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| 52. |
- Velikyan, Irina, et al.
(författare)
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The importance of high specific radioactivity in the performance of Ga-68-labeled peptide.
- 2008
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Ingår i: Nuclear Medicine and Biology. - : Elsevier BV. - 0969-8051 .- 1872-9614. ; 35:5, s. 529-536
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Tidskriftsartikel (refereegranskat)abstract
- The Use of Ga-68-labeled peptides in diagnosis, dosimetry, therapy planning and follow-up of response to chemo- and radiotherapy requires accurate quantification of tracer binding characteristics in vivo, which may be influenced by the specific radioactivity (SRA) of the tracer. Systematic study of the complexation reaction of DOTA-D-Phe(1)-Tyr(3)-Octreotide (DOTATOC, where DOTA is the chelator 1,4,7,10-tetrauzacyclododecane-1,4,7,10-tetraacetic acid) with Ga-67, Ga-68, Ga-69,Ga-71 and in the presence of competing metal cations [Al(III), Fe(III), In (III)] was performed using conventional and microwave heating techniques and assessed by mass spectrometry. Saturation binding of Ga-68-DOTATOC to Rhesus monkey brain slices was performed using frozen section autoradiography. High SRA was necessary in order to characterize the saturation binding of Ga-68-DOTATOC to somatostatin receptors in Rhesus monkey brain sections. The complexation of Ga(III) with DOTATOC suggested more favorable formation compared to Fe(III) and In(III). The microwave heating mode might influence the selectivity of the complexation reaction, especially when comparing the behavior of Ga(III) and In(III). Al(III)was less critical with contamination and could be tolerated up to a concentration equal to that of the peptide bioconjugate. The SRA of Ga-67-DOTATOC and Ga-67-NODAGA-TATE (NODAGA-Tyr(3)-Octreotate, where NODAGA is 1,4,7-triazacyclononaiie-1-glutaric acid-4,7-diacetic acid) exceeded literature data by a factor of 7 and 5-15, respectively. High SRA was critical for providing sufficient contrast and accurate quantification of PET images. Microwave heating mode apart from the acceleration of the labeling reaction also improved the selectivity of the complexation reaction towards gallium. Fe(III) was shown to be the most critical competitor deteriorating the Ga-68-labeling efficiency.
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| 55. |
- Zetterqvist, J., et al.
(författare)
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Stimulant and non-stimulant attention deficit/hyperactivity disorder drug use : total population study of trends and discontinuation patterns 2006-2009
- 2013
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Ingår i: Acta Psychiatrica Scandinavica. - Hoboken, USA : Wiley-Blackwell. - 0001-690X .- 1600-0447. ; 128:1, s. 70-77
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To explore the prevalence and discontinuation of dispensed medications for attention deficit/hyperactivity disorder (ADHD) drugs from 2006 to 2009.Method: A total population cohort of all individuals aged 6-45 years, alive and registered as residents in Sweden during any calendar year from 2006 to 2009 (N = 5 149 791) included 41 700 patients dispensed with an ADHD drug (methylphenidate, atomoxetine, amphetamine, or dexamphetamine). The dispensing prevalence was calculated for each year, stratified on sex and age. A longitudinal analysis was also performed to compare the rates of treatment discontinuation across the strata.Results: The dispensing prevalence increased from 2.93 per 1000 in 2006 to 6.98 in 2009 (PR = 2.38, 95% CI = 2.34-2.43). The prevalence ratio (PR) was 3.40 for adults, 22-45 years old; 2.41 for adolescents, 15-21 years old; and 1.90 for children aged 6-14. The increase was also greater in women than in men (PR = 2.92 vs. 2.19). Patients aged 15-21 were the most likely to discontinue treatment; after 3 years and 11 months, 27% of those patients were still under treatment.Conclusion: From 2006 to 2009, the number of prescriptions dispensed for ADHD drugs increased substantially. The rate of treatment discontinuation in the age interval 15-21 is higher than expected considering the persistence rates of the disorder.
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