SwePub - sökning: WFRF:(Valletta Martina)

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1.	Valletta, Martina, et al. (författare) Association of mild and complex multimorbidity with structural brain changes in older adults : A population-based study 2024 Ingår i: Alzheimer's & Dementia. - 1552-5260 .- 1552-5279. ; 20:3, s. 1958-1965 Tidskriftsartikel (refereegranskat)abstract INTRODUCTION: We quantified the association of mild (ie, involving one or two body systems) and complex (ie, involving ≥3 systems) multimorbidity with structural brain changes in older adults.METHODS: We included 390 dementia-free participants aged 60+ from the Swedish National Study on Aging and Care in Kungsholmen who underwent brain magnetic resonance imaging at baseline and after 3 and/or 6 years. Using linear mixed models, we estimated the association between multimorbidity and changes in total brain tissue, ventricular, hippocampal, and white matter hyperintensities volumes.RESULTS: Compared to non-multimorbid participants, those with complex multimorbidity showed the steepest reduction in total brain (βtime −0.03, 95% CI −0.05, −0.01) and hippocampal (βtime −0.05, 95% CI −0.08, −0.03) volumes, the greatest ventricular enlargement (βtime 0.03, 95% CI 0.01, 0.05), and the fastest white matter hyperintensities accumulation (βtime 0.04, 95% CI 0.01, 0.07).DISCUSSION: Multimorbidity, particularly when involving multiple body systems, is associated with accelerated structural brain changes, involving both neurodegeneration and vascular pathology.

Valletta, Martina, et al. (författare)
Association of mild and complex multimorbidity with structural brain changes in older adults : A population-based study
2024
Ingår i: Alzheimer's & Dementia. - 1552-5260 .- 1552-5279. ; 20:3, s. 1958-1965
Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: We quantified the association of mild (ie, involving one or two body systems) and complex (ie, involving ≥3 systems) multimorbidity with structural brain changes in older adults.METHODS: We included 390 dementia-free participants aged 60+ from the Swedish National Study on Aging and Care in Kungsholmen who underwent brain magnetic resonance imaging at baseline and after 3 and/or 6 years. Using linear mixed models, we estimated the association between multimorbidity and changes in total brain tissue, ventricular, hippocampal, and white matter hyperintensities volumes.RESULTS: Compared to non-multimorbid participants, those with complex multimorbidity showed the steepest reduction in total brain (β*time −0.03, 95% CI −0.05, −0.01) and hippocampal (β*time −0.05, 95% CI −0.08, −0.03) volumes, the greatest ventricular enlargement (β*time 0.03, 95% CI 0.01, 0.05), and the fastest white matter hyperintensities accumulation (β*time 0.04, 95% CI 0.01, 0.07).DISCUSSION: Multimorbidity, particularly when involving multiple body systems, is associated with accelerated structural brain changes, involving both neurodegeneration and vascular pathology.

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