Adverse reactions to intravenous administration of fusidic acid.

• To study adverse reactions associated with intravenous administration of fusidic acid 6 patients were treated with fusidic acid intravenously in association with a major large bowl operation, and 9 patients were treated in the same way because of staphylococcal infections. The main adverse reaction was thrombophlebitis, which occurred in as many as 12 of 14 patients who were treated for 2 days or longer. Three surgical patients developed postoperative hyperbilirubinaemia, but studies of liver function before and during treatment in 6 of the patients with staphylococcal disease revealed no adverse liver reactions. Intravenous administration of fusidic acid into a peripheral vein for 24 h or more involves an extremely high risk of developing thrombophlebitis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

Adult

Aged

Female

Fusidic Acid

administration & dosage

adverse effects

Humans

Hyperbilirubinemia

chemically induced

Infusions

Parenteral

Male

Middle Aged

Postoperative Complications

etiology

Prospective Studies

Staphylococcal Infections

drug therapy

Thrombophlebitis

chemically induced

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)