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The effect of cph-8...
The effect of cph-82 on the growth of human-lymphocytes in vitro : definition of cytobiological action
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- Dahlqvist, Solbritt Rantapää (författare)
- Umeå universitet,Reumatologi
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- Norberg, B (författare)
- Blood Centre, University Hospital S-901 85 Umeå, Sweden
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- Sondell, K (författare)
- Blood Centre, University Hospital S-901 85 Umeå, Sweden
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- Nordenson, I (författare)
- Department of Clinical Genetics, University Hospital S-901 85 Umeå, Sweden
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- Holmgren, G (författare)
- Department of Clinical Genetics, University Hospital S-901 85 Umeå, Sweden
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(creator_code:org_t)
- Oxford University Press (OUP), 1989
- 1989
- Engelska.
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Ingår i: British Journal of Rheumatology. - : Oxford University Press (OUP). - 0263-7103 .- 1460-2172. ; 28:5, s. 418-421
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A drug composed of two semisynthetic podophyltine derivatives, CPH 82, has recently been launched for the treatment of severe rheumatoid arthritis. The present in vitro study of PHA-stimulated human T-lymphocytes showed that CPH 82 arrested cell division in a metaphase-like configuration. The cell cycle effects of CPH 82 were indistinguishable from the cell cycle effects of the classical microtubule depolymerizers, Colcemid (a colchicine derivative) and podophyllotoxin. A CPH 82 concentration of 1 (µg/ml, which is close to therapeutic serum concentrations, had an almost maximal effect on cell division. It is suggested that at least part of the anti-inflammatory effect of CPH 82 is due to a colchicine-like activity on, for example, proliferating lymphocytes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Podophylline derivative
- CPH 82
- Antimitotic effects
- Arrest
- Rheumatology
- Reumatologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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