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Sökning: WFRF:(Casselbrant Anna 1970)

  • Resultat 51-52 av 52
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51.
  • Söfteland, John M., 1977, et al. (författare)
  • Luminal polyethylene-glycol solution delays the onset of preservation injury in the human intestine.
  • 2021
  • Ingår i: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. - : Elsevier BV. - 1600-6143. ; 21:6, s. 2220-2230
  • Tidskriftsartikel (refereegranskat)abstract
    • The organ damage incurred during the cold storage (CS) of intestinal grafts has short and long-term consequences. Animal studies suggest that additional luminal preservation (LP) with polyethylene-glycol (PEG) may alleviate this damage. This study aims to validate these findings using human intestines. Ileal segments, perfused intravascularly with IGL-1 solution, were procured from 32 multiorgan donors and divided into two parts: one containing a PEG 3350-based solution introduced luminally (LP group) and another one without luminal treatment (control). Sampling was performed after 4h, 8h, 14h, and 24h of CS. Histology was assessed using the Chiu/Park score. Tight junctions (TJ), several inflammatory markers, and transcription factors were examined by immunofluorescence, ddPCR, and Western blot. Tissue water content (edema) was also measured. Apoptotic activity was assessed with caspase 2,3 and 9 assays. LP significantly lowered mucosal injury at all time points. Redistribution of TJ proteins occurred earlier and more severely in the control group. After 24h of CS, LP intestines showed an emerging unfolding protein response. Increased caspase-3 and -9 activity were found in the control group. The current results indicate that luminal PEG is safe and effective in reducing damage to the intestinal epithelium during CS.
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52.
  • Söfteland, John M., 1977, et al. (författare)
  • The impact of age and luminal preservation on the development of intestinal preservation injury in rats
  • 2020
  • Ingår i: Transplantation. - 1534-6080. ; 104:1
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Organs from older donors are believed to withstand ischemia worse than those from younger donors. The effect of age on the development of intestinal preservation injury (IPI) is unclear. METHODS: We compared the development of IPI in intestines from young (3 mo), adult (14 mo), and old (20 mo) rat donors and assessed if luminal preservation (LP) is effective in delaying IPI. Small intestines were perfused with, and stored in, preservation solution (Custodiol) with or without LP solution (polyethylene glycol 3350). IPI was studied using histology (Chiu score, Alcian blue staining), Western blot, and electrophysiological assessment (Ussing chamber) at 4, 8, and 14 hours. RESULTS: Intestines of old rats did not show major histological alterations, whereas their aortas and kidneys revealed typical age-related changes (arteriosclerosis and glomerulosclerosis). Intestines from old rats fared similarly to their younger counterparts at all time points regarding preservation injury and goblet cells count. Intestines undergoing LP showed fewer histological signs of damage and higher goblet cells count when compared with samples without LP, regardless of donor age. Ussing chamber experiments indicated a time-dependent deterioration of all parameters studied, which was delayed by the use of LP. CONCLUSIONS: Older intestines did not convincingly demonstrate a faster IPI compared with intestines from adult and young donors. The small differences between the age groups were nullified by the use of LP. LP significantly delayed the IPI in all age groups and may allow for longer preservation periods without an increased risk of mucosal damage.
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  • Resultat 51-52 av 52
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Casselbrant, Anna, 1 ... (52)
Fändriks, Lars, 1956 (33)
Wallenius, Ville, 19 ... (13)
Oltean, Mihai, 1976 (9)
Hellström, Mats, 197 ... (7)
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Lönroth, Hans, 1952 (4)
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le Roux, Carel W (3)
Bove, Mogens, 1949 (3)
Holm, Mathias, 1969 (3)
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Ruth, Magnus, 1953 (3)
Docherty, Neil G. (2)
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Elfvin, Anders, 1971 (2)
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Göteborgs universitet (52)
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