| 51. |
- Degermark, Mikael, et al.
(författare)
-
Evaluation of CRTP performance over cellular radio links
- 2000
-
Ingår i: IEEE personal communications. - : Institute of Electrical and Electronics Engineers (IEEE). - 1070-9916 .- 1558-0652. ; 7:4, s. 20-25
-
Tidskriftsartikel (refereegranskat)abstract
- To make mobile IP telephony over cellular radio systems an economically viable alternative to circuit-switched voice, it is an absolute requirement that the 40-octet IP/UDP/RTP headers on IP telephony packets be reduced in size to conserve bandwidth and radio spectrum. We evaluate the performance of the default header compression scheme for IP/UDP/RTP, CRTP (RFC-2508), over links built on cellular radio access technology. We find that CRTP does not perform adequately over such links, and suggest that a more robust header compression scheme must be developed to make IP telephony over cellular economically viable.
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| 52. |
- Dillenbeck, Emelie, et al.
(författare)
-
The design of the PRINCESS 2 trial: A randomized trial to study the impact of ultrafast hypothermia on complete neurologic recovery after out-of-hospital cardiac arrest with initial shockable
- 2024
-
Ingår i: American Heart Journal. - : MOSBY-ELSEVIER. - 0002-8703 .- 1097-6744. ; 271, s. 97-108
-
Tidskriftsartikel (refereegranskat)abstract
- Background Delayed hypothermia, initiated after hospital arrival, several hours after cardiac arrest with 8-10 hours to reach the target temperature, is likely to have limited impact on overall survival. However, the effect of ultrafast hypothermia, i.e., delivered intra-arrest or immediately after return of spontaneous circulation (ROSC), on functional neurologic outcome after out -of -hospital cardiac arrest (OHCA) is unclear. In two prior trials, prehospital trans -nasal evaporative intra-arrest cooling was safe, feasible and reduced time to target temperature compared to delayed cooling. Both studies showed trends towards improved neurologic recovery in patients with shockable rhythms. The aim of the PRINCESS2-study is to assess whether cooling, initiated either intra-arrest or immediately after ROSC, followed by in -hospital hypothermia, significantly increases survival with complete neurologic recovery as compared to standard normothermia care, in OHCA patients with shockable rhythms. Methods/design In this investigator -initiated, randomized, controlled trial, the emergency medical services (EMS) will randomize patients at the scene of cardiac arrest to either trans -nasal cooling within 20 minutes from EMS arrival with subsequent hypothermia at 33 degrees C for 24 hours after hospital admission (intervention), or to standard of care with no prehospital or in -hospital cooling (control). Fever ( > 37,7 degrees C) will be avoided for the first 72 hours in both groups. All patients will receive post resuscitation care and withdrawal of life support procedures according to current guidelines. Primary outcome is survival with complete neurologic recovery at 90 days, defined as modified Rankin scale (mRS) 0-1. Key secondary outcomes include survival to hospital discharge, survival at 90 days and mRS 0-3 at 90 days. In total, 1022 patients are required to detect an absolute difference of 9% (from 45 to 54%) in survival with neurologic recovery (80% power and one-sided alpha= 0,025, beta = 0,2) and assuming 2,5% lost to follow-up. Recruitment starts in Q1 2024 and we expect maximum enrolment to be achieved during Q4 2024 at 20-25 European and US sites. Discussion This trial will assess the impact of ultrafast hypothermia applied on the scene of cardiac arrest, as compared to normothermia, on 90 -day survival with complete neurologic recover y in OHCA patients with initial shockable rhythm. Trial registration NCT06025123. (Am Heart J 2024;271:97-108.)
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| 53. |
- Docherty, Anna R, et al.
(författare)
-
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.
- 2023
-
Ingår i: The American journal of psychiatry. - : American Psychiatric Association Publishing. - 1535-7228 .- 0002-953X. ; 180:10, s. 723-738
-
Tidskriftsartikel (refereegranskat)abstract
- Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures.This study comprised 22 cohorts, including 43,871 SA cases and 915,025 ancestry-matched controls. Analytical methods across multi-ancestry and individual ancestry admixtures included inverse variance-weighted fixed-effects meta-analyses, followed by gene, gene-set, tissue-set, and drug-target enrichment, as well as summary-data-based Mendelian randomization with brain expression quantitative trait loci data, phenome-wide genetic correlation, and genetic causal proportion analyses.Multi-ancestry and European ancestry admixture GWAS meta-analyses identified 12 risk loci at p values <5×10-8. These loci were mostly intergenic and implicated DRD2, SLC6A9, FURIN, NLGN1, SOX5, PDE4B, and CACNG2. The multi-ancestry SNP-based heritability estimate of SA was 5.7% on the liability scale (SE=0.003, p=5.7×10-80). Significant brain tissue gene expression and drug set enrichment were observed. There was shared genetic variation of SA with attention deficit hyperactivity disorder, smoking, and risk tolerance after conditioning SA on both major depressive disorder and posttraumatic stress disorder. Genetic causal proportion analyses implicated shared genetic risk for specific health factors.This multi-ancestry analysis of suicide attempt identified several loci contributing to risk and establishes significant shared genetic covariation with clinical phenotypes. These findings provide insight into genetic factors associated with suicide attempt across ancestry admixture populations, in veteran and civilian populations, and in attempt versus death.
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| 54. |
- Duffy, Stephen W., et al.
(författare)
-
Mammography screening reduces rates of advanced and fatal breast cancers : Results in 549,091 women
- 2020
-
Ingår i: Cancer. - : John Wiley & Sons. - 0008-543X .- 1097-0142. ; 126:13, s. 2971-2979
-
Tidskriftsartikel (refereegranskat)abstract
- Background: It is of paramount importance to evaluate the impact of participation in organized mammography service screening independently from changes in breast cancer treatment. This can be done by measuring the incidence of fatal breast cancer, which is based on the date of diagnosis and not on the date of death.Methods: Among 549,091 women, covering approximately 30% of the Swedish screening‐eligible population, the authors calculated the incidence rates of 2473 breast cancers that were fatal within 10 years after diagnosis and the incidence rates of 9737 advanced breast cancers. Data regarding each breast cancer diagnosis and the cause and date of death of each breast cancer case were gathered from national Swedish registries. Tumor characteristics were collected from regional cancer centers. Aggregated data concerning invitation and participation were provided by Sectra Medical Systems AB. Incidence rates were analyzed using Poisson regression.Results: Women who participated in mammography screening had a statistically significant 41% reduction in their risk of dying of breast cancer within 10 years (relative risk, 0.59; 95% CI, 0.51‐0.68 [P < .001]) and a 25% reduction in the rate of advanced breast cancers (relative risk, 0.75; 95% CI, 0.66‐0.84 [P < .001]).Conclusions: Substantial reductions in the incidence rate of breast cancers that were fatal within 10 years after diagnosis and in the advanced breast cancer rate were found in this contemporaneous comparison of women participating versus those not participating in screening. These benefits appeared to be independent of recent changes in treatment regimens.
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| 55. |
- Edlinger, Michael, et al.
(författare)
-
Blood pressure and other metabolic syndrome factors and risk of brain tumour in the large population-based Me-Can cohort study
- 2012
-
Ingår i: Journal of Hypertension. - 0263-6352 .- 1473-5598. ; 30:2, s. 290-296
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES:: Brain tumour has few established determinants. We assessed to which extent risk of brain tumour was related to metabolic syndrome factors in adults. METHODS:: In the Me-Can project, 580 000 individuals from Sweden, Austria, and Norway were followed for a median of 10 years after baseline measurement. Data on brain tumours were obtained from national cancer registries. The factors of metabolic syndrome (BMI, SBP and DBP, and blood levels of glucose, cholesterol, and triglycerides), separately and combined, were analysed in quintiles and for transformed z-scores (mean transformed to 0 and standard deviation to 1). Cox proportional hazards multivariate regression models were used, with corrections for measurement error. RESULTS:: During follow-up, 1312 primary brain tumours were diagnosed, predominantly meningioma (n = 348) and high-grade glioma (n = 436). For meningioma, the hazard ratio was increased for z-scores of SBP [hazard ratio = 1.27 per unit standard deviation, 95% confidence interval (CI) 1.03-1.57], of DBP (hazard ratio = 1.29, 95% CI 1.04-1.58), and of the combined metabolic syndrome score (hazard ratio = 1.31, 95% CI 1.11-1.54). An increased risk of high-grade glioma was found for DBP (hazard ratio = 1.23, 95% CI 1.01-1.50) and triglycerides (hazard ratio = 1.35, 95% CI 1.05-1.72). For both meningioma and high-grade glioma, the risk was more than double in the fifth quintiles of DBP compared to the lowest quintile. For meningioma this risk was even larger for SBP. CONCLUSION:: Increased blood pressure was associated with risk of brain tumours, especially of meningiomas.
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| 56. |
- Ekbladh, Elin, 1974-
(författare)
-
Return to Work : Assessment of Subjective Psychosocial and Environmental Factors
- 2008
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Introduktion: Sjukfrånvaron i Sverige är hög och kunskap om vad som påverkar återgång i arbete efter sjukskrivning behöver utvecklas. I processen kring återgång i arbete är bedömning av arbetsförmåga en viktig del. Bristen på valida, reliabla och teoretiskt förankrade bedömningsinstrument inom området är dock ett bekymmer eftersom tillförlitliga bedömningar av arbetsförmåga är en förutsättning för utformning och genomförande av interventioner för att stödja återgång i arbete. Denna typ av interventioner kräver multidisciplinär kompetens där arbetsterapeuter utgör en viktig funktion. Vid bedömning av arbetsförmåga bör personens subjektiva uppfattning om sin situation beaktas, då den har betydelse för utfallet av återgång i arbete. Worker Role Interview (WRI) och Work Environment Impact Scale (WEIS) är två arbetsrelaterade intervjuinstrument, som har utvecklats i syfte att bedöma subjektiva psykosociala och miljömässiga faktorers påverkan på arbetsförmåga. Den teoretiska grunden till WRI och WEIS är Model of Human Occupation, som är en modell med fokus på aktivitetsutförande i relation till psykosociala faktorer. Inledande prövningar av WRI och WEIS reliabilitet och validitet har genomförts. Bedömningsinstrumenten har bearbetats och översatts till svenska och används främst av arbetsterapeuter, som arbetar med personer med arbetsrelaterad problematik.Syfte: Det övergripande syftet med avhandlingen är att undersöka användbarheten av bedömningsinstrumenten Worker Role Interview och Work Environment Impact Scale för identifiering av psykosociala och miljömässiga rehabiliteringsbehov av betydelse för återgång i arbete.Metod: Avhandlingen består av fem empiriska studier. I samtliga studier har erhållen information bearbetats kvantitativt. I studie IV har även kvalitativ bearbetning genomförts. Studie I, II och IV är tvärsnittsstudier och studie II och V är två års longitudinella studier. I studie I samlades information in via enkät. I studie II, III och V bestod den huvudsakliga informationen av skattningar utifrån WRI variabler och i studie IV var bedömningar utifrån WEIS i form av skattningar och nedskrivna kommentarer till skattningarna den huvudsakliga informationen.Resultat: I studie I undersöktes vilka teoretiska utgångspunkter och professionsspecifika modeller arbetsterapeuter i Sverige ansåg påverka den psykiatriska vården och den psykiatriska arbetsterapin. Det psykosociala perspektivet var den teoretiska utgångspunkt som hade störst påverkan både på psykiatrisk vård och på psykiatrisk arbetsterapi. Den arbetsterapeutiska modell som flest identifierade var Model of Human Occupation. Detta resultat indikerar att Model of Human Occupation verkar vara användbar inom arbetsterapi och motiverade vidare användning av modellen i denna avhandling. Det som dock också framkom i studie I var att arbetsterapeuter inom psykiatrisk vård använde professionsspecifika modeller i en relativt liten utsträckning. Ett sätt att öka tillämpningen av teori i praktik är att använda teoretiskt grundade bedömningsinstrument. I studie II, III, IV och V har endera av de Model of Human Occupation- baserade bedömningsinstrumenten WRI och WEIS använts och värderats.I studie II och V prövades WRI:s förmåga att predicera återgång i arbete efter långvarig sjukskrivning. Det område i WRI som uppvisade bäst prediktivitet var området ”Självuppfattning” vars variabler beaktar personens motivation för återgång i arbete i form av personens upplevelse av kompetens och effektivitet för att utföra arbetsuppgifter och hantera utmaningar i arbetet. De två WRI variabler som bäst kunde predicera vilka som skulle återgå respektive inte återgå i arbete vid uppföljning efter två år var: ”Tro på sin arbetsförmåga”, och ”Dagliga vanor och rutiner”. Resultaten tyder på att kunskap om hur tro på den egna förmågan stärks och kunskap om dagliga vanor och rutiners påverkan på utförande av arbete är central vid genomförande av interventioner i syfte att stödja personer att återgå till arbete efter sjukskrivning.I studie III prövades WRI:s konstrukturella validitet i en internationell studie. Samtliga variabler i WRI, förutom de som tillhör miljöområdet, uppvisade en god konstrukturell validitet dvs mätte psykosociala faktorers påverkan på arbetsförmågan. WRI:s skattningsskala verkar stabil och valid mellan olika länder och för personer med olika diagnoser. I analysen framkom att WRI kunde särskilja mellan personers psykosociala arbetsförmåga på tre olika nivåer.I studie IV undersöktes hur personer med erfarenhet av långtidssjukskrivning uppfattar att faktorer i arbetsmiljön stödjer respektive hindrar personens utförande av arbete och välbefinnande genom bedömningar utifrån WEIS. De faktorer som uppfattades som meststödjande var olika former av sociala interaktioner på arbetet samt uppfattningen om arbetets värde och mening. De faktorer som uppfattades som mest hindrande var olika krav i relation till arbetsgenomförandet samt den belöning som erhålls för arbetet.Konklusion: Sammanfattningsvis så kan WRI användas för bedömning av psykosociala faktorers påverkan på arbetsförmågan. I WRI ingår variabler som kan predicera återgång till arbete upp till två år efter genomförd bedömning. WEIS verkar användbart för att identifiera arbetsmiljöfaktorer som stödjer respektive hindrar personers välbefinnande och utförande av arbete. Att komplettera olika datainsamlingsmetoder är en förutsättning för att uppnå en så god bedömning av arbetsförmåga som möjligt. Den information som WRI- och WEISintervjuer genererar är värdefull, då den kan utgöra en viktig grund för planering av individspecifika rehabiliteringsinsatser. Bedömningsinstrumenten WRI och WEIS med sin teoretiska förankring i Model of Human Occupation kan anses vara användbara för att identifiera psykosociala och miljömässiga rehabiliteringsbehov i syfte att stödja personer i processen åter till arbete efter sjukskrivning.
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| 57. |
- Ekholm, Hans, et al.
(författare)
-
Öppet intag - En väg till drogfrihet? Rapport 1 : Beskrivning av klienter vid Vårnäs behandlingshem.
- 1999
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Centrum för välfärdsforskning åtog sig våren 1999 att utvärdera behandlingsformen Öppet intag – på Vårnäs behandlingshem i Vingåker – åt Vårdförbundet Sörmland. Verksamheten, som startade som ett pilotprojekt i Katrineholm den 1 juli 1996, har idag stöd av samtliga Sörmlandskommuner. Närmare 500 personer har varit i kontakt med Öppet intag. Det är en intressant och spännande behandlingsform, som är väl värd att studera och utvärdera både ur ett vetenskapligt, samhälleligt och individuellt perspektiv. Uppläggning av utvärderingen bygger på diskussioner med den politiska ledningsgruppen för Vårdförbundet Sörmland och samtal med personal på Vårnäs. Utvärderingen är tänkt att utgöra underlag för beslut om fortsatt verksamhet och för vidareutveckling av densamma.
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| 58. |
- Ekman, Diana, et al.
(författare)
-
Stratified genetic analysis reveals sex differences in MPO-ANCA-associated vasculitis
- 2023
-
Ingår i: Rheumatology. - : Oxford University Press. - 1462-0324 .- 1462-0332. ; 62:9, s. 3213-3218
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To identify and genetically characterize subgroups of patients with ANCA-associated vasculitides (AAV) based on sex and ANCA subtype. Methods: A previously established SNP dataset derived from DNA sequencing of 1853 genes and genotyping of 1088 Scandinavian cases with AAV and 1589 controls was stratified for sex and ANCA subtype and analysed for association with five top AAV SNPs. rs9274619, a lead variant at the HLA-DQB1/HLA-DQA2 locus previously associated with AAV positive for myeloperoxidase (MPO)-ANCA, was analysed for association with the cumulative disease involvement of ten different organ systems. Results: rs9274619 showed a significantly stronger association to MPO-ANCA-positive females than males [P = 2.0 × 10-4, OR = 2.3 (95% CI 1.5, 3.5)], whereas proteinase 3 (PR3)-ANCA-associated variants rs1042335, rs9277341 (HLA-DPB1/A1) and rs28929474 (SERPINA1) were equally associated with females and males with PR3-ANCA. In MPO-ANCA-positive cases, carriers of the rs9274619 risk allele were more prone to disease engagement of eyes [P = 0.021, OR = 11 (95% CI 2.2, 205)] but less prone to pulmonary involvement [P = 0.026, OR = 0.52 (95% CI 0.30, 0.92)]. Moreover, AAV with both MPO-ANCA and PR3-ANCA was associated with the PR3-ANCA lead SNP rs1042335 [P = 0.0015, OR = 0.091 (95% CI 0.0022, 0.55)] but not with rs9274619. Conclusions: Females and males with MPO-ANCA-positive AAV differ in genetic predisposition to disease, suggesting at least partially distinct disease mechanisms between the sexes. Double ANCA-positive AAV cases are genetically similar to PR3-ANCA-positive cases, providing clues to the clinical follow-up and treatment of these patients.
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| 59. |
- Ekvall, Hans, et al.
(författare)
-
Least-Cost Allocation of Measures to Increase the Amount of Coarse Woody Debris in Forest Estates
- 2013
-
Ingår i: Journal of Forest Economics. - : Now Publishers. - 1104-6899 .- 1618-1530. ; 19:3, s. 267-285
-
Tidskriftsartikel (refereegranskat)abstract
- Coarse woody debris (CWD) is crucial for maintaining biodiversity in forests but conservation measures to increase CWD must be performed cost efficiently. We estimate least-cost combinations of CWD-increasing measures in a spruce-dominated Swedish forest estate. Specifically, we investigate how using combinations of the measures tree retention, creating high stumps, manual scarification, prolonged rotations, and retention of dying trees impacts the amount of CWD and net present value at the estate level. We found that by combining CWD-increasing measures in an optimal way the amount of CWD on the estate could be increased 322% with a decrease in present value of only 10%. The optimal combination of conservation measures depends on the desired increase in CWD. The analysis thus shows that huge improvements in cost-efficiency of biodiversity-oriented forestry are possible.
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| 60. |
- Emanuelson, Ingrid, et al.
(författare)
-
Traumatic brain injury in children treated at the neurosurgical unit at Sahlgrenska University Hospital in 1987-1991 and 1997-2001: An analysis of the process of care
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: In 1992, a new volume targeted treatment, the “Lund Protocol”, was introduced in the field of neurosurgical care at Sahlgrenska University Hospital. The mortality rate for adults dropped markedly while the number of patients in a vegetative state remained at the same level. As yet, changes in mortality and outcome for children have not been investigated in detail. Aim: To describe the causes and severity of injury, process of care from emergency care to rehabilitation, and the rate of received rehabilitation and to follow-up two cohorts treated for child traumatic brain injury (CTBI) before and after the initiation of the “Lund Protocol”. For group 2, treated after the initiation of the “Lund Protocol” an additional aim was to relate brain injury severity parameters in the acute care stage to functional outcome. Methods: A retrospective population-based study of patient records of former paediatric patients treated neurosurgically for CTBI between 1987-1991 and 1997-2001. Epidemiological results are presented as descriptive statistics. To evaluate the relationship between brain injury parameters and outcome an exploratory cluster analysis was performed on the data from group 2. Results: For both groups traffic accidents were the most common cause of injury. The Glasgow Coma Scale indicated a more severe injury level in group1. The mortality rate in group1 was 8 % compared with 2 % in group 2 (n.s.). The Glasgow outcome score was on the same level (median 5), and the rate of received rehabilitation was equally low in both groups, 27 % versus 33 %. The cluster analysis revealed that length of care and time in a respirator had a stronger relationship with outcome than the Reaction Level Scale (RLS). Conclusion: There is still no stable process of care after CTBI as 67 % in the later treated group did not receive rehabilitation and 50 % of those did not receive any medical check- ups in the long- term perspective.
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| 61. |
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| 62. |
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| 63. |
- Engström, Joakim, et al.
(författare)
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Maintenance of Airway Pressure During Filter Exchange Due to Auto-Triggering
- 2014
-
Ingår i: Respiratory care. - : Daedalus Enterprises. - 0020-1324 .- 1943-3654. ; 59:8, s. 1210-1217
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Daily routine ventilator-filter exchange interrupts the integrity of the ventilator circuit. We hypothesized that this might reduce positive airway pressure in mechanically ventilated ICU patients, inducing alveolar collapse and causing impaired oxygenation and compliance of the respiratory system. METHODS: We studied 40 consecutive ICU subjects (P-aO2/F-IO2 ratio <= 300 mm Hg), mechanically ventilated with pressure-regulated volume control or pressure support and PEEP >= 5 cm H2O. Before the filter exchange, (baseline) tidal volume, breathing frequency,end-inspiratory plateau pressure, and PEEP were recorded. Compliance of the respiratory system was calculated; F-IO2, blood pressure, and pulse rate were registered; and P-aO2, P-aCO2, pH, and base excess were measured. Measurements were repeated 15 and 60 min after the filter exchange. In addition, a bench test was performed with a precision test lung with similar compliance and resistance as in the clinical study. RESULTS: The exchange of the filter took 3.5 +/- 1.2 s (mean +/- SD). There was no significant change in P-aO2 (89 +/- 16 mm Hg at baseline vs 86 +/- 16 mm Hg at 15 min and 88 +/- 18 mm Hg at 60 min, P = .24) or in compliance of the respiratory system (41 +/- 11 mL/cm H2O at baseline vs 40 +/- 12 mL/cm H2O at 15 min and 40 +/- 12 mL/cm H2O at 60 min, P = .32). The bench study showed that auto-triggering by the ventilator when disconnecting from the expiratory circuit kept the tracheal pressure above PEEP for at least 3 s with pressure controlled ventilation. CONCLUSIONS: This study showed that a short disconnection of the expiratory ventilator circuit from the ventilator during filter exchange was not associated with any significant deterioration in lung function 15 and 60 min later. This result may be explained by auto-triggering of the ventilator with high inspiratory flows during the filter exchange, maintaining airway pressure. (ISRCTN.org registration ISRCTN76631800.)
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| 64. |
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| 65. |
- Entesarian, Miriam, et al.
(författare)
-
Mutations in the gene encoding fibroblast growth factor 10 are associated with
- 2005
-
Ingår i: Nat Genet. - 1061-4036. ; 37:2, s. 125-7
-
Tidskriftsartikel (refereegranskat)abstract
- Autosomal dominant aplasia of lacrimal and salivary glands (ALSG; OMIM 180920 and OMIM 103420) is a rare condition characterized by irritable eyes and dryness of the mouth. We mapped ALSG to 5p13.2-5q13.1, which coincides with the gene fibroblast growth factor 10 (FGF10). In two extended pedigrees, we identified heterozygous mutations in FGF10 in all individuals with ALSG. Fgf10(+/-) mice have a phenotype similar to ALSG, providing a model for this disorder. We suggest that haploinsufficiency for FGF10 during a crucial stage of development results in ALSG.
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| 66. |
- Entesarian, Miriam, et al.
(författare)
-
Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.
- 2005
-
Ingår i: Nat Genet. ; 37:2, s. 125-7
-
Tidskriftsartikel (refereegranskat)abstract
- Autosomal dominant aplasia of lacrimal and salivary glands (ALSG; OMIM 180920 and OMIM 103420) is a rare condition characterized by irritable eyes and dryness of the mouth. We mapped ALSG to 5p13.2-5q13.1, which coincides with the gene fibroblast growth factor 10 (FGF10). In two extended pedigrees, we identified heterozygous mutations in FGF10 in all individuals with ALSG. Fgf10(+/-) mice have a phenotype similar to ALSG, providing a model for this disorder. We suggest that haploinsufficiency for FGF10 during a crucial stage of development results in ALSG.
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| 67. |
- Eriksson, Gunilla, et al.
(författare)
-
Occupation of Elderhood
- 2015. - 4
-
Ingår i: Occupational therapy. - Thorofare, NJ, USA : SLACK Incorporated. - 9781617110504 ; , s. 169-183
-
Bokkapitel (refereegranskat)
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| 68. |
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| 69. |
- Eriksson, Therese, et al.
(författare)
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A comparison of perceived occupational gaps between people with stress-related ill health or musculoskeletal pain and a reference group
- 2012
-
Ingår i: Scandinavian Journal of Occupational Therapy. - : Informa UK Limited. - 1103-8128 .- 1651-2014. ; 19:5, s. 411-420
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: To describe and compare how occupational gaps were reported in everyday occupations in a rehabilitation group of people with musculoskeletal pain or stress-related ill health and in a reference group from the Swedish population.Method: Seventy-two persons with musculoskeletal pain or stress-related ill health and 261 people from the Swedish population were included. The Occupational Gaps Questionnaire, measuring to what extent individuals perceive a discrepancy between what they want to do and what they actually do, was completed by the participants. Descriptive statistics were used to analyse the data.Results: Occupational gaps were reported more often in the rehabilitation group. Leisure activities were the gaps reported most often. The occupational repertoire seemed to decrease over time as the number of activities was decreasing, particularly leisure and work-related activities. Instrumental ADL were more desirable as the length of sick leave extended.Conclusions: Being on sick leave appears to start a process towards occupational deprivation where the areas that remain in the occupational repertoire become more important. Our study highlights the need to emphasize the whole occupational repertoire in rehabilitation and to facilitate engagement in valued activities to create a sound base for the process of returning to work.
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| 70. |
- Erlandsson, M C, et al.
(författare)
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Oestrogen receptor specificity in oestradiol-mediated effects on B lymphopoiesis and immunoglobulin production in male mice.
- 2003
-
Ingår i: Immunology. - 0019-2805. ; 108:3, s. 346-51
-
Tidskriftsartikel (refereegranskat)abstract
- Oestrogen treatment down-regulates B lymphopoiesis in the bone marrow of mice. Meanwhile it up-regulates immunoglobulin production. To understand better the oestrogen action on bone marrow male mice lacking oestrogen receptor alpha (ERalpha; ERKO mice), lacking ERbeta (BERKO mice), lacking both receptors (DERKO mice) or wild-type (wt) littermates were castrated and treated for 2.5 weeks with 30 microg/kg 17beta-oestradiol (E2) or vehicle oil as controls. The B lymphopoiesis in the bone marrow was examined by flow cytometry and mature B-cell function was studied using an ELISPOT assay enumerating the B cells in bone marrow and spleen that were actively producing immunoglobulins. In wt mice the frequency of B-lymphopoietic (B220+) cells in the bone marrow decreased from 15% to 5% upon E2 treatment. In ERKO and BERKO mice significant reduction was seen but not of the same magnitude. In DERKO mice no reduction of B lymphopoiesis was seen. In addition, our results show that E2 mediated reduction of different steps in B lymphopoiesis require only ERalpha or both receptors. In wt and BERKO mice E2 treatment resulted in significantly increased levels of B cells actively producing immunoglobulin, while in ERKO and DERKO mice no such change was seen. Similar results were found in both bone marrow and spleen. In conclusion our results clearly show that both ERalpha and ERbeta are required for complete down-regulation of B lymphopoiesis while only ERalpha is needed to up-regulate immunoglobulin production in both bone marrow and spleen.
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| 71. |
- Erlandsson, M C, et al.
(författare)
-
Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice.
- 2002
-
Ingår i: The Journal of endocrinology. - 0022-0795. ; 175:2, s. 319-27
-
Tidskriftsartikel (refereegranskat)abstract
- Raloxifene is a selective estrogen receptor modulator approved for the prevention of osteoporosis in postmenopausal women. It is selective by having estrogen-agonistic effects on bone, vessels and blood lipids while it is antagonistic on mammary and uterine tissue. Our aim was to study the agonistic and antagonistic properties of the raloxifene analogue LY117018 (LY) on uterus, bone, B lymphopoiesis and B cell function. Oophorectomized and sham-operated animals were treated with s.c. injections of equipotent anti-osteoporotic doses of 17beta-estradiol (E2) (0.1 mg/kg) or LY (3 mg/kg) or vehicle as controls. Effects on bone mineral density (BMD) were studied using peripheral quantitative computed tomography, uterine weight was examined, B lymphopoiesis was examined using flow cytometry and B cell function in bone marrow and spleen was studied by the use of an ELISPOT assay. E2 and LY had similar effects on BMD and bone marrow B lymphopoiesis, while LY had a clear antagonistic effect on endogenous estrogen in uterine tissue and no stimulating effect on the frequency of Ig-producing B cells in sham-operated animals. Our results are discussed in the context of estrogen receptor biology, relations between the immune system and bone metabolism and also with respect to the estrogen-mediated effects on rheumatic diseases.
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| 72. |
- Fava, Cristiano, et al.
(författare)
-
Novel mutations in the SLC12A3 gene causing Gitelman's syndrome in Swedes
- 2007
-
Ingår i: DNA Sequence. - : Informa UK Limited. - 1029-2365 .- 1042-5179. ; 18:5, s. 395-399
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: Gitelman's syndrome (GS) is an inherited autosomal recessive disorder due to loss of function mutations in the SLC12A3 gene encoding the Na-Cl co-transporter (NCCT), the target of thiazide diuretics. The defective function of the NCCT, which normally is expressed in the apical membrane of the distal convolute tubule in the kidney, leads to mild hypotension, hypokalemia, hyperreninemic hyperaldosteronism, mild metabolic alkalosis, hypomagnesemia and hypocalciuria. Up to now, more than 100 mutations of the SLC12A3 gene have been described in GS patients. METHODS: We have collected 30 patients from Sweden with a clinical diagnosis of GS and undertaken a mutation screening by SSCP and successive sequencing of the 26 exons and intronic boundaries. Both mutations were identified in most (n = 28, 93%) and at least one mutation was identified in all patients. RESULTS: We found 22 different mutations evenly distributed throughout the gene, 11 of which have not been described previously. The new variants include 8 missense mutations (Glu68Lys, His69Asn, Argl45His, Vall53Met, Gly230Asp, Gly342Ala, Val677Leu and Gly867Ser), 1 insertion (c.834_835insG on exon 6) and 2 splice-site mutations (c.2667 + lT>G substitution in splicing donor site after exon 22, c.1569-1G>A substitution in the splicing acceptor site before exon 13). CONCLUSION: In Swedish patients with the clinical features of GS, disease-causing mutations in the SLC12A3 gene were identified in most patients. The spectrum of GS mutations is wide making full mutation screening of the SLC12A3 gene necessary to confirm the diagnosis.
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| 73. |
- Folkesson, Joakim, et al.
(författare)
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Rectal cancer survival in the Nordic countries and Scotland
- 2009
-
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 125:10, s. 2406-12
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to present detailed population-based survival estimates for patients with a rectal adenocarcinoma, using cancer register data supplemented with clinical data. Based on cancer register data, differences in rectal cancer survival have been reported between countries in Europe. Variation in the distribution of stage at diagnosis, initial therapy including surgical technique, and comorbidity are possible explanatory factors. Adenocarcinomas in the rectum, diagnosed in 1997 and identified in the national cancer registries in the Nordic countries and Scotland were included. Age standardized 5-year relative survival and multiplicative regression models for the relative excess mortality were calculated. 3888 patients were included in the survival study. Men in Denmark, Finland and Iceland had lower 5-year relative survival and poorer stage distribution compared to Norway, Sweden and Scotland. Danish men had the highest rate of excess deaths in the first six months after diagnosis. Stage adjusted, the elevated relative excess mortality decreased and after six months the excess mortality rates were the same in all countries. The poor 5-year relative survival in Danish men was mainly due to a high excess rate of death during the first six months after diagnosis. The low survival in Finland and Iceland was not in accordance with other periods. For both countries this may be explained by random variation due to small numbers. The study emphasizes the need for high quality and detailed data in order to understand international survival differences, and cautions comparisons between large national samples and those of smaller areas.
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| 74. |
- Forslund, Tomas, et al.
(författare)
-
More with atrial fibrillation, anticoagulants since the coming of NOAK [Fler med förmaksflimmer får antikoagulantia sedan NOAK kom]
- 2015
-
Ingår i: Läkartidningen. - : Läkartidningen AB. - 0023-7205 .- 1652-7518. ; 112
-
Forskningsöversikt (övrigt vetenskapligt/konstnärligt)abstract
- Sedan introduktionen av NOAK (non-vitamin K antagonist oral anticoagulants) som trombosprofylax vid förmaksflimmer har det skett en markant ökning av antalet diagnostiserade patienter med förmaksflimmer i Stockholms läns landsting. Andelen som är behandlade med antikoagulantia har samtidigt ökat från 47 till 58 procent. Vid nyinsättning är NOAK lika vanliga som warfarin i nuläget. Förskrivningen av ASA sjunker kraftigt. NOAK-förskrivningen har varit avvaktande avseende de äldsta patienterna med hög risk för stroke, blödning och nedsatt njurfunktion.
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| 75. |
- Frangou, Sophia, et al.
(författare)
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Cortical thickness across the lifespan : Data from 17,075 healthy individuals aged 3-90 years
- 2022
-
Ingår i: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 431-451
-
Tidskriftsartikel (refereegranskat)abstract
- Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
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| 76. |
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| 77. |
- Fritzell, Peter, et al.
(författare)
-
Cost-effectiveness of lumbar fusion and nonsurgical treatment for chronic low back pain in the Swedish lumbar spine study : A multicenter, randomized, controlled trial from the Swedish Lumbar Spine Study Group
- 2004
-
Ingår i: Spine. - : Lippincott Williams & Wilkins. - 0362-2436 .- 1528-1159. ; 29:4, s. 421-434
-
Tidskriftsartikel (refereegranskat)abstract
- Study Design. A cost-effectiveness study was performed from the societal and health care perspectives. Objective. To evaluate the costs-effectiveness of lumbar fusion for chronic low back pain (CLBP) during a 2-year follow-up. Summary of Background Data. A full economic evaluation comparing costs related to treatment effects in patients with CLBP is lacking. Patients and Methods. A total of 284 of 294 patients with CLBP for at least 2 years were randomized to either lumbar fusion or a nonsurgical control group. Costs for the health care sector ( direct costs), and costs associated with production losses ( indirect costs) were calculated. Societal total costs were identified as the sum of direct and indirect costs. Treatment effects were measured using patient global assessment of improvement, back pain ( VAS), functional disability (Owestry), and return to work. Results. The societal total cost per patient ( standard deviations) in the surgical group was significantly higher than in the nonsurgical group: Swedish kroner (SEK) 704,000 ( 254,000) vs. SEK 636,000 ( 208,000). The cost per patient for the health care sector was significantly higher for the surgical group, SEK 123,000 ( 60,100) vs. 65,200 ( 38,400) for the control group. All treatment effects were significantly better after surgery. The incremental cost-effectiveness ratio ( ICER), illustrating the extra cost per extra effect unit gained by using fusion instead of nonsurgical treatment, were for improvement: SEK 2,600 ( 600 - 5,900), for back pain: SEK 5,200 ( 1,100 - 11,500), for Oswestry: SEK 11,300 ( 1,200 - 48,000), and for return to work: SEK 4,100 ( 100 21,400). Conclusion. For both the society and the health care sectors, the 2-year costs for lumbar fusion was significantly higher compared with nonsurgical treatment but all treatment effects were significantly in favor of surgery. The probability of lumbar fusion being cost-effective increased with the value put on extra effect units gained by using surgery.
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| 78. |
- Gabrielsson, Jon, et al.
(författare)
-
Combining process and spectroscopic data to improve batch modeling
- 2006
-
Ingår i: AIChE Journal. - : Wiley. - 0001-1541 .- 1547-5905. ; 52:9, s. 3164-72
-
Tidskriftsartikel (refereegranskat)abstract
- Pharmaceutical production is at present characterized by static processes where quality is guaranteed by controlling the purity of the final product. Achieving better control throughout the process, as a means for improving product quality, is one of the objectives of the PAT initiative by the FDA. A data set consisting of 11 batches characterized by UV spectroscopy together with process data was used in this study. Design of experiments was used to introduce controlled process variation in test batches. The objective was to investigate possible advantages of MSPC using a combined data set, compared to separate models of the respective data sets. Individual models for the separate data sets show that they contain complementary information. A major advantage of combining spectroscopic and process data is that deviations that would go unnoticed using just an individual model can be detected and interpreted. All process manipulations were detected by the combined data set model. Implementation of these methods to batch processes in primary and secondary pharmaceutical production is feasible. An enhanced understanding of the process together with control tools should lead to a well-understood process and, ultimately, real time release. © 2006 American Institute of Chemical Engineers AIChE J, 2006
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| 79. |
- Gabrielsson, Jon, et al.
(författare)
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OPLS methodology for analysis of pre-processing effects on spectroscopic data
- 2006
-
Ingår i: Chemometrics and Intelligent Laboratory Systems. - : Elsevier BV. - 0169-7439. ; 84:1-2, s. 153-8
-
Tidskriftsartikel (refereegranskat)abstract
- Pre-processing of spectroscopic data is commonly applied to remove unwanted systematic variation. Possible loss of information and ambiguity regarding discarded variation are issues that complicate pre-treatment of data. In this paper, OPLS methodology is applied to evaluate different techniques for pre-processing of spectroscopic data gathered from a batch process. The objective is to present a rational scheme for analysis of pre-processing in order to understand the influence and effect of pre-treatment.O2PLS uses linear regression to divide the systematic variation in X and Y into three parts; one part with joint X–Y covariation, i.e. related to both X and Y, one part of X with Y-orthogonal variation and one part of Y with X-orthogonal variation.All of the investigated pre-treatment methods removed an additive baseline as expected. In the analysis of raw and differentiated data variation associated with the baseline was found in the Y-orthogonal part of X. Orthogonal information was also found in Y, which suggests that this pre-processing procedure not only removed variation. This would have been more difficult to detect without the O2PLS model since both raw and differentiated data must be analysed simultaneously.Development of a knowledge based strategy with OPLS methodology is an important step towards eliminating trial and error approaches to pre-processing.
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| 80. |
- Gabrielsson, Jon, et al.
(författare)
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The OPLS methodology for analysis of multi-block batch process data
- 2006
-
Ingår i: Journal of Chemometrics. - : Wiley. - 0886-9383 .- 1099-128X. ; 20:8-10, s. 362-9
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Tidskriftsartikel (refereegranskat)abstract
- With increasing availability of different process analysers multiple data sources are commonly available and this will impose new challenges and enable new types of investigations. The ability to separate joint, complementary and redundant information in multiple block data will be of increasing importance. In this study data from a batch mini plant were collected and O2PLS was implemented to facilitate a combined analysis of spectroscopic and process data. This enables assessment of both the joint and complementary variations in the respective data sets. The different types of variation that were separated were then modelled together to evaluate their individual correlation to a time response. By combining data of different origin an uncomplicated summary of the variation was accomplished and a deeper understanding of process interactions was gained. The analysis of separated variation with a response variable proved useful for verifying the supposed correlation between the joint variation and time.
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| 81. |
- Gamage, Sampath, et al.
(författare)
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Reflective and transparent cellulose-based passive radiative coolers
- 2021
-
Ingår i: Cellulose. - : Springer. - 0969-0239 .- 1572-882X. ; 28, s. 9383-9393
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Tidskriftsartikel (refereegranskat)abstract
- Radiative cooling passively removes heat from objects via emission of thermal radiation to cold space. Suitable radiative cooling materials absorb infrared light while they avoid solar heating by either reflecting or transmitting solar radiation, depending on the application. Here, we demonstrate a reflective radiative cooler and a transparent radiative cooler solely based on cellulose derivatives manufactured via electrospinning and casting, respectively. By modifying the microstructure of cellulose materials, we control the solar light interaction from highly reflective (> 90%, porous structure) to highly transparent (approximate to 90%, homogenous structure). Both cellulose materials show high thermal emissivity and minimal solar absorption, making them suitable for daytime radiative cooling. Used as coatings on silicon samples exposed to sun light at daytime, the reflective and transparent cellulose coolers could passively reduce sample temperatures by up to 15 degrees C and 5 degrees C, respectively.
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| 82. |
- Gamage, Sampath, et al.
(författare)
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Transparent nanocellulose metamaterial enables controlled optical diffusion and radiative cooling
- 2020
-
Ingår i: Journal of Materials Chemistry C. - : Royal Society of Chemistry. - 2050-7526 .- 2050-7534. ; 8:34, s. 11687-11694
-
Tidskriftsartikel (refereegranskat)abstract
- Materials that provide independent control of infrared thermal radiation and haze in the visible could benefit many areas and applications, including clothing, packaging and photovoltaics. Here, we study this possibility for a metamaterial composite paper based on cellulose nanofibrils (CNF) and silicon dioxide (SiO2) microparticles with infrared (IR) Fröhlich phonon resonances. This CNF-SiO2composite shows outstanding transparency in the visible wavelength range, with the option of controlling light diffusion and haze from almost zero to 90% by varying the SiO2microparticle concentration. We further show that the transparent metamaterial paper could maintain high thermal emissivity in the atmospheric IR window, as attributed to strong IR absorption of both the nanocellulose and the resonant SiO2microparticles. The high IR emissivity and low visible absorption make the paper suitable for passive radiative cooling and we demonstrate cooling of the paper to around 3 °C below ambient air temperature by exposing it to the sky.
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| 83. |
- Gaulton, Kyle J, et al.
(författare)
-
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
- 2015
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:12, s. 1415-1415
-
Tidskriftsartikel (refereegranskat)abstract
- We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association. We confirmed that the T2D risk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells. We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression. Our study demonstrates how integration of genetic and genomic information can define molecular mechanisms through which variants underlying association signals exert their effects on disease.
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| 84. |
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| 85. |
- Grönstedt, Tomas, 1970, et al.
(författare)
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Multidisciplinary assessment of a year 2035 turbofan propulsion system
- 2022
-
Ingår i: 33rd Congress of the International Council of the Aeronautical Sciences, ICAS 2022. - : International Council of the Aeronautical Sciences. - 9781713871163 ; 7, s. 4981-4990
-
Konferensbidrag (refereegranskat)abstract
- A conceptual design of a year 2035 turbofan is developed and integrated onto a year 2035 aircraft model. The mission performance is evaluated for CO2, noise and NOx and is compared with a notional XWB/A350-model. An OGV heat exchanger is then studied rejecting heat from an electric generator, and its top-level performance is evaluated. The fan, the booster and the low-pressure turbine of the propulsion system are subject to more detailed aero design based on using commercial design tools and CFD-optimization. Booster aerodynamic modelling output is introduced back into the performance model to study the integrated performance of the component. The top-level performance aircraft improvements are compared to top-level-trends and ICAO estimates of technology progress potential, attempting to evaluate whether there is some additional margin for efficiency improvement beyond the ICAO technology predictions for the same time frame.
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| 86. |
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| 87. |
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| 88. |
- Gustafsson, Hans, et al.
(författare)
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Development of low-emitting building materials
- 1999
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Ingår i: Proceedings of the 8th International Conference on Indoor Air Quality and Climate. Indoor Air '99, Edinburgh, Scotland, 8-13 August 1999. - : Construction Research Communications.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 89. |
- Gustafsson, Hans-Olof, et al.
(författare)
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Hållbart pedagogiskt ledarskap och kollegialt lärande som forum för kvalitets- och utvecklingsarbete i förskolan.
- 2019
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Projektet har bedrivits i två forskningscirklar och där arbetet bedrivs i enlighet med vad Skolverket och aktuell skolforskning lyfter fram om kvalitets- och utvecklingsarbete. Utgångspunkten utgörs av Skolverkets modell för kvalitetsarbete med grund i frågeställningarna Var är vi? Vart ska vi? Hur kommer vi dit? (Skolverket, 2015). Med stöd av frågorna har såväl utvecklingsområden som goda exempel på vad som fungerar väl och vad det är som gör att de fungerar väl identifierats. Gemensamt för de båda forskningscirklarna är även en strävan att arbeta i enlighet med vad skollagen anger om att ”Utbildningen ska vila på vetenskaplig grund och beprövad erfarenhet” (SFS 2010:800, § 5). I arbetet i forskningscirklarna kommer detta till uttryck genom att deltagarna i samarbete med den deltagande forskaren med ett vetenskapligt förhållningssätt belyser erfarenheter, tankar och idéer om kvalitet och kvalitetsutveckling med användning av styrdokument, material från Skolinspektionen samt forskningsinriktad litteratur.
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| 90. |
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| 91. |
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| 92. |
- Hammarlund, Cecilia, et al.
(författare)
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Intäkter för svenska kräftfiskare på västkusten
- 2018
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Havskräfta är en viktig art för svenskt fiske. Kräftan fångas antingen med bur eller med trål i Kattegatt och Skagerrak. På uppdrag av Havs- och vattenmyndigheten analyseras yrkesfiskets intäkter och fartygens landningsmönster för att ge underlag till en bedömning av effekterna av att minska utrymmet för trålfiske och öka utrymmet för burfiske.Analysen visar att trålfisket generellt sett är mindre beroende av havskräfta än burfisket, men att det finns ett antal fiskare, framför allt de med mindre trålfartyg, som får stora delar av sina intäkter från de aktuella områdena. Förändrade områden för fisket påverkar inte bara fördelningen mellan trål- och burfiske, utan kan också förändra var landningarna av havskräfta sker. Vissa landningshamnar har idag stora landningar av trålfiskad kräfta men endast marginella landningar av burfångad.
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| 93. |
- Hansen, Violeta, 1979, et al.
(författare)
-
Naturally occurring radionuclides assessment in the Arctic
- 2023
-
Ingår i: The XIX conference of the Nordic Society for Radiation Protection, held at Malmö Live, Malmö, Sweden, June 5-9, 2023. - https://nsfs.org/?lang=en : The Nordic Society for Radiation Protection (NSFS).
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Naturally occurring radionuclides (NORs), primarily 210Po, accumulates in seafood, marine, and terrestrial mammals, which are an important part of the traditional Arctic diet. Arctic seafood plays an important role in the worldwide seafood industry. NORs were measured in glaciers from Svalbard, the Arctic Ocean, surface seawater and sediments from Norwegian marine areas, seabirds from Greenland, seafood and marine mammals from the Nordic region, Faroe Islands, Greenland, and Canada, terrestrial mammals from Greenland, and lake sediments in northernmost Finland. Outdoor 222Rn was measured in Finland, Canada, and Norway and atmospheric 210Pb, 212Pb, and 7Be were measured in Norway, Sweden, Finland, Iceland, and Canada. Deposited 210Pb and 7Be were measured in Sweden and Finland. Glaciers and marine sediment results show oil and gas, coal combustion, and ore mining as anthropogenic sources. NORs are long-range transported via atmospheric and oceanic currents in the Arctic. 210Pb has a long atmospheric residence time, especially in winter. 228Ra activities in the Transpolar Drift approximately doubled between 2007 and 2015, indicating that climate-driven changes may be increasing the release of shelf-derived elements to the open Arctic Ocean. Results showed no effect of climate change on 210Pb deposition in sediments in Lake Kevojarvi in northernmost Finland. 210Po is the major contributor to the annual effective dose via seafood and marine and terrestrial mammal consumption in the Arctic population, far exceeding dose contributions from 137Cs, 226Ra, 228Ra, and 210Pb. 210Po absorbed dose rates to studied biota are several orders of magnitude lower than the recommended dose rate screening value of 10 µGy h-1. NORs atmospheric results follow an annual cycle, which is mainly driven by seasonal weather and climate changes. Understanding the sources and associated doses from NORs is necessary to assess risks and public perception of risks, support science-based decision-making, and policy development engaging public and Indigenous peoples.
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| 94. |
- Hansson, Hans, et al.
(författare)
-
A logic for reasoning about time and reliability
- 1990. - 1
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We present a logic for stating properties such as, "after a request for service there is at least a 98\045 probability that the service will be carried out within 2 seconds". The logic extends the temporal logic CTL by Emerson, Clarke and Sistla with time and probabilities. Formulas are interpreted over discrete time Markov chains. We give algorithms for checking that a given Markov chain satis- fies a formula in the logic. The algorithms require a polynomial number of arithmetic operations, in size of both the formula and\003This research report is a revised and extended version of a paper that has appeared under the title "A Framework for Reasoning about Time and Reliability" in the Proceeding of the 10thIEEE Real-time Systems Symposium, Santa Monica CA, December 1989. This work was partially supported by the Swedish Board for Technical Development (STU) as part of Esprit BRA Project SPEC, and by the Swedish Telecommunication Administration.1the Markov chain. A simple example is included to illustrate the algorithms.
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| 95. |
- Hatherly, Robert, et al.
(författare)
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Technical Requirements for Na18F PET Bone Imaging of Patients Being Treated Using a Taylor Spatial Frame.
- 2014
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Ingår i: Journal of nuclear medicine technology. - : Society of Nuclear Medicine. - 1535-5675 .- 0091-4916.
-
Tidskriftsartikel (refereegranskat)abstract
- Diagnosis of new bone growth in patients with compound tibia fractures or deformities treated using a Taylor spatial frame is difficult with conventional radiography because the frame obstructs the images and creates artifacts. The use of Na(18)F PET studies may help to eliminate this difficulty.METHODS: Patients were positioned on the pallet of a clinical PET/CT scanner and made as comfortable as possible with their legs immobilized. One bed position covering the site of the fracture, including the Taylor spatial frame, was chosen for the study. A topogram was performed, as well as diagnostic and attenuation correction CT. The patients were given 2 MBq of Na(18)F per kilogram of body weight. A 45-min list-mode acquisition was performed starting at the time of injection, followed by a 5-min static acquisition 60 min after injection. The patients were examined 6 wk after the Taylor spatial frame had been applied and again at 3 mo to assess new bone growth.RESULTS: A list-mode reconstruction sequence of 1 × 1,800 and 1 × 2,700 s, as well as the 5-min static scan, allowed visualization of regional bone turnover.CONCLUSION: With Na(18)F PET/CT, it was possible to confirm regional bone turnover as a means of visualizing bone remodeling without the interference of artifacts from the Taylor spatial frame. Furthermore, dynamic list-mode acquisition allowed different sequences to be performed, enabling, for example, visualization of tracer transport from blood to the fracture site.
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| 96. |
- Haugen, Susanne, 1968-
(författare)
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Från bautasten till bautastor : studier över fornvästnordiska bautasteinn och svenska ord bildade med bauta(-)
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Avhandlingen tar sin utgångspunkt i två uppslagsord i Svenska Akademiens Ordlista 2006: bautasten och bauta-. Övergripande syfte är att beskriva och förklara lexikala förändringar hos ord bildade med bauta(-) i svenskan under perioden 1664–2006, med särskild hänsyn till dessa förändringars relation till ordens etableringsgrad. Materialet består av 838 belägg för ord bildade med baut- eller böt-, och därutöver undersöks 30 ordböcker. Ordet bautasten är ett isländskt lånord i svenskan. Undersökningen av fornvästnordiska ord visar att bautasteinn kan vara ’sten som är slagen ned i jorden’ eller ’sten rest över en fallen krigare’, två betydelser som kan sammanföras i betydelsen ’minnessten’. Denna betydelse framträder också tydligt i samtliga texter. Historiens höga status under stormaktstiden har haft stor betydelse för att ordet bautasten lånades in i svenskan år 1664. Språkstrukturella faktorer har sannolikt lett till att ordet har uppmärksammats och att det har kunnat användas i svenskan. Under perioden 1664–1790 har etableringsgraden hos bautasten inte har varit hög, men vissa tecken tyder på att den höjs under perioden. Fram till ca 1900 stiger etableringsgraden hos bautasten, men den avtar sedan fram till 1973. I avhandlingen antas att ordets växlande etableringsgrad har varit beroende av synen på historien. I början av 1970-talet stiger etableringsgraden åter hos bautasten och 1985 finns första belägget för bauta- som förstärkande förled, vilket med stor sannolikhet har sin orsak att söka hos den stora populariteten hos och spridningen av seriealbumet Asterix. Förleden bauta- har visat sig vara mycket användbar som förstärkande förled. I materialet finns 3 ord bildade med bauta(-) som inte är etablerade i språksamfundet.
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| 97. |
- Hedbom, Hans, et al.
(författare)
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A Comparison of the Security of Windows NT and UNIX
- 1998
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Konferensbidrag (refereegranskat)abstract
- This paper presents a brief comparison of two operating systems, Windows NT and UNIX. The comparison covers two different aspects. First, we compare the main security features of the two operating systems and then we make a comparison of a selection of vulnerabilities most of which we know have been used for making real intrusions. We found that Windows NT has slightly more rigorous security features than standard UNIX but the two systems display similar vulnerabilities. The conclusion is that there are no significant differences in the real level of security between these systems
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| 98. |
- Hedbom, Hans, et al.
(författare)
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A Preliminary Evaluation of the Security of a Non-Distributed Version of Windows NT
- 1997
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Konferensbidrag (refereegranskat)abstract
- In this paper we present a preliminary evaluation of the security of a non-distributed version of Windows NT. The objectives of the work are twofold: first, to learn more about the security system; and, second, to find out how secure the system actually is. Thus the architecture and security mechanisms of Windows NT have been studied. Furthermore, the paper contains a few examples of successful intrusions on the target system, which was a standard personal computer with Windows NT Workstation 3.51 and one with NT Workstation 4.0, both working in a stand-alone mode. We have also found some evidence that other, more severe security flaws exist in the system
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| 99. |
- Hedbom, Hans, et al.
(författare)
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A Security Evaluation of a Non-Distributed Version of Windows NT
- 1997
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Rapport (refereegranskat)abstract
- In this paper we present an evaluation of the security in Windows NT. The objectives of the work are twofold: first, to learn more about the security system; and, second, to find out how secure the system actually is. To investigate the latter, the authors, have adopted the role of attackers. This paper contains results from several attempts to violate the security of Windows NT. In some cases, the attempts were successful, meaning that we gained access to information or resources that should be protected. The target systems were standard personal computers with Windows NT Workstation 3.51 and Windows NT Workstation 4.0 respectively, both working in stand-alone mode
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| 100. |
- Hedbom, Hans, et al.
(författare)
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Analysis of the Security of Windows NT
- 1998
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Rapport (refereegranskat)abstract
- This paper presents an analysis of the security in Windows NT 4.0, working in both stand-alone and networking mode. The objective of the work was to find out how secure this operating system actually is. A technical overview of the system, and in particular its security features is given. The system security was analyzed and practical intrusion attempts were made in order to verify vulnerabilities or to find new ones. All vulnerabilities are described in detail and classified according to a classification scheme. A comparison to commonly known UNIX weaknesses was made. It revealed generic similarities between the two systems to a surprisingly high degree. Finally a number of recommendations are given. The paper concludes that there are ample opportunities to improve the security of Windows NT. We have reason to believe that it is probably not higher than that of UNIX
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