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Träfflista för sökning "WFRF:(von Haeseler A) "

Search: WFRF:(von Haeseler A)

  • Result 1-4 of 4
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1.
  • Allen, Marie, et al. (author)
  • Mitochondrial DNA sequencing of shed hairs and saliva on robbery caps : sensitivity and matching probabilities
  • 1998
  • In: Journal of Forensic Sciences. - 0022-1198 .- 1556-4029. ; 43:3, s. 453-464
  • Journal article (peer-reviewed)abstract
    • Sequencing of mitochondrial DNA (mtDNA) has been used for human identification based on teeth and skeletal remains. Here, we describe an amplification system for the mtDNA control region (D-loop) suited for the analysis of shed hair, which constitutes the most common biological evidence material in forensic investigations. The success rate was over 90% when applied to evidence materials such as shed hair, saliva stains and saliva on stamps. The analysis of evidence materials collected from three similar robberies revealed the presence of mtDNA sequences identical to those of the suspects in the three crimes. The use of mtDNA control region sequences for individual identification was evaluated. The probability of identity by chance for the mtDNA types of the suspects in the robberies was found to vary between Pr = 0.017 - < 0.0017, depending on the reference population used, emphasizing the need for large population databases to obtain the appropriate estimate.
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3.
  • Muhar, Matthias, et al. (author)
  • SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis
  • 2018
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 360:6390, s. 800-805
  • Journal article (peer-reviewed)abstract
    • Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology and disease. We combined SLAM-seq [thiol(SH)-linked alkylation for the metabolic sequencing of RNA], a method for direct quantification of newly synthesized messenger RNAs (mRNAs), with pharmacological and chemical-genetic perturbation in order to define regulatory functions of two transcriptional hubs in cancer, BRD4 and MYC, and to interrogate direct responses to BET bromodomain inhibitors (BETis). We found that BRD4 acts as general coactivator of RNA polymerase II-dependent transcription, which is broadly repressed upon high-dose BETi treatment. At doses triggering selective effects in leukemia, BETis deregulate a small set of hypersensitive targets including MYC. In contrast to BRD4, MYC primarily acts as a selective transcriptional activator controlling metabolic processes such as ribosome biogenesis and de novo purine synthesis. Our study establishes a simple and scalable strategy to identify direct transcriptional targets of any gene or pathway.
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4.
  • Krings, M, et al. (author)
  • A view of Neandertal genetic diversity
  • 2000
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 26:2, s. 144-146
  • Journal article (peer-reviewed)
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