| 1. |
- Gerold, Gisa, 1979-, et al.
(författare)
-
What is the role of Toll-like receptors in bacterial infections?
- 2007
-
Ingår i: Seminars in Immunology. - : Elsevier BV. - 1044-5323 .- 1096-3618. ; 19:1, s. 41-7
-
Tidskriftsartikel (refereegranskat)abstract
- Innate immunity relies on signalling by Toll-like receptors (TLRs) to alert the immune system of the presence of invading bacteria. TLR activation leads to the release of cytokines that allow for effective innate and adaptive immune responses. However, the contribution of different TLRs depends on the site of the infection and the pathogen. This review will describe the involvement of TLRs in the development of three different bacterial infections as well as our current understanding of the role of TLRs during microbial pathogenesis.
|
|
| 2. |
- Le Pendu, Jacques, et al.
(författare)
-
Mendelian resistance to human norovirus infections
- 2006
-
Ingår i: Seminars in Immunology. - : Elsevier BV. - 1044-5323 .- 1096-3618. ; 18:6, s. 375-386
-
Tidskriftsartikel (refereegranskat)abstract
- Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the α1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2-/-), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. Moreover, the capsid protein from distinct strains shows different HBGA specificities, suggesting a host-pathogen co-evolution driven by carbohydrate-protein interactions. © 2006.
|
|
| 3. |
- Lokmic, Zerina, et al.
(författare)
-
The extracellular matrix of the spleen as a potential organizer of immune cell compartments.
- 2008
-
Ingår i: Seminars in immunology. - : Elsevier BV. - 1044-5323. ; 20:1, s. 4-13
-
Forskningsöversikt (refereegranskat)abstract
- Until recently little information was available on the molecular details of the extracellular matrix (ECM) of secondary lymphoid tissues. There is now growing evidence that these ECMs are unique structures, combining characteristics of basement membranes and interstitial or fibrillar matrices, resulting in scaffolds that are strong and highly flexible and, in certain secondary lymphoid compartments, also forming conduit networks for rapid fluid transport. This review will address the structural characteristics of the ECM of the murine spleen and its potential role as an organizer of immune cell compartments, with reference to the lymph node where relevant.
|
|
| 4. |
- Loskog, Angelica, et al.
(författare)
-
The Janus faces of CD40 in cancer
- 2009
-
Ingår i: Seminars in Immunology. - : Elsevier BV. - 1044-5323 .- 1096-3618. ; 21:5, s. 301-307
-
Forskningsöversikt (refereegranskat)abstract
- CD40 is a TNF receptor family member that is widely recognized for its prominent role in immune regulation and homeostasis. Expression of CD40 is not restricted to normal lymphoid cells but is also evident in the majority of haemopoietic and epithelial malignancies where it has been implicated in oncogenic events. Accumulating evidence, however, suggests that the CD40 pathway can be exploited for cancer therapy by virtue of its ability to stimulate the host anti-tumor immune response, normalize the tumor microenvironment and directly suppress the growth of CD40-positive tumors. Here, we provide an overview of the multifaceted functions of the CD40 pathway in cancer and its emerging role in the treatment of malignancy.
|
|
| 5. |
- Luc, Sidinh, et al.
(författare)
-
Delineating the cellular pathways of hematopoietic lineage commitment.
- 2008
-
Ingår i: Seminars in Immunology. - : Elsevier BV. - 1096-3618 .- 1044-5323. ; 20, s. 213-220
-
Tidskriftsartikel (refereegranskat)abstract
- The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver.
|
|
