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- Bjarnason, B, et al.
(författare)
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Reactivity at edges of corticosteroid patch tests may be an indicator of a strong positive test response
- 1999
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Ingår i: Dermatology (Basel, Switzerland). - : S. Karger AG. - 1018-8665 .- 1421-9832. ; 199:2, s. 130-134
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Tidskriftsartikel (refereegranskat)abstract
- <b>Background:</b> The importance of the reactivity at the edges of corticosteroid patch tests is unknown. <b>Objective:</b> To study the clinical importance of edge reactivity in budesonide patch tests. <b>Methods:</b> Ten subjects previously positive for budesonide patch tests were retested with 0.1% budesonide in Finn Chambers<sup>®</sup> and with budesonide-printed polyester squares in serial doses (150–0.074 μg/cm<sup>2</sup>). Six exposure periods were used for each polyester square dose (3 h to 4 days). Tests were followed up to 11 days. Doubtful or weakly visible reactivity at the test edges was assessed additionally by test perfusion assessments. <b>Results:</b> Nine of 10 subjects reacted with some edge reactivity and later exhibited positive reactions. Perfusion assessments helped to confirm early edge reactivity. Some allergic subjects showed edge reactivity only at high doses, while longer applications were required for weaker doses. <b>Conclusion:</b> Edge reactivity may be an indicator of a strong suppressed test response.
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- Emtestam, L, et al.
(författare)
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Electrical impedance of nodular basal cell carcinoma: a pilot study
- 1998
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Ingår i: Dermatology (Basel, Switzerland). - : S. Karger AG. - 1018-8665 .- 1421-9832. ; 197:4, s. 313-316
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Tidskriftsartikel (refereegranskat)abstract
- Background: Previously, we have explored the use of measurements of electrical impedance and devised 4 physically distinct indices named magnitude index (MIX), phase index, real part index and imaginary part index (IMIX) from the impedance data. Our results indicated that these indices could characterize contact reactions. Objective: The goal of the present study was to use the electrical impedance method for the preoperative assessment of nodular basal cell carcinoma (BCC). Methods: We included 11 patients with a total of 12 nodular BCC, diagnosed clinically and histologically. The noninvasive measurements were performed by transepidermal water loss (TEWL) and electrical impedance. For reference, normal looking contralateral or ipsilateral skin was used. Results: Compared to controls, the mean TEWL of BCC was increased, but this finding was not statistically significant. The electrical impedance measurements of BCC tissue revealed statistically significant changes of the impedance indices MIX and IMIX (p ≤0.001). Conclusion: The results suggest that the measurement of electrical impedance might become useful for investigations of BCC.
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