| 51. |
- Espada, J, et al.
(författare)
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Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
- 2008
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Ingår i: The Journal of cell biology. - : Rockefeller University Press. - 1540-8140 .- 0021-9525. ; 181:1, s. 27-35
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Tidskriftsartikel (refereegranskat)abstract
- Nuclear lamina alterations occur in physiological aging and in premature aging syndromes. Because aging is also associated with abnormal stem cell homeostasis, we hypothesize that nuclear envelope alterations could have an important impact on stem cell compartments. To evaluate this hypothesis, we examined the number and functional competence of stem cells in Zmpste24-null progeroid mice, which exhibit nuclear lamina defects. We show that Zmpste24 deficiency causes an alteration in the number and proliferative capacity of epidermal stem cells. These changes are associated with an aberrant nuclear architecture of bulge cells and an increase in apoptosis of their supporting cells in the hair bulb region. These alterations are rescued in Zmpste24−/−Lmna+/− mutant mice, which do not manifest progeroid symptoms. We also report that molecular signaling pathways implicated in the regulation of stem cell behavior, such as Wnt and microphthalmia transcription factor, are altered in Zmpste24−/− mice. These findings establish a link between age-related nuclear envelope defects and stem cell dysfunction.
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| 52. |
- Gonzalez-Alfonso, E., et al.
(författare)
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HIGH-LYING OH ABSORPTION, [C II] DEFICITS, AND EXTREME LFIR/MH2 RATIOS IN GALAXIES
- 2015
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Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 800:1, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- Herschel/PACS observations of 29 local (ultra) luminous infrared galaxies, including both starburst and active galactic nucleus (AGN) dominated sources as diagnosed in the mid-infrared/optical, show that the equivalent width of the absorbing OH 65 mu m.3/2 J = 9/2-7/2 line (Weq(OH65)) with lower level energy Elow 300 K, is anticorrelated with the [Cii] 158 mu m line to far-infrared luminosity ratio, and correlated with the far-infrared luminosity per unit gas mass and with the 60-to-100 mu m far-infrared color. While all sources are in the active LIR/MH2 > 50L /M mode as derived from previous CO line studies, the OH65 absorption shows a bimodal distribution with a discontinuity at LFIR/MH2 100L /M . In the most buried sources, OH65 probes material partially responsible for the silicate 9.7 mu m absorption. Combined with observations of the OH 71 mu m.1/2 J = 7/2-5/2 doublet (Elow 415 K), radiative transfer models characterized by the equivalent dust temperature, Tdust, and the continuum optical depth at 100 mu m, t100, indicate that strong [C ii] 158 mu m deficits are associated with far-IR thick (t100 0.7, NH 1024 cm-2), warm (Tdust 60 K) structures where the OH 65 mu m absorption is produced, most likely in circumnuclear disks/tori/cocoons. With their high LFIR/MH2 ratios and columns, the presence of these structures is expected to give rise to strong [C ii] deficits. Weq(OH65) probes the fraction of infrared luminosity arising from these compact/warm environments, which is 30%-50% in sources with high Weq(OH65). Sources with high Weq(OH65) have surface densities of both LIR and MH2 higher than inferred from the half-light (CO or UV/optical) radius, tracing coherent structures that represent the most buried/active stage of (circum) nuclear starburst-AGN co-evolution.
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| 53. |
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| 54. |
- Kunz, Susanna, V, et al.
(författare)
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A simplified approach to thermally activated delayed fluorescence (TADF) bipolar host polymers
- 2022
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Ingår i: Polymer Chemistry. - : Royal Society of Chemistry. - 1759-9954 .- 1759-9962. ; 13:29, s. 4241-4248
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Tidskriftsartikel (refereegranskat)abstract
- Organic Light Emitting Diodes (OLEDs) are a critical part of current consumer electronics, from mobile device displays to solid-state lighting. Thus demand for the development of industrially compatible OLED materials continues to increase. Herein, we introduce a series of solution-processible polymers incorporating a Thermally Activated Delayed Fluorescence (TADF) emitter and a host species in the side chain to finely adjust the charge transport properties. For balanced charge transport, a bipolar host polymer based on carbazole and alpha-carboline was investigated in addition to the commonly employed unipolar host mCP and an electron transporting version thereof. We demonstrate that the combination of unipolar co-hosts on one polymer chain can generate, with less synthetic effort, the same optoelectronic properties as a polymer carrying the corresponding bipolar host molecule as a pendant.
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| 55. |
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| 56. |
- Mauffret, Aourell, et al.
(författare)
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LAS degradability by marine biofilms derived from seawater in Spain and Sweden
- 2011
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Ingår i: Ecotoxicology and Environmental Safety. - : Elsevier BV. - 0147-6513 .- 1090-2414. ; 74:5, s. 1250-1256
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Tidskriftsartikel (refereegranskat)abstract
- Marine biofilms were established on glass beads with or without deliberate pre-exposure to LAS (20 mg/L) in Spain (Cadiz) and Sweden (Kristineberg). The ability of each community to mineralize LAS (100 mg/L) was then assessed in biometers at four experimental temperatures (between 6 and 21 1C). Genetic diversity and biomass of the biofilms were assessed by genetic fingerprinting (DGGE) and direct bacterial counts. With biofilms fromSweden, where LAS was not detected in seawater (n¼3), deliberate pre-exposure to LAS resulted in lower genetic diversity and higher mineralization rate constant; however, with biofilms from Spain, where 6.473.9 mgLAS/L (n¼3) was measured during the colonization, pre-exposure did not affect the bacterial community. Bacterial acclimation therefore appeared to have been induced at environmental concentrations o6 mgLAS/L. Environmental pre-exposure was not a pre-requisite for featuring the full consortia of LAS degraders in the biometers. The mineralization rate was described using an Arrhenius equation at experimental temperatures within the typical annual range; however, they departed from this model below this range.
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