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Träfflista för sökning "L773:0163 2116 OR L773:1573 2568 srt2:(1995-1999)"

Sökning: L773:0163 2116 OR L773:1573 2568 > (1995-1999)

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1.
  • Raab, Y, et al. (författare)
  • Eosinophil activation in ulcerative colitis : studies on mucosal release and localization of eosinophil granule constituents.
  • 1998
  • Ingår i: Digestive Diseases and Sciences. - 0163-2116 .- 1573-2568. ; 43:5, s. 1061-70
  • Tidskriftsartikel (refereegranskat)abstract
    • Activation of eosinophil granulocytes (eosinophils) seems to contribute to the pathophysiology of several inflammatory conditions. This process was evaluated in 18 patients with ulcerative colitis and in 18 healthy controls using intraluminal segmental perfusion of the sigmoid colon and rectum and immunoanalysis for eosinophil cationic protein (ECP) in the perfusate. Immunohistochemistry for eosinophils and neutrophils was made in simultaneously taken biopsies and in biopsies from surgical specimens taken from additional 10 patients. The mucosal release of ECP was increased severalfold in patients with UC. The bowel biopsies demonstrated a lamina propria infiltrated with eosinophils. The degree of eosinophil activation/degranulation was related to the intensity of the inflammatory reaction. Activated eosinophils and extracellular deposits of ECP were, in particular, seen in crypt abscesses and in areas with damaged surface epithelium. Since ECP is highly cytotoxic, its release at the site of inflammatory bowel lesions might reflect a potential pathophysiological mechanism.
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  • Duan, R D, et al. (författare)
  • Distribution of alkaline sphingomyelinase activity in human beings and animals. Tissue and species differences
  • 1996
  • Ingår i: Digestive Diseases and Sciences. - 1573-2568. ; 41:9, s. 1801-1806
  • Tidskriftsartikel (refereegranskat)abstract
    • The alkaline sphingomyelinase (SMase) was first found in rat intestinal brush border. The important roles of this enzyme in digestion of sphingomyelin and in mucosal cell proliferation have been suggested. In the present work, the distribution of the alkaline SMase in the tissues of human beings and animals have been studied. By assaying the enzyme activity in human biopsy samples, we found that the alkaline SMase activity was absent in the stomach, increased in the duodenum, present at high levels in the small intestine, and slightly declined in the colon and rectum. High activities were found similarly in the intestinal contents of the healthy adults and infants. The activities were also found in the intestinal mucosa of rats, normal and germ-free mice, and hamsters with the same distribution pattern as in humans, but not in the intestinal mucosa of guinea pigs. Apart from the intestinal tract, a SMase activity preferring alkaline pH was identified in human and guinea pig bile, but not in the bile of rat, pig, sheep, and cow. No activity was found in either pancreatic tissue or pancreatic juice in all species tested, and none was detected in human urine and milk. In conclusion, alkaline SMase exists predominantly in the digestive system with considerable tissue and species differences.
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  • Resultat 1-13 av 13

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