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- Ekdahl, Kristina N., et al.
(författare)
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Complement inhibition in biomaterial- and biosurface-induced thromboinflammation
- 2016
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Ingår i: Seminars in Immunology. - : Elsevier BV. - 1044-5323 .- 1096-3618. ; 28:3, s. 268-277
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Tidskriftsartikel (refereegranskat)abstract
- Therapeutic medicine today includes a vast number of procedures involving the use of biomaterials, transplantation of therapeutic cells or cell clusters, as well as of solid organs. These treatment modalities are obviously of great benefit to the patient, but also present a great challenge to the innate immune system, since they involve direct exposure of non-biological materials, cells of non-hematological origin as well as endothelial cells, damaged by ischemia-perfusion in solid organs to proteins and cells in the blood. The result of such an exposure may be an inappropriate activation of the complement and contact/kallikrein systems, which produce mediators capable of triggering the platelets and PMNs and monocytes, which can ultimately result in thrombotic and inflammatory (i.e., a thrombo-inflammatory) response to the treatment modality. In this concept review, we give an overview of the mechanisms of recognition within the innate immunity system, with the aim to identify suitable points for intervention. Finally, we discuss emerging and promising techniques for surface modification of biomaterials and cells with specific inhibitors in order to diminish thromboinflammation and improve clinical outcome.
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- Harandi, Ali M, 1968
(författare)
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Systems analysis of human vaccine adjuvants
- 2018
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Ingår i: Seminars in Immunology. - : Elsevier BV. - 1044-5323. ; 39:C (Special Issue: SI ), s. 30-34
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Tidskriftsartikel (refereegranskat)abstract
- The discovery and wide spread use of vaccines have saved millions of lives in the past few decades. Vaccine adjuvants represent an integral part of the modem vaccines. Despite numerous efforts, however, only a handful of vaccine adjuvants is currently available for human use. A comprehensive understanding of the mechanisms of action of adjuvants is pivotal to harness the potential of existing and new adjuvants in mounting desirable immune responses to counter human pathogens. Decomposing the host response to vaccines and its components at systems level has recently been made possible owing to the recent advancements in Omics technology and cutting edge immunological assays powered by systems biology approaches. This approach has begun to shed light on the molecular signatures of several human vaccines and adjuvants. This review is an attempt to provide an overview of the recent efforts in systems analysis of vaccine adjuvants that are currently in clinic.
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- Holmes, TD, et al.
(författare)
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Natural killer cell memory in context
- 2016
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Ingår i: Seminars in immunology. - : Elsevier BV. - 1096-3618 .- 1044-5323. ; 28:4, s. 368-376
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Tidskriftsartikel (refereegranskat)
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- Wan, M, et al.
(författare)
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Biosynthesis of leukotriene B4
- 2017
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Ingår i: Seminars in immunology. - : Elsevier BV. - 1096-3618 .- 1044-5323. ; 33:C, s. 3-15
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Tidskriftsartikel (refereegranskat)
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