| 1. |
|
|
| 2. |
|
|
| 3. |
- Sandén, Annika, 1969-
(författare)
-
Stadsgemenskapens resurser och villkor : Samhällssyn och välfärdsstrategier i Linköping 1600-1620
- 2005
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation studies early seventeenth century local government, both the secular and religious, in order to investigate that period’s concepts of ”the good society”, and the strategies that were used to achieve and retain this ideal. The goal of the investigation is to give a broader understanding of early modern society at the local level. Order and balance appear to have been the overriding goal for the local institutions in Linköping. Justice and well-being were not a question of individual rights, but rather were found in corporative associations in which differences together created a hierarchical harmony and order. People who stood outside these were threatened by marginalization. For those who were “on the inside” resources were available. In the town were found material resources such as wells and gristmills, the community of the parish and the rådsturätt. Local authorities do not express any concept of development or a utopia of change. It did not seek to redistribute material resources or systematize support for specific vulnerable groups. A fundamental welfare strategy was to fit people into households within which they could support themselves. In the same way the religious punishments, can be seen as an important welfare strategy. To recreate order was also a way of appeasing God. If God liked what he saw, then perhaps he would rest his hand over the congregation. In summary it can thus be said that the local government tried to formulate the conditions for welfare by creating the premises for two important spheres—the home and the parish.
|
|
| 4. |
- Zhao, Qinghai, et al.
(författare)
-
Effects of dextranation on the pharmacokinetics of short peptides : A PETstudy on mEGF
- 1999
-
Ingår i: Bioconjugate chemistry. - : American Chemical Society (ACS). - 1043-1802 .- 1520-4812. ; 10:6, s. 938-946
-
Tidskriftsartikel (refereegranskat)abstract
- The effects of dextranation on the biodistribution of mouse epidermal growth factor (mEGF, 6 kDa) were assessed. By reductive amination, mEGF was coupled to 13 and 46 kDa dextran. The two dextranated conjugates and free mEGF were labeled with the positron-emitting nuclide (76)Br (T(1/2) = 16 h). After intravenous administration to Sprague Dawley rats, the radioactivity biodistribution was evaluated by positron emission tomography (PET) and by measurements of dissected tissues. The dextranation prolonged the retention time in blood, especially when the dextran chain was long. [(76)Br]mEGF-dextran conjugates were shown to have significantly, more than 5 times, lower kidney accumulation than the nonconjugated [(76)Br]mEGF. In conclusion, dextranation affects the biodistribution of mEGF in vivo giving a prolonged circulation time, a decreased uptake in kidney, and an increased spleen accumulation.
|
|
| 5. |
- Abrahamsson, L., et al.
(författare)
-
Behöver arbetslinjen inte forskning?
- 2007
-
Ingår i: Svenska Dagbladet Brännpunkt (debattinlägg). ; :2007-11-28
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 6. |
- Almén, Niclas, 1971-, et al.
(författare)
-
Behavioral Stress Recovery Management Intervention for People With High Levels of Perceived Stress : A Randomized Controlled Trial
- 2020
-
Ingår i: International Journal of Stress Management. - : American Psychological Association (APA). - 1072-5245 .- 1573-3424. ; 27:2, s. 183-194
-
Tidskriftsartikel (refereegranskat)abstract
- Continuous and prolonged exposure to stressors or unsuccessfully dealing with such exposure has been suggested as precursors for burnout. Current research indicates that such stress problems could be conceptualized as deficiencies in recovery between periods of stress. The purpose of this study was to evaluate the efficacy of a behaviorally oriented stress recovery management intervention for people experiencing high levels of stress. A total of 73 individuals with experiences of stress symptoms and high levels of perceived stress (>= 25 on the Perceived Stress Scale) were randomly allocated to either a 10-week intervention group or a waiting-list control group. Participants were assessed at preintervention, postintervention, and 3-month follow-up. The Perceived Stress Scale, questions about tension, and the Shirom-Melamed Burnout Questionnaire were used as primary outcome measures. and the Hospital Anxiety and Depression Scale was used as a secondary outcome measure. Data were analyzed following the intention-to-treat principle. The analysis demonstrated statistically significant improvements for all measures at posttreatment and at follow-up. The between-groups effect sizes were high at posttreatment and moderate-to-high at follow-up. Intervention focused on stress recovery behavior seems to be an effective way of reducing perceived stress, tension, burnout symptoms, anxiety, and depression in people with stress symptoms and high levels of perceived stress in everyday life. The tested intervention warrants further research. Other stress recovery behavior interventions need to be tested to draw conclusions on the efficacy of stress recovery behavior interventions in general regarding stress and burnout.
|
|
| 7. |
- Almén, Niclas, 1971-, et al.
(författare)
-
Effects of a Recovery-Focused Intervention for Stress Management : A Randomized Controlled Trial
- 2015
-
Konferensbidrag (refereegranskat)abstract
- AbstractINTRODUCTIONStress symptoms, burnout, poor mental health and long-term sick leave related to these are major problems in Sweden and elsewhere. Evidence-based prevention and treatment efforts are lacking. Research indicates that stress related health problems primarily could be conceptualized as deficiencies in recovery responses between stress periods rather than high level of stress responses per se. Therefore it is relevant to examine whether it is effective to intervene the recovery behavior – instead of the stress behavior - of people with stress symptoms.OBJECTIVESThe primary purpose of this study was to investigate if a behavioral oriented recovery management intervention could enhance “recovery behaviors” and experiences of recovery and reduce stress related ill health.METHODS A group based intervention program focusing exclusively on “recovery behavior” in everyday life (earlier developed and tested in two pilot studies) was evaluated in an experimental group study. The intervention consisted of seven group sessions of 2.5 hours over a period of approximately 10 weeks supplemented by an internet based treatment support system. Self- referred subjects with scores above 24.4 on the Perceived stress scale were randomized to the intervention (n=26) or a waiting-list (n=33).RESUL TStatistically significant and clinically relevant effects were achieved for the intervention group compare to the waiting-list group: recovery behaviors and experiences of recovery were increased, and levels of perceived stress, worry, anxiety, depression and exhaustion were decreased.DISCUSSION These results are in line with two previous pilot studies that we have done. A behavioral and recovery oriented intervention seems to be effective to increase the recovery of the individual and decrease stress related ill health. There are reasons to continue to explore the potential of recovery-oriented interventions for example for different populations (such as people with more extensive clinical health problems) and in different contexts.
|
|
| 8. |
- Andersson Ersman, Peter, et al.
(författare)
-
Integration of Screen Printed Piezoelectric Sensors for Force Impact Sensing in Smart Multifunctional Glass Applications
- 2022
-
Ingår i: Advanced Engineering Materials. - : John Wiley & Sons, Ltd. - 1438-1656 .- 1527-2648. ; 24:11
-
Tidskriftsartikel (refereegranskat)abstract
- Screen printed piezoelectric polyvinylidene fluoride?trifluoro ethylene (PVDF?TrFE)-based sensors laminated between glass panes in the temperature range 80?110?°C are presented. No degradation of the piezoelectric signals is observed for the sensors laminated at 110?°C, despite approaching the Curie temperature of the piezoelectric material. The piezoelectric sensors, here monitoring force impact in smart glass applications, are characterized by using a calibrated impact hammer system and standardized impact situations. Stand-alone piezoelectric sensors and piezoelectric sensors integrated on poly(methyl methacrylate) are also evaluated. The piezoelectric constants obtained from the measurements of the nonintegrated piezoelectric sensors are in good agreement with the literature. The piezoelectric sensor response is measured by using either physical electrical contacts between the piezoelectric sensors and the readout electronics, or wirelessly via both noncontact capacitive coupling and Bluetooth low-energy radio link. The developed sensor concept is finally demonstrated in smart window prototypes, in which integrated piezoelectric sensors are used to detect break-in attempts. Additionally, each prototype includes an electrochromic film to control the light transmittance of the window, a screen printed electrochromic display for status indications and wireless communication with an external server, and a holistic approach of hybrid printed electronic systems targeting smart multifunctional glass applications.
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
- Calissendorff, Jan, et al.
(författare)
-
68Ga-DOTA-TOC-PET/CT detects heart metastases from ileal neuroendocrine tumors
- 2014
-
Ingår i: Endocrine. - : Springer Science and Business Media LLC. - 1559-0100 .- 1355-008X. ; 47:1, s. 169-176
-
Tidskriftsartikel (refereegranskat)abstract
- Metastases from ileal neuroendocrine tumors (NETs) to the myocardium are rare and generally seen in patients with widespread metastatic NET disease. The objectives of this investigation were to describe the frequency of intracardiac metastases in ileal NET patients examined by 68Ga-DOTA-TOC-PET/CT and to describe the cases in detail. All 68Ga-DOTA-TOC-PET/CT examinations performed at the Karolinska University Hospital since 2010 until April 2012 were reviewed. In all, 128 out of 337 examinations were in patients with ileal NETs. Four patients had seven myocardiac metastases, yielding a frequency of 4.3 % in patients with ileal NETs. One patient had cardiac surgery while three were treated with somatostatin analogs. The cardiac metastases did not affect the patients’ activity of daily life. 68Ga-DOTA-TOC-PET/CT is an established imaging modality in identifying cardiac metastases in ileal NETs. Prospective studies are needed to confirm the true clinical value of 68Ga-DOTA-TOC-PET/CT in detecting cardiac metastases in both ileal and non-ileal NETs.
|
|
| 12. |
- Calissendorff, Jan, et al.
(författare)
-
Adrenal cysts : an emerging condition.
- 2023
-
Ingår i: Nature Reviews Endocrinology. - : Springer Nature. - 1759-5029 .- 1759-5037. ; 19, s. 398-406
-
Tidskriftsartikel (refereegranskat)abstract
- Adrenal cysts are rare lesions representing approximately 1-2% of adrenal incidentalomas. The majority of these rare lesions are benign. Rarely, phaeochromocytomas and adrenal malignant masses can present as cystic lesions and can occasionally be difficult to distinguish from benign cysts. Histologically, adrenal cysts are subdivided into pseudocysts, endothelial cysts, epithelial cysts and parasitic cysts. The radiological appearance of an adrenal cyst is generally similar to that of cysts in the kidney. They are thus well demarcated, usually rounded, with a thin wall and homogenous internal structure, low attenuating (<20 Hounsfield Units) on CT, low signalling on T1-weighted MRI sequences and high signalling on T2-weighted MRI sequences, and anechoic or hypoechoic on ultrasonography. Benign adrenal cysts have a slight female predominance and are usually diagnosed between the ages of 40 and 60. Most adrenal cysts are asymptomatic and are detected incidentally, although very large adrenal cysts can lead to mass effect symptoms, with surgery required to alleviate the symptoms. Thus, conservative management is usually recommended for asymptomatic cysts. However, when uncertainty exists regarding the benign nature of the cyst, additional work-up or follow-up is needed. The management of an adrenal cyst should preferably be discussed at an adrenal multidisciplinary team meeting.
|
|
| 13. |
- Calissendorff, Jan, et al.
(författare)
-
Adrenal myelolipomas
- 2021
-
Ingår i: The Lancet Diabetes and Endocrinology. - : Elsevier. - 2213-8587 .- 2213-8595. ; 9:11, s. 767-776
-
Forskningsöversikt (refereegranskat)abstract
- Adrenal myelolipomas are benign, lipomatous tumours with elements of myeloid cells, most of which present as adrenal incidentalomas and comprise 3·3-6·5% of all adrenal masses. Adrenal myelolipomas are usually unilateral (in 95% of cases), variable in size, most often found during midlife, and affect both sexes almost equally. On imaging, adrenal myelolipomas show pathognomonic imaging features consistent with the presence of macroscopic fat. Large adrenal myelolipomas can cause symptoms of mass effect, and can occasionally be complicated by haemorrhage. In the event of a concomitant adrenal cortical adenoma or hyperplasia, adrenal hormone excess might be detected in patients with adrenal myelolipoma. Patients with congenital adrenal hyperplasia exhibit a higher prevalence of adrenal myelolipomas than other patient groups, and are at risk of developing large and bilateral lesions. This Review discusses the pathogenesis, clinical presentation, and management of adrenal myelolipomas.
|
|
| 14. |
- Calissendorff, Jan, et al.
(författare)
-
Ileal neuroendocrine tumors and heart : not only valvular consequences
- 2015
-
Ingår i: Endocrine. - : Springer Science and Business Media LLC. - 1355-008X .- 1559-0100. ; 48:3, s. 743-755
-
Forskningsöversikt (refereegranskat)abstract
- Ileal neuroendocrine tumors (NETs) often progress slowly, but because of their generally nonspecific symptoms, they have often metastasized to local lymph nodes and to the liver by the time the patient presents. Biochemically, most of these patients have increased levels of whole blood serotonin, urinary 5-hydroxyindoleacetic acid, and chromogranin A. Imaging work-up generally comprises computed tomography or magnetic resonance imaging and somatostatin receptor scintigraphy, or in recent years positron emission tomography with Ga-68-labeled somatostatin analogs, allowing for detection of even sub-cm lesions. Carcinoid heart disease with affected leaflets, mainly to the right side of the heart, is a well-known complication and patients routinely undergo echocardiography to diagnose and monitor this. Multitasking surgery is currently recognized as first-line treatment for ileal NETs with metastases and carcinoid heart disease. Open heart surgery and valve replacement are advocated in patients with valvular disease and progressive heart failure. When valvulopathy in the tricuspid valve results in right-sided heart failure, a sequential approach, performing valve replacement first before intra-abdominal tumor-reductive procedures are conducted, reduces the risk of bleeding. Metastases to the myocardium from ileal NETs are seen in <1-4.3% of patients, depending partly on the imaging technique used, and are generally discovered in those affected with widespread disease. Systemic treatment with somatostatin analogs, and sometimes alpha interferon, is first-line medical therapy in metastatic disease to relieve hormonal symptoms and stabilize the tumor. This treatment is also indicated when heart metastases are detected, with the addition of diuretics and fluid restriction in cases of heart failure. Myocardial metastases are rarely treated by surgical resection.
|
|
| 15. |
- Carlsson, Hanna, et al.
(författare)
-
Educating for democracy? : The role of media and information literacy education for pupils in Swedish compulsory school
- 2020
-
Ingår i: Sustainable Digital Communities : 15th International Conference, iConference 2020, Boras, Sweden, March 23–26, 2020, Proceedings - 15th International Conference, iConference 2020, Boras, Sweden, March 23–26, 2020, Proceedings. - Cham : Springer International Publishing. - 1611-3349 .- 0302-9743. - 9783030436865 - 9783030436872 ; 12051, s. 307-326
-
Konferensbidrag (refereegranskat)abstract
- This paper reports a study of pupils’ experiences of media and information literacy education in five Swedish schools by answering the following overarching question, what roles do the teaching of information seeking and critical assessment of information play for pupils in their school-work as well as in their everyday life? Pupils in ninth grade were asked to fill in a questionnaire regarding their use of digital technology as well as their thoughts on media and information literacy education. The study shows that many pupils are knowledgeable about the terms of production pertaining to content in most online sources they mention. Still, infrastructural meaning-making that take into consideration issues of personalization, data integrity and surveillance, are largely lacking. The study also shows that the school’s teaching is central to the pupils’ development of a critical stance towards the information that they encounter online. These findings underline the importance of how schools choose to treat media and information literacy education. It is concerning then that infrastructural meaning-making is quite absent in the pupils’ responses.
|
|
| 16. |
- Carlsson, Jörgen, et al.
(författare)
-
Conjugate chemistry and cellular processing of EGF-dextran
- 1999
-
Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 38:3, s. 313-321
-
Tidskriftsartikel (refereegranskat)abstract
- Conjugates with specific binding to the epidermal growth factor receptor, EGFR, of interest for radionuclide based imaging and therapy were prepared using mouse epidermal growth factor, mEGF, and dextran. In one type of conjugate, mEGF was coupled to dextran by reductive amination in which the free amino group on the mEGF N-terminal reacted with the aldehyde group on the reductive end of dextran. The end-end coupled conjugate could be further activated by the cyanopyridinium agent CDAP, thereby introducing tyrosines to the dextran part. In the other type of conjugate, the cyanylating procedure using CDAP was applied, first to activate dextran and then allowing for the amino terminus of mEGF to randomly attach to the dextran. In the latter case, radionuclide-labelled tyrosines or glycines could be added in the same conjugation step. All types of mEGF-dextran conjugates had EGFR-specific binding since the binding could be displaced by an excess of non-radioactive mEGF. The conjugates were to a large extent internalized in the test cells and the associated radioactivity was retained intracellularly for different times depending on both the type of cells and conjugate applied. Different intracellular 'traffic routes' for the radionuclides are discussed as well as applications for both imaging and therapy.
|
|
| 17. |
- Castensson, Reinhold, et al.
(författare)
-
Urban Water Supply and Improvement of Health Conditions
- 1988
-
Ingår i: Society, Health and Population during the Demographic Transition. - Stockholm : Almqvist and Wiksell International. - 9122012168 ; , s. 273-298
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)
|
|
| 18. |
- Dahlberg, Stefan, 1975, et al.
(författare)
-
The Quality of Government Expert Survey 2008-2011: A Report.
- 2013
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The literature on the quality of government generally, and corruption more specifically, focus main-ly on the political side of the state. There are however strong reasons to believe that bureaucratic structures have important effects on political, economic, and social outcomes, but with very few exceptions there are no cross-country datasets. In order to meet this challenge, and provide data on the bureaucratic structure on a large number of countries in the developed and the developing parts of the world, this paper presents the Quality of Government Expert Survey. The survey covers a variety of topics relevant to the structure and functioning of the public administration, such as mer-itocratic recruitment, internal promotion and career stability, salaries, impartiality, NPM reforms, effectiveness/efficiency, and bureaucratic representation of, for example, ethnic groups and gender. This paper describe the data-collection, provide some basic facts about the data and about the ex-perts, and, finally, analyze how experts have answered the items in the questionnaire in order to evaluate potential respondent perception bias.
|
|
| 19. |
- Dogra, Prerna, et al.
(författare)
-
Rare benign adrenal lesions
- 2023
-
Ingår i: European Journal of Endocrinology. - : Oxford University Press. - 0804-4643 .- 1479-683X. ; 188:4, s. 407-420
-
Tidskriftsartikel (refereegranskat)abstract
- While most benign lesions of the adrenal glands represent either an adrenocortical adenoma or a myelolipoma, the advent and frequent use of high-resolution radiological investigations have led to relatively increased incidental discovery of rare adrenal lesions, specifically benign adrenal cysts, adrenal ganglioneuromas, adrenal schwannomas, adrenal hemorrhage, and adrenal calcifications. Radiological characteristics of the different rare benign adrenal lesions could vary from distinct to indeterminate. Though typically nonfunctional, these rare lesions require evaluation for adrenal hormone excess, as they may phenotypically appear similar to pheochromocytoma or adrenocortical carcinoma and could sometimes be associated with or conceal an underlying functional adrenal tumor. In this review, we discuss the various rare benign adrenal lesions, emphasizing a practical perspective.
|
|
| 20. |
- Eriksson, Lina J. K., et al.
(författare)
-
The interactive effect of the Behavioral Inhibition System (BIS) and response inhibition on accuracy in a modified stop-signal task
- 2016
-
Ingår i: Personality and Individual Differences. - : Elsevier BV. - 0191-8869 .- 1873-3549. ; 97, s. 198-202
-
Tidskriftsartikel (refereegranskat)abstract
- The ability to adjust to a changing environment is an important aspect of every-day life and successful goal directed behavior requires the ability to suppress responses that are no longer appropriate. The main purpose of the present study was to examine if the relationship between inhibitory control (as indexed by stop-signal reaction time, SSRT) and behavioral precision is dependent on levels of Gray and McNaughton's Behavioral Inhibition System (BIS). Additionally, the relationship between BIS and electrodermal activity, and the Behavioral Approach System (BAS) and heart rate activity was investigated. A modified stop-signal task was used. The results showed that there was an interaction effect of BIS and SSRT on accuracy, suggesting that among individuals with higher levels of BIS, longer SSRT (i.e. poorer inhibitory ability) was associated with decreased accuracy. There were no significant correlations between trait variables and physiological variables. The results were discussed in terms of higher levels of BIS being a vulnerability factor when the individual's inhibitory ability simultaneously is poor in situations where the ability to inhibit inappropriate behavioral routines is important for task performance.
|
|
| 21. |
- Eriksson, Olof, et al.
(författare)
-
Quantitative Imaging of Serotonergic Biosynthesis and Degradation in the Endocrine Pancreas
- 2014
-
Ingår i: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 55:3, s. 460-465
-
Tidskriftsartikel (refereegranskat)abstract
- Serotonergic biosynthesis in the endocrine pancreas, of which the islets of Langerhans is the major constituent, has been implicated in insulin release and β cell proliferation. In this study, we investigated the feasibility of quantitative noninvasive imaging of the serotonergic metabolism in the pancreas using the PET tracer (11)C-5-hydroxy-l-tryptophan ((11)C-5-HTP).METHODS: Uptake of (11)C-5-HTP, and its specificity for key enzymes in the serotonergic metabolic pathway, was assessed in vitro (INS-1 and PANC1 cells and human islet and exocrine preparations) and in vivo (nonhuman primates and healthy and diabetic rats).RESULTS: In vitro tracer uptake in endocrine cells (INS-1 and human islets), but not PANC1 and exocrine cells, was mediated specifically by intracellular conversion into serotonin. Pancreatic uptake of (11)C-5-HTP in nonhuman primates was markedly decreased by inhibition of the enzyme dopa decarboxylase, which converts (11)C-5-HTP to (11)C-serotonin and increased after inhibition of monoamine oxidase-A, the main enzyme responsible for serotonin degradation. Uptake in the rat pancreas was similarly modulated by inhibition of monoamine oxidase-A and was reduced in animals with induced diabetes.CONCLUSION: The PET tracer (11)C-5-HTP can be used for quantitative imaging of the serotonergic system in the endocrine pancreas.
|
|
| 22. |
- Eriksson, Olof, et al.
(författare)
-
The Positron Emission Tomography ligand [11C]5-Hydroxy-Tryptophan can be used as a surrogate marker for the human endocrine pancreas
- 2014
-
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 63:10, s. 3428-3437
-
Tidskriftsartikel (refereegranskat)abstract
- In humans a well-developed serotonin system is localized to the pancreatic islets while being absent in exocrine pancreas. Assessment of pancreatic serotonin biosynthesis could therefore be used to estimate the human endocrine pancreas. Proof of concept was tested in a prospective clinical trial by comparisons of type 1 diabetic (T1D) patients, with extensive reduction of beta cells, with healthy volunteers (HV).C-peptide negative (i.e. insulin-deficient) T1D subjects (n=10) and HV (n=9) underwent dynamic Positron Emission Tomography with the radiolabeled serotonin precursor [(11)C]5-Hydroxy-Tryptophan ([(11)C]5-HTP).A significant accumulation of [(11)C]5-HTP was obtained in the pancreas of the HV, with large inter-individual variation. A substantial and highly significant reduction (66%) in the pancreatic uptake of [(11)C]5-HTP in T1D subjects was observed, and this was most evident in the corpus and caudal regions of the pancreas where beta-cells normally are the major constituent of the islets.[(11)C]5-HTP retention in the pancreas was reduced in T1D compared to non-diabetic subjects. Accumulation of [(11)C]5-HTP in the pancreas of both HV and subjects with T1D were in agreement with previously reported morphological observations on the beta cell volume implying that [(11)C]5-HTP retention is a useful non-invasive surrogate marker for the human endocrine pancreas.
|
|
| 23. |
- Ewerman, Lea, et al.
(författare)
-
Immunomodulating Effects Depend on Prolactin Levels in Patients with Hyperprolactinemia
- 2020
-
Ingår i: Hormone and Metabolic Research. - Stuttgart : Thieme Medical Publishers. - 0018-5043 .- 1439-4286. ; 52:04, s. 228-235
-
Tidskriftsartikel (refereegranskat)abstract
- Prolactin is known to have immune modulatory effects acting through the prolactin receptor, which is present on a variety of immune cells. Certain chemokines contribute to form the type of T helper (Th) preponderance in the immune response. The objective of this work was to assess if hyperprolactinemia not related to pregnancy is associated with changes in circulating levels of chemokines and other immunological markers. In this cross sectional study, 35 patients with hyperprolactinemia (5 men), and 102 healthy blood donors (19 men) were included. Serum levels of Th1- Th2- and Th17-associated chemokines, C-reactive protein, immunoglobulins, and the B cell attracting chemokine CXCL13 were assessed. The hyperprolactinemic group had significantly higher levels of Th2 associated CCL22 (p=0.022), Th17 associated CXCL1 (p=0.001), B cell attracting CXCL13 (p=0.003), and C-reactive protein (p<0.001) compared to controls, and these proteins were also positively correlated with prolactin levels. While differences in CCL22, CXCL1, CXCL13, and C-reactive protein were present in patients with low or moderate hyperprolactinemia, no differences were observed at high (>3600 mU/l) prolactin levels. To evaluate a possible dose-associated response to prolactin, an in vitro model was used, showing prolactin-induced increase in T-helper cell activation at moderate levels, while activation decreased at higher levels. Hyperprolactinemia seems to have several immunomodulatory effects and was associated with increased levels of chemokines associated with Th2 and Th17 responses and B cell attraction. However, patients with greatly increased prolactin had normal levels of chemokines, and in vitro, high levels of prolactin decreased T-helper cell activation.
|
|
| 24. |
- Forsman, Henrietta, et al.
(författare)
-
Clusters of competence: Relationship between self-reported professional competence and achievement on a national examination among graduating nursing students
- 2020
-
Ingår i: Journal of Advanced Nursing. - Hoboken, NJ : John Wiley & Sons. - 0309-2402 .- 1365-2648. ; 76:1, s. 199-208
-
Tidskriftsartikel (refereegranskat)abstract
- AimsTo identify clusters based on graduating nursing students’ self‐reported professional competence and their achievement on a national examination. Furthermore, to describe and compare the identified clusters regarding sample characteristics, students’ perceptions of overall quality of the nursing programme and students’ general self‐efficacy.DesignA cross‐sectional study combining survey data and results from a national examination.MethodsData were collected at two universities and one university college in Sweden in January 2017, including 179 students in the final term of the nursing programme. The study was based on the Nurse Professional Competence Scale, the General Self‐Efficacy scale and results from the National Clinical Final Examination. A Two‐Step Cluster Analysis was used to identify competence profiles, followed by comparative analyses between clusters.ResultsThree clusters were identified illustrating students’ different competence profiles. Students in Cluster 1 and 2 passed the examination, but differed in their self‐assessments of competence, rating themselves under and above the overall median value respectively. Students in Cluster 3 failed the examination but rated themselves at the overall median level or higher.ConclusionThe study illustrates how nursing students’ self‐assessed competence might differ from competency assessed by examination, which is challenging for nursing education. Self‐evaluation is a key learning outcome and is, in the long run, essential to patient safety.ImpactThe study has identified clusters of students where some overestimate and others underestimate their competence. Students who assessed their competence low but passed the exam assessed their general self‐efficacy lower than other students. The findings illuminate the need for student‐centered strategies in nursing education, including elements of self‐assessment in relation to examination to make the students more aware of their clinical competence.
|
|
| 25. |
- Fredrikson, Mats, et al.
(författare)
-
Forskningsresultaten inom KBT är otvetydiga : Replik
- 2009
-
Ingår i: Läkartidningen. - Stockholm : Sveriges läkarförbund. - 0023-7205 .- 1652-7518. ; 106:18-19, s. 1294-1296
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 26. |
|
|
| 27. |
- Fredrikson, Mats, et al.
(författare)
-
Regeringens storsatsning mot psykisk ohälsa äventyrar patientsäkerheten
- 2009
-
Ingår i: Läkartidningen. - Stockholm : Sveriges läkarförbund. - 0023-7205 .- 1652-7518. ; 106:13, s. 946-947
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Regeringens rehabiliteringsgaranti kan få förödande konsekvenser för tilltron till kognitiv beteendeterapi som behandlingsmetod och för den enskilda patienten som tror sig få KBT av en kompetent behandlare. Orsaken är regeringens lågt ställda krav på behandlarnas kompetens. Rehabiliteringsgarantin bör omformuleras, anser nio KBT-företrädare.
|
|
| 28. |
|
|
| 29. |
|
|
| 30. |
|
|
| 31. |
- Hansson, Joacim, 1966-, et al.
(författare)
-
Profession, utbildning, forskning : biblioteks- och informationsvetenskap för en stärkt bibliotekarieprofession
- 2018
-
Rapport (populärvet., debatt m.m.)abstract
- Sekretariatet för nationell biblioteksstrategi vid Kungliga Biblioteket har givit de fem biblioteks- och informationsvetenskapliga utbildningarna vid Högskolan i Borås, Linnéuniversitetet, Lunds univeritet, Umeå universitet och Uppsala universitet uppdraget att utreda och formulera förslag kring utbildning och forskning för en stärkt bibliotekarieprofession. Syftet med föreliggande rapport är, att visa situationen för svensk biblioteks- och informationsvetenskap, tydliggöra relationen till bibliotekarieprofessionen och lämna strategiska förslag på hur ämnet kan förstärkas till förmån för en stärkt professionsutvecklig. En omvärldsanalys med riktning mot bibliotekssektorn görs samt en beskrivning av nuläget för biblioteks- och informationsvetenskaplig utbildning och forskning. Biblioteks- och informationsvetenskapens centrala betydelse för bibliotekarieprofessionen lyfts fram. Utbildingsprogrammen i ämnet attraherar gott om studenter och som svar på bibliotekens konstaterade behov av biblioteks- och informationsvetenskapligt utbildad personal argumenterar rapportförfattarna för möjligheten att expandera utbildningarna på kandidat- och masternivå vid samtliga fem lärosäten. Inom forskningen konstateras, att trots att ämnet idag i grunden fungerar väl finns ännu svårigheter att erhålla finansiering för professionsinriktad biblioteksforskning. Omvärldsanalysen visar upp ett behov av en tydligare struktur för kontinuerlig kompetensutveckling inom bibliotekarieprofessionen. Rapporten mynnar ut i fem strategiska förslag rörande grundutbildning, forskning och kontinuerlig kompetensutveckling:En ökning av antalet studieplatser på program på kandidat- och masternivå i biblioteks- och informationsvetenskap.Nationell forskarskola för biblioteksforskning.Inrättande av en externfinansierad professur med inriktning mot biblioteksforskning.Stärkt finansieringsstruktur för biblioteksforskning.Etablerande av en samlad nationell struktur för kontinuerlig kompetensutveckling.
|
|
| 32. |
- Herold, Nikolas, et al.
(författare)
-
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
- 2017
-
Ingår i: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 23:2, s. 256-263
-
Tidskriftsartikel (refereegranskat)abstract
- The cytostatic deoxycytidine analog cytarabine (ara-C) is the most active agent available against acute myelogenous leukemia (AML). Together with anthracyclines, ara-C forms the backbone of AML treatment for children and adults'. In AML, both the cytotoxicity of ara-C in vitro and the clinical response to ara-C therapy are correlated with the ability of AML blasts to accumulate the active metabolite ara-C triphosphate (ara-CTP)(2-5), which causes DNA damage through perturbation of DNA synthesis(6). Differences in expression levels of known transporters or metabolic enzymes relevant to ara-C only partially account for patient-specific differential ara-CTP accumulation in AML blasts and response to ara-C treatment(7-9). Here we demonstrate that the deoxynucleoside triphosphate (dNTP) triphosphohydrolase SAM domain and HD domain 1 (SAMHD1) promotes the detoxification of intracellular ara-CTP pools. Recombinant SAMHD1 exhibited ara-CTPase activity in vitro, and cells in which SAMHD1 expression was transiently reduced by treatment with the simian immunodeficiency virus (SIV) protein Vpx were dramatically more sensitive to ara-C-induced cytotoxicity. CRISPR-Cas9-mediated disruption of the gene encoding SAMHD1 sensitized cells to ara-C, and this sensitivity could be abrogated by ectopic expression of wild-type (WT), but not dNTPase-deficient, SAMHD1. Mouse models of AML lacking SAMHD1 were hypersensitive to ara-C, and treatment ex vivo with Vpx sensitized primary patient derived AML blasts to ara-C. Finally, we identified SAMHD1 as a risk factor in cohorts of both pediatric and adult patients with de novo AML who received ara-C treatment. Thus, SAMHD1 expression levels dictate patient sensitivity to ara-C, providing proof-of-concept that the targeting of SAMHD1 by Vpx could be an attractive therapeutic strategy for potentiating ara-C efficacy in hematological malignancies.
|
|
| 33. |
- Hofman-Bang, Claes, et al.
(författare)
-
Two year results of a controlled study of a residential rehabilitation for patients treated with percutaneous transluminal coronary angioplasty : A randomized study of a multifactorial programme
- 1999
-
Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 20:20, s. 1465-1474
-
Tidskriftsartikel (refereegranskat)abstract
- Aims In a multifactorial lifestyle behaviour programme, of 2 years duration, to study the maintenance of achieved behaviour and risk factor-related changes. Methods and Results Out of a consecutive population of 151 patients treated with percutaneous transluminal angioplasty under 65 years of age, 87 were randomly allocated to an intervention group (n=46) or to a control group (n=41). The programme started with a 4 week residential stay, which was focused on health education and the achievement of behaviour change. During the first year of follow-up, a maintenance programme included regular contacts with a nurse, while no further rehabilitative efforts were offered during the second year. One patient died (control). During the second year the proportion of hospitalized patients was lower in the intervention group (4% vs 20%;P<0·05). Patients in the intervention group improved several lifestyle dependent behaviours: diet (index at 0, 12 and 24 months): 10·5±3·4, 12·9±2·5 and 12·4±2·6 in the intervention group (I) vs 10·1±3·2, 10·7±3·0 and 11·8±3·2 in the control group (C);P<0·05, exercise sessions per week: 2·5±2·3, 4·5±1·9 and 4·4±2·1 (I) vs 3·1±2·2, 3·5±2·3 and 3·7±2·7 (C);P<0·05, and smoking; 18%, 6% and 9% (I) vs 12%, 21% and 18% (C);P<0·05. This corresponded to improvement in exercise capacity (0, 12 and 24 months): 156±42, 174±49 and 165±47W (I) vs 164±40, 163±49 and 156±48 watts (C);P<0·05. There were no significant differences between the two groups with regard to serum cholesterol levels at 0 and 24 months: 5·4±0·8 and 5·2±0·9mmol.l–1(I) vs 5·4±1·0 and 4·9±0·9mmol.l–1(C); ns, low density lipoprotein cholesterol level: 3·6±0·8 and 3·4±0·8mmol.l–1(I) vs 3·7±0·9 and 3·3±0·7mmol.l–1(C); ns, triglyceride level: 2·2±1·6 and 1·8±1·3mmol.l–1(I) vs 2·2±1·4 and 1·6±0·6mmol.l–1(C); ns, body mass index (0, 12 and 24 months): 27·5±4·5, 27·0±4·3 and 27·4± 4·5kg.m–2(I) vs 26·8±2·8, 26·9±2·7 and 26·9± 3·2kg.m–2(C); ns, waist/hip ratio or blood pressure. The two groups did not differ in quality of life, or psychological factors. Return to work after 12 and 24 months was 74% and 78% (I) vs 68% and 61% (C); ns. Conclusion This rehabilitation programme influenced important lifestyle behaviour and reduced some, but not all, important risk factors Key Words: Rehabilitation, risk factors
|
|
| 34. |
- Kallionen, Markus, et al.
(författare)
-
Psykisk ohälsa ett stort problem hos primärvårdens patienter. Enkät besvarad av över 2000 patienter
- 2010
-
Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 107:23, s. 1545-1547
-
Tidskriftsartikel (refereegranskat)abstract
- A survey comprising more than 2000 patients visiting primary care units during a 2-week period in November 2008 was carried out in the county of Västernorrland, Sweden. The results show that approximately 18.5 % of the patients came on account of psychological ill health, either as sole reason (1.5%) or in combination with other cause(s). Roughly 14.7 % (309) of these scored higher or equivalent to clinically meaningful cut off scores on scales measuring anxiety, depression and exhaustion (burnout). An additional 322 of the remaining sample (27 % of the females and 16 % of the males) had high scores on scales measuring psychological ill health.
|
|
| 35. |
|
|
| 36. |
- Kihlberg, Jan, et al.
(författare)
-
Synthetic receptor analogues: preparation and calculated conformations of the 2-deoxy, 6-O-methyl, 6-deoxy, and 6-deoxy-6-fluoro derivatives of methyl 4-O-α-D-galactopyranosyl-β-D-galactopyranoside (methyl β-D-galabioside)
- 1988
-
Ingår i: Carbohydrate Research. - : Elsevier BV. - 1873-426X .- 0008-6215. ; 176:2, s. 271-286
-
Tidskriftsartikel (refereegranskat)abstract
- The 2-deoxy (7), 6-O-methyl (15), 6-deoxy (22), and 6-deoxy-6-fluoro (31) derivatives of methyl β-d-galabioside (1) have been synthesised. Thus, 7 was prepared by xanthate reduction using tributyltin hydride, whereas 22 was obtained by catalytic hydrogenation of a 6-deoxy-6-iodogalabioside. Regioselective mono-fluorination of methyl 2,3-di-O-benzoyl-β-d-galactopyranoside with Et2NSF3 and subsequent α-d-galactosylation provided 31. Molecular mechanics calculations yielded similar conformations for 1, 7, 15, 22, and 31 with differes in φH and ψH of 5°. No indications of intramolecular hydrogen bonds, as displayed by 1 in the crystal, were found for 7, 15, 22, or 31.
|
|
| 37. |
- Kurek, Magdalena, et al.
(författare)
-
Spermatogonia Loss Correlates with LAMA 1 Expression in Human Prepubertal Testes Stored for Fertility Preservation
- 2021
-
Ingår i: Cells. - : MDPI AG. - 2073-4409. ; 10:2
-
Tidskriftsartikel (refereegranskat)abstract
- Fertility preservation for male childhood cancer survivors not yet capable of producing mature spermatozoa, relies on experimental approaches such as testicular explant culture. Although the first steps in somatic maturation can be observed in human testicular explant cultures, germ cell depletion is a common obstacle. Hence, understanding the spermatogonial stem cell (SSC) niche environment and in particular, specific components such as the seminiferous basement membrane (BM) will allow progression of testicular explant cultures. Here, we revealed that the seminiferous BM is established from 6 weeks post conception with the expression of laminin alpha 1 (LAMA 1) and type IV collagen, which persist as key components throughout development. With prepubertal testicular explant culture we found that seminiferous LAMA 1 expression is disrupted and depleted with culture time correlating with germ cell loss. These findings highlight the importance of LAMA 1 for the human SSC niche and its sensitivity to culture conditions.
|
|
| 38. |
- Kvarnström, Lasse, et al.
(författare)
-
Historia i Linköping
- 1999
-
Bok (övrigt vetenskapligt/konstnärligt)abstract
- Forskningsinriktningen vid den historiska avdelningen vid Linköpings universitet har sedan länge en stark socialhistorisk profil. kollektivens vardag studeras på en rad områden, på olika nivåer och över sinsemellan skilda tidsperioder. Det gäller inom såväl agrara som industriella miljöer, på samhällelig liksom på grupp-, familje- och individnivå samt över tid som omspänner senantiken till det sena 1900-talets historia. Hur identiteter skapas, tillägnas och förändras är en alltmer växande inriktning, liksom anknytningen till socialpolitiska ideer, normsystem, attityder, värderingar och mentaliteter. Även den rättshistoriska och ekonomiskhistoriska forskningen ryms inom detta fält. Den historiska demografin utgör också traditionellt en stark del av det socialhistoriska fältet. Studier av arbeta och ohälsa, sjuklighet, dödlighet och hälsopolitik ligger långt framme. Bredden i den socialhistoriska profilen morsvaras av en mångfald melodologiska inslag.Skriftserien Socialhistoria i Linköping uppmärksammar denna profil och vilka uttryck den tar sig i grundutbildningen. I serien publiceras i första hand uppsatser skrivna på C- och D- nivå, men även bidrag från lärare och doktorander vid avdelningen förekommer.Detta nummer av Socialhistoria i Linköping är en specialutgåva till Svenska historikermötet i Linköping 23-25 april 1999
|
|
| 39. |
- Lahtinen, Atte K., et al.
(författare)
-
Decreased spermatogonial numbers in boys with severe haematological diseases
- 2024
-
Ingår i: British Journal of Haematology. - : John Wiley & Sons. - 0007-1048 .- 1365-2141.
-
Tidskriftsartikel (refereegranskat)abstract
- This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.
|
|
| 40. |
- Linghag, Sophie, 1970-
(författare)
-
Från medarbetare till chef : Kön och makt i chefsförsörjning och karriär
- 2009
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The younger generation is often expected to be part of changes in management gender distribution, concepts of leadership and gender power relations. Parallel with this, there are ongoing gender segregation processes within the organisations resulting in the dominance of men among managers. The aim of this thesis is to describe and understand the transition from staff to management, and in particular how gender is done in this process. The perspective on organisation and gender adopted is social constructionist. Thestudy was carried out in a large Swedish banking company between 2000 and 2005. Analysis was drawn up in order to successively answer four research questions: 1) in what way is the management sourcing process designed and how are candidates for management evaluated?, 2) how do management candidates look upon their career opportunities?, 3) how is gender done in the sourcing of new managers?, and 4) how is gender done in the careers of future managers? The empirical material consists of observations of a management development programme for potential managers, statements on management sourcing and careers, and document material. The statements come from interviews with 11 staff members, six women and five men, identified as potential managers, as well as seven people working with HR at the bank. The 11 management candidates were interviewed three times during a two-year period.The thesis develops knowledge on how gender and management are done in situations characterised by a balanced gender distribution and simultaneous male dominance. The management development programme serves as a hub for those working with sourcing new managers through its importance in identifying, developing and evaluating candidates for management. The evaluation of women and men among management candidates shows that potential is linked to women and men in different ways and that women and men are evaluated on the basis of different expectations on them as managers. Career is almost exclusively conceived as linear hierarchical movements. Nevertheless, the hierarchical view of career is confirmed almost entirely in the way men orient themselves. The career themes of the men express expectations on having a career. The experiences of the women are diverse. But even among those who have experienced encouragement to develop, this is not reflected in expectations on the future. Instead, the hope expressed is one of being allowed to continue a career. The different empowerment of the women and men express the gender power relations in the organisation and the norm of men as managers, which both men and women relate to.Two aspects are involved in the doing of gender in management sourcing and careers: construction of gender and gender ordering. Firstly, gender is constructed and ordered in the sourcing of new managers through the gendering of potential, resulting in different opportunities for women and men in organisations. Secondly, gender is constructed and ordered in careers, where careers may be understood as gendered, i.e. where expectations are created in men and hopes in women. The result is different empowerment in women and men. And thirdly, the results point to a complexity in relation to change. Gender equality initiatives and radical practices in combination with individualism and gender neutrality both put gender hierarchy into question and preserve it. Management sourcing involves several practices where the doing of gender is integrated in different ways, both conscious through gender equality initiatives, and sub-conscious through individualised and gender-neutral ideology. Thus, change requires greater consciousness and new practice.
|
|
| 41. |
|
|
| 42. |
- Lisspers, Jan, et al.
(författare)
-
Behavioral effects of a comprehensive, multifactorial program for lifestyle change after percutaneous transluminal coronary angioplasty : A prospective, randomized, controlled study
- 1999
-
Ingår i: Journal of Psychosomatic Research. - 0022-3999. ; 46:2, s. 143-154
-
Tidskriftsartikel (refereegranskat)abstract
- A group of 93 coronary patients recently treated with percutaneous transluminal coronary angioplasty (PTCA) were randomly assigned to either an intervention or a control group. Subjects in the intervention group participated in a comprehensive behaviorally oriented program aimed at achieving significant long-term changes in risk factor–related lifestyle behavior. Assessments of lifestyle behaviors, psychological factors, biological risk factors, and rehabilitation as well as secondary prevention endpoints were carried out, at inclusion and after 12 months. Results showed that the intervention patients, as compared with controls, improved significantly on measures assessing smoking, exercise, and diet habits. These self-rated changes were confirmed by weight reductions and improved exercise capacity, as well as by between-group differences in subclinical chest pain during an exercise test. However, few effects were found on the different psychological variables, as well as on morbidity or return to work.
|
|
| 43. |
- Lisspers, Jan, et al.
(författare)
-
Long-term effects of lifestyle behavior change in coronary artery disease : Effects on recurrent coronary events after Percutaneous Coronary Intervention
- 2005
-
Ingår i: Health Psychology. - : American Psychological Association (APA). - 0278-6133 .- 1930-7810. ; 24:1, s. 41-48
-
Tidskriftsartikel (refereegranskat)abstract
- This study evaluated the effects of a behaviorally oriented cardiac rehabilitation and secondary prevention program on lifestyle changes and on coronary recurrence rates. Patients recently treated with percutaneous coronary intervention (PCI) were randomized to an intervention with an aggressive focus on lifestyle changes (smoking, diet, exercise, and stress; n = 46) or to a standard-care control group (n = 42). Results showed that the intervention group had significantly larger overall lifestyle changes than the control group after 12, 24, 36, and 60 months. The intervention group had significantly lower rates of all coronary events (acute myocardial infarction, coronary artery bypass graft, PCI, cardiac death; 30.4% vs. 53.7%), and of cardiovascular mortality (2.2% vs. 14.6%). The need for future large-scale and long-term evaluations of lifestyle-oriented secondary prevention interventions of this kind is emphasized. (PsycINFO Database Record (c) 2007 APA, all rights reserved)
|
|
| 44. |
|
|
| 45. |
- Lisspers, Jan, et al.
(författare)
-
Long-term effects of lifestyle behaviour change intervention after PTCA: Effects on lifestyle, progression of CAD, and on cardiac events. : The VI Nordic Congress on Cardiac Rehabilitation, June 14th-16th 2002, Reykjavik, Iceland.
- 2002
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Föredrag vid The VI Nordic Congress on Cardiac Rehabilitation, June 14th-16th 2002, Reykjavik, Iceland (Belönades med titeln: First price for an outstanding oral presentation at the VI Nordic Congress on Cardiac Rehabilitation, Reykjavik, 2002).
|
|
| 46. |
- Lisspers, Jan, et al.
(författare)
-
Multifactorial evaluation of a program for lifestyle behavior change in rehabilitation and secondary prevention of coronary artery disease
- 1999
-
Ingår i: Scandinavian Cardiovascular Journal. - : Informa UK Limited. - 1401-7431 .- 1651-2006. ; 33:1, s. 9-16
-
Tidskriftsartikel (refereegranskat)abstract
- A comprehensive, multifactorial lifestyle behavior change program was developed for rehabilitation and secondary prevention of subjects with coronary artery disease. The purpose of the present report is to describe this intervention model and to analyze results achieved in a first group of consecutive participants. Main inclusion criteria for the 292 subjects were a recent history of acute myocardial infarction, coronary artery bypass surgery, or percutaneous transluminal coronary angioplasty. The program commenced with a 4-week residential stay, with the focus on health education and the achievement of behavior change in major lifestyle areas. During the year of follow-up a systematic maintenance program included regular contact with a nurse. Morbidity and mortality was low. Self-reported quality of life improved and there were significant improvements in blood lipids, exercise capacity and body mass index. There were also significant changes both in psychological variables such as Type A behavior, anger, hostility, and in major lifestyle areas such as stress reactions, diet, exercise and smoking. These changes compared favorably with data from relevant samples from the Swedish normal population. This program had a considerable effect on a number of important factors for rehabilitation and secondary prevention of coronary artery disease.
|
|
| 47. |
- Lisspers, Jan, et al.
(författare)
-
The Effects of a Recovery-Focused Program for Stress Management in Women — An Exploratory Study
- 2014
-
Ingår i: Health. - : Scientific Research Publishing, Inc.. - 1949-4998 .- 1949-5005. ; 06:20, s. 2825-2836
-
Tidskriftsartikel (refereegranskat)abstract
- Current research indicates that stress problems primarily could be conceptualized as deficiencies in recovery and recuperation between stress periods. Accordingly, interventions should put more emphasis on this aspect. A group based intervention program focusing exclusively on recovery behavior in everyday life was evaluated in this quasi-experimental, waiting-list control group study, where the control group was also treated in a second phase. Thirty-two self-referred female subjects, considering themselves in need of treatment for stress related health problems, were available for analyzes. Fifteen of these constituted the first phase treatment group (INT), while the remaining 17 subjects were placed on waiting list (WLC). Adding a few late applicants leaved 20 subjects later treated in the second intervention phase. Significant and clinically meaningful positive effects emerged in the INT—compared to the WLC-group on recovery behaviors, stress—and recovery experiences, as well as on burn-out symptoms, worry, anxiety and depression. Secondary analyzes of all treated subjects indicated that the positive change the primary clinical endpoint was predicted by the increase in frequency of recovery behaviors and by the decrease in the worrylevel. Thus, the present intervention model merits further research with more rigorous experimental design as well as with follow-up assessments.
|
|
| 48. |
- Lisspers, Jan, et al.
(författare)
-
The effects on and off depression : An Exploratory Study of Rehabilitation and Secondary Prevention in Coronary Artery Disease
- 1999
-
Ingår i: Scandinavian Journal of Behaviour Therapy. - : Informa UK Limited. - 0284-5717. ; 28:1, s. 9-18
-
Tidskriftsartikel (refereegranskat)abstract
- Forty consecutive participants in a comprehensive, behaviourally oriented coronary rehabilitation and secondary prevention program were followed for three years. Changes in depression (as measured with the Beck Depression Inventory) as well as the influence of baseline levels of depression on achieved changes in lifestyle behaviour and on rehabilitation and secondary prevention effects were analyzed. Subjects with moderate levels of baseline depression experienced short-term reductions of depression, which was maintained at the 12-month follow-up. Clinically depressed subjects experienced less positive results, with smaller immediate reductions as well as relapse to baseline levels after 12 months, specifically in non-physical, cognitive-affective depression symptoms. There were, however, no differences in lifestyle changes or in hospital treatment between groups with different pre-treatment depression levels. These results are discussed in relation to earlier research on the detrimental effects of depression on the prognosis of coronary artery disease.
|
|
| 49. |
- Lubberink, Mark, et al.
(författare)
-
Positron emission tomography and radioimmunotargeting : aspects ofquantification and dosimetry
- 1999
-
Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 38:3, s. 343-349
-
Tidskriftsartikel (refereegranskat)abstract
- Positron emission tomography (PET) is a medical imaging tool with high resolution and good quantitative properties, which makes it suitable for in vivo quantification of radioimmunotargeting agents. Most radionuclides used in radioimmunotherapy have positron-emitting analogues, which can be used for PET imaging, and this opens the possibility of performing dosimetry with PET. These isotopes, however, often emit gamma radiation and high-energy positrons in their decay, influencing the imaging properties of PET. Spatial resolution, reconstructed background and line source recovery for a number of non-pure positron emitters were investigated and compared with the imaging properties of 18F. PET imaging properties did not degrade severely for these non-pure positron emitters, but caution has to be applied when doing quantitative measurements. To assess the possibility of conducting PET studies during therapy, by combining, for example, a small amount of 124I with 131I, the influence of the presence of large amounts of gamma radiation on PET count rate characteristics was studied. The results of these studies were related to the necessary amounts of radioactivity needed for treatment of post-operative remains of glioma. The results indicate that the count rate capabilities of 2D PET permit PET studies for dose evaluation during radioimmunotherapy.
|
|
| 50. |
- Lundqvist, Hans, et al.
(författare)
-
Positron emission tomography and radioimmunotargeting : general aspects
- 1999
-
Ingår i: Acta Oncologica. - 0284-186X .- 1651-226X. ; 38:3, s. 335-341
-
Tidskriftsartikel (refereegranskat)abstract
- To optimize radioimmunotherapy, in vivo information on individual patients, such as radionuclide uptake, kinetics, metabolic patterns and optimal administration methods, is important. An overriding problem is to determine accurately the absorbed dose in the target organ as well as critical organs. Positron Emission Tomography (PET) is a superior technique to quantify regional kinetics in vivo with a spatial resolution better than 1 cm3 and a temporal resolution better than 10 s. However, target molecules often have distribution times of several hours to days. Conventional PET nuclides are not applicable and alternative positron-emitting nuclides with matching half-lives and with suitable labelling properties are thus necessary. Over many years we have systematically developed convenient production methods and labelling techniques of suitable positron nuclides, such as 110In(T(1/2) = 1.15 h), 86Y(T(1/2) = 14 h), 76Br(T(1/2) = 16 h) and 124I(T(1/2) = 4 days). 'Dose planning' can be done, for example, with 86Y- or 124I-labelled ligands before therapy, and 90Y- and 131I-labelled analogues and double-labelling, e.g. with a 86Y/90Y-labelled ligand, can be used to determine the true radioactivity integral from a pure beta-emitting nuclide. The usefulness of these techniques was demonstrated in animal and patient studies by halogen-labelled MAbs and EGF-dextran conjugates and peptides chelated with metal ions.
|
|
