrup as a point of departure, interviews with six principals and fourteen teachers have been conducted. At first, the principals were interviewed about situations they perceived had trust in the relation with teachers. Secondly, teachers were interviewed about the same situation. The analyses point to that principals’ attitude affect the way they act. This attitude toward the other could be central on how principals create a space in their relations to teachers where trust can exist, use time to the other and interact in the situation. The study contributes to a deeper understanding of an interacting leadership that create a space for trust in the relations between principals and teachers.
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| 35. |
- Bröms, Tina
(författare)
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Rektorns beslutsfattande om skolans organisation : Navigering utifrån beslutslogiker i oländig terräng
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Over the past several years, there has been a greater demand for accountability of principal´s for the education they provide. Through the Education Act (SFS 2010:800), the Swedish parliament has increased the regulation and clarification of the principal´s responsibility in several areas, for example the responsibility to decide on the school’s internal organization. This thesis takes an interest for the principal´s decision-making, more accurately the aim is to develop knowledge about the principal´s decision-making through logics of decisions (Brunsson & Brunsson, 2017). The concept of logics of decisions is central in this study and are used as an analytical framework to understand and explain how the principal make decision about the internal school organization. Through a reflexive research process (Alvesson & Sköldberg, 2017) the aim is explored thorough three methods: a survey, observations and interviews (Creswell). The results demonstrate thorough logics of decisions that even if principal´s experience mandate, legitimacy and authority, they have a limited room for action options in their decision-making. In the discussion, I argue from a decision-theory perspective that the state, the school board, the staff and the local community essentially control the principal preferences. The legal regulations make the logic of appropriateness with its focus on laws and regulations visible in decision-making. Since the legal regulations are governed by a rationality where there is a best way for the principal to make decision, the logic of imitation will also appear in the decision-making. I also argue that the logic experimentation which is rather invisible in the principal decision-making possibly create at different way for decision-making from those that dominate today. The logic of experimental can become a means of critical examination in the principal own decision-making and practice. Overall, the thesis theoretical contribution is to use a decision-theoretic perspective through the conceptualization of logics of decisions to provide new dimensions of the principal´s decision-making in a context where it has not been used before, the school context.
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| 36. |
- Calefato, Jean-Marc, et al.
(författare)
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Assessing educational priorities in genetics for general practitioners and specialists in five countries: factor structure of the Genetic-Educational Priorities (Gen-EP) scale
- 2008
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Ingår i: Genetics in Medicine. - 1098-3600. ; 10:2, s. 99-106
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: A scale assessing primary care physicians' priorities for genetic education (The Gen-EP scale) was developed and tested in five European countries. The objective of this study was to determine its factor structure, to test scaling assumptions and to determine internal consistency. Methods: The sample consisted of 3686 practitioners (general practitioners, gyneco-obstetricians, pediatricians) sampled in France, Germany, the Netherlands, Sweden, and United Kingdom. We first determined the factor structure of the Gen-EP scale (30 items) on the whole sample. Scaling assumptions were then tested on each country using multitrait scaling analysis. Internal consistency was assessed across the five countries. Results: Six factors were identified accounting for 63.3% of the variance of the items. They represented the following priorities for genetic education: "Genetics of Common Diseases"; "Ethical, Legal, and Public Health Issues"; "Approaching Genetic Risk Assessment in Clinical Practice"; "Basic Genetics and Congenital Malformations"; "Techniques and Innovation in Genetics" and "Psychosocial and Counseling Issues." In each country, convergent and discriminant validity were satisfactory. Internal-consistency reliability coefficients (Cronbach's alpha) were all above the acceptable threshold (0.70). Conclusion: The Gen-EP scale could be a helpful instrument in different countries to organize and evaluate the impact of genetic educational programs for primary care providers.
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| 37. |
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| 38. |
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Children´s Rights in Education : Experiences from 16 countries in Global South during 18 years as researchers and teachers
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this report book in Sociology of Law, and Child Rights Institute, Lund University, is to gather, sum up and report, in a summarizing overview in an introduction followed by three concluding articles, our main experiences as researchers and teachers after 2016.That year, 2016, the English version of the Sida-funded international training program, Child Rights, Classroom and School Management, was finished. However, there was a lot of continued work to come with Children´s Rights at Lund University after that.This report could be viewed as an interesting example of how to achieve spin-off effects through strategies for sustainability and dissemination of knowledge and experiences from international cooperation on implementation of children’s rights.
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| 39. |
- de Vries, Paul S., et al.
(författare)
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Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
- 2019
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Ingår i: American Journal of Epidemiology. - : Oxford University Press. - 0002-9262 .- 1476-6256. ; 188:6, s. 1033-1054
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Tidskriftsartikel (refereegranskat)abstract
- A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 x 10(-6)) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 x 10(-8) using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.
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| 40. |
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| 41. |
- Evangelou, Evangelos, et al.
(författare)
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
- 2018
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:10, s. 1412-1425
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Tidskriftsartikel (refereegranskat)abstract
- High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
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| 42. |
- Furer, Victoria, et al.
(författare)
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2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases
- 2020
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 79:1, s. 39-52
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Tidskriftsartikel (refereegranskat)abstract
- To update the European League Against Rheumatism (EULAR) recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) published in 2011. Four systematic literature reviews were performed regarding the incidence/prevalence of vaccine-preventable infections among patients with AIIRD; efficacy, immunogenicity and safety of vaccines; effect of anti-rheumatic drugs on the response to vaccines; effect of vaccination of household of AIIRDs patients. Subsequently, recommendations were formulated based on the evidence and expert opinion. The updated recommendations comprise six overarching principles and nine recommendations. The former address the need for an annual vaccination status assessment, shared decision-making and timing of vaccination, favouring vaccination during quiescent disease, preferably prior to the initiation of immunosuppression. Non-live vaccines can be safely provided to AIIRD patients regardless of underlying therapy, whereas live-attenuated vaccines may be considered with caution. Influenza and pneumococcal vaccination should be strongly considered for the majority of patients with AIIRD. Tetanus toxoid and human papilloma virus vaccination should be provided to AIIRD patients as recommended for the general population. Hepatitis A, hepatitis B and herpes zoster vaccination should be administered to AIIRD patients at risk. Immunocompetent household members of patients with AIIRD should receive vaccines according to national guidelines, except for the oral poliomyelitis vaccine. Live-attenuated vaccines should be avoided during the first 6 months of life in newborns of mothers treated with biologics during the second half of pregnancy. These 2019 EULAR recommendations provide an up-to-date guidance on the management of vaccinations in patients with AIIRD.
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| 43. |
- Furer, Victoria, et al.
(författare)
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Incidence and prevalence of vaccine preventable infections in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) : A systemic literature review informing the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD
- 2019
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Ingår i: RMD Open. - : BMJ. - 2056-5933. ; 5:2
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Tidskriftsartikel (refereegranskat)abstract
- Objectives The aims of this study were to update the evidence on the incidence and prevalence rates of vaccine preventable infections (VPI) in patients with autoimmune inflammatory rheumatic diseases (AIIRD) and compare the data to the general population when available. Methods A literature search was performed using Medline, Embase and Cochrane library (October 2009 to August 2018). The primary outcome was the incidence or prevalence of VPI in the adult AIIRD population. Meta-analysis was performed when appropriate. Results Sixty-three publications out of 3876 identified records met the inclusion criteria: influenza (n=4), pneumococcal disease (n=7), hepatitis B (n=10), herpes zoster (HZ) (n=29), human papillomavirus (HPV) infection (n=13). An increased incidence of influenza and pneumococcal disease was reported in patients with AIIRD. HZ infection-pooled incidence rate ratio (IRR) was 2.9 (95% CI 2.4 to 3.3) in patients with AIIRD versus general population. Among AIIRD, inflammatory myositis conferred the highest incidence rate (IR) of HZ (pooled IRR 5.1, 95% CI 4.3 to 5.9), followed by systemic lupus erythematosus (SLE) (pooled IRR 4.0, 95% CI 2.3 to 5.7) and rheumatoid arthritis (pooled IRR 2.3, 95% CI 2.1 to 2.6). HPV infection-pooled prevalence ratio was 1.6, 95% CI 0.7 to 3.4 versus general population, based on studies mainly conducted in the SLE population in Latin America and Asia. Pooled prevalence of hepatitis B surface antigen and hepatitis B core antibody in patients with AIIRD was similar to the general population, 3%, 95% CI 1% to 5% and 15%, 95% CI 7% to 26%, respectively. Conclusion Current evidence shows an increased risk of VPI in patients with AIIRD, emphasising that prevention of infections is essential in these patients.
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| 44. |
- Gorski, Mathias, et al.
(författare)
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1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
- 2017
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10(-8) previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our previous analyses. Among those, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism, cardiac septum development and glucose metabolism. These results highlight the utility of re-imputing from denser reference panels, until whole-genome sequencing becomes feasible in large samples.
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| 45. |
- Grimm, Frida, 1978-
(författare)
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Ledarskap för lärares lärande : förstelärare som lärarledare
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Today, new teacher leader functions are emerging in several parts of the world. Previous research has highlighted the potential of teacher leadership to enhance teacher learning, but also recorded resistance among teachers to being collectively led in efforts to improve teaching and learning. The aim of this thesis is to draw attention to, and contribute knowledge about, local school actors’ explicit and implicit teacher leadership constructions in schools. Three overarching research questions are addressed: 1) How is teacher leadership constructed in schools? 2) How do these constructions enhance and constrain possibilities to lead teacher learning? 3) How can visualising explicit and implicit teacher leadership practices contribute to learning about leadership for teacher learning?Spillane’s model of distributed leadership and Wenger’s theories of social learning are used to study, analyse, and create knowledge about teacher leadership constructions. Empirically, the thesis is based on material collected in two qualitative studies conducted in Swedish schools in 2019 and 2021/22. This included interviews (58) with visual material and video-observations (6) designed to capture relevant understandings and practices, both explicit and implicit. The results show that egalitarian and autonomous norms strongly influence teacher leadership constructions, while ‘first teachers’, whose roles are supposed to include leadership, are solely regarded as teachers, not leaders, with unrecognized functions and practices. The mainly acknowledging and facilitative teacher leader practices both enhance and constrain teachers’ learning. On one hand, teachers are encouraged to share ideas and try out alternative teaching methods, while on the other hand, current methods and perspectives on teaching and learning tend to be conserved rather than challenged. Supportive and acknowledging leadership practices therefore need to be combined with challenging of perspectives and a habit of inquiry. By visualising explicit and implicit understandings and teacher leadership practices, local school actors and researchers can gain new insights about ways to develop and improve teacher leadership to promote learning. Four conclusions are drawn: 1) Local school actors’ understandings of teacher leadership need to be nuanced, challenged, and developed. 2) Leaders for learning need to manage learning as both individual and collective, concrete and abstract, acknowledging and challenging. 3) Conscious choices and changes are needed at all organisational levels to utilise teacher leaders’ capacities. 4) Visualisation of, and reflection on, explicit and implicit understandings and practices contribute to more conscious choices and changes in leadership for learning.
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| 46. |
- Gunnulfsen, Ann Elisabeth, et al.
(författare)
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Principals' Roles in a Nordic Education Context : Shared Responsibility and Pedagogical Engagement
- 2023
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Ingår i: Education and Democracy in the Nordic Countries. - Cham : Springer. - 9783031331947 - 9783031331954 ; , s. 115-132
-
Bokkapitel (refereegranskat)abstract
- The purpose of this paper is to examine and discuss the role of Nordic school principals in a cross-national context and to highlight the implications for the leadership roles in research and practice. The data builds on the country-wide reports in this book, the findings in the TALIS report (2018), and the perspectives of pedagogical leadership. The ways in which school leadership roles are perceived and dealt with are relatively similar across national school contexts. Nordic school principals seem to experience their practice with shared responsibilities, providing opportunities and educational engagement by acting as pedagogical leaders with a collective approach to their leadership role, even though there are differences in Nordic education policy contexts. Pedagogical leadership in a Nordic context means leadership tasks primarily related to curriculum, teaching activities, and the core values of schooling. Power, trust, control in the form of governance and leadership in the Nordic countries needs high attention.
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| 47. |
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| 48. |
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| 49. |
- Håkansson, Carita, et al.
(författare)
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Organizational and social work environment factors, occupational balance and no or negligible stress symptoms among Swedish principals : a cross-sectional study
- 2021
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Ingår i: BMC Public Health. - : BioMed Central. - 1471-2458. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Few studies have assessed the mental health of principals, or studied associations with both organizational and social work environment factors and occupational balance. The purpose of the present study was therefore to investigate associations between supporting and demanding organizational and social work environment factors, occupational balance and stress symptoms in principals. Methods: A total of 4309 surveys (2316 from the first round, 1992 from the second round), representing 2781 Swedish principals who had responded to at least one of two surveys, were included in the present study. The surveys include questions about socio-demographic factors, occupational balance, overtime work, and supporting and demanding organizational and social work environment factors, as well as questions about personal stress and exhaustion. Generalized Estimating Equations (GEE) models were used to specify a repeated measures model with a dichotomous outcome (binary logistic regression) and multiple independent factors. Data from two surveys were combined, taking into account dependent observations due to the fact that many study subjects had participated in both surveys. Results: Associations were found between occupational balance (Q1: OR 2.52, 95% CI 2.03–3.15; Q2: OR 4.95, 95% CI 3.86–6.35; Q3: OR 9.29, 95% CI 6.99–12.34), overtime work (Once a week: OR 1.51, 95% CI 1.10–2.08; Sometimes a week: OR 1.31, 95% CI 1.03–1.66), supportive private life (OR 1.50, 95% CI 1.36–1.66), supportive colleagues at the leadership level (OR 1.24, 95% CI 1.14–1.36), supportive management (OR 1.17, 95% CI 1.07–1.28) and no or negligible stress symptoms. In addition, role demands (OR 0.72, 95% CI 0.63–0.83), having a container function (OR 0.72, 95% CI 0.64–0.82), collaboration with employees (OR 0.77, 95% CI 0.66–0.89), role conflicts (OR 0.75, 95% CI 0.66–0.89) and having a buffer function (OR 0.86, 95% CI 0.77–0.97) were associated with lower likelihood to rate no or negligible stress symptoms. Conclusions: The occupational balance of principals is strongly associated with no or negligible stress symptoms, and thus is a promising venue for promoting well-being. Improvements should be made to several factors in the organizational and social work environments to improve principals’ chances of having occupational balance, and therefore better mental health.
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| 50. |
- Irestedt, Martin, 1968-, et al.
(författare)
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No Signs of Genetic Erosion in a 19th Century Genome of the Extinct Paradise Parrot (Psephotellus pulcherrimus)
- 2019
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Ingår i: DIVERSITY-BASEL. - : MDPI. ; 11:4
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Tidskriftsartikel (refereegranskat)abstract
- The Paradise Parrot, Psephotellus pulcherrimus, was a charismatic Australian bird that became extinct around 1928. While many extrinsic factors have been proposed to explain its disappearance, it remains unclear as to what extent genetic erosion might have contributed to the species’ demise. In this study, we use whole-genome resequencing to reconstruct a 15x coverage genome based on a historical museum specimen and shed further light on the evolutionary history that preceded the extinction of the Paradise Parrot. By comparing the genetic diversity of this genome with genomes from extant endangered birds, we show that during the species’ dramatic decline in the second half of the 19th century, the Paradise Parrot was genetically more diverse than individuals from species that are currently classified as endangered. Furthermore, demographic analyses suggest that the population size of the Paradise Parrot changed with temperature fluctuations during the last glacial cycle. We also confirm that the Golden-shouldered Parrot, Psephotellus chrysopterygius, is the closest living relative of this extinct parrot. Overall, our study highlights the importance of museum collections as repositories of biodiversity across time and demonstrates how historical specimens can provide a broader context on the circumstances that lead to species extinctions.
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