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51.	Kohonen, P, et al. (author) The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing 2013 In: Molecular informatics. - : Wiley. - 1868-1743. ; 32:1, s. 47-63 Journal article (peer-reviewed)
52.	Kumar, A, et al. (author) Age-associated changes in gene expression in human brain and isolated neurons 2013 In: Neurobiology of aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 34:4, s. 1199-1209 Journal article (peer-reviewed)
53.	Larsson, M, et al. (author) A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk 2014 In: Science translational medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 6:222, s. 222ra17- Journal article (peer-reviewed)abstract Blocking the enzyme that initiates the intrinsic coagulation pathway protects against thrombosis in bypass systems and does not cause excess bleeding in vivo.
54.	Larsson, M, et al. (author) When Life-Saving Is Life-Threatening 2014 In: SCIENCE TRANSLATIONAL MEDICINE. - 1946-6234. ; 6:222 Journal article (other academic/artistic)
55.	Tikhonoff, V., et al. (author) Symptoms of anxiety and depression across adulthood and blood pressure in late middle age: the 1946 British birth cohort 2014 In: Journal of Hypertension. - : Ovid Technologies (Wolters Kluwer Health). - 0263-6352. ; 32:8, s. 1590-1599 Journal article (peer-reviewed)abstract Objective: Previous studies testing the hypothesis that symptoms of anxiety and depression increase blood pressure (BP) levels show inconsistent and limited findings. We examined the association between those symptoms across adult life and BP in late middle age. Methods: Using data from 1683 participants from the MRC NSHD, we investigated associations between affective symptoms at ages 36, 43, 53 and 60-64 years and SBP and DBP at age 60-64. Multivariable linear regression was used to examine the effect on BP of affective symptoms at each age separately and as a categorical cumulative score based on the number of times an individual was classified as a 'case'. Models were adjusted for sex, BMI, educational attainment, socioeconomic position, heart rate, lifestyle factors and antihypertensive treatment. Results: In fully adjusted models, we observed lower SBP in study members with case-level symptoms at one to two time-points [-1.83mmHg; 95% confidence interval (CI) -3.74 to 0.01] and at three to four time-points (-3.93 mmHg; 95% CI -7.19 to -0.68) compared with those never meeting case criteria suggesting a cumulative inverse impact of affective symptoms on SBP across adulthood (P value for trend 0.022). Sex and BMI had a large impact on the estimates while not other confounders. Potential mediators such as heart rate and lifestyle behaviours had a little impact on the association. SBP at age 36 and behavioural changes across adulthood, as additional covariates, had a little impact on the association. A similar but weaker trend was observed for DBP. Conclusion: A cumulative effect of symptoms of anxiety and depression across adulthood results in lower SBP in late middle age that is not explained by lifestyle factors and antihypertensive treatment. Mechanisms by which mood may impact BP should be investigated.
56.	Willighagen, E, et al. (author) Sharing dose response data and analysis across the SEURAT-1 cluster 2012 In: TOXICOLOGY LETTERS. - : Elsevier BV. - 0378-4274. ; 211, s. S161-S161 Conference paper (other academic/artistic)

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Type of publication: journal article (52); conference paper (2); research review (2)

Type of content: peer-reviewed (53); other academic/artistic (3)

Author/Editor: Bertsche, W. (19); Butler, E. (19); Charlton, M. (19); Fajans, J. (19); Friesen, T. (19); Hardy, W. N. (19); show more...; Jonsell, Svante (19); Madsen, N. (19); Menary, S. (19); Olchanski, K. (19); Pusa, P. (19); Sarid, E. (19); So, C. (19); Baquero-Ruiz, M. (18); Cesar, C. L. (18); Fujiwara, M. C. (18); Gill, D. R. (18); Hangst, J. S. (18); Kurchaninov, L. (18); Olin, A. (18); Robicheaux, F. (18); Silveira, D. M. (18); Thompson, R. I. (18); Ashkezari, M. D. (18); Nolan, P. (17); van der Werf, D. P. (17); Hayden, M. E. (17); Wurtele, J. S. (16); Povilus, A. (15); Chapman, S. (14); Andresen, G. B. (13); Humphries, A. J. (13); Hydomako, R. (13); Yamazaki, Y. (12); Gutierrez, A. (12); Eriksson, S. (12); Storey, J. W. (12); Deller, A. (10); McKenna, J. T. K. (8); Amole, C. (8); Rasmussen, C. O. (7); Capra, A. (7); Isaac, C. A. (7); Hardy, John (7); Hardy, J (6); Little, A. (6); Hardy, Rebecca (5); Kuh, Diana (5); Stracka, S. (5); Napoli, S. C. (5); show less...

University: Stockholm University (22); Karolinska Institutet (21); University of Gothenburg (9); Uppsala University (8); Lund University (8); Linköping University (3); show more...; Umeå University (2); Royal Institute of Technology (1); Chalmers University of Technology (1); Karlstad University (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (56)

Research subject (UKÄ/SCB): Natural sciences (20); Medical and Health Sciences (19); Social Sciences (2); Engineering and Technology (1)

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