| 51. |
- Kankare, E., et al.
(författare)
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SN 2009kn-the twin of the Type IIn supernova 1994W
- 2012
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 424:2, s. 855-873
-
Tidskriftsartikel (refereegranskat)abstract
- We present an optical and near-infrared photometric and spectroscopic study of supernova (SN) 2009kn spanning similar to 1.5 yr from the discovery. The optical spectra are dominated by the narrow (full width at half-maximum similar to 1000 km s-1) Balmer lines distinctive of a Type IIn SN with P Cygni profiles. Contrarily, the photometric evolution resembles more that of a Type IIP SN with a large drop in luminosity at the end of the plateau phase. These characteristics are similar to those of SN 1994W, whose nature has been explained with two different models with different approaches. The well-sampled data set on SN 2009kn offers the possibility to test these models, in the case of both SN 2009kn and SN 1994W. We associate the narrow P Cygni lines with a swept-up shell composed of circumstellar matter and SN ejecta. The broad emission line wings, seen during the plateau phase, arise from internal electron scattering in this shell. The slope of the light curve after the post-plateau drop is fairly consistent with that expected from the radioactive decay of 56Co, suggesting an SN origin for SN 2009kn. Assuming radioactivity to be the main source powering the light curve of SN 2009kn in the tail phase, we infer an upper limit for 56Ni mass of 0.023 M?. This is significantly higher than that estimated for SN 1994W, which also showed a much steeper decline of the light curve after the post-plateau drop. We also observe late-time near-infrared emission which most likely arises from newly formed dust produced by SN 2009kn. As with SN 1994W, no broad lines are observed in the spectra of SN 2009kn, not even in the late-time tail phase.
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| 52. |
- Klintenberg, Mattias, et al.
(författare)
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Evolving properties of two-dimensional materials : from graphene to graphite
- 2009
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Ingår i: Journal of Physics. - : IOP Publishing. - 0953-8984 .- 1361-648X. ; 21:33, s. 335502-
-
Tidskriftsartikel (refereegranskat)abstract
- We have studied theoretically, using density functional theory, several material properties when going from one C layer in graphene to two and three graphene layers and on to graphite. The properties we have focused on are the elastic constants, electronic structure (energy bands and density of states), and the dielectric properties. For any of the properties we have investigated the modification due to an increase in the number of graphene layers is within a few per cent. Our results are in agreement with the analysis presented recently by Kopelevich and Esquinazi (unpublished).
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| 53. |
- Kristiansson, Helena, et al.
(författare)
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Dura Management Strategies in the Surgical Treatment of Adult Chiari Type I Malformation : A Retrospective, Multicenter, Population-Based Parallel Cohort Case Series
- 2022
-
Ingår i: Operative Neurosurgery. - : Lippincott Williams & Wilkins. - 2332-4252 .- 2332-4260. ; 23:4, s. 304-311
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Symptomatic Chiari I malformation is treated with suboccipital decompression and C1 laminectomy. However, whether the dura should be opened (durotomy) or enlarged with a graft (duraplasty) remains unclear. OBJECTIVE: To compare outcomes in adult Chiari I malformation patients treated with duraplasty, durotomy, or without dural opening ("mini-decompression").METHODS: A retrospective, multicenter, population-based cohort study was performed of all adult patients surgically treated for a Chiari I malformation at 3 regional neurosurgical centers between 2005 and 2017. Three different dura management strategies were favored by the participating hospitals, with data stratified accordingly. The primary outcome was measured using the Chicago Chiari Outcome Scale (CCOS), dichotomized into favorable (CCOS >= 13) or unfavorable (CCOS <= 12). Propensity score matching was used to adjust for potential confounders in outcome comparisons.RESULTS: In total, 318 patients were included, of whom 52% were treated with duraplasty, 37% with durotomy, and 11% with mini-decompression. In total, 285 (90%) showed a favorable surgical outcome (CCOS >= 13). Duraplasty was associated with more favorable CCOS and shorter hospital stay compared with durotomy, both in unadjusted (93% vs 84%. P = .018 and 6.0 vs 8.0 days, P < .001) and adjusted analyses (92% vs 84%, P = .044 and 6.0 vs 8.0 days, P < .001). Mini-decompression was excluded from the adjusted analyses because of its small sample size.CONCLUSION: In this study of adult Chiari I malformation, posterior fossa decompression with duraplasty was associated with more favorable postoperative outcome, as determined by the CCOS, compared with posterior fossa decompression with durotomy alone.
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| 54. |
- Lankinen, Åsa, et al.
(författare)
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Allocation to pollen competitive ability versus seed production in Viola tricoloras an effect of plant size, soil nutrients and presence of a root competitor
- 2012
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Ingår i: Oikos. - : John Wiley & Sons. - 0030-1299 .- 1600-0706. ; 122:5, s. 779-789
-
Tidskriftsartikel (refereegranskat)abstract
- In hermaphroditic plants, the effect of a social environment on sex allocation has not been studied to our knowledge, while in hermaphroditic animals such effects are known to be common. In recent years, studies on root competition beyond the effects of nutrients have shown that plants can respond to their conspecific root competitors (social environment), making it interesting to ask if these effects could also influence sex allocation in addition to more commonly studied factors, such as plant size or resources. In this study on hermaphroditic Viola tricolor, we investigated how plant size, soil nutrients and presence of a root competitor influenced allocation to pollen competitive ability versus seed production, i.e. male and female reproductive functions. We allowed plants to grow in pairs with partly intermingled or separate roots in the same amount of soil. In additional treatments with intermingled roots (as part of the same experiment) one of the two competitors was given combinations of nitrogen (N), phosphorous (P) and micro nutrients. We found that pollen performance but not seed production increased when plants were in contact in the soil. Additionally, pollen performance was negatively correlated to plant size across fertilisation treatments. For seed production, the opposite relation to plant size was seen, indicating that large, fertilized plants invest relatively more in the female function. In conclusion, in violets, sex allocation appears to be size-dependent and influenced by both the presence of a root competitor and by nutrients. These results suggest that social environment can influence sex allocation in plants as well as in animals, indicating that such effects are important to consider in sex allocation studies across taxa.
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| 55. |
- Lindgren, Nils, et al.
(författare)
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Data assimilation in stand level forest inventory – first results
- 2015
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Ingår i: Natural resources and bioeconomy studies. - 2342-7639. ; 29, s. 37-37
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Data assimilation in stand-level forest inventory – first results Nils Lindgren 1 , Mattias Nyström1 , Jörgen Wallerman 1 , Sarah Ehlers 1 , Anton Grafström1 , Anders Muszta 1 , Kenneth Nyström1 , Erik Willen 2 , Johan Fransson 1 , Jonas Bohlin 1 , Håkan Olsson 1 , Göran Ståhl 1 1Swedish University of Agricultural Sciences, Umeå, Sweden 2Skogforsk, Uppsala, Sweden As we are entering an era of increased supply of remote sensing data, we believe that data assimilation has a large potential for keeping forest stand registers up to date (Ehlers et al. 2013). Data assimilation combines forecasts of previous estimates with new observations of the current state in an optimal way based on the uncertainties in the forecast and the observations. These forecasting and updating steps can be repeated with new available observations to get improved estimations. In the present study, we use canopy height models obtained from matching of digital aerial photos over the test site Remningstorp in Sweden, acquired 2003, 2005, 2007, 2009, 2010 and 2012 and normalized with a DEM from airborne laser scanning. Stem volume was estimated for each data acquisition and stand, using regression functions based on field reference data from sample plots. Forecasting was done with growth functions constructed from National Forest Inventory plots. The remote sensing estimates for each time point were assimilated with the forecasts of the previous estimates, using extended Kalman filtering. Validation was done on 40 m radius sample plots dominated by Norway spruce. Early results for three stands show that the variances were lower when using assimilation of new estimates and there was less fluctuation compared to repeated remote sensing estimates. The results for the assimilated data at year 2011 were also consistently closer to the validation data measured in 2011 compared to the remote sensing estimates from year 2011.
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| 56. |
- Lindgren, Nils, et al.
(författare)
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Improved Prediction of Forest Variables Using Data Assimilation of Interferometric Synthetic Aperture Radar Data
- 2017
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Ingår i: Canadian Journal of Remote Sensing. - : Informa UK Limited. - 0703-8992 .- 1712-7971. ; 43, s. 374-383
-
Tidskriftsartikel (refereegranskat)abstract
- The statistical framework of data assimilation provides methods for utilizing new data for obtaining up-to-date forest data: existing forest data are forecasted and combined with each new remote sensing data set. This new paradigm for updating forest database, well known from other fields of study, will provide a framework for utilizing all available remote sensing data in proportion to their quality to improve prediction. It also solves the problem that not all remote sensing data sets provide information for the entire area of interest, since areas with no remote sensing data can be forecasted until new remote sensing data become available. In this study, extended Kalman filtering was used for assimilating data from 19 TanDEM-X InSAR images on 137 sample plots, each of 10-meter radius at a test site in southern Sweden over a period of 4 years. At almost all time points data assimilation resulted in predictions closer to the reference value than predictions based on data from that single time point. For the study variables Lorey's mean height, basal area, and stem volume, the median reduction in root mean square error was 0.4 m, 0.9 m(2)/ha, and 15.3 m(3)/ha (2, 3, and 6 percentage points), respectively.
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| 57. |
- Magnusson, Mattias, et al.
(författare)
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Airborne low-frequency synthetic aperture radar and optical satellite data as complementary data sources for forest stem volume estimation
- 2010
-
Ingår i: Scandinavian Journal of Forest Research. - : Informa UK Limited. - 0282-7581 .- 1651-1891. ; 25, s. 89-99
-
Tidskriftsartikel (refereegranskat)abstract
- Forest stem volume estimation using a combination of airborne CARABAS-II low-frequency synthetic aperture radar (SAR) and multispectral optical Landsat ETM+ satellite data was evaluated and compared with aerial photo-interpretation. The study was performed in coniferous-dominated hemi-boreal forests at a test site located in southern Sweden. The stem volume for the stands included in the analysis was in the range of 15-585 m(3) ha(-1) (average 266 m(3) ha(-1)) and the average size of the stands was 3.5 ha. Regression analysis was used to develop stem volume models. The accuracy in terms of root mean square error (RMSE) was found to be 18.5% (of the average stem volume) for CARABAS-II, 24.8% for Landsat ETM+, and 14.3% for the combination. CARABAS-II gave the best results for high stem volumes, and Landsat ETM+ was more accurate for lower stem volumes. Hence, the two data sources supplement each other providing in combination better results over the whole range of stem volumes. Using conventional aerial photo-interpretation in panchromatic photographs for stem volume estimation the RMSE was found to be 23.7% (21.1% after correction for systematic errors). In conclusion, the method of combining airborne low-frequency SAR and optical satellite data for stem volume estimation gave an accuracy that was significantly better than aerial photo-interpretation and comparable with airborne laser scanning.
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| 58. |
- Mani, Katrin, et al.
(författare)
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Prion or amyloid-b-derived Cu(II)- or free Zn(II)-ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.
- 2003
-
Ingår i: Journal of Biological Chemistry. - 1083-351X. ; 278:40, s. 38956-38965
-
Tidskriftsartikel (refereegranskat)abstract
- Copper are generally bound to proteins, e.g. the prion and the amyloid beta proteins. We have previously shown that copper ions are required to nitrosylate thiol groups in the core protein of glypican-1, a heparan sulfate-substituted proteoglycan. When S-nitrosylated glypican-1 is then exposed to an appropriate reducing agent, such as ascorbate, nitric oxide is released and autocatalyzes deaminative cleavage of the glypican-1 heparan sulfate side chains at sites where the glucosamines are N-unsubstituted. These processes take place in a stepwise manner, whereas glypican-1 recycles via a caveolin-1-associated pathway where copper ions could be provided by the prion protein. Here we show, by using both biochemical and microscopic techniques, that (a) the glypican-1 core protein binds copper(II) ions, reduces them to copper(I) when the thiols are nitrosylated and reoxidizes copper(I) to copper(II) when ascorbate releases nitric oxide; (b) maximally S-nitrosylated glypican-1 can cleave its own heparan sulfate chains at all available sites in a nitroxyl ion-dependent reaction; (c) free zinc(II) ions, which are redox inert, also support autocleavage of glypican-1 heparan sulfate, probably via transnitrosation, whereas they inhibit copper(II)-supported degradation; and (d) copper(II)-loaded but not zinc(II)-loaded prion protein or amyloid beta peptide support heparan sulfate degradation. As glypican-1 in prion null cells is poorly S-nitrosylated and as ectopic expression of cellular prion protein restores S-nitrosylation of glypican-1 in these cells, we propose that one function of the cellular prion protein is to deliver copper(II) for the S-nitrosylation of recycling glypican-1.
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| 59. |
- Mani, Katrin, et al.
(författare)
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Tumor attenuation by 2(6-hydroxynaphthyl)-{beta}-D-xylopyranoside requires priming of heparan sulfate and nuclear targeting of the products.
- 2004
-
Ingår i: Glycobiology. - : Oxford University Press (OUP). - 1460-2423. ; 14:5, s. 387-397
-
Tidskriftsartikel (refereegranskat)abstract
- We have previously reported that the heparan sulfate-priming glycoside 2-(6-hydroxynaphthyl)-ß-D-xylopyranoside selectively inhibits growth of transformed or tumor-derived cells. To investigate the specificity of this xyloside various analogs were synthesized and tested in vitro. Selective growth inhibition was dependent on the presence of a free 6-hydroxyl in the aglycon. Because cells deficient in heparan sulfate synthesis were insensitive to the xyloside, we conclude that priming of heparan sulfate synthesis was required for growth inhibition. In growth-inhibited cells, heparan sulfate chains primed by the active xyloside were degraded to products that contained anhydromannose and appeared in the nuclei. Hence the degradation products were generated by nitric oxide–dependent cleavage. Accordingly, nitric oxide depletion reduced nuclear localization of the degradation products and counteracted the growth-inhibitory effect of the xyloside. We propose that 2-(6-hydroxynaphthyl)-ß-D-xylopyranoside entered cells and primed synthesis of heparan sulfate chains that were subsequently degraded by nitric oxide into products that accumulated in the nucleus. In vivo experiments demonstrated that the xyloside administered subcutaneously, perorally, or intraperitoneally was adsorbed and made available to tumor cells located subcutaneously. Treatment with the xyloside reduced the average tumor load by 70–97% in SCID mice. The present xyloside may serve as a lead compound for the development of novel antitumor strategies.
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| 60. |
- Mellander, Helena, et al.
(författare)
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Virtual monoenergetic images by spectral detector computed tomography may improve image quality and diagnostic ability for ischemic lesions in acute ischemic stroke
- 2023
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Ingår i: Acta Radiologica. - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 64:4, s. 1631-1640
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Tidskriftsartikel (refereegranskat)abstract
- Background: Acute ischemic lesions are challenging to detect by conventional computed tomography (CT). Virtual monoenergetic images may improve detection rates by increased tissue contrast. Purpose: To compare the ability to detect ischemic lesions of virtual monoenergetic with conventional images in patients with acute stroke. Material and Methods: We included consecutive patients at our center that underwent brain CT in a spectral scanner for suspicion of acute stroke, onset <12 h, with or without (negative controls) a confirmed cortical ischemic lesion in the initial scan or a follow-up CT or magnetic resonance imaging. Attenuation was measured in predefined areas in ischemic gray (guided by follow-up exams), normal gray, and white matter in conventional images and retrieved in spectral diagrams for the same locations in monoenergetic series at 40–200 keV. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. Visual assessment of diagnostic measures was performed by independent review by two neuroradiologists blinded to reconstruction details. Results: In total, 29 patients were included (January 2018 to July 2019). SNR was higher in virtual monoenergetic compared to conventional images, significantly at 60–150 keV. CNR between ischemic gray and normal white matter was higher in monoenergetic images at 40–70 keV compared to conventional images. Virtual monoenergetic images received higher scores in overall image quality. The sensitivity for diagnosing acute ischemia was 93% and 97%, respectively, for the reviewers, compared to 55% of the original report based on conventional images. Conclusion: Virtual monoenergetic reconstructions of spectral CIs may improve image quality and diagnostic ability in stroke assessment.
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| 61. |
- Månsson, Anne, et al.
(författare)
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TLR3 in human eosinophils: functional effects and decreased expression during allergic rhinitis.
- 2010
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Ingår i: International archives of allergy and immunology. - : S. Karger AG. - 1423-0097 .- 1018-2438. ; 151:2, s. 118-28
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND/AIM: Viral respiratory infections are increasingly implicated in allergic exacerbations. Virus-induced activation of eosinophils through Toll-like receptors (TLRs) could be involved. The present study was designed to examine TLR3 expression in eosinophils from bone marrow (BM) and peripheral blood (PB) during symptomatic allergic rhinitis, and to evaluate the functional responsiveness of TLR3 in purified eosinophils. METHODS: BM and PB samples were obtained from healthy volunteers and patients with seasonal allergic rhinitis outside and during the pollen season. Eosinophils were analyzed for TLR3 expression by flow cytometry. Polyinosinic:polycytidylic acid [poly(I:C)], an agonist for TLR3, was used to assess its functional role in purified eosinophils and the intracellular signaling pathways involved. RESULTS: TLR3 expression was demonstrated in BM and PB eosinophils. It was higher in BM-derived than in circulating cells and it was downregulated in both compartments during symptomatic allergic rhinitis. TLR3 expression was also downregulated in the presence of interleukin (IL)-4 and IL- 5. Stimulation with poly(I:C) increased the percentage of CD11b+ cells and enhanced the secretion of IL-8, effects mediated via the p38 mitogen-activated protein kinases and nuclear factor-kappaB signaling pathways. Moreover, pretreatment with IL-5 augmented the poly(I:C)-induced IL-8 release. CONCLUSIONS: Eosinophils activated via TLR3 might be more able to home and recruit leukocytes to sites of inflammation. The decreased TLR3 expression during symptomatic allergic rhinitis and in the presence of Th2 cytokines indicates a role in allergic airway inflammation. Thus, eosinophils might function as a link between viral infections and exacerbations of allergic disease.
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| 62. |
- Nordanstig, Joakim, et al.
(författare)
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Mortality with Paclitaxel-Coated Devices in Peripheral Artery Disease.
- 2020
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Ingår i: The New England journal of medicine. - : Massachusetts Medical Society. - 1533-4406 .- 0028-4793. ; 383, s. 2538-46
-
Tidskriftsartikel (refereegranskat)abstract
- The results of a recent meta-analysis aroused concern about an increased risk of death associated with the use of paclitaxel-coated angioplasty balloons and stents in lower-limb endovascular interventions for symptomatic peripheral artery disease.We conducted an unplanned interim analysis of data from a multicenter, randomized, open-label, registry-based clinical trial. At the time of the analysis, 2289 patients had been randomly assigned to treatment with drug-coated devices (the drug-coated-device group, 1149 patients) or treatment with uncoated devices (the uncoated-device group, 1140 patients). Randomization was stratified according to disease severity on the basis of whether patients had chronic limb-threatening ischemia (1480 patients) or intermittent claudication (809 patients). The single end point for this interim analysis was all-cause mortality.No patients were lost to follow-up. Paclitaxel was used as the coating agent for all the drug-coated devices. During a mean follow-up of 2.49 years, 574 patients died, including 293 patients (25.5%) in the drug-coated-device group and 281 patients (24.6%) in the uncoated-device group (hazard ratio, 1.06; 95% confidence interval, 0.92 to 1.22). At 1 year, all-cause mortality was 10.2% (117 patients) in the drug-coated-device group and 9.9% (113 patients) in the uncoated-device group. During the entire follow-up period, there was no significant difference in the incidence of death between the treatment groups among patients with chronic limb-threatening ischemia (33.4% [249 patients] in the drug-coated-device group and 33.1% [243 patients] in the uncoated-device group) or among those with intermittent claudication (10.9% [44 patients] and 9.4% [38 patients], respectively).In this randomized trial in which patients with peripheral artery disease received treatment with paclitaxel-coated or uncoated endovascular devices, the results of an unplanned interim analysis of all-cause mortality did not show a difference between the groups in the incidence of death during 1 to 4 years of follow-up. (Funded by the Swedish Research Council and others; ClinicalTrials.gov number, NCT02051088.).
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| 63. |
- Nyström, Mattias, et al.
(författare)
-
Assimilating remote sensing data with forest growth models
- 2015
-
Konferensbidrag (refereegranskat)abstract
- As we are entering an era of increased supply of remote sensing data, we believe that dataassimilation that combines growth forecasts of previous estimates with new observations of thecurrent state has a large potential for keeping forest stand registers up to date (Ehlers et al. 2013).The data assimilation will update a forest model e in an optimal way based on the uncertainties inthe forecast and the observations, each time new data becomes available. These forecasting andupdating steps can be repeated with new available observations to get improved estimations. In thisstudy we present the first practical results from data assimilation of mean tree height, basal area andgrowing stock. The remote sensing data used were canopy height models obtained from matching ofdigital aerial photos over the test site Remningstorp in Sweden. The photos were acquired 2003,2005, 2007, 2009, 2010 and 2012 and normalized with a DEM from airborne laser scanning.The procedure for the data assimilation was as follows: mean tree height, basal area and growingstock were predicted on 18 m × 18 m raster cells using the area based method. Ten meter radiussample plots were used as field calibration data. For each photo year, the field data were adjustedfor growth to have the same state year as each acquisition year of the photos. Growth models wereconstructed from National Forest Inventory plot data. Data assimilation could then be performed onraster cell level by initially start with the estimates from 2003 year´s photos. This prediction was thenforecasted to year 2005 by calculating the growth for the raster cell. This forecasted value is thenblended with the new remote sensing estimation collected 2005. The process was then repeated forthe following years where new measurements were available. In this study, extended Kalmanfiltering was used to blend the forecasted values with the new remote sensing measurements.Validation was done for 40 m radius field plots. Further, the results were also compared with twoalternative approaches: the first was to forecast the first remote sensing estimate to the endpointand the second was to use remote sensing data acquired at the endpoint only.The preliminary results for the eight forest stands show that the variances were lower when usingassimilation of new estimates and there were less fluctuation compared to only using remote sensingdata from the endpoint. However, the mean deviation from the measured value 2011 was lowerwhen only data from the endpoint were used. The assimilated values 2011 were consistently closerto the validation data compared to only forecasting the starting estimate from 2003 to 2011.
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| 64. |
- Nyström, Mattias, et al.
(författare)
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Data assimilation in forest inventory: first empirical results
- 2015
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Ingår i: Forests. - : MDPI AG. - 1999-4907. ; 6, s. 4540-4557
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Tidskriftsartikel (refereegranskat)abstract
- Data assimilation techniques were used to estimate forest stand data in 2011 bysequentially combining remote sensing based estimates of forest variables with predictions fromgrowth models. Estimates of stand data, based on canopy height models obtained from imagematching of digital aerial images at six different time-points between 2003 and 2011, served asinput to the data assimilation. The assimilation routines were built on the extended Kalman filter.The study was conducted in hemi-boreal forest at the Remningstorp test site in southern Sweden(lat. 13˝371 N; long. 58˝281 E). The assimilation results were compared with two other methodsused in practice for estimation of forest variables: the first was to use only the most recent estimateobtained from remotely sensed data (2011) and the second was to forecast the first estimate (2003)to the endpoint (2011). All three approaches were validated using nine 40 m radius validation plots,which were carefully measured in the field. The results showed that the data assimilation approachprovided better results than the two alternative methods. Data assimilation of remote sensing timeseries has been used previously for calibrating forest ecosystem models, but, to our knowledge,this is the first study with real data where data assimilation has been used for estimating forestinventory data. The study constitutes a starting point for the development of a framework usefulfor sequentially utilizing all types of remote sensing data in order to provide precise and up-to-dateestimates of forest stand parameters.
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| 65. |
- Nyström, Mattias, et al.
(författare)
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Detection of windthrown trees using airborne laser scanning
- 2014
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Ingår i: International Journal of Applied Earth Observation and Geoinformation. - : Elsevier BV. - 0303-2434 .- 1569-8432. ; 30, s. 21-29
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Tidskriftsartikel (refereegranskat)abstract
- In this study, a method has been developed for the detection of windthrown trees under a forest canopy, using the difference between two elevation models created from the same high density (65 points/m(2)) airborne laser scanning data. The difference image showing objects near the ground was created by subtracting a standard digital elevation model (DEM) from a more detailed DEM created using an active surface algorithm. Template matching was used to automatically detect windthrown trees in the difference image. The 54 ha study area is located in hemi-boreal forest in southern Sweden (Lat. 58 degrees 29' N, Long. 13 degrees 38' E) and is dominated by Norway spruce (Picea abies) with 3.5% deciduous species (mostly birch) and 1.7% Scots pine (Pinus sylvestris). The result was evaluated using 651 field measured windthrown trees. At individual tree level, the detection rate was 38% with a commission error of 36%. Much higher detection rates were obtained for taller trees; 89% of the trees taller than 27 m were detected. For pine the individual tree detection rate was 82%, most likely due to the more easily visible stem and lack of branches. When aggregating the results to 40 m square grid cells, at least one tree was detected in 77% of the grid cells which according to the field measurements contained one or more windthrown trees. (C) 2014 Elsevier B.V. All rights reserved.
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| 66. |
- Ragnehed, Mattias, 1976-
(författare)
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Functional Magnetic Resonance Imaging for Clinical Diagnosis : Exploring and Improving the Examination Chain
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Functional Magnetic Resonance Imaging (fMRI) is a relatively new imaging technique, first reported in 1992, which enables mapping of brain functions with high spatial resolution. Functionally active areas are distinguished by a small signal increase mediated by changes in local blood oxygenation in response to neural activity. The ability to non-invasively map brain function and the large number of MRI scanners quickly made the method very popular, and fMRI have had a huge impact on the study of brain function, both in healthy and diseased subjects.The most common clinical application of fMRI is pre-surgical mapping of brain functions in order to optimise surgical interventions. The clinical fMRI examination procedure can be divided into four integrated parts: (1) patient preparation, (2) image acquisition, (3) image analysis and (4) clinical decision. In this thesis, important aspects of all parts of the fMRI examination procedure are explored with the aim to provide recommendations and methods for prosperous clinical usage of the technique.The most important results of the thesis were: (I) administration of low doses of diazepam to reduce anxiety did not invalidate fMRI mapping results of primary motor and language areas, (II) the choice of visual stimuli equipment can have severe impact on the mapping of visual areas, (III) three-dimensional fMRI imaging sequences did not perform better than two-dimensional imaging sequences, (IV) adaptive spatial filtering can improve the fMRI data analysis, (V) clinical decisions should not be based on activation results from a single statistical threshold.
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| 67. |
- Roy, Rupak, et al.
(författare)
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SN 2012aa : A transient between Type Ibc core-collapse and superluminous supernovae
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 596
-
Tidskriftsartikel (refereegranskat)abstract
- Context. Research on supernovae (SNe) over the past decade has confirmed that there is a distinct class of events which are much more luminous (by similar to 2 mag) than canonical core-collapse SNe (CCSNe). These events with visual peak magnitudes less than or similar to-21 are called superluminous SNe (SLSNe). The mechanism that powers the light curves of SLSNe is still not well understood. The proposed scenarios are circumstellar interaction, the emergence of a magnetar after core collapse, or disruption of a massive star through pair production. Aims. There are a few intermediate events which have luminosities between these two classes. They are important for constraining the nature of the progenitors of these two different populations and their environments and powering mechanisms. Here we study one such object, SN 2012aa. Methods. We observed and analysed the evolution of the luminous Type Ic SN 2012aa. The event was discovered by the Lick Observatory Supernova Search in an anonymous galaxy (z approximate to 0.08). The optical photometric and spectroscopic follow-up observations were conducted over a time span of about 120 days. Results. With an absolute V-band peak of similar to-20 mag, the SN is an intermediate-luminosity transient between regular SNe Ibc and SLSNe. SN 2012aa also exhibits an unusual secondary bump after the maximum in its light curve. For SN 2012aa, we interpret this as a manifestation of SN-shock interaction with the circumstellar medium (CSM). If we assume a Ni-56-powered ejecta, the quasi-bolometric light curve requires roughly 1.3 M-circle dot of Ni-56 and an ejected mass of similar to 14 M-circle dot. This also implies a high kinetic energy of the explosion, similar to 5.4 x 10(51) erg. On the other hand, the unusually broad light curve along with the secondary peak indicate the possibility of interaction with CSM. The third alternative is the presence of a central engine releasing spin energy that eventually powers the light curve over a long time. The host of SN 2012aa is a star-forming Sa/Sb/Sbc galaxy. Conclusions. Although the spectral properties of SN 2012aa and its velocity evolution are comparable to those of normal SNe Ibc, its broad light curve along with a large peak luminosity distinguish it from canonical CCSNe, suggesting that the event is an intermediate-luminosity transient between CCSNe and SLSNe at least in terms of peak luminosity. In comparison to other SNe, we argue that SN 2012aa belongs to a subclass where CSM interaction plays a significant role in powering the SN, at least during the initial stages of evolution.
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| 68. |
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| 69. |
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| 70. |
- Skorup, Paul, et al.
(författare)
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Evaluation of an extracorporeal ozone-based bactericide system for the treatment of Escherichia coli sepsis
- 2022
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Ingår i: Intensive Care Medicine Experimental. - : Springer Nature. - 2197-425X. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Sepsis is associated with substantial mortality rates. Antibiotic treatment is crucial, but global antibiotic resistance is now classified as one of the top ten global public health risks facing humanity. Ozone (O-3) is an inorganic molecule with no evident function in the body. We investigated the bactericide properties of ozone, using a novel system of extracorporeal ozone blood treatment. We hypothesized that ozone would decrease the concentration of viable Escherichia coli (E. coli) in human whole blood and that the system would be technically feasible and physiologically tolerable in a clinically relevant model of E. coli sepsis in swine. Methods: The E. coli strain B09-11822, a clinical isolate from a patient with septic shock was used. The in vitro study treated E. coli infected human whole blood (n = 6) with ozone. The in vivo 3.5-h sepsis model randomized swine to E. coli infusion and ozone treatment (n = 5) or E. coli infusion and no ozone treatment (n = 5). Live E. coli, 5 x 10(7) colony-forming units (CFU/mL) was infused in a peripheral vein. Ozone treatment was initiated with a duration of 30 min after 1.5 h. Results: The single pass in vitro treatment decreased E. coli by 27%, mean 1941 to 1422 CFU/mL, mean of differences - 519.0 (95% CI - 955.0 to - 82.98,P= 0.0281). pO(2) increased (95% CI 31.35 to 48.80, P= 0.0007), pCO(2) decreased (95% CI -3.203 to - 1.134, P= 0.0069), oxyhemoglobin increased (95% CI 1.010 to 3.669, P= 0.0113). Methemoglobin was not affected. In the sepsis model, 9/10 swine survived. One swine randomized to ozone treatment died from septic shock before initiation of the treatment. Circulatory, respiratory, and metabolic parameters were not affected by the ozone treatment. E. coli in arterial blood, in organs and in aerobic and anaerobic blood cultures did not differ. Hemoglobin, leucocytes, and methemoglobin were not affected by the treatment. Conclusions: Ozone decreased the concentration of viable E. coli in human whole blood. The system was technically feasible and physiologically tolerable in porcine sepsis/septic shock and should be considered for further studies towards clinical applications.
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| 71. |
- Sundström, Timmy, 1981-, et al.
(författare)
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Prognostics of electronic systems through power supply current trends
- 2008
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Ingår i: IEEE Internatioanl Conference on Prognostics and Health Management. - Denver, USA : Institute of Electrical and Electronics Engineers (IEEE).
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- As today's avionic systems highly rely on electronic components, the prognostic of electronic systems in the context of avionics has become crucial. This paper presents a prognostic method applicable to electronic components and systems based on the analysis of the power supply current. In this method, the focus is on trends in the measured power supply current of the device under prognostic process. The discussion in this paper reveals that there is a measurable relationship between the supply current and the remaining lifetime of the electronic devices. The presented methodology is supported by circuit simulations performed on a system consisting of reference circuitry. The prognostic method shows great promise due to the ability of being applicable at any prognostic level.
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| 72. |
- Sverdrup, Harald, et al.
(författare)
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Modeling recovery of Swedish ecosystems from acidification
- 2005
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Ingår i: Ambio: a Journal of Human Environment. - 0044-7447. ; 34:1, s. 25-31
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Tidskriftsartikel (refereegranskat)abstract
- Dynamic models complement existing time series of observations and static critical load calculations by simulating past and future development of chemistry in forest and lake ecosystems. They are used for dynamic assessment of the acidification and to produce target load functions, that describe what combinations of nitrogen and sulfur emission reductions are needed to achieve a chemical or biological criterion in a given target year. The Swedish approach has been to apply the dynamic acidification models MAGIC, to 133 lakes unaffected by agriculture and SAFE, to 645 productive forest sites. While the long-term goal is to protect 95% of the area, implementation of the Gothenburg protocol will protect approximately 75% of forest soils in the long term. After 2030, recovery will be very slow and involve only a limited geographical area. If there had been no emission reductions after 1980, 87% of the forest area would have unwanted soil status in the long term. In 1990, approximately 17% of all Swedish lakes unaffected by agriculture received an acidifying deposition above critical load. This fraction will decrease to 10% in 2010 after implementation of the Gothenburg protocol. The acidified lakes of Sweden will recover faster than the soils. According to the MAGIC model the median pre-industrial ANC of 107 mueq L-1 in acid sensitive lakes decreased to about 60 mueq L-1 at the peak of the acidification (1975-1990) and increases to 80 mueq L-1 by 2010. Further increases were small, only 2 mueq L-1 between 2010 and 2040. Protecting 95% of the lakes will require further emission reductions below the Gothenburg protocol levels. More than 7000 lakes are limed regularly in Sweden and it is unlikely that this practice can be discontinued in the near future without adverse effects on lake chemistry and biology.
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| 73. |
- Taddia, Francesco, et al.
(författare)
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A metallicity study of 1987A-like supernova host galaxies
- 2013
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 558
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Tidskriftsartikel (refereegranskat)abstract
- Context. The origin of the blue supergiant (BSG) progenitor of Supernova (SN) 1987A has long been debated, along with the role that its sub-solar metallicity played. We now have a sample of SN 1987A-like events that arise from the rare core collapse (CC) of massive (similar to 20 M-circle dot) and compact (less than or similar to 100 R-circle dot) BSGs. Aims. The metallicity of the explosion sites of the known BSG SNe is investigated, as well as the association of BSG SNe to star-forming regions. Methods. Both indirect and direct metallicity measurements of 13 BSG SN host galaxies are presented, and compared to those of other CC SN types. Indirect measurements are based on the known luminosity-metallicity relation and on published metallicity gradients of spiral galaxies. In order to provide direct metallicity measurements based on strong line diagnostics, we obtained spectra of each BSG SN host galaxy both at the exact SN explosion sites and at the positions of other H II regions. We also observed these hosts with narrow H alpha and broad R-band filters in order to produce continuum-subtracted H alpha images. This allows us to measure the degree of association between BSG SNe and star-forming regions, and to compare it to that of other SN types. Results. BSG SNe are found to explode either in low-luminosity galaxies or at large distances from the nuclei of luminous hosts. Therefore, their indirectly measured metallicities are typically lower than those of SNe IIP and Ibc. This result is confirmed by the direct metallicity estimates, which show slightly sub-solar oxygen abundances (12 + log (O/H) similar to 8.3-8.4 dex) for the local environments of BSG SNe, similar to that of the Large Magellanic Cloud (LMC), where SN 1987A exploded. However, we also note that two objects of our sample (SNe 1998A and 2004em) were found at near solar metallicity. SNe IIb have a metallicity distribution similar to that of our BSG SNe. Finally, we find that the degree of association to star-forming regions is similar among BSG SNe, SNe IIP and IIn. Conclusions. Our results suggest that LMC metal abundances play a role in the formation of some 1987A-like SNe. This would naturally fit in a single star scenario for the progenitors. However, the existence of two events at nearly solar metallicity suggests that also other channels, e.g. binarity, contribute to produce BSG SNe.
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| 74. |
- Taddia, Francesco, et al.
(författare)
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Long-rising Type II supernovae from Palomar Transient Factory and Caltech Core-Collapse Project
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 588
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Tidskriftsartikel (refereegranskat)abstract
- Context. Supernova (SN) 1987A was a peculiar hydrogen-rich event with a long-rising (similar to 84 d) light curve, stemming from the explosion of a compact blue supergiant star. Only a few similar events have been presented in the literature in recent decades. Aims. We present new data for a sample of six long-rising Type II SNe (SNe II), three of which were discovered and observed by the Palomar Transient Factory (PTF) and three observed by the Caltech Core-Collapse Project (CCCP). Our aim is to enlarge this small family of long-rising SNe II, characterizing their differences in terms of progenitor and explosion parameters. We also study the metallicity of their environments. Methods. Optical light curves, spectra, and host-galaxy properties of these SNe are presented and analyzed. Detailed comparisons with known SN 1987A-like events in the literature are shown, with particular emphasis on the absolute magnitudes, colors, expansion velocities, and host-galaxy metallicities. Bolometric properties are derived from the multiband light curves. By modeling the early-time emission with scaling relations derived from the SuperNova Explosion Code (SNEC) models of MESA progenitor stars, we estimate the progenitor radii of these transients. The modeling of the bolometric light curves also allows us to estimate other progenitor and explosion parameters, such as the ejected Ni-56 mass, the explosion energy, and the ejecta mass. Results. We present PTF12kso, a long-rising SN II that is estimated to have the largest amount of ejected Ni-56 mass measured for this class. PTF09gpn and PTF12kso are found at the lowest host metallicities observed for this SN group. The variety of early light-curve luminosities depends on the wide range of progenitor radii of these SNe, from a few tens of R-circle dot (SN 2005ci) up to thousands (SN 2004ek) with some intermediate cases between 100 R-circle dot (PTF09gpn) and 300 R-circle dot (SN 2004em). Conclusions. We confirm that long-rising SNe II with light-curve shapes closely resembling that of SN 1987A generally arise from blue supergiant (BSG) stars. However, some of them, such as SN 2004em, likely have progenitors with larger radii (similar to 300 R-circle dot, typical of yellow supergiants) and can thus be regarded as intermediate cases between normal SNe IIP and SN 1987A-like SNe. Some extended red supergiant (RSG) stars such as the progenitor of SN 2004ek can also produce long-rising SNe II if they synthesized a large amount of Ni-56 in the explosion. Low host metallicity is confirmed as a characteristic of the SNe arising from compact BSG stars.
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| 75. |
- Taddia, Francesco, et al.
(författare)
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Metallicity at the explosion sites of interacting transients
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 580
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Tidskriftsartikel (refereegranskat)abstract
- Context: Some circumstellar-interacting (CSI) supernovae (SNe) are produced by the explosions of massive stars that have lost mass shortly before the SN explosion. There is evidence that the precursors of some SNe IIn were luminous blue variable (LBV) stars. For a small number of CSI SNe, outbursts have been observed before the SN explosion. Eruptive events of massive stars are named SN impostors (SN IMs) and whether they herald a forthcoming SN or not is still unclear. The large variety of observational properties of CSI SNe suggests the existence of other progenitors, such as red supergiant (RSG) stars with superwinds. Furthermore, the role of metallicity in the mass loss of CSI SN progenitors is still largely unexplored.Aims: Our goal is to gain insight into the nature of the progenitor stars of CSI SNe by studying their environments, in particular the metallicity at their locations. Methods. We obtain metallicity measurements at the location of 60 transients (including SNe IIn, SNe Ibn, and SN IMs) via emission-line diagnostic on optical spectra obtained at the Nordic Optical Telescope and through public archives. Metallicity values from the literature complement our sample. We compare the metallicity distributions among the different CSI SN subtypes, and to those of other core-collapse SN types. We also search for possible correlations between metallicity and CSI SN observational properties.Results: We find that SN IMs tend to occur in environments with lower metallicity than those of SNe IIn. Among SNe IIn, SN IIn-L(1998S-like) SNe show higher metallicities, similar to those of SNe IIL/P, whereas long-lasting SNe IIn (1988Z-like) show lower metallicities, similar to those of SN IMs. The metallicity distribution of SNe IIn can be reproduced by combining the metallicity distributions of SN IMs (which may be produced by major outbursts of massive stars like LBVs) and SNe IIP (produced by RSGs). The same applies to the distributions of the normalized cumulative rank (NCR) values, which quantifies the SN association to HII regions. For SNe IIn, we find larger mass-loss rates and higher CSM velocities at higher metallicities. The luminosity increment in the optical bands during SN IM outbursts tend to be larger at higher metallicity, whereas the SN IM quiescent optical luminosities tend to be lower.Conclusions: The difference in metallicity between SNe IIn and SN IMs indicates that LBVs are only one of the progenitor channels for SNe IIn, with 1988Z-like and 1998S-like SNe possibly arising from LBVs and RSGs, respectively. Finally, even though line-driven winds likely do not primarily drive the late mass-loss of CSI SN progenitors, metallicity has some impact on the observational properties of these transients.
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| 76. |
- Taddia, Francesco, et al.
(författare)
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The Type II supernovae 2006V and 2006au : two SN 1987A-like events
- 2012
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 537
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Tidskriftsartikel (refereegranskat)abstract
- Context. Supernova 1987A revealed that a blue supergiant (BSG) star can end its life as a core-collapse supernova (SN). SN 1987A and other similar objects exhibit properties that distinguish them from ordinary Type II Plateau (IIP) SNe, whose progenitors are believed to be red supergiants (RSGs). Similarities among 1987A-like events include a long rise to maximum, early luminosity fainter than that of normal Type IIP SNe, and radioactivity acting as the primary source powering the light curves.Aims. We present and analyze two SNe monitored by the Carnegie Supernova Project that are reminiscent of SN 1987A.Methods. Optical and near-infrared (NIR) light curves, and optical spectroscopy of SNe 2006V and 2006au are presented. These observations are compared to those of SN 1987A, and are used to estimate properties of their progenitors.Results. Both objects exhibit a slow rise to maximum and light curve evolution similar to that of SN 1987A. At the earliest epochs, SN 2006au also displays an initial dip which we interpret as the signature of the adiabatic cooling phase that ensues shock break-out. SNe 2006V and 2006au are both found to be bluer, hotter and brighter than SN 1987A. Spectra of SNe 2006V and 2006au are similar to those of SN 1987A and other normal Type II objects, although both consistently exhibit expansion velocities higher than SN 1987A. Semi-analytic models are fit to the UVOIR light curve of each object from which physical properties of the progenitors are estimated. This yields ejecta mass estimates of Mej ≈ 20 M⊙, explosion energies of E ≈ 2−3 × 1051 erg s-1, and progenitor radii of R ≈ 75−100 R⊙ for both SNe.Conclusions. The progenitors of SNe 2006V and 2006au were most likely BSGs with a larger explosion energy as compared to that of SN 1987A.
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| 77. |
- Zhou, Qin, et al.
(författare)
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The C-terminal amidated analogue of the Substance P (SP) fragment SP (1-7) attenuates the expression of naloxone- precipitated withdrawal in morphine dependent rats
- 2009
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Ingår i: Peptides. - : Elsevier BV. - 0196-9781 .- 1873-5169. ; 30:12, s. 2418-2422
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Tidskriftsartikel (refereegranskat)abstract
- We previously demonstrated that intracerebroventricular (i.c.v.) administration of the substance P (SP) aminoterminal fragment SP(1-7) attenuates the expression of morphine withdrawal in the male rat. In this study we have used a synthetic analogue of this peptide, i.e. the SP(1-7) amide showing higher binding potency than the native heptapeptide, in a similar experimental set-up. Thus, Wistar male rats were made tolerant to morphine by daily injections of the opiate during 8 days. Following peptide administration (i.c.v.) and a subsequent naloxone challenge a variety of physical syndromes of withdrawal were recorded. We observed that the SP(1-7) amide potently and dose-dependently reduced several signs of reaction to morphine withdrawal. Interestingly, the effect of the peptide amide was significantly attenuated by the addition of the sigma agonist (+)-SKF-10047. We conclude that the SP(1-7) amide mimics the effect of the native SP fragment and that the mechanisms for its action involve a sigma receptor site.
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| 78. |
- Ångqvist, Mattias, 1989, et al.
(författare)
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ICET - A Python Library for Constructing and Sampling Alloy Cluster Expansions
- 2019
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Ingår i: Advanced Theory and Simulations. - : Wiley. - 2513-0390. ; 2:7
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Tidskriftsartikel (refereegranskat)abstract
- Alloy cluster expansions (CEs) provide an accurate and computationally efficient mapping of the potential energy surface of multi-component systems that enables comprehensive sampling of the many-dimensional configuration space. Here, integrated cluster expansion toolkit (ICET), a flexible, extensible, and computationally efficient software package, is introduced for the construction and sampling of CEs. ICET is largely written in Python for easy integration in comprehensive workflows, including first-principles calculations for the generation of reference data and machine learning libraries for training and validation. The package enables training using a variety of linear regression algorithms with and without regularization, Bayesian regression, feature selection, and cross-validation. It also provides complementary functionality for structure enumeration and mapping as well as data management and analysis. Potential applications are illustrated by two examples, including the computation of the phase diagram of a prototypical metallic alloy and the analysis of chemical ordering in an inorganic semiconductor.
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