| 1. |
- Ellervall, E, et al.
(författare)
-
Antibiotic prophylaxis in oral healthcare - the agreement between Swedish recommendations and evidence.
- 2010
-
Ingår i: British Dental Journal. - : Springer Science and Business Media LLC. - 1476-5373 .- 0007-0610. ; 208:3, s. 5-115
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Almost all (17/20) Swedish counties have pharmaceutical committees that establish recommendations for the use of antibiotic prophylaxis in oral healthcare.Objective To evaluate the evidence for the use of antibiotic prophylaxis in oral healthcare and the agreement between Swedish recommendations and evidence. MATERIAL AND METHODS: We conducted a systematic literature search in PubMed and the Cochrane Controlled Trials Register. The MeSH terms 'antibiotic prophylaxis' and 'dentistry' were used in the database search. Abstracts were reviewed according to specific inclusion and exclusion criteria. A total of 186 articles were read in full text by the four authors independently. Data extraction and interpretation of data was carried out using a pre-defined protocol. In the end, one case-control study was included for evaluation of evidence. RESULTS: The case-control study included patients with specific cardiac conditions. The study reported a 49% protective efficacy (odds ratio: 0.51) of antibiotic prophylaxis for first-time episodes of endocarditis within 30 days of procedure. This result was not statistically significant. The quality of the evidence was low. No studies were evaluated on patients with other medical conditions. The recommendations included several cardiac and other medical conditions for which there is a lack of evidence or no evidence to support the use of antibiotic prophylaxis.CONCLUSIONS: There is a lack of evidence to support the use of antibiotic prophylaxis. To avoid the risk of adverse events from antibiotics and the risk of developing resistant bacterial strains, the use of antibiotic prophylaxis should be minimised and recommendations in Sweden should be revised to be more evidence-based.
|
|
| 2. |
- Kharazmi, Mohammad, et al.
(författare)
-
Oral surgery : Prominent bone shelves
- 2014
-
Ingår i: British Dental Journal. - : Springer Science and Business Media LLC. - 0007-0610 .- 1476-5373. ; 216:10, s. 544-545
-
Tidskriftsartikel (refereegranskat)
|
|
| 3. |
- Sandy, J, et al.
(författare)
-
Using service rationalisation to build a research network : lessons from the centralisation of UK services for children with cleft lip and palate
- 2012
-
Ingår i: British Dental Journal. - 0007-0610 .- 1476-5373. ; 212:11, s. 553-5
-
Tidskriftsartikel (refereegranskat)abstract
- In the UK around a thousand children are born annually with a cleft lip and/or palate that requires treatment. In the last decade services have been centralised in the UK reducing the 57 centres operating on these children in 1998, down to 11 centres or managed clinical networks in 2011. While the rationale for centralisation was to improve the standard of care (and in so doing the outcome) for children born with cleft lip and/or palate, research was central to this process. We illustrate how research informed and shaped this service rationalisation and how it facilitated the emergence of a research culture within the newly configured teams. We also describe how these changes in service provision were linked to the development of a national research strategy and to the identification of the resources necessary to support this strategy.
|
|
| 4. |
- Sandy, J, et al.
(författare)
-
Why are multi-centre clinical observational studies still so difficult to run?
- 2011
-
Ingår i: British Dental Journal. - 0007-0610 .- 1476-5373. ; 211:2, s. 59-61
-
Tidskriftsartikel (refereegranskat)abstract
- Despite the introduction of IRAS, obtaining R&D approvals for multicentre studies is a major rate limiting step. Our experience with cleft research demonstrates that this approvals process must be drastically and rapidly improved if we wish to continue attract clinical research to the UK.
|
|
| 5. |
- Trachtenberg, F L, et al.
(författare)
-
Dental composite materials and renal function in children.
- 2014
-
Ingår i: British dental journal. - : Springer Science and Business Media LLC. - 1476-5373 .- 0007-0610. ; 216:2
-
Tidskriftsartikel (refereegranskat)abstract
- To examine whether greater exposure to resin-based composite materials, which may intra-orally release bisphenol A (BPA), is associated with worse renal function outcomes in children.
|
|
