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Sökning: WFRF:(Kirsten M.)

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51.
  • Coppin, K. E. K., et al. (författare)
  • The SCUBA-2 Cosmology Legacy Survey: the submillimetre properties of Lyman-break galaxies at z=3-5
  • 2015
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 446:2, s. 1293-1304
  • Tidskriftsartikel (refereegranskat)abstract
    • We present detections at 850 mu m of the Lyman-break galaxy (LBG) population at z approximate to 3, 4, and 5 using data from the Submillimetre Common User Bolometer Array 2 Cosmology Legacy Survey in the United Kingdom Infrared Deep Sky Survey 'Ultra Deep Survey' field. We employ stacking to probe beneath the survey limit, measuring the average 850 mu m flux density of LBGs at z approximate to 3, 4, and 5 with typical ultraviolet luminosities of L-1700 approximate to 10(29) erg s(-1) Hz(-1). We measure 850 mu m flux densities of (0.25 +/- 0.03), (0.41 +/- 0.06), and (0.88 +/- 0.23) mJy, respectively, finding that they contribute at most 20 per cent to the cosmic far-infrared (IR) background at 850 mu m. Fitting an appropriate range of spectral energy distributions to the z similar to 3, 4, and 5 LBG stacked 24-850 mu m fluxes, we derive IR luminosities of L8-1000 (mu m) approximate to 3.2, 5.5, and 11.0 x 10(11) L-circle dot [and star formation rates (SFRs) of approximate to 50-200M(circle dot) yr(-1)], respectively. We find that the evolution in the IR luminosity density of LBGs is broadly consistent with model predictions for the expected contribution of luminous-to-ultraluminous IR galaxies at these epochs. We observe a positive correlation between stellar mass and IR luminosity and confirm that, for a fixed mass, the reddest LBGs (UV slope beta -> 0) are redder due to dust extinction, with SFR (IR)/SFR (UV) increasing by about an order of magnitude over -2
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52.
  • Hewitt, Dante M., et al. (författare)
  • Milliarcsecond localization of the hyperactive repeating FRB 20220912A
  • 2024
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 529:2, s. 1814-1826
  • Tidskriftsartikel (refereegranskat)abstract
    • We present very long-baseline interferometry (VLBI) observations of the hyperactive repeating FRB 20220912A using the European VLBI Network (EVN) outside of regular observing sessions (EVN-Lite). We detected 150 bursts from FRB 20220912A over two observing epochs in 2022 October. Combining the burst data allows us to localize FRB 20220912A to a precision of a few milliarcseconds, corresponding to a transverse scale of less than 10 pc at the distance of the source. This precise localization shows that FRB 20220912A lies closer to the centre of its host galaxy than previously found, although still significantly offset from the host galaxy's nucleus. On arcsecond scales, FRB 20220912A is coincident with a persistent continuum radio source known from archival observations; however, we find no compact persistent emission on milliarcsecond scales. The 5σ upper limit on the presence of such a compact persistent radio source is 120 μJy, corresponding to a luminosity limit of (D/362.4 Mpc)erg s-1 Hz-1. The persistent radio emission is thus likely to be from star formation in the host galaxy. This is in contrast to some other active FRBs, such as FRB 20121102A and FRB 20190520B.
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53.
  • Kokorev, V., et al. (författare)
  • ALMA Lensing Cluster Survey: Hubble Space Telescope and Spitzer Photometry of 33 Lensed Fields Built with CHArGE
  • 2022
  • Ingår i: Astrophysical Journal, Supplement Series. - : American Astronomical Society. - 1538-4365 .- 0067-0049. ; 263:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a set of multiwavelength mosaics and photometric catalogs in the Atacama Large Millimeter/ submillimeter Array (ALMA) lensing cluster survey fields. The catalogs were built by the reprocessing of archival data from the Complete Hubble Archive for Galaxy Evolution compilation, taken by the Hubble Space Telescope (HST) in the Reionization Lensing Cluster Survey, Cluster Lensing And Supernova survey with Hubble, and Hubble Frontier Fields. Additionally, we have reconstructed the Spitzer Infrared Array Camera 3.6 and 4.5 μm mosaics, by utilizing all the available archival IPAC Infrared Science Archive/Spitzer Heritage Archive exposures. To alleviate the effect of blending in such a crowded region, we have modeled the Spitzer photometry by convolving the HST detection image with the Spitzer point-spread function using the novel GOLFIR software. The final catalogs contain 218,000 sources, covering a combined area of 690 arcmin2, a factor of ∼2 improvement over the currently existing photometry. A large number of detected sources is a result of reprocessing of all available and sometimes deeper exposures, in conjunction with a combined optical–near-IR detection strategy. These data will serve as an important tool in aiding the search of the submillimeter galaxies in future ALMA surveys, as well as follow-ups of the HST dark and high-z sources with JWST. Coupled with the available HST photometry, the addition of the 3.6 and 4.5 μm bands will allow us to place a better constraint on the photometric redshifts and stellar masses of these objects, thus giving us an opportunity to identify high-redshift candidates for spectroscopic follow-ups and to answer the important questions regarding the Epoch of Reionization and formation of the first galaxies. The mosaics, photometric catalogs, and the best-fit physical properties are publicly available at https:// github.com/dawn-cph/alcs-clusters.
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54.
  • Vogelezang, Suzanne, et al. (författare)
  • Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
  • 2020
  • Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 16:10
  • Tidskriftsartikel (refereegranskat)abstract
    • The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
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55.
  • Boone, F., et al. (författare)
  • An extended Herschel drop-out source in the center of AS1063: A normal dusty galaxy at z = 6.1 or SZ substructures?
  • 2013
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 559, s. L1-
  • Tidskriftsartikel (refereegranskat)abstract
    • In the course of our 870 μm APEX/LABOCA follow-up of the Herschel Lensing Survey we have detected a source in AS1063 (RXC J2248.7-4431) that has no counterparts in any of the Herschel PACS/SPIRE bands, it is a Herschel "drop-out" with S870=S500 ≥ 0:5. The 870 μm emission is extended and centered on the brightest cluster galaxy, suggesting either a multiply imaged background source or substructure in the Sunyaev-Zel'dovich increment due to inhomogeneities in the hot cluster gas of this merging cluster. We discuss both interpretations with emphasis on the putative lensed source. Based on the observed properties and on our lens model we find that this source may be the first submillimeter galaxy (SMG) with a moderate far-infrared (FIR) luminosity (LFIR. © ESO 2013.
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56.
  • Bourne, N., et al. (författare)
  • Evolution of cosmic star formation in the SCUBA-2 Cosmology Legacy Survey
  • 2017
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 467:2, s. 1360-1385
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a new exploration of the cosmic star formation history and dust obscuration in massive galaxies at redshifts 0.5 10(10) M-O galaxies at 0.5 10. One third of this is accounted for by 450 mu m-detected sources, while one-fifth is attributed to UV-luminous sources (brighter than L-UV(*)), although even these are largely obscured. By extrapolating our results to include all stellar masses, we estimate a total SFRD that is in good agreement with previous results from IR and UV data at z
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57.
  • Coppin, K. E. K., et al. (författare)
  • Herschel-PACS observations of [O I]63 μm towards submillimetre galaxies at z~1
  • 2012
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 427:1, s. 520-532
  • Tidskriftsartikel (refereegranskat)abstract
    • We present Herschel-PACS spectroscopy of the [O I]63 μm far-infrared cooling line from a sample of six unlensed and spectroscopically confirmed 870 μm selected submillimetre (submm) galaxies (SMGs) at 1.1
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58.
  • Gadalla, Shahinaz M, et al. (författare)
  • Outcomes of allogeneic hematopoietic cell transplant in patients with dyskeratosis congenita.
  • 2013
  • Ingår i: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. - : Elsevier BV. - 1523-6536. ; 19:8, s. 1238-1243
  • Tidskriftsartikel (refereegranskat)abstract
    • We describe outcomes after allogeneic transplantation in 34 patients with dyskeratosis congenita transplanted between 1981 and 2009. The median age at transplantation was 13 years (range 2 - 35). Approximately 50% of transplants were from related donors. Bone marrow was the predominant source of stem cells (n=24/34). The day-28 probability of neutrophil recovery was 73% and the day-100 platelet recovery was 72%. The day-100 probability of grade II-IV acute GVHD and the 3-year probability of chronic GVHD were 24% and 37%, respectively. The 10-year probability of survival was 30%; 14 patients were alive at last follow-up. Ten deaths occurred within 4 months from transplantation due to graft failure (n=6) or other transplant-related complications; 9 of these patients had been transplanted from mismatched related or from unrelated donors. Another 10 deaths occurred after 4 months; 6 of them occurred more than 5 years from transplantation, 4 of these were attributed to pulmonary failure. Transplant-regimen intensity and transplants from mismatched related or unrelated donors were associated with early mortality. Transplantation of grafts from HLA-matched siblings with cyclophosphamide-containing non-radiation regimens was associated with early low toxicity. Late mortality was attributed mainly to pulmonary complications and likely related to the underlying disease.
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59.
  • Giménez-Arteaga, C., et al. (författare)
  • Outshining in the spatially resolved analysis of a strongly lensed galaxy at z = 6.072 with JWST NIRCam
  • 2024
  • Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 686
  • Tidskriftsartikel (refereegranskat)abstract
    • We present JWST/NIRCam observations of a strongly lensed, sub-L∗, multiply imaged galaxy at z=6.072, with magnification factors μ³20 across the galaxy. The galaxy has rich HST, MUSE, and ALMA ancillary observations across a broad wavelength range. Aiming to quantify the reliability of stellar mass estimates of high redshift galaxies, we performed a spatially resolved analysis of the physical properties at scales of ~200 pc, inferred from spectral energy distribution (SED) modelling of five JWST/NIRCam imaging bands covering 0.16 μm < λrest < 0.63 μm on a pixel-by-pixel basis. We find young stars surrounded by extended older stellar populations. By comparing Hα+[Nâ¯II] and [Oâ¯III]+Hβ maps inferred from the image analysis with our additional NIRSpec integral field unit (IFU) data, we find that the spatial distribution and strength of the line maps are in agreement with the IFU measurements. We explore different parametric star formation history (SFH) forms with BAGPIPES on the spatially integrated photometry, finding that a double power-law (DPL) star formation history retrieves the closest value to the spatially resolved stellar mass estimate, and other SFH forms suffer from the dominant outshining emission from the youngest stars, thus underestimating the stellar mass - up to ~0.5 dex. On the other hand, the DPL cannot match the IFU-measured emission lines. Additionally, the ionising photon production efficiency may be overestimated in a spatially integrated approach by ~0.15 dex, when compared to a spatially resolved analysis. The agreement with the IFU measurements implies that our pixel-by-pixel results derived from the broadband images are robust, and that the mass discrepancies we find with spatially integrated estimates are not just an effect of SED-fitting degeneracies or the lack of NIRCam coverage. Additionally, this agreement points towards the pixel-by-pixel approach as a way to mitigate the general degeneracy between the flux excess from emission lines and underlying continuum, especially when lacking photometric medium-band coverage and/or IFU observations. This study stresses the importance of studying galaxies as the complex systems that they are, resolving their stellar populations when possible, or using more flexible SFH parameterisations. This can aid our understanding of the early stages of galaxy evolution by addressing the challenge of inferring robust stellar masses and ionising photon production efficiencies of high redshift galaxies.
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60.
  • Gurholt, Tiril P., et al. (författare)
  • Intracranial and subcortical volumes in adolescents with early‐onset psychosis : A multisite mega‐analysis from the ENIGMA consortium
  • 2020
  • Ingår i: Human Brain Mapping. - Stockholm : Wiley. - 1065-9471 .- 1097-0193. ; 43:1, s. 373-384
  • Tidskriftsartikel (refereegranskat)abstract
    • Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early-onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early-onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early-onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41). We used linear mixed-effects models to investigate differences in intracranial and subcortical volumes across the patient sample, diagnostic subgroup and antipsychotic medication, relative to controls. We observed significantly lower intracranial (Cohen's d = −0.39) and hippocampal (d = −0.25) volumes, and higher caudate (d = 0.25) and pallidum (d = 0.24) volumes in patients relative to controls. Intracranial volume was lower in both early-onset schizophrenia (d = −0.34) and affective psychosis (d = −0.42), and early-onset schizophrenia showed lower hippocampal (d = −0.24) and higher pallidum (d = 0.29) volumes. Patients who were currently treated with antipsychotic medication (n = 193) had significantly lower intracranial volume (d = −0.42). The findings demonstrate a similar pattern of brain alterations in early-onset psychosis as previously reported in adult psychosis, but with notably low intracranial volume. The low intracranial volume suggests disrupted neurodevelopment in adolescent early-onset psychosis.
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61.
  • Hodge, J. A., et al. (författare)
  • ALMA Reveals Potential Evidence for Spiral Arms, Bars, and Rings in High-redshift Submillimeter Galaxies
  • 2019
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 876:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We present subkiloparsec-scale mapping of the 870 mu m ALMA continuum emission in six luminous (LIR similar to 5 x 10(12 )L(circle dot)) submillimeter galaxies (SMGs) from the ALESS survey of the Extended Chandra Deep Field South. Our high-fidelity 0 ''.07-resolution imaging (similar to 500 pc) reveals robust evidence for structures with deconvolved sizes of less than or similar to 0.5-1 kpc embedded within (dominant) exponential dust disks. The large-scale morphologies of the structures within some of the galaxies show clear curvature and/or clump-like structures bracketing elongated nuclear emission, suggestive of bars, star-forming rings, and spiral arms. In this interpretation, the ratio of the "ring" and "bar" radii (1.9 +/- 0.3) agrees with that measured for such features in local galaxies. These potential spiral/ring/bar structures would be consistent with the idea of tidal disturbances, with their detailed properties implying flat inner rotation curves and Toomre-unstable disks (Q < 1). The inferred one-dimensional velocity dispersions (sigma(r) less than or similar to 70-160 km s(-1)) are marginally consistent with the limits implied if the sizes of the largest structures are comparable to the Jeans length. We create maps of the star formation rate density (Sigma(SFR)) on similar to 500 pc scales and show that the SMGs are able to sustain a given (galaxy-averaged) E-SFR over much larger physical scales than local (ultra)luminous infrared galaxies. However, on 500 pc scales, they do not exceed the Eddington limit set by radiation pressure on dust. If confirmed by kinematics, the potential presence of nonaxisymmetric structures would provide a means for net angular momentum loss and efficient star formation, helping to explain the very high star formation rates measured in SMGs.
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62.
  • Hodge, J. A., et al. (författare)
  • An ALMA Survey of Submillimeter Galaxies in the Extended Chandra Deep Field South: Source Catalog and Multiplicity
  • 2013
  • Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 768:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present an Atacama Large Millimeter/submillimeter Array (ALMA) Cycle 0 survey of 126 submillimeter sources from the LABOCA ECDFS Submillimeter Survey (LESS). Our 870 mu m survey with ALMA (ALESS) has produced maps similar to 3x deeper and with a beam area similar to 200x smaller than the original LESS observations, doubling the current number of interferometrically-observed submillimeter sources. The high resolution of these maps allows us to resolve sources that were previously blended and accurately identify the origin of the submillimeter emission. We discuss the creation of the ALESS submillimeter galaxy (SMG) catalog, including the main sample of 99 SMGs and a supplementary sample of 32 SMGs. We find that at least 35% (possibly up to 50%) of the detected LABOCA sources have been resolved into multiple SMGs, and that the average number of SMGs per LESS source increases with LESS flux density. Using the (now precisely known) SMG positions, we empirically test the theoretical expectation for the uncertainty in the single-dish source positions. We also compare our catalog to the previously predicted radio/mid-infrared counterparts, finding that 45% of the ALESS SMGs were missed by this method. Our similar to 1 ''.6 resolution allows us to measure a size of similar to 9 kpc x 5 kpc for the rest-frame similar to 300 mu m emission region in one resolved SMG, implying a star formation rate surface density of 80 M-circle dot yr(-1) kpc(-2), and we constrain the emission regions in the remaining SMGs to be
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63.
  • Hodge, J. A., et al. (författare)
  • Kiloparsec-Scale Dust Disks in High-Redshift Luminous Submillimeter Galaxies
  • 2016
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 833:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present high-resolution (0 ''.6) 870 mu m Atacama Large Millimeter/submillimeter Array (ALMA) imaging of 16 luminous (LIR similar to 4 x 10(12) L-circle dot) submillimeter galaxies (SMGs) from the ALESS survey of the Extended Chandra Deep Field South. This dust imaging traces the dust-obscured star formation in these z similar to 2.5 galaxies on similar to 1.3 kpc scales. The emission has a median effective radius of R-e = 0 ''.24 +/- 0 ''.02, corresponding to a typical physical size of R-e= 1.8 +/- 0.2 kpc. We derive a median Sersic index of n = 0.9 +/- 0.2, implying that the dust emission is remarkably disk-like at the current resolution and sensitivity. We use different weighting schemes with the visibilities to search for clumps on 0 ''.12. (similar to 1.0 kpc) scales, but we find no significant evidence for clumping in the majority of cases. Indeed, we demonstrate using simulations that the observed morphologies are generally consistent with smooth exponential disks, suggesting that caution should be exercised when identifying candidate clumps in even moderate signal-to-noise ratio interferometric data. We compare our maps to comparable-resolution Hubble Space Telescope H-160-band images, finding that the stellar morphologies appear significantly more extended and disturbed, and suggesting that major mergers may be responsible for driving the formation of the compact dust disks we observe. The stark contrast between the obscured and unobscured morphologies may also have implications for SED fitting routines that assume the dust is co-located with the optical/near-IR continuum emission. Finally, we discuss the potential of the current bursts of star formation to transform the observed galaxy sizes and light profiles, showing that the z similar to 0 descendants of these SMGs are expected to have stellar masses, effective radii, and gas surface densities consistent with the most compact massive (M* similar to 1-2 x 10(11) M-circle dot) early-type galaxies observed locally.
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64.
  • Karim, A., et al. (författare)
  • An ALMA survey of submillimetre galaxies in the Extended Chandra Deep Field South: high-resolution 870 mu m source counts
  • 2013
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 432:1, s. 2-9
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the first counts of faint submillimetre galaxies (SMGs) in the 870-mu m band derived from arcsecond-resolution observations with the Atacama Large Millimeter Array (ALMA). We have used ALMA to map a sample of 122 870-mu m-selected submillimetre sources drawn from the 0 degrees.5x0 degrees.5 the Large Apex BOlometer CAmera (LABOCA) Extended Chandra Deep Field South submillimetre survey (LESS). These ALMA maps have an average depth of sigma 870(mu m) similar to 0.4 mJy, some approximately three times deeper than the original LABOCA survey and critically the angular resolution is more than an order of magnitude higher, FWHM of similar to 1.5 arcsec compared to similar to 19 arcsec for the LABOCA discovery map. This combination of sensitivity and resolution allows us to precisely pinpoint the SMGs contributing to the submillimetre sources from the LABOCA map, free from the effects of confusion. We show that our ALMA-derived SMG counts broadly agree with the submillimetre source counts from previous, lower resolution single-dish surveys, demonstrating that the bulk of the submillimetre sources are not caused by blending of unresolved SMGs. The difficulty which well-constrained theoretical models have in reproducing the high surface densities of SMGs, thus remains. However, our observations do show that all of the very brightest sources in the LESS sample, S-870 (mu m) greater than or similar to 12 mJy, comprise emission from multiple, fainter SMGs, each with 870-mu m fluxes of less than or similar to 9 mJy. This implies a natural limit to the star formation rate in SMGs of less than or similar to 10(3) M-circle dot yr(-1), which in turn suggests that the space densities of z > 1 galaxies with gas masses in excess of similar to 5 x 10(10) M-circle dot is
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65.
  • Kehoe, Laura, et al. (författare)
  • Make EU trade with Brazil sustainable
  • 2019
  • Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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66.
  • Koprowski, M. P., et al. (författare)
  • A resolved map of the infrared excess in a Lyman Break Galaxy at z= 3
  • 2016
  • Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 828:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We have observed the dust continuum of 10 z = 3.1 Lyman break galaxies with the Atacama Large Millimeter/submillimeter Array at similar to 450 mas resolution in Band 7. We detect and resolve the 870 mu m emission in one of the targets with a flux density of S-870 = 192 +/- 57 mu Jy, and measure a stacked 3 sigma signal of S-870 = 67 +/- 23 mu Jy for the remaining nine. The total infrared luminosities are L8-1000 = (8.4 +/- 2.3) x 10(10) L-circle dot for the detection and L8-1000 = (2.9 +/- 0.9) x 10(10) L-circle dot for the stack. With Hubble Space Telescope Advanced Camera for Surveys I-band imaging we map the rest-frame UV emission on the same scale as the dust, effectively resolving the "infrared excess" (IRX = L-FIR/L-UV) in a normal galaxy at z = 3. Integrated over the galaxy we measure IRX = 0.56 +/- 0.15, and the galaxy-averaged UV slope is beta = -1.25 +/- 0.03. This puts the galaxy a factor of similar to 10 below the IRX-beta relation for local starburst nuclei of Meurer et al. However, IRX varies by more than a factor of 3 across the galaxy, and we conclude that the complex relative morphology of the dust relative to UV emission is largely responsible for the scatter in the IRX-beta relation at high-z. A naive application of a Meurer-like dust correction based on the UV slope would dramatically overestimate the total star formation rate, and our results support growing evidence that when integrated over the galaxy, the typical conditions in high-z star-forming galaxies are not analogous to those in the local starburst nuclei used to establish the Meurer relation.
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67.
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68.
  • Liu, Jimmy Z, et al. (författare)
  • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.
  • 2013
  • Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:6, s. 670-5
  • Tidskriftsartikel (refereegranskat)abstract
    • Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16. Despite comorbidity with inflammatory bowel disease (IBD) in 72% of the cases, 6 of the 12 loci showed significantly stronger association with PSC than with IBD, suggesting overlapping yet distinct genetic architectures for these two diseases. We incorporated association statistics from 7 diseases clinically occurring with PSC in the analysis and found suggestive evidence for 33 additional pleiotropic PSC risk loci. Together with network analyses, these findings add to the genetic risk map of PSC and expand on the relationship between PSC and other immune-mediated diseases.
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69.
  • Manning, Sinclaire M., et al. (författare)
  • Characterization of Two 2 mm detected Optically Obscured Dusty Star-forming Galaxies
  • 2022
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 925:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The 2 mm Mapping Obscuration to Reionization with ALMA (MORA) Survey was designed to detect high-redshift (z greater than or similar to 4), massive, dusty star-forming galaxies (DSFGs). Here we present two likely high-redshift sources, identified in the survey, whose physical characteristics are consistent with a class of optical/near-infrared (OIR)-invisible DSFGs found elsewhere in the literature. We first perform a rigorous analysis of all available photometric data to fit spectral energy distributions and estimate redshifts before deriving physical properties based on our findings. Our results suggest the two galaxies, called MORA-5 and MORA-9, represent two extremes of the "OIR-dark" class of DSFGs. MORA-5 (z(phot) = 4.3(-1.3)(+1.5)) is a significantly more active starburst with a star formation rate (SFR) of 830(-190)(+340) M-circle dot yr(-1) compared to MORA-9 (z(phot) = 4.3(-1.0)(+1.3)), whose SFR is a modest 200(-60)(+250) M-circle dot yr(-1). Based on the stellar masses (M-star approximate to 10(10-11) M-circle dot), space density (n similar to (5 +/- 2) x 10(-6) Mpc(-3), which incorporates two other spectroscopically confirmed OIR-dark DSFGs in the MORA sample at z = 4.6 and z = 5.9), and gas depletion timescales (<1 Gyr) of these sources, we find evidence supporting the theory that OIR-dark DSFGs are the progenitors of recently discovered 3 < z < 4 massive quiescent galaxies.
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70.
  • Mantzouki, Evanthia, et al. (författare)
  • Temperature Effects Explain Continental Scale Distribution of Cyanobacterial Toxins
  • 2018
  • Ingår i: Toxins. - : MDPI. - 2072-6651. ; 10:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect effects of temperature were the main drivers of the spatial distribution in the toxins produced by the cyanobacterial community, the toxin concentrations and toxin quota. Generalized linear models showed that a Toxin Diversity Index (TDI) increased with latitude, while it decreased with water stability. Increases in TDI were explained through a significant increase in toxin variants such as MC-YR, anatoxin and cylindrospermopsin, accompanied by a decreasing presence of MC-LR. While global warming continues, the direct and indirect effects of increased lake temperatures will drive changes in the distribution of cyanobacterial toxins in Europe, potentially promoting selection of a few highly toxic species or strains.
  •  
71.
  • Mendez-Hernandez, H., et al. (författare)
  • VALES VI: ISM enrichment in star-forming galaxies up to z similar to 0.2 using (CO)-C-12(1-0), (CO)-C-13(1-0), and (CO)-O-18(1-0) line luminosity ratios
  • 2020
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 497:3, s. 2771-2785
  • Tidskriftsartikel (refereegranskat)abstract
    • We present Atacama Large Millimeter/sub-millimeter Array (ALMA) observations towards 27 low-redshift (0.02< z< 0.2) starforming galaxies taken from the Valpara ' iso ALMA/APEX Line Emission Survey. We perform stacking analyses of the (CO)-C-12(1-0), (CO)-C-13(1-0), and (CO)-O-18(1-0) emission lines to explore the L' [(CO)-C-12(1-0)]/L' [(CO)-C-13(1-0)] [hereafter L' ((CO)-C-12)/L' ((CO)-C-13)] and L' [(CO)-C-13(1-0)]/L' [(CO)-O-18(1-0)] [hereafter L' ((CO)-C-13)/L' ((CO)-O-18)] line luminosity ratio dependence as a function of different global galaxy parameters related to the star formation activity. The sample has far-IR luminosities of 1010.1-11.9 L and stellar masses of 109.8-10.9M(circle dot) corresponding to typical star-forming and starburst galaxies at these redshifts. On average, we find an L' (12CO)/L' ((CO)-C-13) line luminosity ratio value of 16.1 +/- 2.5. Galaxies with pieces of evidence of possible merging activity tend to show higher L' ((CO)-C-12)/L' (13CO) ratios by a factor of 2, while variations of this order are also found in galaxy samples with higher star formation rates (SFRs) or star formation efficiencies (SFEs). We also find an average L' ((CO)-C-13)/L' ((CO)-O-18) line luminosity ratio of 2.5 +/- 0.6, which is in good agreement with those previously reported for starburst galaxies. We find that galaxy samples with high LIR, SFR, and SFE show low L' ((CO)-C-13)/L' ((CO)-O-18) line luminosity ratios with high L' ((CO)-C-12)/L' ((CO)-C-13) line luminosity ratios, suggesting that these trends are produced by selective enrichment of massive stars in young starbursts.
  •  
72.
  • Patterson, Nick, et al. (författare)
  • Large-scale migration into Britain during the Middle to Late Bronze Age
  • 2022
  • Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; , s. 588-594
  • Tidskriftsartikel (refereegranskat)abstract
    • Present-day people from England and Wales harbour more ancestry derived from Early European Farmers (EEF) than people of the Early Bronze Age1. To understand this, we generated genome-wide data from 793 individuals, increasing data from the Middle to Late Bronze and Iron Age in Britain by 12-fold, and Western and Central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of Iron Age people of England and Wales, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and Britain's independent genetic trajectory is also reflected in the rise of the allele conferring lactase persistence to ~50% by this time compared to ~7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period.
  •  
73.
  • Pleunis, Z., et al. (författare)
  • LOFAR Detection of 110-188MHz emission and frequency-dependent activity from FRB20180916B
  • 2021
  • Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 911:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The object FRB 20180916B is a well-studied repeating fast radio burst source. Its proximity (∼150 Mpc), along with detailed studies of the bursts, has revealed many clues about its nature, including a 16.3 day periodicity in its activity. Here we report on the detection of 18 bursts using LOFAR at 110-188 MHz, by far the lowest-frequency detections of any FRB to date. Some bursts are seen down to the lowest observed frequency of 110 MHz, suggesting that their spectra extend even lower. These observations provide an order-of-magnitude stronger constraint on the optical depth due to freëCfree absorption in the source's local environment. The absence of circular polarization and nearly flat polarization angle curves are consistent with burst properties seen at 300-1700 MHz. Compared with higher frequencies, the larger burst widths (∼40-160 ms at 150 MHz) and lower linear polarization fractions are likely due to scattering. We find ∼2-3 rad m variations in the Faraday rotation measure that may be correlated with the activity cycle of the source. We compare the LOFAR burst arrival times to those of 38 previously published and 22 newly detected bursts from the uGMRT (200-450 MHz) and CHIME/FRB (400-800 MHz). Simultaneous observations show five CHIME/FRB bursts when no emission is detected by LOFAR. We find that the burst activity is systematically delayed toward lower frequencies by about 3 days from 600 to 150 MHz. We discuss these results in the context of a model in which FRB 20180916B is an interacting binary system featuring a neutron star and high-mass stellar companion.
  •  
74.
  • Rodríguez, M. Jimena, et al. (författare)
  • PHANGS–JWST First Results : Dust-embedded Star Clusters in NGC 7496 Selected via 3.3 μm PAH Emission
  • 2023
  • Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8205 .- 2041-8213. ; 944:2
  • Tidskriftsartikel (refereegranskat)abstract
    • The earliest stages of star formation occur enshrouded in dust and are not observable in the optical. Here we leverage the extraordinary new high-resolution infrared imaging from JWST to begin the study of dust-embedded star clusters in nearby galaxies throughout the Local Volume. We present a technique for identifying dust-embedded clusters in NGC 7496 (18.7 Mpc), the first galaxy to be observed by the PHANGS–JWST Cycle 1 Treasury Survey. We select sources that have strong 3.3 μm PAH emission based on a F300M − F335M color excess and identify 67 candidate embedded clusters. Only eight of these are found in the PHANGS-HST optically selected cluster catalog, and all are young (six have SED fit ages of ∼1 Myr). We find that this sample of embedded cluster candidates may significantly increase the census of young clusters in NGC 7496 from the PHANGS-HST catalog; the number of clusters younger than ∼2 Myr could be increased by a factor of 2. Candidates are preferentially located in dust lanes and are coincident with the peaks in the PHANGS-ALMA CO (2–1) maps. We take a first look at concentration indices, luminosity functions, SEDs spanning from 2700 Å to 21 μm, and stellar masses (estimated to be between ∼104 and 105 M⊙). The methods tested here provide a basis for future work to derive accurate constraints on the physical properties of embedded clusters, characterize the completeness of cluster samples, and expand analysis to all 19 galaxies in the PHANGS–JWST sample, which will enable basic unsolved problems in star formation and cluster evolution to be addressed.
  •  
75.
  • Simpson, J. M., et al. (författare)
  • AN ALMA SURVEY OF SUBMILLIMETER GALAXIES IN THE EXTENDED CHANDRA DEEP FIELD SOUTH: THE REDSHIFT DISTRIBUTION AND EVOLUTION OF SUBMILLIMETER GALAXIES
  • 2014
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 788:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We present the first photometric redshift distribution for a large sample of 870 mu m submillimeter galaxies (SMGs) with robust identifications based on observations with ALMA. In our analysis we consider 96 SMGs in the Extended Chandra Deep Field South, 77 of which have 4-19 band photometry. We model the SEDs for these 77 SMGs, deriving a median photometric redshift of z(phot) = 2.3 +/- 0.1. The remaining 19 SMGs have insufficient photometry to derive photometric redshifts, but a stacking analysis of Herschel observations confirms they are not spurious. Assuming that these SMGs have an absolute H-band magnitude distribution comparable to that of a complete sample of z similar to 1-2 SMGs, we demonstrate that they lie at slightly higher redshifts, raising the median redshift for SMGs to zphot = 2.5 +/- 0.2. Critically we show that the proportion of galaxies undergoing an SMG-like phase at z >= 3 is at most 35% +/- 5% of the total population. We derive a median stellar mass of M star = (8 +/- 1) x 10(10) M circle dot, although there are systematic uncertainties of up to 5 x for individual sources. Assuming that the star formation activity in SMGs has a timescale of similar to 100 Myr, we show that their descendants at z similar to 0 would have a space density and MH distribution that are in good agreement with those of local ellipticals. In addition, the inferred mass-weighted ages of the local ellipticals broadly agree with the look-back times of the SMG events. Taken together, these results are consistent with a simple model that identifies SMGs as events that form most of the stars seen in the majority of luminous elliptical galaxies at the present day.
  •  
76.
  • Simpson, J. M., et al. (författare)
  • THE SCUBA-2 COSMOLOGY LEGACY SURVEY: ALMA RESOLVES the BRIGHT-END of the SUB-MILLIMETER NUMBER COUNTS
  • 2015
  • Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 807:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We present high-resolution 870 μm Atacama Large Millimeter/sub-millimeter Array (ALMA) continuum maps of 30 bright sub-millimeter sources in the UKIDSS UDS field. These sources are selected from deep, 1 degree2 850 μm maps from the SCUBA-2 Cosmology Legacy Survey, and are representative of the brightest sources in the field (median SSCUBA-2= 8.7 ± 0.4 mJy). We detect 52 sub-millimeter galaxies (SMGs) at >4σ significance in our 30 ALMA maps. In 61-15+19% of the ALMA maps the single-dish source comprises a blend of ≥2 SMGs, where the secondary SMGs are Ultra-luminous Infrared Galaxies (ULIRGs) with LIR ≳ 1012 L⊙. The brightest SMG contributes on average 80-2+6% of the single-dish flux density, and in the ALMA maps containing ≥2 SMGs the secondary SMG contributes 25-5+1% of the integrated ALMA flux. We construct source counts and show that multiplicity boosts the apparent single-dish cumulative counts by 20% at S870 > 7.5 mJy, and by 60% at S870 > 12 mJy. We combine our sample with previous ALMA studies of fainter SMGs and show that the counts are well-described by a double power law with a break at 8.5 ± 0.6 mJy. The break corresponds to a luminosity of ∼6 × 1012 L⊙ or a star formation rate (SFR) of ∼103 M⊙ yr-1. For the typical sizes of these SMGs, which are resolved in our ALMA data with Re = 1.2 ± 0.1 kpc, this yields a limiting SFR density of ∼100 M⊙ yr-1 kpc-2 Finally, the number density of S870 ≳ 2 mJy SMGs is 80 ± 30 times higher than that derived from blank-field counts. An over-abundance of faint SMGs is inconsistent with line-of-sight projections dominating multiplicity in the brightest SMGs, and indicates that a significant proportion of these high-redshift ULIRGs are likely to be physically associated.
  •  
77.
  • Smith, Bradley N., et al. (författare)
  • The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder
  • 2013
  • Ingår i: European Journal of Human Genetics. - London : Nature Publishing Group. - 1018-4813 .- 1476-5438. ; 21:1, s. 102-108
  • Tidskriftsartikel (refereegranskat)abstract
    • A massive hexanucleotide repeat expansion mutation (HREM) in C9ORF72 has recently been linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we describe the frequency, origin and stability of this mutation in ALS+/-FTD from five European cohorts (total n = 1347). Single-nucleotide polymorphisms defining the risk haplotype in linked kindreds were genotyped in cases (n = 434) and controls (n = 856). Haplotypes were analysed using PLINK and aged using DMLE+. In a London clinic cohort, the HREM was the most common mutation in familial ALS+/-FTD: C9ORF72 29/112 (26%), SOD1 27/112 (24%), TARDBP 1/112 (1%) and FUS 4/112 (4%) and detected in 13/216 (6%) of unselected sporadic ALS cases but was rare in controls (3/856, 0.3%). HREM prevalence was high for familial ALS+/-FTD throughout Europe: Belgium 19/22 (86%), Sweden 30/41 (73%), the Netherlands 10/27 (37%) and Italy 4/20 (20%). The HREM did not affect the age at onset or survival of ALS patients. Haplotype analysis identified a common founder in all 137 HREM carriers that arose around 6300 years ago. The haplotype from which the HREM arose is intrinsically unstable with an increased number of repeats (average 8, compared with 2 for controls, P<10(-8)). We conclude that the HREM has a single founder and is the most common mutation in familial and sporadic ALS in Europe.
  •  
78.
  • Stanley, Flora, 1990, et al. (författare)
  • The mean star formation rates of unobscured QSOs: searching for evidence of suppressed or enhanced star formation
  • 2017
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 472:2, s. 2221-2240
  • Tidskriftsartikel (refereegranskat)abstract
    • We investigate the mean star formation rates (SFRs) in the host galaxies of similar to 3000 optically selected quasi-stellar objects (QSOs) from the Sloan Digital Sky Survey within the Herschel-ATLAS fields, and a radio-luminous subsample covering the redshift range of z = 0.2-2.5. Using Wide-field Infrared Survey Explorer (WISE) and Herschel photometry (12-500 mu m) we construct composite spectral energy distributions (SEDs) in bins of redshift and active galactic nucleus (AGN) luminosity. We perform SED fitting to measure the mean infrared luminosity due to star formation, removing the contamination from AGN emission. We find that the mean SFRs show a weak positive trend with increasing AGN luminosity. However, we demonstrate that the observed trend could be due to an increase in black hole (BH) mass (and a consequent increase of inferred stellar mass) with increasing AGN luminosity. We compare to a sample of X-ray selected AGN and find that the two populations have consistent mean SFRs when matched in AGN luminosity and redshift. On the basis of the available virial BH masses, and the evolving BH mass to stellar mass relationship, we find that the mean SFRs of our QSO sample are consistent with those of main sequence star-forming galaxies. Similarly the radio-luminous QSOs have mean SFRs that are consistent with both the overall QSO sample and with star-forming galaxies on the main sequence. In conclusion, on average QSOs reside on the main sequence of star-forming galaxies, and the observed positive trend between the mean SFRs and AGN luminosity can be attributed to BH mass and redshift dependencies.
  •  
79.
  • Swinbank, A. M., et al. (författare)
  • An ALMA survey of sub-millimetre Galaxies in the Extended Chandra Deep Field South: the far-infrared properties of SMGs
  • 2014
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 438:2, s. 1267-1287
  • Tidskriftsartikel (refereegranskat)abstract
    • We exploit Atacama Large Millimeter Array (ALMA) 870 mu m observations of sub-millimetre sources in the Extended Chandra Deep Field South to investigate the far-infrared properties of high-redshift sub-millimetre galaxies (SMGs). Using the precisely located 870 mu m ALMA positions of 99 SMGs, together with 24 mu m and radio imaging, we deblend the Herschel/SPIRE imaging to extract their far-infrared fluxes and colours. The median redshifts for ALMA LESS (ALESS) SMGs which are detected in at least two SPIRE bands increases with wavelength of the peak in their spectral energy distributions (SEDs), with z = 2.3 +/- 0.2, 2.5 +/- 0.3 and 3.5 +/- 0.5 for the 250, 350 and 500 mu m peakers, respectively. 34 ALESS SMGs do not have a >3 sigma counterpart at 250, 350 or 500 mu m. These galaxies have a median photometric redshift derived from the rest-frame UV-mid-infrared SEDs of z = 3.3 +/- 0.5, which is higher than the full ALESS SMG sample; z = 2.5 +/- 0.2. We estimate the far-infrared luminosities and characteristic dust temperature of each SMG, deriving L-IR = (3.0 +/- 0.3) x 10(12) L-circle dot (SFR = 300 +/- 30 M-circle dot yr(-1)) and T-d = 32 +/- 1 K. The characteristic dust temperature of these high-redshift SMGs is Delta T-d = 3-5K lower than comparably luminous galaxies at z = 0, reflecting the more extended star formation in these systems. We show that the contribution of S-870 mu m >= 1 mJy SMGs to the cosmic star formation budget is 20 per cent of the total over the redshift range z similar to 1-4. Adopting an appropriate gas-to-dust ratio, we estimate a typical molecular mass of the ALESS SMGs of M-H2 = (4.2 +/- 0.4) x 10(10) M-circle dot. Finally, we show that SMGs with S-870 mu m > 1 mJy (L-IR greater than or similar to 10(12) L-circle dot) contain similar to 10 per cent of the z similar to 2 volume-averaged H-2 mass density.
  •  
80.
  • Aulchenko, Yurii S, et al. (författare)
  • Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
  • 2009
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 41:1, s. 47-55
  • Tidskriftsartikel (refereegranskat)abstract
    • Recent genome-wide association (GWA) studies of lipids have been conducted in samples ascertained for other phenotypes, particularly diabetes. Here we report the first GWA analysis of loci affecting total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides sampled randomly from 16 population-based cohorts and genotyped using mainly the Illumina HumanHap300-Duo platform. Our study included a total of 17,797-22,562 persons, aged 18-104 years and from geographic regions spanning from the Nordic countries to Southern Europe. We established 22 loci associated with serum lipid levels at a genome-wide significance level (P < 5 x 10(-8)), including 16 loci that were identified by previous GWA studies. The six newly identified loci in our cohort samples are ABCG5 (TC, P = 1.5 x 10(-11); LDL, P = 2.6 x 10(-10)), TMEM57 (TC, P = 5.4 x 10(-10)), CTCF-PRMT8 region (HDL, P = 8.3 x 10(-16)), DNAH11 (LDL, P = 6.1 x 10(-9)), FADS3-FADS2 (TC, P = 1.5 x 10(-10); LDL, P = 4.4 x 10(-13)) and MADD-FOLH1 region (HDL, P = 6 x 10(-11)). For three loci, effect sizes differed significantly by sex. Genetic risk scores based on lipid loci explain up to 4.8% of variation in lipids and were also associated with increased intima media thickness (P = 0.001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors.
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81.
  • Barth, Claudia, et al. (författare)
  • In vivo white matter microstructure in adolescents with early-onset psychosis : a multi-site mega-analysis
  • 2023
  • Ingår i: Molecular Psychiatry. - : Springer Nature. - 1359-4184 .- 1476-5578. ; 28, s. 1159-1169
  • Tidskriftsartikel (refereegranskat)abstract
    • Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls using diffusion tensor imaging (DTI). Our sample included 321 adolescents with EOP (median age=16.6 years, interquartile range (IQR)=2.14, 46.4% females) and 265 adolescent healthy controls (median age=16.2 years, IQR=2.43, 57.7% females) pooled from nine sites. All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant. ComBat harmonization was performed for all DTI measures to adjust for scanner differences. Multiple linear regression models were fitted to investigate case-control differences and associations with clinical variables in regional DTI measures. We found widespread lower FA in EOP compared to healthy controls, with the largest effect sizes in the superior longitudinal fasciculus (Cohen's d=0.37), posterior corona radiata (d=0.32), and superior fronto-occipital fasciculus (d=0.31). We also found widespread higher RD and more localized higher MD and AD. We detected significant effects of diagnostic subgroup, sex, and duration of illness, but not medication status. Using the largest EOP DTI sample to date, our findings suggest a profile of widespread white matter microstructure alterations in adolescents with EOP, most prominently in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness.
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82.
  • Calvert, Clara, et al. (författare)
  • Changes in preterm birth and stillbirth during COVID-19 lockdowns in 26 countries
  • 2023
  • Ingår i: Nature Human Behaviour. - : Springer Nature. - 2397-3374. ; 7:4, s. 529-544
  • Tidskriftsartikel (refereegranskat)abstract
    • Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from -90% to +30%, were reported in many countries following early COVID-19 pandemic response measures ('lockdowns'). It is unclear whether this variation reflects real differences in lockdown impacts, or perhaps differences in stillbirth rates and/or study designs. Here we present interrupted time series and meta-analyses using harmonized data from 52 million births in 26 countries, 18 of which had representative population-based data, with overall PTB rates ranging from 6% to 12% and stillbirth ranging from 2.5 to 10.5 per 1,000 births. We show small reductions in PTB in the first (odds ratio 0.96, 95% confidence interval 0.95-0.98, P value <0.0001), second (0.96, 0.92-0.99, 0.03) and third (0.97, 0.94-1.00, 0.09) months of lockdown, but not in the fourth month of lockdown (0.99, 0.96-1.01, 0.34), although there were some between-country differences after the first month. For high-income countries in this study, we did not observe an association between lockdown and stillbirths in the second (1.00, 0.88-1.14, 0.98), third (0.99, 0.88-1.12, 0.89) and fourth (1.01, 0.87-1.18, 0.86) months of lockdown, although we have imprecise estimates due to stillbirths being a relatively rare event. We did, however, find evidence of increased risk of stillbirth in the first month of lockdown in high-income countries (1.14, 1.02-1.29, 0.02) and, in Brazil, we found evidence for an association between lockdown and stillbirth in the second (1.09, 1.03-1.15, 0.002), third (1.10, 1.03-1.17, 0.003) and fourth (1.12, 1.05-1.19, <0.001) months of lockdown. With an estimated 14.8 million PTB annually worldwide, the modest reductions observed during early pandemic lockdowns translate into large numbers of PTB averted globally and warrant further research into causal pathways.
  •  
83.
  • Caputi, K. I., et al. (författare)
  • ALMA Lensing Cluster Survey: An ALMA Galaxy Signposting a MUSE Galaxy Group at z=4.3 Behind "El Gordo"
  • 2021
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 908:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the discovery of a Multi Unit Spectroscopic Explorer (MUSE) galaxy group at z = 4.32 lensed by the massive galaxy cluster ACT-CL J0102-4915 (aka El Gordo) at z = 0.87, associated with a 1.2 mm source that is at a 2.07 0.88 kpc projected distance from one of the group galaxies. Three images of the whole system appear in the image plane. The 1.2 mm source has been detected within the Atacama Large Millimetre/submillimetre Array (ALMA) Lensing Cluster Survey (ALCS). As this ALMA source is undetected at wavelengths lambda < 2 mu m, its redshift cannot be independently determined, however, the three lensing components indicate that it belongs to the same galaxy group at z = 4.32. The four members of the MUSE galaxy group have low to intermediate stellar masses (similar to 10(7)-10(10) M) and star formation rates (SFRs) of 0.4-24 M yr(-1), resulting in high specific SFRs (sSFRs) for two of them, which suggest that these galaxies are growing fast (with stellar mass doubling times of only similar to 2 x 10(7) yr). This high incidence of starburst galaxies is likely a consequence of interactions within the galaxy group, which is compact and has high velocity dispersion. Based on the magnification-corrected sub-/millimeter continuum flux density and estimated stellar mass, we infer that the ALMA source is classified as an ordinary ultra-luminous infrared galaxy (with associated dust-obscured SFR similar to 200-300 M yr(-1)) and lies on the star formation main sequence. This reported case of an ALMA/MUSE group association suggests that some presumably isolated ALMA sources are in fact signposts of richer star-forming environments at high redshifts.
  •  
84.
  • Casey, Caitlin M., et al. (författare)
  • Physical Characterization of an Unlensed, Dusty Star-forming Galaxy at z = 5.85
  • 2019
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 887:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a physical characterization of MM J100026.36+021527.9 (a.k.a. "Mambo-9"), a dusty star-forming galaxy (DSFG) at z = 5.850 ± 0.001. This is the highest-redshift unlensed DSFG (and fourth most distant overall) found to date and is the first source identified in a new 2 mm blank-field map in the COSMOS field. Though identified in prior samples of DSFGs at 850 μm to 1.2 mm with unknown redshift, the detection at 2 mm prompted further follow-up as it indicated a much higher probability that the source was likely to sit at z > 4. Deep observations from the Atacama Large Millimeter and submillimeter Array (ALMA) presented here confirm the redshift through the secure detection of 12CO(J = 6→5) and p-H2O (21,1 → 20,2). Mambo-9 is composed of a pair of galaxies separated by 6 kpc with corresponding star formation rates of 590 M o˙ yr-1 and 220 M o˙ yr-1, total molecular hydrogen gas mass of (1.7 ± 0.4) × 1011 M o˙, dust mass of (1.3 ± 0.3) × 109 M o˙, and stellar mass of (3.2-1.5+1.0) × 109 M o˙. The total halo mass, (3.3 ± 0.8) × 1012 M o˙, is predicted to exceed 1015 M o˙ by z = 0. The system is undergoing a merger-driven starburst that will increase the stellar mass of the system tenfold in τ depl = 40-80 Myr, converting its large molecular gas reservoir (gas fraction of 96-2+1) into stars. Mambo-9 evaded firm spectroscopic identification for a decade, following a pattern that has emerged for some of the highest-redshift DSFGs found. And yet, the systematic identification of unlensed DSFGs like Mambo-9 is key to measuring the global contribution of obscured star formation to the star formation rate density at z ⪆ 4, the formation of the first massive galaxies, and the formation of interstellar dust at early times (≲1 Gyr).
  •  
85.
  • Chen, C. C., et al. (författare)
  • A Spatially Resolved Study of Cold Dust, Molecular Gas, H II Regions, and Stars in the z = 2.12 Submillimeter Galaxy ALESS67.1
  • 2017
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 846:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We present detailed studies of a z = 2.12 submillimeter galaxy, ALESS67.1, using sub-arcsecond resolution ALMA, adaptive optics-aided VLT/SINFONI, and Hubble Space Telescope (HST)/CANDELS data to investigate the kinematics and spatial distributions of dust emission (870 ?m continuum), 12CO(J = 3-2), strong optical emission lines, and visible stars. Dynamical modeling of the optical emission lines suggests that ALESS67.1 is not a pure rotating disk but a merger, consistent with the apparent tidal features revealed in the HST imaging. Our sub-arcsecond resolution data set allows us to measure half-light radii for all the tracers, and we find a factor of 4-6 smaller sizes in dust continuum compared to all the other tracers, including 12CO; also, ultraviolet (UV) and H? emission are significantly offset from the dust continuum. The spatial mismatch between the UV continuum and the cold dust and gas reservoir supports the explanation that geometrical effects are responsible for the offset of the dusty galaxy on the IRX-? diagram. Using a dynamical method we derive an , consistent with other submillimeter galaxies (SMGs) that also have resolved CO and dust measurements. Assuming a single value we also derive resolved gas and star formation rate surface densities, and find that the core region of the galaxy ( kpc) follows the trend of mergers on the Schmidt-Kennicutt relationship, whereas the outskirts ( kpc) lie on the locus of normal star-forming galaxies, suggesting different star formation efficiencies within one galaxy. Our results caution against using single size or morphology for different tracers of the star formation activity and gas content of galaxies, and therefore argue the need to use spatially resolved, multi-wavelength observations to interpret the properties of SMGs, and perhaps even for galaxies in general.
  •  
86.
  • da Cunha, E., et al. (författare)
  • Measurements of the Dust Properties in z similar or equal to 1-3 Submillimeter Galaxies with ALMA
  • 2021
  • Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 919:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present Atacama Large Millimeter/submillimeter Array (ALMA) 2 mm continuum observations of a complete and unbiased sample of 99 870 mu m selected submillimeter galaxies (SMGs) in the Extended Chandra Deep Field South (ALESS). Our observations of each SMG reach average sensitivities of 53 mu Jy beam(-1). We measure the flux densities for 70 sources, for which we obtain a typical 870 mu m-to-2 mm flux ratio of 14 +/- 5. We do not find a redshift dependence of this flux ratio, which would be expected if the dust emission properties of our SMGs were the same at all redshifts. By combining our ALMA measurements with existing Herschel/SPIRE observations, we construct a (biased) subset of 27 galaxies for which the cool dust emission is sufficiently well sampled to obtain precise constraints on their dust properties using simple isothermal models. Thanks to our new 2 mm observations, the dust emissivity index is well constrained and robust against different dust opacity assumptions. The median dust emissivity index of our SMGs is beta similar or equal to 1.9 +/- 0.4, consistent with the emissivity index of dust in the Milky Way and other local and high-redshift galaxies, as well as classical dust-grain model predictions. We also find a negative correlation between the dust temperature and beta, similar to low-redshift observational and theoretical studies. Our results indicate that beta similar or equal to 2 in high-redshift dusty star-forming galaxies, implying little evolution in dust-grain properties between our SMGs and local dusty galaxy samples, and suggesting that these high-mass and high-metallicity galaxies have dust reservoirs driven by grain growth in their interstellar medium.
  •  
87.
  • Dai, Qile, et al. (författare)
  • OTTERS: a powerful TWAS framework leveraging summary-level reference data
  • 2023
  • Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in broader settings and enhance power due to increased reference sample size. Thus, we develop a TWAS framework called OTTERS (Omnibus Transcriptome Test using Expression Reference Summary data) that adapts multiple polygenic risk score (PRS) methods to estimate eQTL weights from summary-level eQTL reference data and conducts an omnibus TWAS. We show that OTTERS is a practical and powerful TWAS tool by both simulations and application studies.
  •  
88.
  • Dichgans, Martin, et al. (författare)
  • METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration : An initiative of the Joint Programme for Neurodegenerative Disease Research
  • 2016
  • Ingår i: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 12:12, s. 1235-1249
  • Tidskriftsartikel (refereegranskat)abstract
    • Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically “silent” cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors. New large collaborative studies with long follow-up are expensive and time consuming, yet substantial data to advance the field are available. In an initiative funded by the Joint Programme for Neurodegenerative Disease Research, 55 international experts surveyed and assessed available data, starting with European cohorts, to promote data sharing to advance understanding of how vascular disease affects brain structure and function, optimize methods for cerebrovascular disease in neurodegeneration research, and focus future research on gaps in knowledge. Here, we summarize the results and recommendations from this initiative. We identified data from over 90 studies, including over 660,000 participants, many being additional to neurodegeneration data initiatives. The enthusiastic response means that cohorts from North America, Australasia, and the Asia Pacific Region are included, creating a truly global, collaborative, data sharing platform, linked to major national dementia initiatives. Furthermore, the revised World Health Organization International Classification of Diseases version 11 should facilitate recognition of vascular-related brain damage by creating one category for all cerebrovascular disease presentations and thus accelerate identification of targets for dementia prevention.
  •  
89.
  • Dixon, Stephanie B., et al. (författare)
  • The Future of Childhood Cancer Survivorship : Challenges and Opportunities for Continued Progress
  • 2020
  • Ingår i: Pediatric Clinics of North America. - : Elsevier BV. - 0031-3955. ; 67:6, s. 1237-1251
  • Forskningsöversikt (refereegranskat)abstract
    • As treatment evolves and the population who survive childhood cancer ages and increases in number, researchers must use novel approaches to prevent, identify and mitigate adverse effects of treatment. Future priorities include collaborative efforts to pool large cohort data to improve detection of late effects, identify late effects of novel therapies, and determine the contribution of genetic factors along with physiologic and accelerated aging among survivors. This knowledge should translate to individual risk prediction and prevention strategies. Finally, we must utilize health services research and implementation science to improve adoption of survivorship care recommendations outside of specialized pediatric oncology centers.
  •  
90.
  • Donis, Daphne, et al. (författare)
  • Stratification strength and light climate explain variation in chlorophyll a at the continental scale in a European multilake survey in a heatwave summer
  • 2021
  • Ingår i: Limnology and Oceanography. - : John Wiley & Sons. - 0024-3590 .- 1939-5590. ; 66:12, s. 4314-4333
  • Tidskriftsartikel (refereegranskat)abstract
    • To determine the drivers of phytoplankton biomass, we collected standardized morphometric, physical, and biological data in 230 lakes across the Mediterranean, Continental, and Boreal climatic zones of the European continent. Multilinear regression models tested on this snapshot of mostly eutrophic lakes (median total phosphorus [TP] = 0.06 and total nitrogen [TN] = 0.7 mg L-1), and its subsets (2 depth types and 3 climatic zones), show that light climate and stratification strength were the most significant explanatory variables for chlorophyll a (Chl a) variance. TN was a significant predictor for phytoplankton biomass for shallow and continental lakes, while TP never appeared as an explanatory variable, suggesting that under high TP, light, which partially controls stratification strength, becomes limiting for phytoplankton development. Mediterranean lakes were the warmest yet most weakly stratified and had significantly less Chl a than Boreal lakes, where the temperature anomaly from the long-term average, during a summer heatwave was the highest (+4 degrees C) and showed a significant, exponential relationship with stratification strength. This European survey represents a summer snapshot of phytoplankton biomass and its drivers, and lends support that light and stratification metrics, which are both affected by climate change, are better predictors for phytoplankton biomass in nutrient-rich lakes than nutrient concentrations and surface temperature.
  •  
91.
  • Donovan, Mary K., et al. (författare)
  • Combining fish and benthic communities into multiple regimes reveals complex reef dynamics
  • 2018
  • Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Coral reefs worldwide face an uncertain future with many reefs reported to transition from being dominated by corals to macroalgae. However, given the complexity and diversity of the ecosystem, research on how regimes vary spatially and temporally is needed. Reef regimes are most often characterised by their benthic components; however, complex dynamics are associated with losses and gains in both fish and benthic assemblages. To capture this complexity, we synthesised 3,345 surveys from Hawai'i to define reef regimes in terms of both fish and benthic assemblages. Model-based clustering revealed five distinct regimes that varied ecologically, and were spatially heterogeneous by island, depth and exposure. We identified a regime characteristic of a degraded state with low coral cover and fish biomass, one that had low coral but high fish biomass, as well as three other regimes that varied significantly in their ecology but were previously considered a single coral dominated regime. Analyses of time series data reflected complex system dynamics, with multiple transitions among regimes that were a function of both local and global stressors. Coupling fish and benthic communities into reef regimes to capture complex dynamics holds promise for monitoring reef change and guiding ecosystem-based management of coral reefs.
  •  
92.
  • Furtak, Lukas J., et al. (författare)
  • A variable active galactic nucleus at z = 2.06 triply-imaged by the galaxy cluster MACS J0035.4−2015
  • 2023
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 522:4, s. 5142-5151
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the discovery of a triply imaged active galactic nucleus (AGN), lensed by the galaxy cluster MACS J0035.4−2015 (z d = 0.352). The object is detected in Hubble Space Telescope imaging taken for the RELICS program. It appears to have a quasi-stellar nucleus consistent with a point-source, with a de-magnified radius of re ≲ 100 pc. The object is spectroscopically confirmed to be an AGN at z spec = 2.063 ± 0.005 showing broad rest-frame UV emission lines, and detected in both X-ray observations with Chandra and in ALCS ALMA band 6 (1.2 mm) imaging. It has a relatively faint rest-frame UV luminosity for a quasar-like object, MUV, 1450 = −19.7 ± 0.2. The object adds to just a few quasars or other X-ray sources known to be multiply lensed by a galaxy cluster. Some diffuse emission from the host galaxy is faintly seen around the nucleus, and there is a faint object nearby sharing the same multiple-imaging symmetry and geometric redshift, possibly an interacting galaxy or a star-forming knot in the host. We present an accompanying lens model, calculate the magnifications and time delays, and infer the physical properties of the source. We find the rest-frame UV continuum and emission lines to be dominated by the AGN, and the optical emission to be dominated by the host galaxy of modest stellar mass M✶ ≃ 109.2 M⊙. We also observe some variation in the AGN emission with time, which may suggest that the AGN used to be more active. This object adds a low-redshift counterpart to several relatively faint AGN recently uncovered at high redshifts with HST and JWST.
  •  
93.
  • Guerrero, Andrea, et al. (författare)
  • ALMA Lensing Cluster Survey: Average dust, gas, and star-formation properties of cluster and field galaxies from stacking analysis
  • 2023
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 526:2, s. 2423-2439
  • Tidskriftsartikel (refereegranskat)abstract
    • We develop new tools for continuum and spectral stacking of Atacama Large Millimeter/submillimeter Array (ALMA) data, and apply these to the ALMA Lensing Cluster Survey. We derive average dust masses, gas masses, and star-formation rates (SFRs) from the stacked observed 260-GHz continuum of 3402 individually undetected star-forming galaxies, of which 1450 are cluster galaxies and 1952 field galaxies, over three redshift and stellar mass bins (over z = 0-1.6 and log-11.7), and derive the average molecular gas content by stacking the emission line spectra in a SFR-selected subsample. The average SFRs and specific SFRs of both cluster and field galaxies are lower than those expected for main-sequence (MS) star-forming galaxies, and only galaxies with stellar mass of log-10.6 show dust and gas fractions comparable with those in the MS. The ALMA-Traced average 'highly obscured' SFRs are typically lower than the SFRs observed from optical to near-infrared spectral analysis. Cluster and field galaxies show similar trends in their contents of dust and gas, even when field galaxies were brighter in the stacked maps. From spectral stacking we find a potential CO (J = 4 → 3) line emission (signal-To-noise ratio being ∼4) when stacking cluster and field galaxies with the highest SFRs.
  •  
94.
  • Heintz, K. E., et al. (författare)
  • The Gas and Stellar Content of a Metal-poor Galaxy at z = 8.496 as Revealed by JWST and ALMA
  • 2023
  • Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 944:2
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a joint analysis of the galaxy S04590 at z = 8.496 based on NIRSpec, NIRCam, and NIRISS observations obtained as part of the Early Release Observations program of the James Webb Space Telescope (JWST) and the far-infrared [C ii] 158 μm emission line detected by dedicated Atacama Large Millimeter/submillimeter Array (ALMA) observations. We determine the physical properties of S04590 from modeling of the spectral energy distribution (SED) and through the redshifted optical nebular emission lines detected with JWST/NIRSpec. The best-fit SED model reveals a low-mass (M ⋆ = 107.2-108 M ⊙) galaxy with a low oxygen abundance of 12 + log ( O / H ) = 7.16 − 0.12 + 0.10 derived from the strong nebular and auroral emission lines. Assuming that [C ii] effectively traces the interstellar medium, we estimate the total gas mass of the galaxy to be M gas = (8.0 ± 4.0) × 108 M ⊙ based on the luminosity and spatial extent of [C ii]. This yields an exceptionally high gas fraction, f gas = M gas/(M gas + M ⋆) ≳ 90%, though one still consistent with the range expected for low metallicity. We further derive the metal mass of the galaxy based on the gas mass and gas-phase metallicity, which we find to be consistent with the expected metal production from Type II supernovae. Finally, we make the first constraints on the dust-to-gas (DTG) and dust-to-metal (DTM) ratios of galaxies in the epoch of reionization at z ≳ 6, showing overall low mass ratios of logDTG < −3.8 and logDTM < −0.5, though they are consistent with established scaling relations and in particular with those of the local metal-poor galaxy I Zwicky 18. Our analysis highlights the synergy between ALMA and JWST in characterizing the gas, metal, and stellar content of the first generation of galaxies.
  •  
95.
  • Hrycik, Allison R., et al. (författare)
  • Earlier winter/spring runoff and snowmelt during warmer winters lead to lower summer chlorophyll-a in north temperate lakes
  • 2021
  • Ingår i: Global Change Biology. - : John Wiley & Sons. - 1354-1013 .- 1365-2486. ; 27:19, s. 4615-4629
  • Tidskriftsartikel (refereegranskat)abstract
    • Winter conditions, such as ice cover and snow accumulation, are changing rapidly at northern latitudes and can have important implications for lake processes. For example, snowmelt in the watershed—a defining feature of lake hydrology because it delivers a large portion of annual nutrient inputs—is becoming earlier. Consequently, earlier and a shorter duration of snowmelt are expected to affect annual phytoplankton biomass. To test this hypothesis, we developed an index of runoff timing based on the date when 50% of cumulative runoff between January 1 and May 31 had occurred. The runoff index was computed using stream discharge for inflows, outflows, or for flows from nearby streams for 41 lakes in Europe and North America. The runoff index was then compared with summer chlorophyll-a (Chl-a) concentration (a proxy for phytoplankton biomass) across 5–53 years for each lake. Earlier runoff generally corresponded to lower summer Chl-a. Furthermore, years with earlier runoff also had lower winter/spring runoff magnitude, more protracted runoff, and earlier ice-out. We examined several lake characteristics that may regulate the strength of the relationship between runoff timing and summer Chl-a concentrations; however, our tested covariates had little effect on the relationship. Date of ice-out was not clearly related to summer Chl-a concentrations. Our results indicate that ongoing changes in winter conditions may have important consequences for summer phytoplankton biomass and production.
  •  
96.
  • Huynh, M. T., et al. (författare)
  • Physical conditions of the gas in an ALMA C II -identified submillimetre galaxy at z=4.44
  • 2013
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966 .- 1745-3933 .- 1745-3925. ; 431:1, s. L88-L92
  • Tidskriftsartikel (refereegranskat)abstract
    • We present (CO)-C-12(2-1) observations of the submillimetre galaxy ALESS65.1 performed with the Australia Telescope Compact Array (ATCA) at 42.3 GHz. A previous Atacama Large Millimeter Array study of submillimetre galaxies (SMGs) in the Extended Chandra Deep Field South detected [C II] 157.74 mu m emission from this galaxy at a redshift of z= 4.44. No (CO)-C-12(21) emission was detected but we derive a firm upper limit to the cold gas mass in ALESS65.1 of M-gas 4 SMGs being the likely progenitors of massive red-and-dead galaxies at z > 2. The ratio of the [CII], (CO)-C-12 and far-infrared luminosities implies a strong far-ultraviolet field of G(0) greater than or similar to 103, as seen in Galactic star-forming regions or local ultraluminous infrared galaxies (ULIRGs). The observed L-[C II]/L-FIR = 2.3 x 10(-3) is high compared to local ULIRGs and, combined withLL([CII])/L-CO greater than or similar to 2700, it is consistent with ALESS65.1 either having an extended (several kpc) [C II] emitting region or lower than solar metallicity.
  •  
97.
  • Jouffray, Jean-Baptiste, et al. (författare)
  • Parsing human and biophysical drivers of coral reef regimes
  • 2019
  • Ingår i: Proceedings of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8452 .- 1471-2954. ; 286:1896
  • Tidskriftsartikel (refereegranskat)abstract
    • Coral reefs worldwide face unprecedented cumulative anthropogenic effects of interacting local human pressures, global climate change and distal social processes. Reefs are also bound by the natural biophysical environment within which they exist. In this context, a key challenge for effective management is understanding how anthropogenic and biophysical conditions interact to drive distinct coral reef configurations. Here, we use machine learning to conduct explanatory predictions on reef ecosystems defined by both fish and benthic communities. Drawing on the most spatially extensive dataset available across the Hawaiian archipelago-20 anthropogenic and biophysical predictors over 620 survey sites-we model the occurrence of four distinct reef regimes and provide a novel approach to quantify the relative influence of human and environmental variables in shaping reef ecosystems. Our findings highlight the nuances of what underpins different coral reef regimes, the overwhelming importance of biophysical predictors and how a reef's natural setting may either expand or narrow the opportunity space for management interventions. The methods developed through this study can help inform reef practitioners and hold promises for replication across a broad range of ecosystems.
  •  
98.
  • KC, Ashish, 1982-, et al. (författare)
  • Changes in preterm birth and stillbirth during COVID-19 lockdowns in 26 countries.
  • 2023
  • Ingår i: Nature human behaviour. - : Springer Science and Business Media LLC. - 2397-3374. ; 7:4, s. 529-544
  • Tidskriftsartikel (refereegranskat)abstract
    • Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from -90% to +30%, were reported in many countries following early COVID-19 pandemic response measures ('lockdowns'). It is unclear whether this variation reflects real differences in lockdown impacts, or perhaps differences in stillbirth rates and/or study designs. Here we present interrupted time series and meta-analyses using harmonized data from 52 million births in 26 countries, 18 of which had representative population-based data, with overall PTB rates ranging from 6% to 12% and stillbirth ranging from 2.5 to 10.5 per 1,000 births. We show small reductions in PTB in the first (odds ratio 0.96, 95% confidence interval 0.95-0.98, P value <0.0001), second (0.96, 0.92-0.99, 0.03) and third (0.97, 0.94-1.00, 0.09) months of lockdown, but not in the fourth month of lockdown (0.99, 0.96-1.01, 0.34), although there were some between-country differences after the first month. For high-income countries in this study, we did not observe an association between lockdown and stillbirths in the second (1.00, 0.88-1.14, 0.98), third (0.99, 0.88-1.12, 0.89) and fourth (1.01, 0.87-1.18, 0.86) months of lockdown, although we have imprecise estimates due to stillbirths being a relatively rare event. We did, however, find evidence of increased risk of stillbirth in the first month of lockdown in high-income countries (1.14, 1.02-1.29, 0.02) and, in Brazil, we found evidence for an association between lockdown and stillbirth in the second (1.09, 1.03-1.15, 0.002), third (1.10, 1.03-1.17, 0.003) and fourth (1.12, 1.05-1.19, <0.001) months of lockdown. With an estimated 14.8 million PTB annually worldwide, the modest reductions observed during early pandemic lockdowns translate into large numbers of PTB averted globally and warrant further research into causal pathways.
  •  
99.
  • Kirsten, Franz, 1983, et al. (författare)
  • Detection of two bright radio bursts from magnetar SGR 1935 + 2154
  • 2021
  • Ingår i: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 5:4, s. 414-422
  • Tidskriftsartikel (refereegranskat)abstract
    • Fast radio bursts are millisecond-duration, bright radio signals (fluence 0.1-100 Jy ms) emitted from extragalactic sources of unknown physical origin. The recent CHIME/FRB and STARE2 detection of an extremely bright (fluence similar to MJy ms) radio burst from the Galactic magnetar SGR 1935+2154 supports the hypothesis that (at least some) fast radio bursts are emitted by magnetars at cosmological distances. In follow-up observations totalling 522.7 h on source, we detect two bright radio bursts with fluences of 112 +/- 22 Jy ms and 24 +/- 5 Jy ms, respectively. Both bursts appear to be affected by interstellar scattering and we measure significant linear and circular polarization for the fainter burst. The bursts are separated in time by similar to 1.4 s, suggesting a non-Poissonian, clustered emission process-similar to those seen in some repeating fast radio bursts. Together with the burst reported by CHIME/FRB and STARE2, as well as a much fainter burst seen by FAST (fluence 60 mJy ms), our observations demonstrate that SGR 1935+2154 can produce bursts with apparent energies spanning roughly seven orders of magnitude, and that the burst rate is comparable across this range. This raises the question of whether these four bursts arise from similar physical processes, and whether the fast radio burst population distribution extends to very low energies (similar to 10(30) erg, isotropic equivalent).
  •  
100.
  • Koprowski, M. P., et al. (författare)
  • A direct calibration of thtae IRX-β relation in Lyman-break Galaxies at z = 3-5
  • 2018
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 479:4, s. 4355-4366
  • Tidskriftsartikel (refereegranskat)abstract
    • We use a sample of 4209 Lyman-break galaxies (LBGs) at z ≃ 3, 4, and 5 in the UKIRT Infrared Deep Sky Survey Ultra Deep Survey field to investigate the relationship between the observed slope of the stellar continuum emission in the ultraviolet, β, and the thermal dust emission, as quantified via the so-called 'infrared excess' (IRX=LIR/LUV). Through a stacking analysis, we directly measure the 850-μm flux density of LBGs in our deep (0.9 mJy) James Clerk Maxwell Telescope SCUBA-2 850-μm map as well as deep public Herschel/SPIRE 250-, 350-, and 500-μm imaging. We establish functional forms for the IRX-β relation to z ~ 5, confirming that there is no significant redshift evolution of the relation, and that the resulting average IRX-β curve is consistent with a Calzetti-like attenuation law. Comparing our results with recent works in the literature, we confirm that discrepancies in the slope of the IRX-β relation are driven by biases in the methodology used to determine the ultraviolet slopes. Consistent results are found when IRX-β is evaluated by stacking in bins of stellar mass, and we argue that the near-linear IRX-M* relationship is a better proxy for correcting observed ultraviolet luminosities to total star formation rates, provided an accurate handle on M* and also gives clues as to the physical driver of the role of dust-obscured star formation in high-redshift galaxies.
  •  
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