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- Frisén, Lars, 1939
(author)
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High-pass resolution perimetry: central-field neuroretinal correlates.
- 1995
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In: Vision research. - 0042-6989. ; 35:2, s. 293-301
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Journal article (peer-reviewed)abstract
- Minimum angles of resolution (MAR) were measured at 0-10 deg horizontal eccentricity in three normal subjects, using high-pass spatial frequency filtered targets, at four different contrast levels. Results were correlated with recent data on human cone and ganglion cell separations in corresponding retinal locations. MARs and cone separations showed a close proportionality through the origin for all contrast levels. Ganglion cell correlates were more difficult to elucidate as the cell bodies are displaced from their input cones. Taking a functional estimate of the displacement into account, the number of ganglion cells appeared to be large enough to uphold an "effective" distribution that obeys the same proportional relationship to MAR that previously has been demonstrated outside 10 deg. Analysis of the nature of age effects provided support for this model.
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- Frisén, Lars, 1939, et al.
(author)
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Relative dispersion analysis enhances perimetric sensitivity.
- 1996
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In: Vision research. - 0042-6989. ; 36:3, s. 491-7
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Journal article (peer-reviewed)abstract
- Objective identification of minor visual field defects is problematic. A possible solution is to examine spatial correlations by means of relative dispersion analysis, a tool of fractal analysis. We studied patients with glaucoma, previous optic neuritis, chiasmal compression and lesions of the brain hemispheres, using high-pass resolution perimetry. One-hundred visual field records were drawn consecutively for each category and ranked according to severity of defects. Records with scores ranking below the 35th percentile, i.e. those with the smallest field defects, were analysed. Relative dispersion analysis recognized 1.3-2.4 times more abnormal subjects than did pattern standard deviation. A previously described form index was intermediate in sensitivity. Specificity was 96%. Relative dispersion analysis appears to capture a novel aspect of visual field abnormality, with good sensitivity and specificity. The analysis is easily performed.
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- Sjöstrand, Johan, 1936, et al.
(author)
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Quantitative estimations of foveal and extra-foveal retinal circuitry in humans
- 1999
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In: Vision Research. - 0042-6989. ; 39:18, s. 2987-2998
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Journal article (peer-reviewed)abstract
- For an understanding of the basis for psychophysical measurement of visual resolution, quantitative morphological studies of retinal neuronal architecture are needed. Here we report on cell densities and retinal ganglion cell:cone ratio (RGC:C) from the foveal border to the peripheral retina (34 degrees eccentricity). Quantitative estimates of RGC and C densities were made using a modified disector method in three vertically sectioned human retinae and were adjusted for RGC displacement. In agreement with our previous data on humans, we found an RGC:C ratio close to 3 at 2-3 degrees eccentricity. Outside the foveal border, the ratio declined to 1.0 at 7.5 degrees eccentricity and to 0.5 at eccentricities larger than 19 degrees. Center-to-center separation of C and RGC in addition to center-to-center separation of estimated 'receptive fields' was calculated at corresponding locations along the superior and inferior hemimeridians. The center-to-center separation of estimated 'receptive fields' was found to be more closely related to resolution thresholds from the fovea to 19 degrees eccentricity than was the separation of RGC and C. On the basis of these quantitative estimates, models for neural circuitry involved in central and peripheral spatial vision can be discussed. (C) 1999 Elsevier Science Ltd. All rights reserved.
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