| 51. |
- He, X. L., et al.
(författare)
-
Fast generation of Schrödinger cat states using a Kerr-tunable superconducting resonator
- 2023
-
Ingår i: Nature Communications. - 2041-1723 .- 2041-1723. ; 14:1
-
Tidskriftsartikel (refereegranskat)abstract
- Schrödinger cat states, quantum superpositions of macroscopically distinct classical states, are an important resource for quantum communication, quantum metrology and quantum computation. Especially, cat states in a phase space protected against phase-flip errors can be used as a logical qubit. However, cat states, normally generated in three-dimensional cavities and/or strong multi-photon drives, are facing the challenges of scalability and controllability. Here, we present a strategy to generate and preserve cat states in a coplanar superconducting circuit by the fast modulation of Kerr nonlinearity. At the Kerr-free work point, our cat states are passively preserved due to the vanishing Kerr effect. We are able to prepare a 2-component cat state in our chip-based device with a fidelity reaching 89.1% under a 96 ns gate time. Our scheme shows an excellent route to constructing a chip-based bosonic quantum processor.
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| 52. |
- Ho, Joshua W. K., et al.
(författare)
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Comparative analysis of metazoan chromatin organization
- 2014
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 512:7515, s. 449-U507
-
Tidskriftsartikel (refereegranskat)abstract
- Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to our understanding of molecular mechanisms of genome function in humans, and have revealed conservation of chromatin components and mechanisms(1-3). Nevertheless, the three organisms have markedly different genome sizes, chromosome architecture and gene organization. On human and fly chromosomes, for example, pericentric heterochromatin flanks single centromeres, whereas worm chromosomes have dispersed heterochromatin-like regions enriched in the distal chromosomal 'arms', and centromeres distributed along their lengths(4,5). To systematically investigate chromatin organization and associated gene regulation across species, we generated and analysed a large collection of genome-wide chromatin data sets from cell lines and developmental stages in worm, fly and human. Here we present over 800 new data sets from our ENCODE and modENCODE consortia, bringing the total to over 1,400. Comparison of combinatorial patterns of histone modifications, nuclear lamina-associated domains, organization of large-scale topological domains, chromatin environment at promoters and enhancers, nucleosome positioning, and DNA replication patterns reveals many conserved features of chromatin organization among the three organisms. We also find notable differences in the composition and locations of repressive chromatin. These data sets and analyses provide a rich resource for comparative and species-specific investigations of chromatin composition, organization and function.
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| 53. |
- Huang, D., et al.
(författare)
-
Electronic structure, defect properties, and optimization of the band gap of the earth-abundant and low-toxicity photovoltaic absorber Cu3SbS4
- 2022
-
Ingår i: Physical Chemistry, Chemical Physics - PCCP. - : Royal Society of Chemistry (RSC). - 1463-9076 .- 1463-9084. ; 24:41, s. 25258-25269
-
Tidskriftsartikel (refereegranskat)abstract
- Searching for an earth-abundant and environment-friendly absorber for thin-film solar cells that provides similar power conversion efficiency to CdTe and Cu(In,Ga)Se2 is of great importance for large-scale applications. Success would change the world's solar energy supply to an even more sustainable material resource. In this paper, we have studied by first-principles calculations the electronic structure and defect properties of the promising absorber Cu3SbS4. Its electronic properties, like direct band gap, high absorption coefficient, and light carrier effective masses, satisfy the requirements for an absorber except for its somewhat too small band gap energy. Sulfur and copper vacancies are easily formed defects in Cu3SbS4, where the S vacancy shrinks the band gap and degrades the material. This probably explains the experimental findings of a rather poor device performance. The suitable preparation conditions for Cu3SbS4 as an absorber are anticipated to be Cu-poor, Sb-moderate, and S-rich conditions. Herein, isovalent element alloying is demonstrated to be an effective way to increase the gap energy and thereby improve the material properties.
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| 54. |
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| 55. |
- Huang, Hongyun, et al.
(författare)
-
The 2022 yearbook of neurorestoratology
- 2023
-
Ingår i: JOURNAL OF NEURORESTORATOLOGY. - : Tsinghua University Press. - 2324-2426. ; 11:2
-
Forskningsöversikt (refereegranskat)abstract
- There was much progress in the field of Neurorestoratology in the year of 2022. It included highlighting advances in understanding the pathogenesis of neurological diseases, neurorestorative mechanisms, and clinical treatments as compiled in the 2022 yearbook of Neurorestoratology. There is still controversy about whether amyloid b-protein and tau protein deposition are the reasons for or the results of Alzheimer's disease (AD) pathology. The fabricated images in important key articles that speculated on the reasons for AD pathogenesis were found. Cholinergic deficiency and decrease or loss in strength of glutamatergic synapse, limited or failing bidirectional cholinergic upregulation in early cognitive impairment, or progressive posterior-to-anterior cortical cholinergic denervation could result in the appearance of AD. Exploration of neurorestorative mechanisms were found in more detail ways in neuromodulation, immunomodulation, neurogenesis, neural network or circuitry reconstruction, neuroprotection, nervous structural repair, and neuroplasticity. Several kinds of cell therapies for neurological diseases showed neurorestorative effects in open-label and/or non-randomized clinical studies or trials. However, mesenchymal stromal cells and mononuclear cells did not demonstrate neurorestorative effects or improve the quality of life for patients with neurodegenerative diseases or neurotrauma including stroke, spinal cord injury (SCI), and amyotrophic lateral sclerosis in randomized, double-blind, placebo-controlled clinical trials (RDPCTs). Clinical treatments through neurostimulation/neuromodulati on and the brain-computer/ machine interface yielded positive results in AD, Parkinson's disease, stroke, SCI, cerebral palsy, and other diseases in RDPCTs. Neurorestorative surgery, pharmaceutical neurorestorative therapy and other interventions have demonstrated neurorestorative effects for various considered incurable neurological diseases in RDPCTs. Thus, this year, additional guidelines, assessment scales, and standards were set up or revised. These included guidelines of clinical neurorestorative treatments for brain trauma (2022 China version), clinical cell therapy guidelines for neurorestoration (IANR/CANR 2022), SCI or dysfunction quality of life rating scale (SCIDQLRS) (IANR 2022 version). Neurorestorative effects of varying therapeutic stra-tegies with higher standards of evidence-based medicine are now benefiting patients with currently incurable neurological diseases. Hopefully some of them may become routine therapeutic interventions for patients with these diseases in the near future.
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| 56. |
- Huang, Hongyun, et al.
(författare)
-
The 2023 yearbook of Neurorestoratology
- 2024
-
Ingår i: JOURNAL OF NEURORESTORATOLOGY. - : Elsevier. - 2324-2426. ; 12:3
-
Forskningsöversikt (refereegranskat)abstract
- Remarkable advancements have been made in understanding the pathogenesis of Alzheimer's disease, Parkinson's disease, and other neurological disease; in our depth of understanding neurorestorative mechanisms such as anti-inflammatory processes, immune regulation, neuromodulation, neovascularization/neural repair, and neuroprotection; and in clinical neurorestorative treatments. Multiple types of cell therapies have been reported, with some positive outcomes. Diverse forms of neurostimulation and neuromodulation as well as brain-computer interfaces have shown good therapeutic outcomes in clinical applications. Further, therapeutic neurorestorative surgery and pharmaceutic therapy have been very impressive. These fundamental achievements are helpful for understanding the pathogenesis of neurological diseases and the mechanisms of neurorestoration. Patients with neurological impairments have benefited from therapeutic progress, but some of these therapies still require confirmation in higher-level randomized clinical trials.
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| 57. |
- Huang, Yi Shu, et al.
(författare)
-
Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis
- 2021
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 118:19
-
Tidskriftsartikel (refereegranskat)abstract
- Chronic inflammatory diseases like rheumatoid arthritis are characterized by a deficit in fully functional regulatory T cells. DNA-methylation inhibitors have previously been shown to promote regulatory T cell responses and, in the present study, we evaluated their potential to ameliorate chronic and acute animal models of rheumatoid arthritis. Of the drugs tested, decitabine was the most effective, producing a sustained therapeutic effect that was dependent on indoleamine 2,3-dioxygenase (IDO) and was associated with expansion of induced regulatory T cells, particularly at the site of disease activity. Treatment with decitabine also caused apoptosis of Th1 and Th17 cells in active arthritis in a highly selective manner. The molecular basis for this selectivity was shown to be ENT1, a nucleoside transporter, which facilitates intracellular entry of the drug and is up-regulated on effector T cells during active arthritis. It was further shown that short-term treatment with decitabine resulted in the generation of a population of regulatory T cells that were able to suppress arthritis upon adoptive transfer. In summary, a therapeutic approach using an approved drug is described that treats active inflammatory disease effectively and generates robust regulatory T cells with the IDO-dependent capacity to maintain remission.
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| 58. |
- Jiang, Bing-Xin, et al.
(författare)
-
Fabrication and bonding of In bumps on Micro-LED with 8 μ m pixel pitch
- 2024
-
Ingår i: ENGINEERING RESEARCH EXPRESS. - 2631-8695. ; 6:2
-
Tidskriftsartikel (refereegranskat)abstract
- Indium (In) is currently used to fabricate metal bumps on micro-light-emitting diode (Micro-LED) chips due to its excellent physical properties. However, as Micro-LED pixel size and pitch decrease, achieving high-quality In bumps on densely packed Micro-LED chips often presents more challenges. This paper describes the process of fabricating In bumps on micro-LEDs using thermal evaporation, highlighting an issue where In tends to grow laterally within the photoresist pattern, ultimately blocking the pattern and resulting in undersized and poorly dense In bumps on the Micro-LED chip. To address this issue, we conducted numerous experiments to study the height variation of In bumps within a range of photoresist aperture sizes (3 mu m -7 mu m) under two different resist thickness conditions (3.8 mu m and 4.8 mu m). The results showed that the resist thickness had a certain effect on the height of In bumps on the Micro-LED chip electrodes. Moreover, we found that, with the photoresist pattern size increasing under constant resist thickness conditions, the height and quality of the bumps significantly improved. Based on this finding, we rationalized the adjustment of the photoresist pattern size within a limited emission platform range to compensate for the height difference of In bumps caused by different resist thicknesses between the cathode and anode regions. Consequently, well-shaped and dense In bumps with a maximum height of up to 4.4 mu m were fabricated on 8 mu m pitch Micro-LED chips. Afterwards, we bonded the Micro-LED chip with indium bumps to the CMOS chip, and we found that we could successfully control the CMOS chip to drive the Micro-LED chip to display specific characters through the Flexible Printed Circuit (FPC). This work is of significant importance for the fabrication of In bumps on Micro-LED chips with pitches below 10 mu m and subsequent bonding processes.
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| 59. |
- Jiao, Zhejing, et al.
(författare)
-
InAs triangular quantum wells grown on InP/SiO 2 /Si heterogeneous substrate for mid-infrared emission
- 2021
-
Ingår i: Materials Science in Semiconductor Processing. - : Elsevier BV. - 1369-8001. ; 136
-
Tidskriftsartikel (refereegranskat)abstract
- The properties of InAs/In0.53Ga0.37As triangular quantum wells (QWs) grown on an InP/SiO2/Si integrated substrate by ion-slicing technology are investigated. The material structure and growth quality are characterized by the X-ray diffraction (XRD) and transmission electron microscope measurements. The photoluminescence (PL) spectra at various temperatures are also analyzed. The PL peak wavelengths red-shift from 1.94 to 2.13 μm with the increase of temperature from 12.4 to 300 K. The experimental results of the QWs on InP/SiO2/Si substrate are found to be comparable with the performance of the same QWs grown on an InP substrate. The results are promising for future integration of Si with InP-based optical devices for the applications of light emission in mid-infrared wavelength range.
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| 60. |
- Ju, Zhiping, et al.
(författare)
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First-principles prediction on Ag3SbS4 as a photovoltaic absorber
- 2023
-
Ingår i: Journal of Physics and Chemistry of Solids. - : Elsevier BV. - 0022-3697 .- 1879-2553. ; 183
-
Tidskriftsartikel (refereegranskat)abstract
- Generally, tetrahedrally coordinated Ag-based chalcogenides have wider band gaps than their Cu-based counterparts. Recent studies have suggested Cu3SbS4 as the absorber in low-cost and low-toxicity photovoltaic (PV), however its band gap is ∼0.5 eV smaller than the ideal value of ∼1.3 eV. In this work, we investigate Ag3SbS4 by first-principles means, since one can anticipate improved optical properties for this compound. The results indeed demonstrate that enargite Ag3SbS4 is a direct-gap semiconductor with a band gap of 1.38 eV, thus optimal for single-junction solar cells. Furthermore, its carrier effective masses, optical coefficients and spectroscopic limited maximum efficiency are comparable to well-established PV compounds. The compound exhibits also thermodynamical and dynamical stability. Hence, based on the present theoretical study we predict that Ag3SbS4 could be a candidate for absorber in high-efficient thin-film PVs.
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| 61. |
- Ke, You, et al.
(författare)
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Defect Passivation for Red Perovskite Light-Emitting Diodes with Improved Brightness and Stability
- 2019
-
Ingår i: The Journal of Physical Chemistry Letters. - : AMER CHEMICAL SOC. - 1948-7185. ; 10:3, s. 380-385
-
Tidskriftsartikel (refereegranskat)abstract
- Efficient and stable red perovskite light-emitting diodes (PeLEDs) are important for realizing full-color display and lighting. Red PeLEDs can be achieved either by mixed-halide or low-dimensional perovskites. However, the device performance, especially the brightness, is still low owing to phase separation or poor charge transport issues. Here, we demonstrate red PeLEDs based on three-dimensional (3D) mixed-halide perovskites where the defects are passivated by using 5-aminovaleric acid. The red PeLEDs with an emission peak at 690 nm exhibit an external quantum efficiency of 8.7% and a luminance of 1408 cd m(-2). A maximum luminance of 8547 cd m(-2) can be further achieved as tuning the emission peak to 662 nm, representing the highest brightness of red PeLEDs. Moreover, those LEDs exhibit a half-life of up to 8 h under a high constant current density of 100 mA cm(-2), which is over 10 times improvement compared to literature results.
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| 62. |
- Köksal, Elif Senem, et al.
(författare)
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Rapid Growth and Fusion of Protocells in Surface-Adhered Membrane Networks
- 2020
-
Ingår i: Small. - : Wiley. - 1613-6810 .- 1613-6829. ; 16:38
-
Tidskriftsartikel (refereegranskat)abstract
- Elevated temperatures might have promoted the nucleation, growth, and replication of protocells on the early Earth. Recent reports have shown evidence that moderately high temperatures not only permit protocell assembly at the origin of life, but can have actively supported it. Here, the fast nucleation and growth of vesicular compartments from autonomously formed lipid networks on solid surfaces, induced by a moderate increase in temperature, are shown. Branches of the networks, initially consisting of self-assembled interconnected nanotubes, rapidly swell into microcompartments which can spontaneously encapsulate RNA fragments. The increase in temperature further causes fusion of adjacent network-connected compartments, resulting in the redistribution of the RNA. The experimental observations and the mathematical model indicate that the presence of nanotubular interconnections between protocells facilitates the fusion process.
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| 63. |
- Lange, Leslie A, et al.
(författare)
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Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.
- 2014
-
Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 94:2, s. 233-245
-
Tidskriftsartikel (refereegranskat)abstract
- Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To determine whether rare or low-frequency coding variants are associated with LDL-C, we exome sequenced 2,005 individuals, including 554 individuals selected for extreme LDL-C (>98(th) or <2(nd) percentile). Follow-up analyses included sequencing of 1,302 additional individuals and genotype-based analysis of 52,221 individuals. We observed significant evidence of association between LDL-C and the burden of rare or low-frequency variants in PNPLA5, encoding a phospholipase-domain-containing protein, and both known and previously unidentified variants in PCSK9, LDLR and APOB, three known lipid-related genes. The effect sizes for the burden of rare variants for each associated gene were substantially higher than those observed for individual SNPs identified from GWASs. We replicated the PNPLA5 signal in an independent large-scale sequencing study of 2,084 individuals. In conclusion, this large whole-exome-sequencing study for LDL-C identified a gene not known to be implicated in LDL-C and provides unique insight into the design and analysis of similar experiments.
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| 64. |
- Leng, Xue-Li, et al.
(författare)
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Spiral Coil Inserts for Heat Transfer Enhancement in a Parallel-plate Channel
- 2014
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Ingår i: Numerical Heat Transfer Part A: Applications. - : Informa UK Limited. - 1040-7782 .- 1521-0634. ; 66:7, s. 756-772
-
Tidskriftsartikel (refereegranskat)abstract
- The flow fields and heat transfer characteristics in a parallel-plate channel with a transversely placed spiral coil insert were investigated by three-dimensional numerical simulation. The structure of multi-longitudinal-vortices (MLVs) induced by the spiral coil and the effects of MLVs on velocity and temperature fields were studied. The three-dimensional spiral coil induces a series of longitudinal vortices in the channel including leading longitudinal vortex, mainstream longitudinal vortices, near-wall longitudinal vortices, and rear central longitudinal vortex. Transport by the longitudinal vortices can increase the mass exchange between the boundary layer and the mainstream, which speeds up the heat migration from the channel walls and enhances the heat diffusion in the mainstream.
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| 65. |
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| 66. |
- Li, Danqin, et al.
(författare)
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n-Doping of photoactive layer in binary organic solar cells realizes over 18.3% efficiency
- 2022
-
Ingår i: Nano Energy. - : ELSEVIER. - 2211-2855 .- 2211-3282. ; 96
-
Tidskriftsartikel (refereegranskat)abstract
- Electronic doping of conjugated semiconductor plays a critical role in the fabrication of high efficiency organic optoelectronic devices. Here, we report an organic solar cell (OSC) by doping n-type DMBI-BDZC into one host binary bulk heterojunction (BHJ) photoactive layer comprised of a polymer donor PM6 and a nonfullerene acceptor Y6. The resulting champion device yields a significantly improved power conversion efficiency from 17.17% to 18.33% with an impressive fill factor of 80.20%. It is found that the electrically doped photoactive layer exhibits enhanced and balanced charge carrier mobilities, more effective exciton dissociation, longer carrier lifetime, and suppressed charge recombination with smaller energy loss. The dopant molecule DMBIBDZC also act as a surface morphology modifier of the photoactive layer with enhanced charge transport. This work demonstrates that manipulation of charge transport via adding a low concentration dopant into photoactive layer is a promising approach for further improvement of BHJ OSC performance.
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| 67. |
- Liang, Pu-Lin, et al.
(författare)
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Three polymethoxyflavones from the peel of Citrus reticulata "Chachi" inhibits oxidized low-density lipoprotein-induced macrophage-derived foam cell formation
- 2022
-
Ingår i: Frontiers in Cardiovascular Medicine. - : Frontiers Media S.A.. - 2297-055X. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Foam cell formation is the hallmark of the development and progression of atherosclerosis. The aim of this study was to investigate the regulatory effects of three polymethoxyflavones (PMFs), namely, tangeretin (TAN), 5,6,7,3 ',4 ',5 '-hexamethoxyflavone (HxMF), and 3,5,6,7,8,3 ',4 '-heptamethoxyflavone (HpMF) on macrophage-derived foam cell formation and to further explore the molecular mechanisms. The RAW264.7 macrophage-derived foam cell model was successfully induced by oxidized low-density lipoprotein (ox-LDL) (80 mu g/ml). It showed that TAN, HxMF, and HpMF alleviated ox-LDL-induced NO release while also inhibiting the expression of IL-1 beta, IL-6, and TNF-alpha in RAW264.7 cells. Uptake of excess ox-LDL was inhibited by TAN, HxMF, and HpMF, resulting in the reduction of its foam cell formation. Moreover, TAN, HxMF, and HpMF promoted HDL-mediated cholesterol efflux. Western blot experiment showed that TAN, HxMF, and HpMF inhibited the expression of scavenger receptor class A type I (SRA1) and cluster of differentiation 36 (CD36), while upregulating peroxisome proliferator-activated receptor gamma (PPAR gamma), liver X receptor alpha (LXR alpha), phospholipid ATP-binding cassette transporter G1 (ABCG1), and scavenger receptor class B type I (SRB1) expression. Together, our findings suggested that PMFs inhibited foam cell formation might inhibit lipid uptake via downregulating SRA1/CD36 expression and promote cholesterol efflux from foam cells via upregulating PPAR gamma/LXR alpha/ABCG1/SRB1 expression. This antiatherosclerotic activity is expected to provide new insights into the development of healthcare uses for PMFs.
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| 68. |
- Lin, Chen, et al.
(författare)
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Concomitant use of Ad5/35 chimeric oncolytic adenovirus with TRAIL gene and taxol produces synergistic cytotoxicity in gastric cancer cells
- 2009
-
Ingår i: Cancer Letters. - : Elsevier BV. - 1872-7980 .- 0304-3835. ; 284:2, s. 141-148
-
Tidskriftsartikel (refereegranskat)abstract
- Chimeric adenoviral vectors possessing fiber derived from human adenovirus subgroup B (Ad35) have been developed for their high infection efficiency in cell types which are refractory to adenovirus serotype 5 (Subgroup C) The present study constructed an E1B-deleted chimeric oncolytic adenovirus, SG235-TRAIL, which carries a human TRAIL gene expression cassette and whose fiber shaft and knob domains are from serotype AM. It was found that SG235-TRAIL preferentially replicated in gastric cancer cell lines, SGC-7901 and BGC-823 compared to in normal human fibroblast BJ cells. Also, when compared with a replication-deficient chimeric vector Ad5/35-TRAIL, SG235-TRAIL mediated a higher level of the transgene expression via viral replication in the cancer cells. Further, because of the more efficient cell-entry and infection, SG235-TRAIL induced stronger cell apoptosis than the Ad5 CRAD vector, ZD55-TRAIL In addition, SG235-TRAIL in combination with the chemotherapeutic drug, taxol, produced a synergistic cytotoxic effect in cancer cells in vitro without causing significant toxicity to normal cells. In the gastric tumor xenograft mouse model, intratumoral SG235-TRAIL injection produced a significant antitumor effect 14 days after treatment. Pathological examination demonstrated TRAIL expression and associated apoptosis in majority of SG235-TRAIL-treated tumor cells. These results suggest that SG235-TRAIL is a potential novel, efficient anti-cancer agent, and in combination with taxol, it would be even more useful with considerably low toxic side effects. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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| 69. |
- Lin, Lizhi, et al.
(författare)
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Anoikis-related genes linked with patient outcome in pancreatic cancer
-
Ingår i: Gene. - 0378-1119. ; 930, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- Anoikis is programmed cell death occurring upon cell detachment from the extracellular matrix. Cancer cells need to evade anoikis to be able to metastasize to distant sites. However, the molecular features and prognostic value of anoikis-related genes (ARGs) in pancreatic cancer remain unclear. In this study, we utilized transcriptome data from the TCGA and GSE102238 databases to identify 64 ARGs significantly associated with prognosis. We used the "ConsensusClusterPlus" R package to stratify patients into high and low-risk prognostic subgroups. The KEGG and GSEA analyses revealed that the clusters with poor prognosis were enriched for the ECM receptor interaction pathway, the TP53 signaling pathway, and the galactose metabolism pathway, and that the cell cycle pathway was upregulated. A prognostic model consisting of seven ARGs (SERPINE1, EGF, E2F1, MSLN, RAB27B, ETV7, MST1) was constructed using LASSO regression and when combined with clinicopathological parameters using Cox regression, a prognostic Nomogram was created, which demonstrated high prognostic utility. Among the biomarker candidates, we report ETV7 as a novel, independent prognostic marker in pancreatic cancer. ETV7 was highly expressed in KRAS and TP53 co-occurrent mutant TCGA patients, indicating that it may be regulated by the two major driver genes of pancreatic cancer. Therefore, targeting ETV7 could be a potential focus for future therapeutic studies.
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| 70. |
- Lin, Qi, et al.
(författare)
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Characterization of lacustrine harmful algal blooms using multiple biomarkers : historical processes, driving synergy, and ecological shifts
- 2023
-
Ingår i: Water Research. - : Elsevier. - 0043-1354 .- 1879-2448. ; 235
-
Tidskriftsartikel (refereegranskat)abstract
- Harmful algal blooms (HABs) producing toxic metabolites are increasingly threatening environmental and human health worldwide. Unfortunately, long-term process and mechanism triggering HABs remain largely unclear due to the scarcity of temporal monitoring. Retrospective analysis of sedimentary biomarkers using up-to-date chromatography and mass spectrometry techniques provide a potential means to reconstruct the past occurrence of HABs. By combining aliphatic hydrocarbons, photosynthetic pigments, and cyanotoxins, we quantified herein century-long changes in abundance, composition, and variability of phototrophs, particularly toxigenic algal blooms, in China's third largest freshwater Lake Taihu. Our multi-proxy limnological reconstruction revealed an abrupt ecological shift in the 1980s characterized by elevated primary production, Microcystis-dominated cyanobacterial blooms, and exponential microcystin production, in response to nutrient enrichment, climate change, and trophic cascades. The empirical results from ordination analysis and generalized additive models support climate warming and eutrophication synergy through nutrient recycling and their feedback through buoyant cyanobacterial proliferation, which sustain bloom-forming potential and further promote the occurrence of increasingly-toxic cyanotoxins (e.g., microcystin-LR) in Lake Taihu. Moreover, temporal variability of the lake ecosystem quantified using variance and rate of change metrics rose continuously after state change, indicating increased ecological vulnerability and declined resilience following blooms and warming. With the persistent legacy effects of lake eutrophication, nutrient reduction efforts mitigating toxic HABs probably be overwhelmed by climate change effects, emphasizing the need for more aggressive and integrated environmental strategies.
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| 71. |
- Lin, Xue, et al.
(författare)
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Controlled release of matrix metalloproteinase-1 plasmid DNA prevents left ventricular remodeling in chronic myocardial infarction of rats.
- 2009
-
Ingår i: Circulation journal : official journal of the Japanese Circulation Society. - 1347-4820. ; 73:12, s. 2315-21
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The present study investigated whether administration of controlled release matrix metalloproteinase-1 (MMP-1) plasmid DNA prevents left ventricular (LV) remodeling in a rat chronic myocardial infarction (MI) model. METHODS AND RESULTS: Rats with a moderate-sized MI were randomized to 2 groups: injection of phosphate buffered saline (PBS) containing microspheres into the peri-infarct area (MI group, n=14) and injection of cationized gelatin microspheres incorporating MMP-1 plasmid DNA (MI+MMP-1 group, 50 microg MMP-1/20 microl; n=14). As a control group (n=14), rats received neither the coronary artery ligation nor the injection of PBS. Echocardiography, cardiac catheterization and histological studies were performed. At 2 and 4 weeks after the treatment, the MI+MMP-1 group had smaller LV end-diastolic and end-systolic dimensions, better fractional area change and smaller akinetic areas than the MI group. The LV end-systolic elastance and time constant of isovolumic relaxation were also better in the MI+MMP-1 group compared with the MI group 4 weeks after the treatment. Fibrosis evaluated with Masson's trichrome staining was less in the MI+MMP-1 group than the MI group. CONCLUSIONS: Gelatin microspheres for the controlled release of MMP-1 plasmid DNA are promising for improving cardiac remodeling and function when they are administered during the chronic phase of MI.
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| 72. |
- Lin, Xue, et al.
(författare)
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Controlled release of matrix metalloproteinase 1 with or without skeletal myoblasts transplantation improves cardiac function of rat hearts with chronic myocardial infarction.
- 2009
-
Ingår i: Tissue engineering. Part A. - : Mary Ann Liebert Inc. - 1937-335X .- 1937-3341. ; 15:9, s. 2699-706
-
Tidskriftsartikel (refereegranskat)abstract
- Skeletal myoblast transplantation has been applied clinically for severe ischemic cardiomyopathy. Matrix metalloproteinase 1 (MMP-1) reduces fibrosis and prevents the progress of heart failure. We hypothesized that MMP-1 administration to the infarct area enhances the efficacy of skeletal myoblast transplantation. The controlled release of MMP-1 improved cardiac functions of rats with chronic myocardiac infarction with or without transplantation of skeletal myoblasts. Improvement in cardiac function and small fibrotic area inside the infarcted area were observed compared with those of myoblast transplantation. In conclusion, controlled release of MMP-1 was effective in cardioprotection in postmyocardial infarction although the combination with cell transplantation showed the similar effect.
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| 73. |
- Liu, Jun, et al.
(författare)
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Microbial community structure and function in sediments from e-waste contaminated rivers at Guiyu area of China
- 2018
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Ingår i: Environmental Pollution. - : Elsevier BV. - 0269-7491. ; 235, s. 171-179
-
Tidskriftsartikel (refereegranskat)abstract
- The release of toxic organic pollutants and heavy metals by primitive electronic waste (e-waste) processing to waterways has raised significant concerns, but little is known about their potential ecological effects on aquatic biota especially microorganisms. We characterized the microbial community composition and diversity in sediments sampled along two rivers consistently polluted by e-waste, and explored how community functions may respond to the complex combined pollution. High-throughput 16S rRNA gene sequencing showed that Proteobacteria (particularly Deltaproteobacteria) dominated the sediment microbial assemblages followed by Bacteroidetes, Acidobacteria, Chloroflexi and Firmicutes. PICRUSt metagenome inference provided an initial insight into the metabolic potentials of these e-waste affected communities, speculating that organic pollutants degradation in the sediment might be mainly performed by some of the dominant genera (such as Sulfuricurvum, Thiobacillus and Burkholderia) detected in situ. Statistical analyses revealed that toxic organic compounds contributed more to the observed variations in sediment microbial community structure and predicted functions (24.68% and 8.89%, respectively) than heavy metals (12.18% and 4.68%), and Benzo(a)pyrene, bioavailable lead and electrical conductivity were the key contributors. These results have shed light on the microbial assemblages in e-waste contaminated river sediments, indicating a potential influence of e-waste pollution on the microbial community structure and function in aquatic ecosystems.
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| 74. |
- Liu, Xue, et al.
(författare)
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Isomorphous Incorporation of Tin Ions into Germanosilicate Framework Assisted by Local Structural Rearrangement
- 2016
-
Ingår i: ACS Catalysis. - : American Chemical Society (ACS). - 2155-5435. ; 6:12, s. 8420-8431
-
Tidskriftsartikel (refereegranskat)abstract
- The crystalline structure of UTL zeolite experienced an unusual orientated collapse and reconstruction within an extremely narrow time window during the structural stabilization process by nitric acid treatment at elevated temperature. Taking full advantage of this unique structural change, extra-large pore Sn-UTL zeolites were postsynthesized via the reaction between the SnCl4 molecules and the silanols in the hydroxyl nests, which occurred concomitantly with the removal of Ge and/or Si species from the dense layer. The original UTL topology was restored thereafter, leading to a Sn-incorporated analogue. The usage of the most seriously collapsed intermediate structure, which was captured by timing during the precisely controlled acid treatment, was vital for achieving Sn-UTL zeolites with a larger amount of isolated Sn species effectively incorporated. With tetrahedrally coordinated Sn ions in the highly stabilized UTL topology consisting of intersecting 12- and 14-membered ring (MR) pore channels, Sn-UTL showed promising catalytic performance in the Meerwein-Pondorf-Verley reaction as well as in the Baeyer-Villiger oxidation reactions of ketones using H2O2 or even bulky tert-butyl hydroperoxide (TBHP) as an oxidant.
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| 75. |
- Ma, Lin Lu, et al.
(författare)
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Coronavirus Disease 2019 Related Clinical Studies : A Cross-Sectional Analysis
- 2020
-
Ingår i: Frontiers in Pharmacology. - : Frontiers Media SA. - 1663-9812. ; 11
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: The quality and rationality of many recently registered clinical studies related to coronavirus disease 2019 (COVID-19) needs to be assessed. Hence, this study aims to evaluate the current status of COVID-19 related registered clinical trial. Methods: We did an electronic search of COVID-19 related clinical studies registered between December 1, 2019 and February 21, 2020 (updated to May 28, 2020) from the ClinicalTrials.gov, and collected registration information, study details, recruitment status, characteristics of the subjects, and relevant information about the trial implementation process. Results: A total of 1,706 studies were included 10.0% of which (n=171) were from France, 943 (55.3%) used an interventional design, and 600 (35.2%) used an observational design. Most of studies (73.6%) aimed to recruit fewer than 500 people. Interferon was the main prevention program, and antiviral drugs were the main treatment program. Hydroxychloroquine and chloroquine (230/943, 24.4%) were widely studied. Some registered clinical trials are incomplete in content, and 37.4% of the 1,706 studies may have had insufficient sample size. Conclusion: The quality of COVID-19 related studies needs to be improved by strengthening the registration process and improving the quality of clinical study protocols so that these clinical studies can provide high-quality clinical evidence related to COVID-19.
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| 76. |
- Nguyen, Thao Duy, et al.
(författare)
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Monobutyrin and monovalerin affect brain short-chain fatty acid profiles and tight-junction protein expression in apoe-knockout rats fed high-fat diets
- 2020
-
Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 12:4
-
Tidskriftsartikel (refereegranskat)abstract
- Monobutyrin (MB) and monovalerin (MV), esters of short-chain fatty acids (SCFAs), have previously been shown to reduce liver cholesterol and inflammation in conventional rats fed high-fat diets. This study explored the potential effects of MB and MV in hypercholesterolemic apolipoprotein E-knockout (ApoE-/-) rats. ApoE-/-rats were fed three high-fat (HF) diets, pure or supplemented with MB or MV (1%), for 5 weeks. One group of conventional rats (C) was also fed the pure high-fat diet and another group of ApoE-/-rats a low-fat (LF) diet. Blood and liver lipids, urinary lactulose/mannitol, SCFAs (blood and brain), tight junction proteins (small intestine and brain), and inflammation-related markers (blood, brain, and liver) were analyzed. MV supplementation elevated serum high-density lipoprotein (HDL) cholesterol and valeric acid concentration (p < 0.05), while the amounts of isovaleric acid in the brain were reduced (p < 0.05). MB increased butyric acid amounts in the brain, while the plasma concentration of interleukin 10 (IL-10) was lowered (p < 0.05). Both MV and MB upregulated the expression of occludin and zonula occludens-1 (ZO-1) in the brain (p < 0.05). Supplementation of MB or MV affected HDL cholesterol, the expression of tight junction proteins, and SCFA profiles. MB and MV may therefore be promising supplements to attenuate lipid metabolic disorders caused by high-fat intake and genetic deficiency.
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| 77. |
- Pang, Xiaodan, Dr., et al.
(författare)
-
200 Gbps/lane IM/DD Technologies for Short Reach Optical Interconnects
- 2020
-
Ingår i: Journal of Lightwave Technology. - 0733-8724 .- 1558-2213. ; 38:2
-
Tidskriftsartikel (refereegranskat)abstract
- Client-side optics are facing an ever-increasing upgrading pace, driven by upcoming 5G related services and datacenter applications. The demand for a single lane data rate is soon approaching 200 Gbps. To meet such high-speed requirements, all segments of traditional intensity modulation direct detection (IM/DD) technologies are being challenged. The characteristics of electrical and optoelectronic components, and the performance of modulation, coding and digital signal processing (DSP) techniques are being stretched to their limits. In this context, we witnessed technological breakthroughs in several aspects, including development of broadband devices, novel modulation formats and coding, and high-performance DSP algorithms for the past few years. A great momentum has been accumulated to overcome the aforementioned challenges. In this paper, we focus on IM/DD transmissions, and provide an overview of recent research and development efforts on key enabling technologies for 200 Gbps per lane and beyond. Our recent demonstrations of 200 Gbps short-reach transmissions with 4-level pulse amplitude modulation (PAM) and discrete multitone signals are also presented as examples to show the system requirements in terms of device characteristics and DSP performance. Apart from digital coherent technologies and advanced direct detection systems, such as Stokes-vector and Kramers-Kronig schemes, we expect high-speed IM/DD systems will remain advantageous in terms of system cost, power consumption and footprint for short reach applications in the short- to mid- term perspective.
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| 78. |
- Pang, Xiaodan, Dr., et al.
(författare)
-
200 Gbps & x002F;Lane IM & x002F;DD Technologies for Short Reach Optical Interconnects
- 2020
-
Ingår i: Journal of Lightwave Technology. - : Institute of Electrical and Electronics Engineers (IEEE). - 0733-8724 .- 1558-2213. ; 38:2, s. 492-503
-
Tidskriftsartikel (refereegranskat)abstract
- Client-side optics are facing an ever-increasing upgrading pace, driven by upcoming 5G related services and datacenter applications. The demand for a single lane data rate is soon approaching 200 Gbps. To meet such high-speed requirement, all segments of traditional intensity modulation direct detection (IM & x002F;DD) technologies are being challenged. The characteristics of electrical and optoelectronic components and the performance of modulation, coding, and digital signal processing (DSP) techniques are being stretched to their limits. In this context, we witnessed technological breakthroughs in several aspects, including development of broadband devices, novel modulation formats and coding, and high-performance DSP algorithms for the past few years. A great momentum has been accumulated to overcome the aforementioned challenges. In this article, we focus on IM & x002F;DD transmissions, and provide an overview of recent research and development efforts on key enabling technologies for 200 Gbps per lane and beyond. Our recent demonstrations of 200 Gbps short-reach transmissions with 4-level pulse amplitude modulation (PAM) and discrete multitone signals are also presented as examples to show the system requirements in terms of device characteristics and DSP performance. Apart from digital coherent technologies and advanced direct detection systems, such as Stokes-vector and Kramers-Kronig schemes, we expect high-speed IM & x002F;DD systems will remain advantageous in terms of system cost, power consumption, and footprint for short reach applications in the short- to mid- term perspective.
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| 79. |
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| 80. |
- Premaratne, Goditha U, et al.
(författare)
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Stromal Vascular Fraction Transplantation as an Alternative Therapy for Ischemic Heart Failure: Anti-inflammatory Role.
- 2011
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Ingår i: Journal of cardiothoracic surgery. - : Springer Science and Business Media LLC. - 1749-8090. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- ABSTRACT: Background The aims of this study were: (1) to show the feasibility of using adipose-derived stromal vascular fraction (SVF) as an alternative to bone marrow mono nuclear cell (BM-MNC) for cell transplantation into chronic ischemic myocardium; and (2) to explore underlying mechanisms with focus on anti-inflammation role of engrafted SVF and BM-MNC post chronic myocardial infarction (MI) against left ventricular (LV) remodelling and cardiac dysfunction. Methods Four weeks after left ante rior descending coronary artery ligation, 32 Male Lewis rats with moderate MI were divided into 3 groups. SVF group (n = 12) had SVF cell transplantation (6 × 106 cells). BM-MNC group (n = 12) received BM-MNCs (6 × 106) and the control (n = 10) had culture medium. At 4 weeks, after the final echocardiography, histological sections were stained with Styrus red and immunohistochemical staining was performed for α-smooth muscle actin, von Willebrand factor, CD3, CD8 and CD20. Results At 4 weeks, in SVF and BM-MNC groups, LV diastolic dimension and LV systolic dimension were smaller and fractional shortening was increased in echocardiography, compared to control group. Histology revealed highest vascular density, CD3+ and CD20+ cells in SVF transplanted group. SVF transplantation decreased myocardial mRNA expression of inflammatory cytokines TNF-α, IL-6, MMP-1, TIMP-1 and inhibited collagen deposition. Conclusions Transplantation of adipose derived SVF cells might be a useful therapeutic option for angiogenesis in chronic ischemic heart disease. Anti-inflammation role for SVF and BM transplantation might partly benefit for the cardioprotective effect for chronic ischemic myocardium.
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| 81. |
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| 82. |
- Shao, Xue-Feng, et al.
(författare)
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Hydroxyl group functionalized graphene oxide nanosheets as additive for improved erythritol latent heat storage performance : A comprehensive evaluation on the benefits and challenges
- 2020
-
Ingår i: Solar Energy Materials and Solar Cells. - : Elsevier BV. - 0927-0248 .- 1879-3398. ; 215
-
Tidskriftsartikel (refereegranskat)abstract
- Graphene oxide (GO) nanosheets were employed as the additive to make composites of erythritol, a promising medium-temperature PCM candidate. GO nanosheets modified with hydroxyl groups were applied to improve the dispersion stability of the composites. A systematic characterization on the latent heat storage performance was performed for both pure and composite erythritol, in order to identify the benefits and challenges of the composites. It was found that the thermal conductivity is increased by nearly twice and the degree of supercooling was lowered from ~64 °C to ~48 °C at the loading of 1.0 wt% GO nanosheets (the maximum loading tested). The addition of GO nanosheets also leads to an increase of the retrievable latent heat during crystallization, from ~187 kJ/kg to ~225 kJ/kg at the same loading, by increasing the crystallinity. However, the introduction of GO nanosheets can also lead to a rise in the dynamic viscosity of erythritol. As a result, the crystallization rate is slowed down and accordingly, the duration of crystallization becomes 62% longer when the loading reaches 1.0 wt%. In addition, favorable dispersion stability of the erythritol composites is observed, and their melting point (~117 °C) remains almost unchanged during 50 melting-crystallization cycles. Functionalized GO nanosheets have been shown to be an efficient additive for improving the performance of erythritol, but a trade-off analysis on the loading would be required to achieve the best overall performance.
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| 83. |
- Shao, Xue-Feng, et al.
(författare)
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Polyvinylpyrrolidone (PVP)-enabled significant suppression of supercooling of erythritol for medium-temperature thermal energy storage
- 2022
-
Ingår i: Journal of Energy Storage. - : Elsevier BV. - 2352-152X .- 2352-1538. ; 46, s. 103915-
-
Tidskriftsartikel (refereegranskat)abstract
- The supercooling effect is deemed to be a crucial issue for thermal energy storage using phase change materials (PCMs). The exploration of promising additives plays a decisive role in effective suppression efforts for suppressing the supercooling effect of a PCM. The present work proposed a potential additive, polyvinylpyrrolidone (PVP), to reduce the supercooling of erythritol, which is the most promising polyol PCM candidate for medium temperature range. PVP with various loadings was dispersed in erythritol to make composites for the proof-of-concept tests. It was shown that the degree of supercooling of erythritol can be reduced significantly from over 64 ? to about 21 ? in the presence of only 1.0 wt.% PVP. Along with the mitigated supercooling effect, the addition of PVP also leads to an increase of the retrievable latent heat during crystallization, from ~187 J/g to ~224 J/g at the same minute PVP loading of 1.0 wt.%, by increasing the crystallinity of erythritol. The PVP-loaded erythritol composites exhibit little sacrifice in latent heat of fusion, i.e., only ~15% loss when the PVP loading reaches 6.0 wt.%. In addition, multiple tests confirmed that PVP can be dissolved in erythritol, thus desirable compatibility was obtained and the composites would have long-term reliability. This proposed additive enables an efficient and cost-effective way for improving the crystallization behaviors of erythritol (and other polyol PCMs) towards real-world applications.
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| 84. |
- Shi, Xue, et al.
(författare)
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A strong, biodegradable, and recyclable all-lignocellulose fabricated triboelectric nanogenerator for self-powered disposable medical monitoring
- 2023
-
Ingår i: Journal of Materials Chemistry A. - 2050-7488 .- 2050-7496. ; 11:22, s. 11730-11739
-
Tidskriftsartikel (refereegranskat)abstract
- The growing demand for fast, reliable, and accessible information in the vastly connected world makes disposable sensors increasingly important. However, reducing their costs, environmental impact, and usability remains challenging. Here, we report a low-cost, biodegradable, and recyclable all-lignocellulosic triboelectric nanogenerator (AL-TENG) for self-powered disposable medical monitoring. Based on a facile in situ lignin regeneration & chemical crosslinking modification strategy, a high-performance lignocellulosic bioplastic is synthesized from resource-abundant and renewable biomass for fabricating the AL-TENG. The whole device has a low environmental impact as it can be easily recycled and biodegraded at its end-of-life. Furthermore, a self-powered smart ward system and a self-powered contactless medical monitoring system are developed to improve the convenience for patients and reduce the risk of mutual infection. This work can expand the application of self-powered systems to disposable medical sensing, which may greatly promote the development of intelligent wards and disposable electronics.
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| 85. |
- Spustova, Karolina, et al.
(författare)
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Manipulation of Lipid Membranes with Thermal Stimuli
- 2022
-
Ingår i: Methods in Molecular Biology. - New York, NY : Springer US. - 1940-6029 .- 1064-3745. ; 2402, s. 209-225
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- We describe a protocol for the assembly and application of infrared (IR-B) laser-based set-ups to be used for localized heating of solid-supported planar and vesicular lipid membrane assemblies.
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| 86. |
- Sun, Hui-Min, et al.
(författare)
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SERPINA4 is a novel independent prognostic indicator and a potential therapeutic target for colorectal cancer
- 2016
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Ingår i: American Journal of Cancer Research. - Madison : E-CENTURY PUBLISHING CORP. - 2156-6976. ; 6:8, s. 1636-1649
-
Tidskriftsartikel (refereegranskat)abstract
- Serpina family A member 4 (SERPINA4), also known as kallistatin, exerts important effects in inhibiting tumor growth and angiogenesis in many malignancies. However, the precise role of SERPINA4 in CRC has not been fully elucidated. The present study aimed to investigate the expression of SERPINA4 and its clinical significance in CRC. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analyses showed that the mRNA and protein expression of SERPINA4 in colorectal cancer (CRC) specimens was significantly decreased than that in adjacent normal mucosa. Immunohistochemistry (IHC) was conducted to characterize the expression pattern of SERPINA4 by using a tissue microarray (TMA) containing 327 archived paraffin-embedded CRC specimens. Statistical analyses revealed that decreased SERPINA4 expression was significantly associated with invasion depth, nodal involvement, distant metastasis, American Joint Committee on Cancer (AJCC) stage, and tumor differentiation. SERPINA4 was also an independent prognostic indicator of disease-free survival and overall survival in patients with CRC. Furthermore, the impact of altered SERPINA4 expression on CRC cells was analyzed with a series of in vitro and in vivo assays. The results demonstrated that SERPINA4 significantly inhibits malignant tumor progression and serves as a novel prognostic indicator and a potential therapeutic target for CRC.
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| 87. |
- Tan, Xiaoqin, et al.
(författare)
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Band gap tailoring in a low toxicity and low-cost solar cell absorber Cu3SbS4 through Na alloying : A first-principles study
- 2023
-
Ingår i: Journal of Crystal Growth. - : Elsevier BV. - 0022-0248 .- 1873-5002. ; 607
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Tidskriftsartikel (refereegranskat)abstract
- High power conversion efficiency, high stability, low cost, and environmentally friendly manufacturing are the main requirements for a commercializable photovoltaic device. Cu3SbS4 is an eco-friendly and earth-abundant compound that is studied as a potential solar cell absorber. However, its band gap is smaller than the ideal value. In this work, the possibility to modulate and improve the band gap by sodium alloying has been investigated by means of the first-principles density functional theory with the HSE06 hybrid functional. Our results demonstrate that the Cu3-xNaxSbS4 alloy with a high alloying concentration should be possible to realize, and that the Na incorporation widens the gap. An alloy concentration of x approximate to 0.64 yields the desired gap for a solar light absorber, which can then lead to a more efficient solar cell.
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| 88. |
- Tang, Hu, et al.
(författare)
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Boron-Rich Molybdenum Boride with Unusual Short-Range Vacancy Ordering, Anisotropic Hardness, and Superconductivity
- 2020
-
Ingår i: Chemistry of Materials. - : AMER CHEMICAL SOC. - 0897-4756 .- 1520-5002. ; 32:1, s. 459-467
-
Tidskriftsartikel (refereegranskat)abstract
- Determination of the structures of materials involving more light elements such as boron-rich compounds is challenging and technically important in understanding their varied compositions and superior functionalities. Here we resolve the long-standing uncertainties in structure and composition about the highest boride (termed MoB4, Mo1-xB3, or MoB3) through the rapid formation of large sized boron-rich molybdenum boride under pressure. Using high-quality single-crystal X-ray diffraction analysis and aberration-corrected scanning transmission electron microscopy, we reveal that boron-rich molybdenum boride with a composition of Mo0.757B3 exhibits P6(3)/mmc symmetry with a partial occupancy of 0.514 in 211 Mo sites (Mol), and direct observations reveal the short-range ordering of cation vacancies in (010) crystal planes. Large anisotropic Young's moduli and Vickers hardness are seen for Mo0.757B3, which may be attributed by its two-dimensional boron distributions. Mo0.757B3 is also found to be superconducting with a transition temperature (T-c) of 2.4 K, which was confirmed by measurements of resistivity and magnetic susceptibility. Theoretical calculations suggest that the partial occupancy of Mo atoms plays a crucial role in the emergence of superconductivity.
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| 89. |
- Wan, Lu Ming, et al.
(författare)
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Heparanase Facilitates PMA-Induced Megakaryocytic Differentiation in K562 Cells via Interleukin 6/STAT3 Pathway
- 2020
-
Ingår i: Thrombosis and Haemostasis. - : GEORG THIEME VERLAG KG. - 0340-6245 .- 2567-689X. ; 120:4, s. 647-657
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Tidskriftsartikel (refereegranskat)abstract
- Heparanase (HPSE) is an endo-beta-D-glucuronidase that cleaves heparan sulfate and hence participates in remodeling of the extracellular matrix, leading to release of cytokines that are immobilized by binding to heparan sulfate proteoglycans (HSPGs), and consequently activating signaling pathways. This function of HPSE is correlated to its expression level that is normally very low in majority of the tissues. Exceptionally, human platelets express high level of HPSE, suggesting a unique physiological role in this cell. Using K562 cell line, we found a progressive increase of HPSE during the megakaryocytic differentiation. Analysis of a series of megakaryocytic differentiation-related heparin-binding proteins (HBPs) in the cell culture medium revealed an exclusive positive correlation between the level of interleukin 6 (IL-6) and HPSE expression. IL-6 modulated megakaryocytic differentiation through activation of STAT3. Further, we demonstrated that overexpression of HPSE potentiates megakaryocytic differentiation, whereas elimination of HPSE led to a delayed differentiation. This function of HPSE is associated with its activity, as overexpression of inactive HPSE had no effect on IL-6 production and megakaryocytic differentiation. The role of HPSE is further supported by the observation in an umbilical cord blood CD34+ cells megakaryocytic differentiation model. Our data propose a novel role for HPSE in platelets production by a HPSE/IL-6/STAT3 positive feedback loop that specifically regulates megakaryocytes maturation.
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| 90. |
- Wang, L., et al.
(författare)
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Development of a land surface model with coupled snow and frozen soil physics
- 2017
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Ingår i: Water Resources Research. - : American Geophysical Union (AGU). - 0043-1397 .- 1944-7973. ; 53:6, s. 5085-5103
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Tidskriftsartikel (refereegranskat)abstract
- Snow and frozen soil are important factors that influence terrestrial water and energy balances through snowpack accumulation and melt and soil freeze-thaw. In this study, a new land surface model (LSM) with coupled snow and frozen soil physics was developed based on a hydrologically improved LSM (HydroSiB2). First, an energy-balance-based three-layer snow model was incorporated into HydroSiB2 (hereafter HydroSiB2-S) to provide an improved description of the internal processes of the snow pack. Second, a universal and simplified soil model was coupled with HydroSiB2-S to depict soil water freezing and thawing (hereafter HydroSiB2-SF). In order to avoid the instability caused by the uncertainty in estimating water phase changes, enthalpy was adopted as a prognostic variable instead of snow/soil temperature in the energy balance equation of the snow/frozen soil module. The newly developed models were then carefully evaluated at two typical sites of the Tibetan Plateau (TP) (one snow covered and the other snow free, both with underlying frozen soil). At the snow-covered site in northeastern TP (DY), HydroSiB2-SF demonstrated significant improvements over HydroSiB2-F (same as HydroSiB2-SF but using the original single-layer snow module of HydroSiB2), showing the importance of snow internal processes in three-layer snow parameterization. At the snow-free site in southwestern TP (Ngari), HydroSiB2-SF reasonably simulated soil water phase changes while HydroSiB2-S did not, indicating the crucial role of frozen soil parameterization in depicting the soil thermal and water dynamics. Finally, HydroSiB2-SF proved to be capable of simulating upward moisture fluxes toward the freezing front from the underlying soil layers in winter.
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| 91. |
- Wang, Zijun, et al.
(författare)
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Quantifying the Spatiotemporal Changes in Evapotranspiration and Its Components Driven by Vegetation Greening and Climate Change in the Northern Foot of Yinshan Mountain
- 2024
-
Ingår i: Remote Sensing. - 2072-4292. ; 16:2
-
Tidskriftsartikel (refereegranskat)abstract
- Evapotranspiration (E), a pivotal phenomenon inherent to hydrological and thermal dynamics, assumes a position of utmost importance within the intricate framework of the water–energy nexus. However, the quantitative study of E on a large scale for the “Grain for Green” projects under the backdrop of climate change is still lacking. Consequently, this study examined the interannual variations and spatial distribution patterns of E, transpiration (Et), and soil evaporation (Eb) in the Northern Foot of Yinshan Mountain (NFYM) between 2000 and 2020 and quantified the contributions of climate change and vegetation greening to the changes in E, Et, and Eb. Results showed that E (2.47 mm/a, p < 0.01), Et (1.30 mm/a, p < 0.01), and Eb (1.06 mm/a, p < 0.01) all exhibited a significant increasing trend during 2000–2020. Notably, vegetation greening emerged as the predominant impetus underpinning the augmentation of both E and Eb, augmenting their rates by 0.49 mm/a and 0.57 mm/a, respectively. In terms of Et, meteorological factors emerged as the primary catalysts, with temperature (Temp) assuming a predominant role by augmenting Et at a rate of 0.35 mm/a. Temp, Precipitation (Pre), and leaf area index (LAI) collectively dominated the proportional distribution of E, accounting for shares of 32.75%, 28.43%, and 25.01%, respectively. Within the spectrum of predominant drivers influencing Et, Temp exerted the most substantial influence, commanding the largest proportion at 33.83%. For Eb, the preeminent determinants were recognized as LAI and Temp, collectively constituting a substantial portion of the study area, accounting for 32.10% and 29.50%, respectively. The LAI exerted a pronounced direct influence on the Et, with no significant effects on E and bare Eb. Wind speed (WS) had a substantial direct impact on both E and Et. Pre exhibited a strong direct influence on E, Et, and Eb. Relative humidity (RH) significantly affected E directly. Temp primarily influenced Eb indirectly through radiation (Rad). Rad exerted a significant direct inhibitory effect on Eb. These findings significantly advanced our mechanistic understanding of how E and its components in the NFYM respond to climate change and vegetation greening, thus providing a robust basis for formulating strategies related to regional ecological conservation and water resources management, as well as supplying theoretical underpinnings for constructing sustainable vegetation restoration strategies involving water resources in the region.
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| 92. |
- Xu, Yingting, et al.
(författare)
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3-Pentanol glycosides from root nodules of the actinorhizal plant Alnus cremastogyne
- 2023
-
Ingår i: Phytochemistry. - : Elsevier BV. - 0031-9422 .- 1873-3700. ; 207
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Tidskriftsartikel (refereegranskat)abstract
- Alnus cremastogyne Burkill (Betulaceae), an actinorhizal plant, can enter a mutualistic symbiosis with Frankia species that leads to the formation of nitrogen fixing root nodules. Some primary metabolites (carbohydrates, dicarboxylic acids, amino acids, citrulline and amides) involved in carbon and nitrogen metabolism in actinorhizal nodules have been identified, while specialized metabolites in A. cremastogyne root nodules are yet to be characterized. In this study, we isolated and identified three undescribed 3-pentanol glycosides, i.e., 3-pentyl α-l-arabinofuranosyl-(1′′→6′)-β-d-glucopyranoside, 3-pentyl α-l-rhamnopyranosyl-(1′′→6′)-β-d-glucopyranoside, and 3-pentyl 6′-(3-hydroxy3-methylglutaryl)-β-d-glucopyranoside, as well as seventeen known compounds from A. cremastogyne root nodules. 3-Pentanol glycosides are abundantly distributed in root nodules, while they are distributed in stems, roots, leaves and fruits at low/zero levels. A. cremastogyne plants treated by root nodule suspension emit 3-pentanol. This study enriches the knowledge about specialized metabolites in the actinorhizal host, and provides preliminarily information on the signal exchange in the actinorhizal symbiosis between A. cremastogyne and Frankia.
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| 93. |
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| 94. |
- Xue, Lei, 1992, et al.
(författare)
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Optics-simplified DSP for 50 Gb/s PON downstream transmission using 10 Gb/s optical devices
- 2020
-
Ingår i: Journal of Lightwave Technology. - 0733-8724 .- 1558-2213. ; 38:3, s. 583-589
-
Tidskriftsartikel (refereegranskat)abstract
- Directly-modulated laser (DML) is widely employed in intensity modulation and direct detection (IMDD) system due to its low cost and high output power. However, the corresponding frequency chirp is regarded as one of the main disadvantages for its application in passive optical networks (PONs). In this paper, we theoretically analyze the frequency response evolution of DML based system under different chirp and dispersion conditions, proving that the system bandwidth can be improved by interactions between negative dispersion and DML chirp. Based on this concept, we experimentally demonstrated downstream 50 Gb/s PAM4 signal transmission over 20 km single-mode fiber (SMF) access based on the 10 Gb/s DML operating at 1310 nm and avalanche photodiode (APD). A dispersion-shifted fiber (DSF) providing -150 ps/nm dispersion at 1310 nm in the optical line terminal (OLT) is used to pre-equalize the frequency response of bandwidth-limited directly modulated signals in the optical domain. Thanks to our proposed dispersion-supported equalization (DSE) technique, the system bandwidth can be improved by 5 GHz. Feed-forward equalization (FFE), decision feedback equalization (DFE) and Volterra filter are employed to evaluate the signal performance improvement, respectively. By evaluating the receiver sensitivity, the DSE combined with FFE scheme shows 2 dB improvement than the complex Volterra algorithm, indicating its potential to reduce the complexity of digital signal processing (DSP) and therefore a lower cost and power consumption in PON.
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| 95. |
- Xue, Lei, 1992, et al.
(författare)
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SOA pattern effect mitigation by neural network based pre-equalizer for 50G PON
- 2021
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Ingår i: Optics Express. - 1094-4087 .- 1094-4087. ; 29:16, s. 24714-24722
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Tidskriftsartikel (refereegranskat)abstract
- Semiconductor optical amplifier (SOA) is widely used for power amplification in O-band, particularly for passive optical networks (PONs) which can greatly benefit its advantages of simple structure, low power consumption and integrability with photonics circuits. However, the annoying nonlinear pattern effect degrades system performance when the SOA is needed as a pre-amplifier in PONs. Conventional solutions for pattern effect mitigation are either based on optical filtering or gain clamping. They are not simple or sufficiently flexible for practical deployment. Neural network (NN) has been demonstrated for impairment compensation in optical communications thanks to its powerful nonlinear fitting ability. In this paper, for the first time, NN-based equalizer is proposed to mitigate the SOA pattern effect for 50G PON with intensity modulation and direct detection. The experimental results confirm that the NN-based equalizer can effectively mitigate the SOA nonlinear pattern effect and significantly improve the dynamic range of receiver, achieving 29-dB power budget with the FEC limit at 1e-2. Moreover, the well-trained NN model in the receiver side can be directly placed at the transmitter in the optical line terminal to pre-equalize the signal for transmission so as to simplify digital signal processing in the optical network unit.
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| 96. |
- Yang, Liting, et al.
(författare)
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NiMn layered double hydroxide nanosheets/NiCo2O4 nanowires with surface rich high valence state metal oxide as an efficient electrocatalyst for oxygen evolution reaction
- 2018
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Ingår i: Journal of Power Sources. - : Elsevier BV. - 0378-7753. ; 392, s. 23-32
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Tidskriftsartikel (refereegranskat)abstract
- High valence transition metal oxide is significant for anode catalyst of proton membrane water electrolysis technique. Herein, we demonstrate NiMn layered double hydroxide nanosheets/NiCo 2 O 4 nanowires hierarchical nanocomposite catalyst with surface rich high valence metal oxide as an efficient catalyst for oxygen evolution reaction. A low overpotential of 310 mV is needed to drive a 10 mA cm −2 with a Tafel slope of 99 mV dec −1 , and a remarkable stability during 8 h is demonstrated in a chronoamperometry test. Theoretical calculation displays the change in the rate-determining step on the nanocomposite electrode in comparison to NiCo 2 O 4 nanowires alone. It is found high valence Ni and Mn oxide in the catalyst system can efficiently facilitate the charge transport across the electrode/electrolyte interface. The enhanced electrical conductivity, more accessible active sites and synergistic effects between NiMn layered double hydroxide nanosheets and NiCo 2 O 4 nanowires can account for the excellent oxygen evolution reaction. The catalytic performance is comparable to most of the best non-noble catalysts and IrO 2 noble catalyst, indicating the promising applications in water-splitting technology. It is an important step in the development of hierarchical nanocomposites by surface valence state tuning as an alternative to noble metals for oxygen evolution reaction.
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| 97. |
- Yang, Xu-Fang, et al.
(författare)
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High efficient isolation and systematic identification of human adipose-derived mesenchymal stem cells
- 2011
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Ingår i: Journal of Biomedical Science. - : Springer Science and Business Media LLC. - 1021-7770 .- 1423-0127. ; 18, s. 59-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Developing efficient methods to isolate and identify human adipose-derived mesenchymal stem cells (hADSCs) remains to be one of the major challenges in tissue engineering. Methods: We demonstrate here a method by isolating hADSCs from abdominal subcutaneous adipose tissue harvested during caesarian section. The hADSCs were isolated from human adipose tissue by collagenase digestion and adherence to flasks. Results: The yield reached around 1 x 10(6) hADSCs per gram adipose tissue. The following comprehensive identification and characterization illustrated pronounced features of mesenchymal stem cells (MSCs). The fibroblast-like hADSCs exhibited typical ultrastructure details for vigorous cell activities. Karyotype mapping showed normal human chromosome. With unique immunophenotypes they were positive for CD29, CD44, CD73, CD105 and CD166, but negative for CD31, CD34, CD45 and HLA-DR. The growth curve and cell cycle analysis revealed high capability for self-renewal and proliferation. Moreover, these cells could be functionally induced into adipocytes, osteoblasts, and endothelial cells in the presence of appropriate conditioned media. Conclusion: The data presented here suggest that we have developed high efficient isolation and cultivation methods with a systematic strategy for identification and characterization of hADSCs. These techniques will be able to provide safe and stable seeding cells for research and clinical application.
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| 98. |
- Yang, Yong, et al.
(författare)
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Nickel Complex with Internal Bases as Efficient Molecular Catalyst for Photochemical H-2 Production
- 2014
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Ingår i: ChemSusChem. - : Wiley. - 1864-5631 .- 1864-564X. ; 7:10, s. 2889-2897
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Tidskriftsartikel (refereegranskat)abstract
- A Ni complex with internal bases that contain bipyridine-derived ligands, [Ni(L)(2)(H2O)(2)](BF4)(2) ([1](BF4)(2), L=2-(2-pyridyl)-1,8-naphthyridine), and a reference complex that bears analogous bipyridine-derived ligands but without an internal base, [Ni(L)(3)](BF4)(2) ([2](BF4)(2), L=2-(2-pyridyl)quinoline), were synthesized and characterized. The electrochemical properties of these complexes were studied in CH3CN, H2O, and a mixture of EtOH/H2O. The fluorescence spectroscopic studies suggest that both dynamic and the sphere-of-action static quenching exist in the fluorescein Fl(2-)/[1](2+) and Fl(2-)/[2](2+) systems. These noble-metal-free molecular systems were studied for photocatalytic H-2 generation. Under optimal conditions, the turnover number of H-2 evolution reaches 3230 based on [1](2+), whereas [2](2+) displays only approximately one third of the turnover of [1](2+). A plausible mechanism for the catalytic H-2 generation by [1](2+) is presented based on DFT calculations.
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| 99. |
- Yanoff, Brian David, et al.
(författare)
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System and method for statistical iterative reconstruction and material decomposition
- 2018
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Patent (populärvet., debatt m.m.)abstract
- A method for imaging an object to be reconstructed includes acquiring projection data corresponding to the object. Furthermore, the method includes generating a measured sinogram based on the acquired projection data and formulating a forward model, where the forward model is representative of a characteristic of the imaging system. In addition, the method includes generating an estimated sinogram based on an estimated image of the object and the forward model and formulating a statistical model based on at least one of pile-up characteristics and dead time characteristics of a detector of the imaging system. Moreover, the method includes determining an update corresponding to the estimated image based on the statistical model, the measured sinogram, and the estimated sinogram and updating the estimated image based on the determined update to generate an updated image of the object. Additionally, the method includes outputting a final image of the object.
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| 100. |
- Yuan, Shuai, et al.
(författare)
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Interleukins and rheumatoid arthritis : bi-directional Mendelian randomization investigation
- 2022
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Ingår i: Seminars in Arthritis & Rheumatism. - : Elsevier. - 0049-0172 .- 1532-866X. ; 53
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To assess the causality of the associations between interleukins (ILs) and rheumatoid arthritis (RA) using Mendelian randomization (MR) design. Methods: Genetic instruments and summary-level data for ten ILs were obtained from three genome-wide association meta-analyses. Corresponding data on RA were obtained from a meta-analysis of 22 genome-wide association studies (14,361 cases and 43,923 controls) and the FinnGen consortium (6236 cases, 4596 seropositive cases, 1937 seronegative cases, and 172,834 controls). Forward and reverse MR analyses were performed. Results: The odds ratios (ORs) of RA were 2.08 (95% confidence interval (CI), 1.56-2.77; p<0.001), 2.14 (95% CI, 1.85-2.49; p<0.001), and 0.95 (95% CI, 0.92-0.97; p<0.001) for one standard deviation increase in genetically predicted IL-1 beta, IL-6 and IL-6 receptor antagonist (IL-6ra) levels, respectively. There were suggestive associations of genetically predicted IL-1 receptor antagonist (IL-1ra) (OR, 0.85, 95% CI, 0.76, 0.96; p=0.010) and IL-18 (OR, 1.07, 95% CI, 1.00, 1.15; p=0.043) levels with RA risk. Subtype-specific associations were observed for seropositive RA (IL-1 beta, IL-1ra, and IL-6) and seronegative RA (IL-2 receptor alpha subunit, IL-8, and IL-18). Reverse MR analysis found a suggestive association between genetic liability to RA and IL-6 receptor antagonist (change 0.015; 95% CI, 0.003-0.028; p=0.015). Conclusions: This MR study suggests that long-term IL-1 and IL-6 inhibition may reduce the risk of RA, particularly seropositive RA. Upregulations of ILs involved in IL-6 signaling pathways appears to be downstream effects of RA, which supports the blocking IL-6 treatment for RA.
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