| 51. |
- Gil, Eduardo, et al.
(author)
-
Heart Rate Turbulence Analysis Based on Photoplethysmography
- 2013
-
In: IEEE Transactions on Biomedical Engineering. - 1558-2531. ; 60:11, s. 3149-3155
-
Journal article (peer-reviewed)abstract
- The goal of this paper is to determine whether the photoplethysmography (PPG) can replace the ECG-based detection of heart rate turbulence. Using the PPG, classification of ventricular premature beats (VPBs) is accomplished with a linear classifier. The two conventional parameters turbulence onset and slope are studied together with a recently introduced parameter characterizing turbulence shape. Performance is studied on a dataset with 4131 VPBs, recorded from a total of 27 patients in different clinical contexts (hemodialysis treatment, intensive care monitoring, and electrophysiological study). The sensitivity/specificity of VPB classification was found to be 90.5/99.9%, with an accuracy of 99.3%, suggesting that classification of VPBs can be reliable made from the PPG. The main difference between the two types of turbulence analysis stems from the fact that the pulse transit time varies largely immediately after the VPB. Out of the 22 patients which had a sufficient number of VPBs, the outcome of the ECG-and PPG-based analysis was identical in 21. It is concluded that the PPG may serve as a surrogate technique for the ECG in turbulence analysis.
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| 52. |
- Gõmez-Elvira, Javier, et al.
(author)
-
Curiosity's rover environmental monitoring station : Overview of the first 100 sols
- 2014
-
In: Journal of Geophysical Research - Planets. - 2169-9097 .- 2169-9100. ; 119:7, s. 1680-1688
-
Journal article (peer-reviewed)abstract
- In the first 100 Martian solar days (sols) of the Mars Science Laboratory mission, the Rover Environmental Monitoring Station (REMS) measured the seasonally evolving diurnal cycles of ultraviolet radiation, atmospheric pressure, air temperature, ground temperature, relative humidity, and wind within Gale Crater on Mars. As an introduction to several REMS-based articles in this issue, we provide an overview of the design and performance of the REMS sensors and discuss our approach to mitigating some of the difficulties we encountered following landing, including the loss of one of the two wind sensors. We discuss the REMS data set in the context of other Mars Science Laboratory instruments and observations and describe how an enhanced observing strategy greatly increased the amount of REMS data returned in the first 100 sols, providing complete coverage of the diurnal cycle every 4 to 6 sols. Finally, we provide a brief overview of key science results from the first 100 sols. We found Gale to be very dry, never reaching saturation relative humidities, subject to larger diurnal surface pressure variations than seen by any previous lander on Mars, air temperatures consistent with model predictions and abundant short timescale variability, and surface temperatures responsive to changes in surface properties and suggestive of subsurface layering. Key Points Introduction to the REMS results on MSL mission Overiview of the sensor information Overview of operational constraints
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| 53. |
- Gonzalez, Jose M., et al.
(author)
-
Spatial and sectoral benefit distribution in water-energy system design
- 2020
-
In: Applied Energy. - : Elsevier BV. - 0306-2619 .- 1872-9118. ; 269
-
Journal article (peer-reviewed)abstract
- The design of water and energy systems has traditionally been done independently or considering simplified interdependencies between the two systems. This potentially misses valuable synergies between them and does not consider in detail the distribution of benefits between different sectors or regions. This paper presents a framework to couple integrated water-power network simulators with multi-objective optimisation under uncertainty to explore the implications of explicitly including spatial topology and interdependencies in the design of multi-sector integrated systems. A synthetic case study that incorporates sectoral dependencies in resource allocation, operation of multi-purpose reservoirs and spatially distributed infrastructure selection in both systems is used. The importance of explicitly modelling the distribution of benefits across different sectors and regions is explored by comparing different spatially aggregated and disaggregated multi-objective optimisation formulations. The results show the disaggregated formulation identifies a diverse set of non-dominated portfolios that enables addressing the spatial and sectoral distribution of benefits, whilst the aggregated formulations arbitrarily induce unintended biases. The proposed disaggregated approach allows for detailed spatial design of interlinked water and energy systems considering their complex regional and sectoral trade-offs. The framework is intended to assist planners in real resource systems where diverse stakeholder groups are mindful of receiving their fair share of development benefits.
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| 54. |
- Gracia-Espino, Eduardo, et al.
(author)
-
Temperature Dependence of Sensors Based on Silver-Decorated Nitrogen-Doped Multiwalled Carbon Nanotubes
- 2016
-
In: Journal of Sensors. - : Hindawi Publishing Corporation. - 1687-725X .- 1687-7268.
-
Journal article (peer-reviewed)abstract
- Vapor sensors are easily fabricated onto alumina substrates using foils of silver-decorated nitrogen-doped multiwalled carbon nanotubes (CNX-MWNTs-Ag) as active sensing material. The vapor sensors are tested using carbon disulfide, acetone, ethanol, and chloroform vapors. The CNX-MWNTs are produced by chemical vapor deposition process and then decorated with 14 nm Ag nanoparticles (Ag-NPs). The samples are characterized using scanning electron microscopy, transmission electron microscopy, and X-ray diffraction. Our results demonstrate that Ag-decorated CNX-MWNTs exhibit a better response and sensitivity when compared with pristine CNX-MWNTs based sensors, making them promising candidates for air-pollutants environmental monitoring. The temperature effect on the sensor performance is also studied; we found that the detection mechanism could be tuned from physisorption, at room temperature, to chemisorption at higher working temperature. Finally, first-principles density functional calculations are carried out to understand the interactions between the systems involved in the sensors, finding good agreement between experimental results and the theoretical approach.
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| 55. |
- Griswold, Max G., et al.
(author)
-
Alcohol use and burden for 195 countries and territories, 1990-2016 : a systematic analysis for the Global Burden of Disease Study 2016
- 2018
-
In: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 392:10152, s. 1015-1035
-
Journal article (peer-reviewed)abstract
- Background: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted life-years (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older.Methods: Using 694 data sources of individual and population-level alcohol consumption, along with 592 prospective and retrospective studies on the risk of alcohol use, we produced estimates of the prevalence of current drinking, abstention, the distribution of alcohol consumption among current drinkers in standard drinks daily (defined as 10 g of pure ethyl alcohol), and alcohol-attributable deaths and DALYs. We made several methodological improvements compared with previous estimates: first, we adjusted alcohol sales estimates to take into account tourist and unrecorded consumption; second, we did a new meta-analysis of relative risks for 23 health outcomes associated with alcohol use; and third, we developed a new method to quantify the level of alcohol consumption that minimises the overall risk to individual health.Findings: Globally, alcohol use was the seventh leading risk factor for both deaths and DALYs in 2016, accounting for 2.2% (95% uncertainty interval [UI] 1.5-3.0) of age-standardised female deaths and 6.8% (5.8-8.0) of age-standardised male deaths. Among the population aged 15-49 years, alcohol use was the leading risk factor globally in 2016, with 3.8% (95% UI 3.2-4-3) of female deaths and 12.2% (10.8-13-6) of male deaths attributable to alcohol use. For the population aged 15-49 years, female attributable DALYs were 2.3% (95% UI 2.0-2.6) and male attributable DALYs were 8.9% (7.8-9.9). The three leading causes of attributable deaths in this age group were tuberculosis (1.4% [95% UI 1. 0-1. 7] of total deaths), road injuries (1.2% [0.7-1.9]), and self-harm (1.1% [0.6-1.5]). For populations aged 50 years and older, cancers accounted for a large proportion of total alcohol-attributable deaths in 2016, constituting 27.1% (95% UI 21.2-33.3) of total alcohol-attributable female deaths and 18.9% (15.3-22.6) of male deaths. The level of alcohol consumption that minimised harm across health outcomes was zero (95% UI 0.0-0.8) standard drinks per week.Interpretation: Alcohol use is a leading risk factor for global disease burden and causes substantial health loss. We found that the risk of all-cause mortality, and of cancers specifically, rises with increasing levels of consumption, and the level of consumption that minimises health loss is zero. These results suggest that alcohol control policies might need to be revised worldwide, refocusing on efforts to lower overall population-level consumption.
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| 56. |
- Gschwendtner, Dda, et al.
(author)
-
The AWAKE Run 2 Programme and Beyond
- 2022
-
In: Symmetry. - : MDPI AG. - 2073-8994. ; 14:8
-
Journal article (peer-reviewed)abstract
- Plasma wakefield acceleration is a promising technology to reduce the size of particle accelerators. The use of high energy protons to drive wakefields in plasma has been demonstrated during Run 1 of the AWAKE programme at CERN. Protons of energy 400 GeV drove wakefields that accelerated electrons to 2 GeV in under 10 m of plasma. The AWAKE collaboration is now embarking on Run 2 with the main aims to demonstrate stable accelerating gradients of 0.5-1 GV/m, preserve emittance of the electron bunches during acceleration and develop plasma sources scalable to 100s of metres and beyond. By the end of Run 2, the AWAKE scheme should be able to provide electron beams for particle physics experiments and several possible experiments have already been evaluated. This article summarises the programme of AWAKE Run 2 and how it will be achieved as well as the possible application of the AWAKE scheme to novel particle physics experiments.
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| 57. |
- Gutiérrez Maestro, Eduardo, 1994-, et al.
(author)
-
Wearable-Based Intelligent Emotion Monitoring in Older Adults during Daily Life Activities
- 2023
-
In: Applied Sciences. - : MDPI. - 2076-3417. ; 13:9
-
Journal article (peer-reviewed)abstract
- We present a system designed to monitor the well-being of older adults during their daily activities. To automatically detect and classify their emotional state, we collect physiological data through a wearable medical sensor. Ground truth data are obtained using a simple smartphone app that provides ecological momentary assessment (EMA), a method for repeatedly sampling people's current experiences in real time in their natural environments. We are making the resulting dataset publicly available as a benchmark for future comparisons and methods. We are evaluating two feature selection methods to improve classification performance and proposing a feature set that augments and contrasts domain expert knowledge based on time-analysis features. The results demonstrate an improvement in classification accuracy when using the proposed feature selection methods. Furthermore, the feature set we present is better suited for predicting emotional states in a leave-one-day-out experimental setup, as it identifies more patterns.
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| 58. |
- Hamilton, Victoria E., et al.
(author)
-
Observations and preliminary science results from the first 100 sols of MSL Rover Environmental Monitoring Station ground temperature sensor measurements at Gale Crater
- 2014
-
In: Journal of Geophysical Research - Planets. - : John Wiley & Sons. - 2169-9097 .- 2169-9100. ; 119:4, s. 745-770
-
Journal article (peer-reviewed)abstract
- We describe preliminary results from the first 100 sols of ground temperature measurements along the Mars Science Laboratory's traverse from Bradbury Landing to Rocknest in Gale. The ground temperature data show long-term increases in mean temperature that are consistent with seasonal evolution. Deviations from expected temperature trends within the diurnal cycle are observed and may be attributed to rover and environmental effects. Fits to measured diurnal temperature amplitudes using a thermal model suggest that the observed surfaces have thermal inertias in the range of 265-375?J m-2 K-1 s-1/2, which are within the range of values determined from orbital measurements and are consistent with the inertias predicted from the observed particle sizes on the uppermost surface near the rover. Ground temperatures at Gale Crater appear to warm earlier and cool later than predicted by the model, suggesting that there are multiple unaccounted for physical conditions or processes in our models. Where the Mars Science Laboratory (MSL) descent engines removed a mobile layer of dust and fine sediments from over rockier material, the diurnal temperature profile is closer to that expected for a homogeneous surface, suggesting that the mobile materials on the uppermost surface may be partially responsible for the mismatch between observed temperatures and those predicted for materials having a single thermal inertia. Models of local stratigraphy also implicate thermophysical heterogeneity at the uppermost surface as a potential contributor to the observed diurnal temperature cycle. Key Points Diurnal ground temperatures vary with location Diurnal temperature curves are not well matched by a homogeneous thermal model GTS data are consistent with a varied stratigraphy and thermophysical properties.
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| 59. |
- Holman, Rury R., et al.
(author)
-
Effect of Nateglinide on the Incidence of Diabetes and Cardiovascular Events
- 2010
-
In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 362:16, s. 1463-1476
-
Journal article (peer-reviewed)abstract
- BACKGROUND The ability of short-acting insulin secretagogues to reduce the risk of diabetes or cardiovascular events in people with impaired glucose tolerance is unknown. METHODS In a double-blind, randomized clinical trial, we assigned 9306 participants with impaired glucose tolerance and either cardiovascular disease or cardiovascular risk factors to receive nateglinide (up to 60 mg three times daily) or placebo, in a 2-by-2 factorial design with valsartan or placebo, in addition to participation in a lifestyle modification program. We followed the participants for a median of 5.0 years for incident diabetes (and a median of 6.5 years for vital status). We evaluated the effect of nateglinide on the occurrence of three coprimary outcomes: the development of diabetes; a core cardiovascular outcome that was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure; and an extended cardiovascular outcome that was a composite of the individual components of the core composite cardiovascular outcome, hospitalization for unstable angina, or arterial revascularization. RESULTS After adjustment for multiple testing, nateglinide, as compared with placebo, did not significantly reduce the cumulative incidence of diabetes (36% and 34%, respectively; hazard ratio, 1.07; 95% confidence interval [CI], 1.00 to 1.15; P = 0.05), the core composite cardiovascular outcome (7.9% and 8.3%, respectively; hazard ratio, 0.94, 95% CI, 0.82 to 1.09; P = 0.43), or the extended composite cardiovascular outcome (14.2% and 15.2%, respectively; hazard ratio, 0.93, 95% CI, 0.83 to 1.03; P = 0.16). Nateglinide did, however, increase the risk of hypoglycemia. CONCLUSIONS Among persons with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors, assignment to nateglinide for 5 years did not reduce the incidence of diabetes or the coprimary composite cardiovascular outcomes. (ClinicalTrials.gov number, NCT00097786.)
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| 60. |
- Holmer, Mattias, et al.
(author)
-
Detection of ventricular premature beats based on the pressure signals of a hemodialysis machine
- 2018
-
In: Medical Engineering and Physics. - : Elsevier BV. - 1350-4533. ; 51, s. 49-55
-
Journal article (peer-reviewed)abstract
- Monitoring of ventricular premature beats (VPBs), being abundant in hemodialysis patients, can provide information on cardiovascular instability and electrolyte imbalance. In this paper, we describe a method for VPB detection which explores the signals acquired from the arterial and the venous pressure sensors, located in the extracorporeal blood circuit of a hemodialysis machine. The pressure signals are mainly composed of a pump component and a cardiac component. The cardiac component, severely overshadowed by the pump component, is estimated from the pressure signals using an earlier described iterative method. A set of simple features is extracted, and linear discriminant analysis is performed to classify beats as either normal or ventricular premature. Performance is evaluated on signals from nine hemodialysis treatments, using leave-one-out crossvalidation. The simultaneously recorded and annotated photoplethysmographic signal serves as the reference signal, with a total of 149,686 normal beats and 3574 VPBs. The results show that VPBs can be reliably detected, quantified by a Youden's J statistic of 0.9, for average cardiac pulse pressures exceeding 1 mmHg; for lower pressures, the J statistic drops to 0.55. It is concluded that the cardiac pressure signal is suitable for VPB detection, provided that the average cardiac pulse pressure exceeds 1 mmHg.
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| 61. |
- Hudson, Lawrence N., et al.
(author)
-
The PREDICTS database : a global database of how local terrestrial biodiversity responds to human impacts
- 2014
-
In: Ecology and Evolution. - : Wiley. - 2045-7758. ; 4:24, s. 4701-4735
-
Journal article (peer-reviewed)abstract
- Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species' threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project - and avert - future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups - including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems - ). We make site-level summary data available alongside this article. The full database will be publicly available in 2015.
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| 62. |
- Huertas-Hernando, Daniel, et al.
(author)
-
Hydropower Flexibility for Power Systems with Variable Renewable Energy Sources: An IEA Task 25 Collaboration
- 2019
-
In: Advances in Energy Systems. - : Wiley. ; , s. 385-405
-
Book chapter (other academic/artistic)abstract
- In order to effectively utilize hydro production flexibility, a sufficient amount of transmission capacity has to be available between the hydro-dominated part of the system and the part that requires operational flexibility. This chapter starts with a rough categorization of “base” hydropower flexibility, investigating the types of hydropower plants installed in power systems today. The “effective” hydropower flexibility available to support the integration of variable generation is a far more complex and case-specific aspect. It is discussed through national experiences. The chapter presents potential developments that would increase the participation of hydropower and discuss the ensuing challenges. Modeling a flow-based hydro system is a complex exercise, as is modeling the power system. Especially important is the correct assessment of hydropower flexibility to support power systems with a large share of variable generation (VG) and its value for storage. With increasing uncertainty and variability, a stochastic scheduling approach should yield lower costs.
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| 63. |
- Jacobo-Martin, Alejandra, et al.
(author)
-
Resilient moth-eye nanoimprinted antireflective and self-cleaning TiO2 sputter-coated PMMA films
- 2022
-
In: Applied Surface Science. - : Elsevier. - 0169-4332 .- 1873-5584. ; 585
-
Journal article (peer-reviewed)abstract
- Moth-eye nanostructures are amongst the most remarkable surfaces in nature because of their multi-functionality including antireflection, self-cleaning and bactericidal ability. Moth-eye surfaces consist of subwavelength arrays of tapered nanostructures, which are challenging to reproduce artificially. Nanoimprint lithography is probably one of the most suited technologies for this purpose. However, the poor mechanical resilience and durability of the polymeric nanocones when exposed to the environment, hinders their use in actual applications. To overcome these limitations, this work demonstrates the use of a thin oxide coating over the polymer moth-eye features imprinted on poly methyl methacrylate (PMMA) films. Particularly TiO2 conformal thin film coatings are deposited by unipolar pulsed dc magnetron sputtering over the antireflective nanopatterns acting as encapsulant. The coating, while preserving the antireflective properties, protects the nanostructures against mechanical scratching and improves substantially their thermal stability to over 250 ?. Furthermore, the TiO2 layer provides additional photoinduced self-cleaning functionality and at the same time it protects the matrix from UV photodegradation. The robust and durable antireflective surfaces developed here may find application on solar cells covers, flat panel displays or on optical components.
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| 64. |
- Jonsson, Robert, 1987, et al.
(author)
-
Communication through quantum fields near a black hole
- 2020
-
In: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 2470-0010 .- 2470-0029. ; 101:12
-
Journal article (peer-reviewed)abstract
- We study the quantum channel between two localized first-quantized systems that communicate in 3 + 1 dimensional Schwarzschild spacetime via a quantum field. We analyze the information carrying capacity of direct and black hole-orbiting null geodesics as well as of the timelike contributions that arise because the strong Huygens principle does not hold on the Schwarzschild background. We find, in particular, that the nondirect-null and timelike contributions, which do not possess an analog on Minkowski spacetime, can dominate over the direct null contributions. We cover the cases of both geodesic and accelerated emitters. Technically, we apply tools previously designed for the study of wave propagation in curved spacetimes to a relativistic quantum information communication setup, first for generic spacetimes, and then for the case of Schwarzschild spacetime in particular.
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| 65. |
- Jonsson, Robert, 1987, et al.
(author)
-
Transmitting qubits through relativistic fields
- 2018
-
In: Journal of Physics A: Mathematical and Theoretical. - : IOP Publishing. - 1751-8121 .- 1751-8113. ; 51:48
-
Journal article (peer-reviewed)abstract
- Wireless communication derives its power from the simultaneous emission of signals in multiple directions. However, in the context of quantum communication, this phenomenon must be reconciled carefully with the no-cloning principle. In this context, we here study how wireless communication of quantum information can be realized via relativistic fields. To this end, we extend existing frameworks to allow for a non-perturbative description of, e.g. quantum state transfer. We consider, in particular, the case of 1+1 spacetime dimensions, which already allows for a number of interesting scenarios, pointing to, for example, new methods for tasks similar to quantum secret sharing.
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| 66. |
- Kalia, Lorraine V, et al.
(author)
-
Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease.
- 2015
-
In: JAMA Neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 72:1, s. 100-105
-
Journal article (peer-reviewed)abstract
- Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson disease (PD) known to date. The clinical features of manifesting LRRK2 mutation carriers are generally indistinguishable from those of patients with sporadic PD. However, some PD cases associated with LRRK2 mutations lack Lewy bodies (LBs), a neuropathological hallmark of PD. We investigated whether the presence or absence of LBs correlates with different clinical features in LRRK2-related PD.
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| 67. |
- Kvist, Laura, et al.
(author)
-
Endangered subspecies of the Reed Bunting (Emberiza schoeniclus witherbyi and E. s. lusitanica) in Iberian Peninsula have different genetic structures.
- 2011
-
In: Journal of Ornithology. - : Springer Science and Business Media LLC. - 2193-7192 .- 2193-7206. ; 152:3, s. 681-693
-
Journal article (peer-reviewed)abstract
- In the Iberian Peninsula, populations of two subspecies of the Reed Bunting Emberiza schoeniclus have become increasingly fragmented during the last decades when suitable habitats have been lost and/or the popula- tions have gone extinct. Presently, both subspecies are endangered. We estimated the amount of genetic variation and population structure in order to define conservation units and management practices for these populations. We found that the subspecies lusitanica has clearly reduced genetic variation in nuclear and mitochondrial markers, has a drastically small effective population size and no genetic differentiation between populations. In contrast, the sub- species witherbyi is significantly structured, but the popu- lations still hold large amounts of variation even though the effective population sizes are smaller than in the non- endangered subspecies schoeniclus. We suggest several management units for the Iberian populations. One unit includes subspecies lusitanica as a whole; the other three units are based on genetically differentiated populations of witherbyi. The most important genetic conservation mea- sure in the case of lusitanica is to preserve the remaining habitats in order to at least maintain the present levels of gene flow. In the case of the three management units within witherbyi, the most urgent conservation measure is to improve the habitat quality to increase the population sizes.
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| 68. |
- Larson, Keith W., et al.
(author)
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Wintering Black Terns Foraging Among Manta Rays in Coastal Guerrero, Mexico
- 2007
-
In: Waterbirds (De Leon Springs, Fla.). - 1524-4695 .- 1938-5390. ; 30:3, s. 448-449
-
Journal article (peer-reviewed)abstract
- Winter observations of Black Terns (Chlidonias niger) in Mexico are rare. On 19 January 2007, we observed over 3,000 Black Terns foraging among hundreds of breaching manta rays one kilometer offshore on the coast of Guerrero, Mexico.
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| 69. |
- Letcher, Susan G., et al.
(author)
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Environmental gradients and the evolution of successional habitat specialization : a test case with 14 Neotropical forest sites
- 2015
-
In: Journal of Ecology. - : Wiley. - 0022-0477 .- 1365-2745. ; 103:5
-
Journal article (peer-reviewed)abstract
- * Successional gradients are ubiquitous in nature, yet few studies have systematically examined the evolutionary origins of taxa that specialize at different successional stages. Here we quantify successional habitat specialization in Neotropical forest trees and evaluate its evolutionary lability along a precipitation gradient. Theoretically, successional habitat specialization should be more evolutionarily conserved in wet forests than in dry forests due to more extreme microenvironmental differentiation between early and late-successional stages in wet forest. * We applied a robust multinomial classification model to samples of primary and secondary forest trees from 14 Neotropical lowland forest sites spanning a precipitation gradient from 788 to 4000 mm annual rainfall, identifying species that are old-growth specialists and secondary forest specialists in each site. We constructed phylogenies for the classified taxa at each site and for the entire set of classified taxa and tested whether successional habitat specialization is phylogenetically conserved. We further investigated differences in the functional traits of species specializing in secondary vs. old-growth forest along the precipitation gradient, expecting different trait associations with secondary forest specialists in wet vs. dry forests since water availability is more limiting in dry forests and light availability more limiting in wet forests. * Successional habitat specialization is non-randomly distributed in the angiosperm phylogeny, with a tendency towards phylogenetic conservatism overall and a trend towards stronger conservatism in wet forests than in dry forests. However, the specialists come from all the major branches of the angiosperm phylogeny, and very few functional traits showed any consistent relationships with successional habitat specialization in either wet or dry forests. * Synthesis. The niche conservatism evident in the habitat specialization of Neotropical trees suggests a role for radiation into different successional habitats in the evolution of species-rich genera, though the diversity of functional traits that lead to success in different successional habitats complicates analyses at the community scale. Examining the distribution of particular lineages with respect to successional gradients may provide more insight into the role of successional habitat specialization in the evolution of species-rich taxa.
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| 70. |
- Manzano-Nunez, Ramiro, et al.
(author)
-
Could resuscitative endovascular balloon occlusion of the aorta improve survival among severely injured patients with post-intubation hypotension?
- 2018
-
In: European Journal of Trauma and Emergency Surgery. - : Springer Berlin/Heidelberg. - 1863-9933 .- 1863-9941. ; 44:4, s. 527-533
-
Research review (peer-reviewed)abstract
- Current literature shows the association of post-intubation hypotension and increased odds of mortality in critically ill non-trauma and trauma populations. However, there is a lack of research on potential interventions that can prevent or ameliorate the consequences of endotracheal intubation and thus improve the prognosis of trauma patients with post-intubation hypotension. This review paper hypothesizes that the deployment of REBOA among trauma patients with PIH, by its physiologic effects, will reduce the odds of mortality in this population. The objective of this paper is to review the current literature on REBOA and post-intubation hypotension, and, furthermore, to provide a rational hypothesis on the potential role of REBOA in severely injured patients with post-intubation hypotension.
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| 71. |
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| 72. |
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| 73. |
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| 74. |
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| 75. |
- Martínez, Eduardo, et al.
(author)
-
Noncollinear magnetism caused by intermixing at ferromagnetic/antiferromagnetic interfaces
- 2006
-
In: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 74:18, s. 184435-
-
Journal article (peer-reviewed)abstract
- Fe-Cr alloy layers on Fe(001) substrates with different atomic environments are theoretically investigated through a self-consistent real-space tight-binding method parametrized to density functional theory and without collinear restriction for the spin directions. We show that the intermixing at the Cr/Fe interface, experimentally observed at the first stages of the Cr growth on Fe, originates noncollinear magnetic arrangements within the system and even induces magnetic walls in the Fe layer with a magnetic domain close to the interface. A different behavior is shown if steps are present at the interface; i.e., noncollinear magnetism becomes more localized and the induced magnetic wall in Fe vanishes.
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| 76. |
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| 77. |
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| 78. |
- Martinez-Galvan, Eduardo, et al.
(author)
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Film Thickness and Heat Transfer Measurements in a Spray Cooling System With R134a
- 2011
-
In: Journal of Electronic Packaging. - : ASME International. - 1043-7398 .- 1528-9044. ; 133:1, s. 011002-
-
Journal article (peer-reviewed)abstract
- Experimental measurements in a spray cooling test rig have been carried out for several heat fluxes in the heater and different spray volumetric fluxes with the dielectric refrigerant R134a. Results of the heat transfer and the sprayed refrigerant film thickness measurements are presented. The film thickness measurements have been made with a high speed camera equipped with a long distance microscope. It has been found that there is a relation between the variation in the average Nusselt number and the film thickness along the spray cooling boiling curve. The heat transfer regimes along that curve are related not only with a variation in the average Nusselt number but also with changes in the film thickness. The qualitative analysis of those variations has served to understand better the heat transfer mechanisms occurring during the spray cooling.
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| 79. |
- Martínez-Galván, Eduardo, et al.
(author)
-
Heat transfer and film thickness measurements in a closed loop spray cooling system with R134a
- 2009
-
In: 15th International Workshop on Thermal Investigations of ICs and Systems, THERMINIC 2009. - : Academic Conferences Publishing. - 9782355000102 ; , s. 180-185
-
Conference paper (peer-reviewed)abstract
- Experimental measurements in a spray cooling test rig have been carried out for different heat fluxes in the heater and different volumetric spray fluxes of the refrigerant. Results of the thermal parameters and the sprayed refrigerant liquid film thickness over the heater are presented. The film thickness measurements have been made with a high speed camera equipped with a long distance microscope. It has been found that there is a relation between the variation of the heat transfer coefficient and the film thickness along the spray boiling curve.
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| 80. |
- Martinez-Galvan, Eduardo, et al.
(author)
-
Influence of surface roughness on a spray cooling system with R134a. Part I : Heat transfer measurements
- 2013
-
In: Experimental Thermal and Fluid Science. - : Elsevier BV. - 0894-1777 .- 1879-2286. ; 46, s. 183-190
-
Journal article (peer-reviewed)abstract
- Experimental measurements in a spray cooling test rig were carried out for two different heater surface roughnesses and for two different types of nozzles with the dielectric refrigerant R134a. In this paper, results of the heat transfer measurements are presented. The analysis of the results explains the influence of the volumetric flow rate, the surface roughness and the type of nozzle (through the spray parameters) on the spray cooling boiling curve, on the Nusselt number and on the efficiency. It has been found that the effect of a smooth roughness is to delay the onset of the nucleate boiling, but once this regime has started, boiling is so fast that the CHF (Critical Heat Flux) is reached at lower heater temperatures and lower heat fluxes. In a companion paper the sprayed refrigerant film thickness measurements and its relation with the heat transfer measurements are presented.
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| 81. |
- Martinez-Galván, Eduardo, et al.
(author)
-
Influence of surface roughness on a spray cooling system with R134a. Part II : Film thickness measurements
- 2013
-
In: Experimental Thermal and Fluid Science. - : Elsevier. - 0894-1777 .- 1879-2286. ; 48, s. 73-80
-
Journal article (peer-reviewed)abstract
- Experimental measurements in a spray cooling test rig were carried out for two different heater surface roughnesses and for two different types of nozzles with the dielectric refrigerant R134a. In this paper, results of the sprayed refrigerant film thickness measurements are presented. The influence of the volumetric flow rate, the surface roughness and the type of nozzle (through the spray parameters) on the total average film thickness is analyzed and discussed. In a companion paper, results of the heat transfer measurements are presented. It has been found that there is a relation between the variations of the average Nusselt number and of the film thickness along the spray cooling boiling curve. The heat transfer regimes along that curve are related not only to a variation in the average Nusselt number but also to changes in the film thickness. The qualitative analysis of those variations served to better understand the heat transfer mechanisms occurring during the spray cooling.
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| 82. |
- Martinez Garcia, Eduardo
(author)
-
Artificial intelligence-based software (AID-FOREST) for tree detection: A new framework for fast and accurate forest inventorying using LiDAR point clouds
- 2022
-
In: International Journal of Applied Earth Observation and Geoinformation. - : Elsevier BV. - 1569-8432 .- 1872-826X. ; 113
-
Journal article (peer-reviewed)abstract
- Forest inventories are essential to accurately estimate different dendrometric and forest stand parameters. However, classical forest inventories are time consuming, slow to conduct, sometimes inaccurate and costly. To address this problem, an efficient alternative approach has been sought and designed that will make this type of field work cheaper, faster, more accurate, and easier to complete. The implementation of this concept has required the development of a specifically designed software called "Artificial Intelligence for Digital Forest (AID-FOREST)", which is able to process point clouds obtained via mobile terrestrial laser scanning (MTLS) and then, to provide an array of multiple useful and accurate dendrometric and forest stand parameters. Singular characteristics of this approach are: No data pre-processing is required either pre-treatment of forest stand; fully automatic process once launched; no limitations by the size of the point cloud file and fast computations.To validate AID-FOREST, results provided by this software were compared against the obtained from in-situ classical forest inventories. To guaranty the soundness and generality of the comparison, different tree spe-cies, plot sizes, and tree densities were measured and analysed. A total of 76 plots (10,887 trees) were selected to conduct both a classic forest inventory reference method and a MTLS (ZEB-HORIZON, Geoslam, ltd.) scanning to obtain point clouds for AID-FOREST processing, known as the MTLS-AIDFOREST method. Thus, we compared the data collected by both methods estimating the average number of trees and diameter at breast height (DBH) for each plot. Moreover, 71 additional individual trees were scanned with MTLS and processed by AID-FOREST and were then felled and divided into logs measuring 1 m in length. This allowed us to accurately measure the DBH, total height, and total volume of the stems.When we compared the results obtained with each methodology, the mean detectability was 97% and ranged from 81.3 to 100%, with a bias (underestimation by MTLS-AIDFOREST method) in the number of trees per plot of 2.8% and a relative root-mean-square error (RMSE) of 9.2%. Species, plot size, and tree density did not significantly affect detectability. However, this parameter was significantly affected by the ecosystem visual complexity index (EVCI). The average DBH per plot was underestimated (but was not significantly different from 0) by the MTLS-AIDFOREST, with the average bias for pooled data being 1.8% with a RMSE of 7.5%. Similarly, there was no statistically significant differences between the two distribution functions of the DBH at the 95.0% confidence level.Regarding the individual tree parameters, MTLS-AIDFOREST underestimated DBH by 0.16 % (RMSE = 5.2 %) and overestimated the stem volume (Vt) by 1.37 % (RMSE = 14.3 %, although the BIAS was not statistically significantly different from 0). However, the MTLS-AIDFOREST method overestimated the total height (Ht) of the trees by a mean 1.33 m (5.1 %; relative RMSE = 11.5 %), because of the different height concepts measured by both methodological approaches. Finally, AID-FOREST required 30 to 66 min per ha-1 to fully automatically process the point cloud data from the *.las file corresponding to a given hectare plot. Thus, applying our MTLS-AIDFOREST methodology to make full forest inventories, required a 57.3 % of the time required to perform classical plot forest inventories (excluding the data postprocessing time in the latter case). A free trial of AID -FOREST can be requested at dielmo@dielmo.com.
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| 83. |
- Martinez-Garcia, Eduardo, et al.
(author)
-
Drought response of the boreal forest carbon sink is driven by understorey-tree composition
- 2024
-
In: Nature Geoscience. - : Springer Nature. - 1752-0894 .- 1752-0908. ; 17, s. 197-204
-
Journal article (peer-reviewed)abstract
- The boreal forest is an important global carbon sink, but its response to drought remains uncertain. Here, we compiled biometric- and chamber-based flux data from 50 boreal forest stands to assess the impact of the 2018 European summer drought on net ecosystem production (NEP) across a 68 km2 managed landscape in northern Sweden. Our results reveal a non-uniform reduction in NEP (on average by 80 +/- 16 g C m-2 yr-1 or 57 +/- 13%) across the landscape, which was greatest in young stands of 20-50 years (95 +/- 39 g C m-2 yr-1), but gradually decreased towards older stands (54 +/- 57 g C m-2 yr-1). This pattern was attributed to the higher sensitivity of forest-floor understorey to drought and its decreasing contribution to production relative to trees during stand development. This suggests that an age-dependent shift in understorey-tree composition with increasing stand age drives the drought response of the boreal forest NEP. Thus, our study advocates the need for partitioning ecosystem responses to improve empirical and modelling assessments of carbon cycle-climate feedbacks in boreal forests. It further implies that the forest age structure may strongly determine the carbon sink response to the projected increase in drought events across the managed boreal landscape. Carbon sink in young boreal forests is more vulnerable to drought than in mature forests due to the greater contribution and drought sensitivity of understorey relative to trees, according to carbon flux assessments of managed boreal forests in northern Sweden during the 2018 European summer drought.
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| 84. |
- Martinez-Garcia, Eduardo, et al.
(author)
-
Overstory dynamics regulate the spatial variability in forest-floor CO2 fluxes across a managed boreal forest landscape
- 2022
-
In: Agricultural and Forest Meteorology. - : Elsevier. - 0168-1923 .- 1873-2240. ; 318
-
Journal article (peer-reviewed)abstract
- The forest-floor represents an important interface for various carbon dioxide (CO2) fluxes, however, our knowledge of their variability and drivers across a managed boreal forest landscape is limited. Here, we used a three-year (2016-2018) data set of biometric- and chamber-based flux measurements to investigate the net forest-floor CO2 exchange (NEff) and its component fluxes across 50 forest stands spanning different soil types, tree species, and age classes within a 68 km2 boreal catchment in Sweden. We found that the forest-floor acted as a net CO2 source with the 10th-90th percentile (used hereafter for describing reported variations) ranging from 149 to 399 g C m- 2 yr-1. Among the key landscape attributes, stand age strongly affected most NEff component fluxes, whereas tree species and soil type effects were weak and absent, respectively. Specifically, forest-floor net CO2 emissions increased with stand age due to declining understory gross and net primary production, ranging between 77-275 and 49-163 g C m- 2 yr- 1, respectively. Furthermore, we observed higher understory production rates in pine than in spruce stands. Across the 50 stands, the total forest-floor respiration ranged between 340 and 549 g C m- 2 yr-1 and its spatial variation was primarily regulated by its autotrophic components, i.e., understory and tree root respiration, which displayed divergent increasing and decreasing age-related trends, respectively. Furthermore, heterotrophic soil respiration remained within a relatively narrow range (154-290 g C m- 2 yr- 1), possibly owing to compensating gradients in forest-floor properties. We further identified tree biomass as the major driver of the landscape-scale variations of CO2 fluxes, likely attributable to modulating effects on forest-floor resource availability and growing conditions. This implies that tree growth responses to forest management and global change will be particularly important for regulating magnitudes and spatial variations of forest-floor CO2 fluxes in boreal forests.
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| 85. |
- Martínez García, Eduardo
(author)
-
Productivity and Seasonality Drive Total Soil Respiration in Semi-Arid Juniper Woodlands (Juniperus thurifera L., Southern Spain)
- 2022
-
In: Forests. - : MDPI AG. - 1999-4907. ; 13
-
Journal article (peer-reviewed)abstract
- We analyzed the relationship between forest productivity (joint effect of forest maturity and soil quality) and total soil respiration (mu mol CO2 m(-2) s(-1)) in semi-arid juniper woodlands (young woodlands growing in abandoned farmlands with deeper soils, and mature woodlands in lithic soils), and investigated the seasonal variation in soil CO2 efflux as a function of soil temperature and the soil water content. We measured the soil CO2 efflux from twelve cylinders in the soil over a three-year period using LI-6400 equipment. The results show that, in the more productive site (young woodland), soil CO2 efflux was higher due to greater respiration, mainly in the driest periods. Soil respiration followed a seasonal trend, being higher in spring and decreasing in cold periods. In both juniper woodlands and especially in the older forest, the CO2 efflux rates were low (<2.5 for Q(10)), typical of slow-growing species. Soil respiration was controlled by soil temperature without drought and in the temperate-warm season, whereas respiration showed sensitivity to soil water content in periods when edaphic humidity was low (but only in the more productive, young forest, which seemed to show better adaptation to drought), and under high soil moisture (soil water > 25%) for both woodlands, coinciding with warm temperatures in the spring. This period also corresponded to the highest CO2 efflux recorded in both woodlands. The accumulation of organic C seems to also be important to maintain elevated soil respiration in summer, especially in young woodlands. Thus, apart from microclimatic conditions, factors related to productivity regulate respiratory activity.
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| 86. |
- Martínez-López, Joseba, et al.
(author)
-
Voltage and Overpotential Prediction of Vanadium Redox Flow Batteries with Artificial Neural Networks
- 2024
-
In: Batteries. - 2313-0105. ; 10:1
-
Journal article (peer-reviewed)abstract
- This article explores the novel application of a trained artificial neural network (ANN) in the prediction of vanadium redox flow battery behaviour and compares its performance with that of a two-dimensional numerical model. The aim is to evaluate the capability of two ANNs, one for predicting the cell potential and one for the overpotential under various operating conditions. The two-dimensional model, previously validated with experimental data, was used to generate data to train and test the ANNs. The results show that the first ANN precisely predicts the cell voltage under different states of charge and current density conditions in both the charge and discharge modes. The second ANN, which is responsible for the overpotential calculation, can accurately predict the overpotential across the cell domains, with the lowest confidence near high-gradient areas such as the electrode membrane and domain boundaries. Furthermore, the computational time is substantially reduced, making ANNs a suitable option for the fast understanding and optimisation of VRFBs.
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| 87. |
- Martinez-Morillo, Eduardo, et al.
(author)
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Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls
- 2014
-
In: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 1432-0533 .- 0001-6322. ; 127:5, s. 633-643
-
Journal article (peer-reviewed)abstract
- The apolipoprotein E (ApoE) epsilon 4 allele is the strongest risk factor of sporadic Alzheimer's disease (AD), however, the fluid concentrations of ApoE and its different isoforms (ApoE2, ApoE3 and ApoE4) in AD patients and among APOE genotypes (APOE epsilon 2, epsilon 3, epsilon 4) remain controversial. Using a novel mass spectrometry-based method, we quantified total ApoE and specific ApoE isoform concentrations and potential associations with age, cognitive status, cholesterol levels and established AD biomarkers in cerebrospinal fluid (CSF) from AD patients versus non-AD individuals with different APOE genotypes. We also investigated plasma total ApoE and ApoE isoform composition in a subset of these individuals. In total n = 43 AD and n = 43 non-AD subjects were included. We found that CSF and plasma total ApoE levels did not correlate with age or cognitive status and did not differ between AD and non-AD subjects deeming ApoE as an unfit diagnostic marker for AD. Also, whereas CSF ApoE levels did not vary between APOE genotypes APOE epsilon 4 carriers exhibited significantly decreased plasma ApoE levels attributed to a specific decrease in the ApoE4 isoform concentrations. CSF total ApoE concentrations were positively associated with CSF, total tau, tau phosphorylated at Thr181 and A beta 1-42 of which the latter association was weaker and only present in APOE epsilon 4 carriers indicating a differential involvement of ApoE in tau versus A beta-linked neuropathological processes. Future studies need to elucidate whether the observed plasma ApoE4 deficiency is a life-long condition in APOE E > 4 carriers and whether this decrease in plasma ApoE predisposes APOE E > 4 carriers to AD.
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| 88. |
- Mastroiacovo, Pierpaolo, et al.
(author)
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Gastroschisis and associated defects : an international study
- 2007
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In: American Journal of Medical Genetics, Part A. - : Wiley. - 1552-4825 .- 1552-4833. ; 143A:7, s. 660-671
-
Journal article (peer-reviewed)abstract
- Our objective was to evaluate the frequency and type of malformations associated with gastroschisis in a large pool of international data, to identify malformation patterns, and to evaluate the role of maternal age in non-isolated cases. Case-by-case information from 24 registries, all members of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), were evaluated. After the exclusion of other abdominal wall defects cases were classified as: (a) isolated; (b) recognizable syndrome, chromosomal or not; (c) multiple congenital anomalies (MCA). Our results showed that out of 3,322 total cases 469 non-isolated cases were registered (14.1%): 41 chromosomal syndromes, 24 other syndromes, and 404 MCA. Among MCA four groups of anomalies were most frequent: CNS (4.5%), cardio-vascular (2.5%), limb (2.2%), and kidney anomalies (1.9%). No similar patterns emerged except two patterns resembling limb-body wall complex and OEIS. In both of them the gastroschisis could be however misclassified. Chromosomal trisomies and possibly non-syndromic MCA are associated with an older maternal age more than isolated cases. On consideration of our data and the most valid studies published in the literature, the best estimate of the proportion of gastroschisis associated with major unrelated defects is about 10%, with a few cases associated to recognizable syndromes. Recognized syndromes with gastroschisis seem to be so exceptional that the well documented and validated cases are worth being published as interesting case report. An appropriate case definition in etiological studies should include only isolated gastroschisis after an appropriate definition of isolated and non-isolated cases and a thorough case-by-case review.
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| 89. |
- McMurray, John J, et al.
(author)
-
Effect of valsartan on the incidence of diabetes and cardiovascular events
- 2010
-
In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 362:16, s. 1477-1490
-
Journal article (peer-reviewed)abstract
- BACKGROUND: It is not known whether drugs that block the renin-angiotensin system reduce the risk of diabetes and cardiovascular events in patients with impaired glucose tolerance. METHODS: In this double-blind, randomized clinical trial with a 2-by-2 factorial design, we assigned 9306 patients with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors to receive valsartan (up to 160 mg daily) or placebo (and nateglinide or placebo) in addition to lifestyle modification. We then followed the patients for a median of 5.0 years for the development of diabetes (6.5 years for vital status). We studied the effects of valsartan on the occurrence of three coprimary outcomes: the development of diabetes; an extended composite outcome of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure, arterial revascularization, or hospitalization for unstable angina; and a core composite outcome that excluded unstable angina and revascularization. RESULTS: The cumulative incidence of diabetes was 33.1% in the valsartan group, as compared with 36.8% in the placebo group (hazard ratio in the valsartan group, 0.86; 95% confidence interval [CI], 0.80 to 0.92; P<0.001). Valsartan, as compared with placebo, did not significantly reduce the incidence of either the extended cardiovascular outcome (14.5% vs. 14.8%; hazard ratio, 0.96; 95% CI, 0.86 to 1.07; P=0.43) or the core cardiovascular outcome (8.1% vs. 8.1%; hazard ratio, 0.99; 95% CI, 0.86 to 1.14; P=0.85). CONCLUSIONS: Among patients with impaired glucose tolerance and cardiovascular disease or risk factors, the use of valsartan for 5 years, along with lifestyle modification, led to a relative reduction of 14% in the incidence of diabetes but did not reduce the rate of cardiovascular events. (ClinicalTrials.gov number, NCT00097786.)
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| 90. |
- Morales Salinas, Alberto, et al.
(author)
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Clinical Perspective on Antihypertensive Drug Treatment in Adults With Grade 1 Hypertension and Low-to-Moderate Cardiovascular Risk : An International Expert Consultation
- 2017
-
In: Current problems in cardiology. - : Elsevier. - 0146-2806 .- 1535-6280. ; 42:7, s. 198-225
-
Research review (peer-reviewed)abstract
- Hypertension is a leading risk factor for disease burden globally. An unresolved question is whether grade 1 hypertension (140-159/90-99 mm Hg) with low (cardiovascular mortality < 1% at 10 years) to moderate (cardiovascular mortality ≥ 1% and <5% at 10 years) absolute total cardiovascular risk (CVR) should be treated with antihypertensive agents. A virtual international consultation process was undertaken to summarize the opinions of select experts. After holistic analysis of all epidemiological, clinical, psychosocial, and public health elements, this consultation process reached the following consensus in hypertensive adults aged < 80 years: (1) The question of whether drug treatment in grade 1 should be preceded by a period of some weeks or months during which only lifestyle measures are recommended cannot be evidence based, but the consensus opinion is to have a period of lifestyle alone reserved only to patients with grade 1 "isolated" hypertension (grade 1 uncomplicated hypertension with low absolute total CVR, and without other major CVR factors and risk modifiers). (2) The initiation of antihypertensive drug therapy in grade 1 hypertension with moderate absolute total CVR should not be delayed. (3) Men ≥ 55 years and women ≥ 60 years with uncomplicated grade 1 hypertension should automatically be classified within the moderate absolute total CVR category, even in the absence of other major CVR factors and risk modifiers. (4) Statins should be considered along with blood-pressure lowering therapy, irrespective of cholesterol levels, in patients with grade 1 hypertensive with moderate CVR.
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| 91. |
- Nguyen‐Duc, Anh, et al.
(author)
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Work‐from‐home impacts on software project : A global study on software development practices and stakeholder perceptions
- 2024
-
In: Software, practice & experience. - : John Wiley & Sons. - 0038-0644 .- 1097-024X. ; 54:5, s. 896-926
-
Journal article (peer-reviewed)abstract
- Context:The COVID-19 pandemic has had a disruptive impact on how people work and collaborate across all global economic sectors, including software business. While remote working is not new for software engineers, forced WFH situations come with both limitations and opportunities. As the ‘new normal’ for working might be based on the current state of Work-from-home (WFH), it is useful to understand what has happened and learn from that.Objective:This study aims to gain insights into how their WFH arrangement impacts project management and software engineering. We are also interested in exploring these impacts in different contexts, such as startups and established companies.Method:We conducted a global-scale, cross-sectional survey during the spring and summer 2021. Our results are based on quantitative and qualitative analysis of 297 valid responses.Results:We characterize the profile of WFH in both spatial and temporal aspects, together with a set of common collaborative tools and coordination and control mechanisms. We revealed some areas of project management that are relatively more challenging during WFH situations, such as coordination, communication and project planning. We also revealed a mixed picture of the perceived impact of WFH on different software engineering activities.Conclusion:WFH is a situational phenomenon which can have both negative and positive impact on software teams. For practitioners, we suggest a unified approach to consider the context of WFH, collaborative tools, associated coordination and control approaches and a process that resolve those aspects that are sensitive to physical interaction.
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| 92. |
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| 93. |
- Pastor, Ada, et al.
(author)
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Local and regional drivers of headwater streams metabolism : insights from the first AIL collaborative project
- 2017
-
In: LIMNETICA. - : Asociacion Iberica de Limnologia. - 0213-8409 .- 1989-1806. ; 36:1, s. 67-85
-
Journal article (peer-reviewed)abstract
- Streams play a key role in the global biogeochemical cycles, processing material from adjacent terrestrial systems and transporting it downstream. However, the drivers of stream metabolism, especially those acting at broad spatial scales, are still not well understood. Moreover, stream metabolism can be affected by hydrological changes associated with seasonality, and thus, assessing the temporality of metabolic rates is a key question to understand stream function. This study aims to analyse the geographical and temporal patterns in stream metabolism and to identify the main drivers regulating the whole ecosystem metabolic rates at local and regional scales. Using a coordinated distributed experiment, we studied ten headwaters streams located across five European ecoregions during summer and fall 2014. We characterized the magnitude and variability of gross primary production (GPP) and ecosystem respiration (ER) with the open-channel method. Moreover, we examined several climatic, geographical, hydrological, morphological, and physicochemical variables that can potentially control stream metabolic rates. Daily rates of stream metabolism varied considerately across streams, with GPP and ER ranging from 0.06 to 4.33 g O-2 m(-2) d(-1) and from 0.72 to 14.20 g O-2 m(-2) d(-1), respectively. All streams were highly heterotrophic (P/R < 1), except the southernmost one. We found that the drier climates tended to have the highest GPP, while humid regions presented the highest ER. Between the sampling periods no statistical differences were found. Partial-least squares models (PLS) explained similar to 80% of the variance in GPP and ER rates across headwater streams and included both local and regional variables. Rates of GPP varied primarily in response to the local variables, such as streambed substrate and stream water temperature. In contrast, regional variables, such as the mean annual temperature or the land use of the catchment, had more relevance to explain ER. Overall, our results highlight that stream metabolism depends on both local and regional drivers and show the positive experience of a young network of researchers to assess scientific challenges across large-scale geographic areas.
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| 94. |
- Peichl, Matthias, et al.
(author)
-
Landscape-variability of the carbon balance across managed boreal forests
- 2023
-
In: Global Change Biology. - : John Wiley & Sons. - 1354-1013 .- 1365-2486. ; 29:4, s. 1119-1132
-
Journal article (peer-reviewed)abstract
- Boreal forests are important global carbon (C) sinks and, therefore, considered as a key element in climate change mitigation policies. However, their actual C sink strength is uncertain and under debate, particularly for the actively managed forests in the boreal regions of Fennoscandia. In this study, we use an extensive set of biometric- and chamber-based C flux data collected in 50 forest stands (ranging from 5 to 211 years) over 3 years (2016-2018) with the aim to explore the variations of the annual net ecosystem production (NEP; i.e., the ecosystem C balance) across a 68 km(2) managed boreal forest landscape in northern Sweden. Our results demonstrate that net primary production rather than heterotrophic respiration regulated the spatio-temporal variations of NEP across the heterogeneous mosaic of the managed boreal forest landscape. We further find divergent successional patterns of NEP in our managed forests relative to naturally regenerating boreal forests, including (i) a fast recovery of the C sink function within the first decade after harvest due to the rapid establishment of a productive understory layer and (ii) a sustained C sink in old stands (131-211 years). We estimate that the rotation period for optimum C sequestration extends to 138 years, which over multiple rotations results in a long-term C sequestration rate of 86.5 t C ha(-1) per rotation. Our study highlights the potential of forest management to maximize C sequestration of boreal forest landscapes and associate climate change mitigation effects by developing strategies that optimize tree biomass production rather than heterotrophic soil C emissions.
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| 95. |
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| 96. |
- Phad, Ganesh E., et al.
(author)
-
Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses
- 2020
-
In: Journal of Experimental Medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 217:2
-
Journal article (peer-reviewed)abstract
- Well-ordered HIV-1 envelope glycoprotein (Env) trimers are prioritized for clinical evaluation, and there is a need for an improved understanding about how elicited B cell responses evolve following immunization. To accomplish this, we prime-boosted rhesus macaques with Glade C NFL trimers and identified 180 unique Ab lineages from similar to 1,000 single-sorted Envspecific memory B cells. We traced all lineages in high-throughput heavy chain (HC) repertoire (Rep-seq) data generated from multiple immune compartments and time points and expressed several as monoclonal Abs (mAbs). Our results revealed broad dissemination and high levels of somatic hypermutation (SHM) of most lineages, including tier 2 virus neutralizing lineages, following boosting. SHM was highest in the Ab complementarity determining regions (CDRs) but also surprisingly high in the framework regions (FRO, especially FR3. Our results demonstrate the capacity of the immune system to affinity-mature large numbers of Env-specific B cell lineages simultaneously, supporting the use of regimens consisting of repeated boosts to improve each Ab, even those belonging to less expanded lineages.
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| 97. |
- Pinedo-Escobar, José Alfonso, et al.
(author)
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Nanoparticulate Double-Heterojunction Photocatalysts Comprising TiO2(Anatase)/WO3/TiO2(Rutile) with Enhanced Photocatalytic Activity toward the Degradation of Methyl Orange under Near-Ultraviolet and Visible Light
- 2021
-
In: ACS Omega. - : American Chemical Society (ACS). - 2470-1343. ; 6:18, s. 11840-11848
-
Journal article (peer-reviewed)abstract
- Nanoparticulate double-heterojunction photocatalysts comprising TiO2(Anatase)/WO3/TiO2(Rutile) were produced by a sol–gel method. The resulting photocatalysts exhibit clear synergistic effects when tested toward the degradation of methyl orange under both UV and visible light. Kinetic studies indicate that the degradation rate on the best double-heterojunction photocatalyst (10 wt % WO3-TiO2) depends mainly on the amount of dye concentration, contrary to pure oxides in which the degradation rate is limited by diffusion-controlled processes. The synergistic effects were confirmed through systematic and careful studies including holes and OH radical formation, X-ray diffraction, electron microscopy, elemental analysis, UV–vis diffuse reflectance spectroscopy, and surface area analysis. Our results indicate that the successful formation of a double heterojunction in the TiO2(Anatase)/WO3/TiO2(Rutile) system leads to enhanced photoactivity when compared to individual oxides and commercial TiO2 P25.
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| 98. |
- Piton, Gabin, et al.
(author)
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Disentangling drivers of soil microbial potential enzyme activity across rain regimes : An approach based on the functional trait framework
- 2020
-
In: Soil Biology and Biochemistry. - : Elsevier BV. - 0038-0717. ; 148
-
Journal article (peer-reviewed)abstract
- The functional trait framework provides a powerful corpus of integrated concepts and theories to assess how environmental factors influence ecosystem functioning through community assembly. While common in plant ecology, this approach is under-used in microbial ecology. After an introduction of this framework in the context of microbial ecology and enzymology, we propose an approach 1) to elucidate new links between soil microbial community composition and microbial traits; and 2) to disentangle mechanisms underlying “total” potential enzyme activity in soil (sum of 7 hydrolase potential activities). We address these objectives using a terrestrial grassland ecosystem model experiment with intact soil monoliths from three European countries (Switzerland, France and Portugal) and two management types (Conventional-intensive and Ecological-intensive), subjected to 4 rain regimes (Dry, Wet, Intermittent and Normal) under controlled conditions in a common climate chamber. We found tight associations between proxies of microbial ecoenzymatic community-weighted mean traits (enzymatic stoichiometry and biomass-specific activity) and community composition, bringing new information on resource acquisition strategy associated with fungi, Gram positive and Gram negative bacteria. We demonstrate that microbial biomass explained most of the total enzyme activity before altered rain regimes, whereas adjustments in biomass-specific activity (enzyme activity per unit of microbial biomass) explained most variation under altered rain regime scenarios. Furthermore, structural equation models revealed that the variation of community composition was the main driver of the variation in biomass-specific enzyme activity prior to rain perturbation, whereas physiological acclimation or evolutionary adaptation became an important driver only under altered rain regimes. This study presents a promising trait-based approach to investigate soil microbial community response to environmental changes and potential consequences for ecosystem functioning. We argue that the functional trait framework should be further implemented in microbial ecology to guide experimental and analytical design.
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| 99. |
- Piton, Gabin, et al.
(author)
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Resistance–recovery trade-off of soil microbial communities under altered rain regimes : An experimental test across European agroecosystems
- 2021
-
In: Journal of Applied Ecology. - : Wiley. - 0021-8901 .- 1365-2664. ; 58:2, s. 406-418
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Journal article (peer-reviewed)abstract
- With the increased occurrence of climate extremes, there is an urgent need to better understand how management strategies affect the capacity of the soil microbial community to maintain its ecosystem functions (e.g. nutrient cycling). To address this issue, intact monoliths were extracted from conventional and ecological managed grasslands in three countries across Europe and exposed under common air condition (temperature and moisture) to one of three altered rain regimes (dry, wet and intermittent wet/dry) as compared to a normal regime. Subsequently, we compared the resistance and recovery of the soil microbial biomass, potential enzyme activities and community composition. The microbial community composition differed with soil management and rain regimes. Soil microbial biomass increased from the wetter to the dryer rain regime, paralleling an increase of available carbon and nutrients, suggesting low sensitivity to soil moisture reduction but nutritional limitations of soil microbes. Conversely, enzyme activities decreased with all altered rain regimes. Resistance and recovery (considering absolute distance between normal and altered rain regime) of the microbial communities depended on soil management. Conventional-intensive management showed higher resistance of two fundamental properties for nutrient cycling (i.e. bacterial biomass and extracellular enzyme activities) yet associated with more important changes in microbial community composition. This suggests an internal community reorganization promoting biomass and activity resistance. Conversely, under ecological management bacterial biomass and enzyme activities showed better recovery capacity, whereas no or very low recovery of these properties was observed under conventional management. These management effects were consistent across the three altered rain regimes investigated, indicating common factors controlling microbial communities’ response to different climate-related stresses. Synthesis and applications. Our study provides experimental evidence for an important trade-off for agroecosystem management between (a) stabilizing nutrient cycling potential during an altered rain regime period at the expense of very low recovery capacity and potential long-term effect (conventional sites) and (b) promoting the capacity of the microbial community to recover its functional potential after the end of the stress (ecological sites). Thus, management based on ecologically sound principles may be the best option to sustain long-term soil functioning under climate change.
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