| 1. |
- Hegazy, Mohamed-Elamir F., et al.
(författare)
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Cytotoxic Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum
- 2011
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Ingår i: Natural Product Communications. - 1934-578X .- 1555-9475. ; 6:12, s. 1809-1812
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Tidskriftsartikel (refereegranskat)abstract
- One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7 alpha,8 beta-dihydroxydecpoxysarcophine (2), 7 beta-acetoxy-8 alpha-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7 beta-Acetoxy-8 alpha-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC(50) values of 3.6, 2.3, and 6.7 mu g/mL, respectively.
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| 2. |
- Almanza, Giovanna R., et al.
(författare)
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Antioxidant and Antimutagenic Polyisoprenylated Benzophenones and Xanthones from Rheedia acuminata
- 2011
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Ingår i: Natural Product Communications. - 1934-578X. ; 6:9, s. 1269-1274
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Tidskriftsartikel (refereegranskat)abstract
- Dichloromethane extract of the stem bark of Rheedia acuminata yielded three benzophenones with antioxidant activity, the new one named acuminophenone A (1), guttiferone K (2) and isoxanthochymol (3), along with the known xanthones formoxanthone C (4) and macluraxanthone (5). The structures were established through interpretation of their spectroscopic data, the stereochemistry of compounds (1) and (2) were resolved by experimental and computational experiments and their antioxidant activities were measured using the DPPH, ABTS and TEAC assays. The antioxidant results showed that metabolites 1, 4 and 5 had a better antioxidant activity than the reference compound quercetin. In addition, we evaluate the mutagenicity and antimutagenicity of the CH2Cl2 extract as well as of the free radical scavenger compounds 1, 4 and 5 by the AMES Salmonella/microsomal test. No mutagenicity was found in the CH2Cl2 extract using Salmonella typhimurium strains TA98, TA100, TA102, TA1537 and TA1538, with or without S9 metabolic activation. The pure compounds neither showed mutagenicity in TA 102 strain and the most important result was the strong reduction of mutagenic effect induced by hydrogen peroxide in S. typhimurium TA 102, with or without S9, showed by the compounds 1 (more than 93%) and 4 (more than 88%) at 0.02 mu g/plate.
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| 3. |
- Sohretoglu, Didem, et al.
(författare)
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A New Acylated Neohesperidoside from Geranium purpureum
- 2011
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Ingår i: Natural Product Communications. - 1934-578X. ; 6:9, s. 1321-1322
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Tidskriftsartikel (refereegranskat)abstract
- A new acylated neohesperoside derivative, 1-octyl-4'-isovaleroyl-neohesperoside (1), was isolated from Geranium purpureum Vill. (Geraniaceae) together with the known compounds quercetin-3-rutinoside and gallic acid. The identification of the isolated compounds was carried out by spectroscopic analysis including 1D- and 2D- NMR (H-1, C-13, COSY, HSQC and HMBC) spectroscopy and ESI-TOF-MS.
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| 4. |
- Sohretoglu, Didem, et al.
(författare)
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Antioxidant Effects of Secondary Metabolites from Geranium psilostemon
- 2010
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Ingår i: Natural Product Communications. - 1934-578X. ; 5:6, s. 899-902
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Tidskriftsartikel (refereegranskat)abstract
- An investigation was made of the effects on endogenous antioxidant enzyme activities and H2O2-induced lipid peroxidation inhibition in human red blood cells of the crude MeOH extract and its EtOAc, n-BuOH, and H2O sub-extracts obtained from aerial parts of Geranium psilostemon Ledeb., as well as compounds isolated from the most active EtOAc extract. Gallic acid (1), methyl gallate (2), pusilagin (3), 1,3,6-tri-O-galloyl-beta-glucopyranoside (4), 1,2,3,4,6-penta-O-galloyl-beta-glucopyranoside (5), kaempferol (6), quercetin (7), kaempferol 7-O-alpha-rhamnopyranoside (8), and quercetin 7-O-alpha-rhamnopyranoside (9) were isolated from the aerial parts of the title plant, and their structures identified from spectroscopic (UV, 1D- and 2D- NMR) and spectrometric (TOF-MS) data. All extracts and isolated compounds inhibited H2O2-induced lipid peroxidation and also enhanced the activity of superoxide dismutase (SOD) and catalase (CAT).
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