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Sökning: L773:0091 3022 OR L773:1095 6808 > (2010-2014)

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1.
  • Alsiö, Johan, et al. (författare)
  • Feed-forward mechanisms : Addiction-like behavioral and molecular adaptations in overeating
  • 2012
  • Ingår i: Frontiers in neuroendocrinology (Print). - : Elsevier BV. - 0091-3022 .- 1095-6808. ; 33:2, s. 127-139
  • Forskningsöversikt (refereegranskat)abstract
    • Food reward, not hunger, is the main driving force behind eating in the modern obesogenic environment. Palatable foods, generally calorie-dense and rich in sugar/fat, are thus readily overconsumed despite the resulting health consequences. Important advances have been made to explain mechanisms underlying excessive consumption as an immediate response to presentation of rewarding tastants. However, our understanding of long-term neural adaptations to food reward that oftentimes persist during even a prolonged absence of palatable food and contribute to the reinstatement of compulsive overeating of high-fat high-sugar diets, is much more limited. Here we discuss the evidence from animal and human studies for neural and molecular adaptations in both homeostatic and non-homeostatic appetite regulation that may underlie the formation of a "feed-forward" system, sensitive to palatable food and propelling the individual from a basic preference for palatable diets to food craving and compulsive, addiction-like eating behavior.
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2.
  • Amandusson, Åsa, et al. (författare)
  • Estrogenic influences in pain processing
  • 2013
  • Ingår i: Frontiers in neuroendocrinology (Print). - : Elsevier. - 0091-3022 .- 1095-6808. ; 34:4, s. 329-349
  • Forskningsöversikt (refereegranskat)abstract
    • Gonadal hormones not only play a pivotal role in reproductive behavior and sexual differentiation, they also contribute to thermoregulation, feeding, memory, neuronal survival, and the perception of somatosensory stimuli. Numerous studies on both animals and human subjects have also demonstrated the potential effects of gonadal hormones, such as estrogens, on pain transmission. These effects most likely involve multiple neuroanatomical circuits as well as diverse neurochemical systems and they therefore need to be evaluated specifically to determine the localization and intrinsic characteristics of the neurons engaged. The aim of this review is to summarize the morphological as well as biochemical evidence in support for gonadal hormone modulation of nociceptive processing, with particular focus on estrogens and spinal cord mechanisms.
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  • Resultat 1-4 av 4

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