| 1. |
- Carville, N. Craig, et al.
(författare)
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Biocompatible Gold Nanoparticle Arrays Photodeposited on Periodically Proton Exchanged Lithium Niobate
- 2016
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Ingår i: ACS Biomaterials Science & Engineering. - : American Chemical Society (ACS). - 2373-9878. ; 2:8, s. 1351-1356
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Tidskriftsartikel (refereegranskat)abstract
- Photodeposition of silver nanoparticles onto chemically patterned lithium niobate having alternating lithium niobate and proton exchanged regions has been previously investigated. Here, the spatially defined photodeposition of gold nanoparticles onto periodically proton exchanged lithium niobate is demonstrated. It is shown that the location where the gold nanoparticles form can be tailored by altering the concentration of HAuCl4. This enables the possibility to sequentially deposit gold and silver in different locations to create bimetallic arrays. The cytocompatibility of photodeposited gold, silver, and bimetallic ferroelectric templates to osteoblast-like cells is also investigated. Gold samples provide significantly greater cell biocompatibility than silver samples. These results highlight a potential route for using photodeposited gold on lithium niobate as a template for applications in cellular biosensing.
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| 2. |
- Leblanc, K. J., et al.
(författare)
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Stability of High Speed 3D Printing in Liquid-Like Solids
- 2016
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Ingår i: ACS Biomaterials Science & Engineering. - : American Chemical Society. - 2373-9878. ; 2:10, s. 1796-1799
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Tidskriftsartikel (refereegranskat)abstract
- Fluid instabilities limit the ability of features to hold their shape in many types of 3D printing as liquid inks solidify into written structures. By 3D printing directly into a continuum of jammed granular microgels, these instabilities are circumvented by eliminating surface tension and body forces. However, this type of 3D printing process is potentially limited by inertial instabilities if performed at high speeds where turbulence may destroy features as they are written. Here, we design and test a high-speed 3D printing experimental system to identify the instabilities that arise when an injection nozzle translates at 1 m/s. We find that the viscosity of the injected material can control the Reynold's instability, and we discover an additional, unanticipated instability near the top surface of the granular microgel medium.
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| 3. |
- Liang, Lijun, et al.
(författare)
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Theoretical Evaluation on Potential Cytotoxicity of Graphene Quantum Dots
- 2016
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Ingår i: ACS Biomaterials Science & Engineering. - : AMER CHEMICAL SOC. - 2373-9878. ; 2:11, s. 1983-1991
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Tidskriftsartikel (refereegranskat)abstract
- Owing to unique morphology, ultrasmall lateral sizes, and exceptional properties, graphene quantum dots (GQDs) hold great potential in many applications, especially in the field of electrochemical biosensors, bioimaging, drug delivery, et cetera. Its biosafety and potential cytotoxicity to human and animal cells has been a growing concern in recent years. In this work, the potential cytotoxicity of GQDs was evaluated by molecular dynamics simulations. Our simulation demonstrates that small size GQDs could easily permeate into the lipid membrane in a vertical way. It is relatively difficult to permeate into the lipid membrane for GQDs that are larger than GQD61 on the nanosecond time-scale. The thickness of the POPC membrane could even be affected by the small size of GQDs. Free energy calculations revealed that the free energy barrier of GQD permeation through the lipid membrane could greatly change with the change of GQD size. Under high GQD concentration, the GQD molecules could rapidly aggregate in water but disaggregate after entering into the membrane interior. Moreover, high concentrations of GQDs could induce changes in the structure properties and diffusion properties of the lipid bilayer, and it may affect the cell signal transduction. However, GQDs with relatively small size are not large enough to mechanically damage the lipid membrane. Our results suggest that the cytotoxicity of GQDs with small size is low and may be appropriate for biomedical application.
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| 4. |
- Pettersson, Maria, et al.
(författare)
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Morphology and dissolution rate of wear debris from silicon nitride coatings
- 2016
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Ingår i: ACS Biomaterials Science & Engineering. - : American Chemical Society (ACS). - 2373-9878. ; 2:6, s. 998-1004
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Tidskriftsartikel (refereegranskat)abstract
- Silicon nitride (SiNx) coatings have recentlY been introduced as a potential material for joint implant bearing surfaces, but there is no data on wear debri morphology nor their dissolution rate, something that could play a central role to implant longevity. In this study, wear debris was generated in a ball-on-disc setup in simulated body fluid. After serum digestion the debris was analyzed with scanning electron microscopy and energy-dispersive X-ray spectroscopy. The particle dissolution rate was evaluated using inductively coupled plasma techniques, on model SiNx particlEs. The wear debris from SiNx coatings was found to be round, in the nm range and formed agglomerates in the submicrometer to micrometer range. Model particles dissolved in simulated body fluid at a rate of: c(t) = 39.45[1 - exp(-1.11 X 10(-6) t], where [c(t)] = mg/L and [t] = s. This study can be used as a preliminary prediction of size, shape, and dissolution rate of wear debris from SiNx coatings.
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| 5. |
- Tummala, Gopi Krishna, 1986-, et al.
(författare)
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Hyperelastic Nanocellulose-Reinforced Hydrogel of High Water Content for Ophthalmic Applications
- 2016
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Ingår i: ACS Biomaterials Science & Engineering. - : American Chemical Society (ACS). - 2373-9878. ; 2:11, s. 2072-2079
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Tidskriftsartikel (refereegranskat)abstract
- A nanocellulose-reinforced poly(vinyl alcohol) hydrogel material of exceptionally high water content for ophthalmic applications is presented (>90 wt %), which also features a hitherto unprecedented combination of optical, mechanical, viscoelastic, oxygen permeability, and biocompatibility properties. The hydrogel combines the desired softness with remarkable strain-dependent mechanical strength and thereby demonstrates hyperelastic, rubber-like mechanical properties. The observed unusual mechanical behavior is due to both high water content and the combination of relatively stiff cellulose nanowhiskers entangled in a soft polymer matrix of poly(vinyl alcohol) (PVA), thus mimicking the structural characteristics of the cornea's main constituents, i.e., water and collagen.
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| 6. |
- Xia, Wei, et al.
(författare)
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Bioactive Spheres: The Way of Treating Dentin Hypersensitivity
- 2016
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Ingår i: Acs Biomaterials-Science & Engineering. - : American Chemical Society (ACS). - 2373-9878. ; 2:5, s. 734-740
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Tidskriftsartikel (refereegranskat)abstract
- Sealing exposed dental tubules is the most effective and long-term way to relieve the pain induced by dental sensitivity. A bioactive hollow sphere (strontium substituted calcium phosphate) was synthesized and added in toothpaste to study its effect on dental hypersensitivity via tooth tubules occlusion and mineralization. The size of spheres is perfect for penetrating into dental tubules, reaching to 20 pm into the tubules. The exposed dental tubules were occluded by spheres and new apatite layer after 3 days brushing. The spheres attached to the surface of dentin and the mineralized surface contained two layers, a porous layer followed by a dense apatite layer. The porous layer can be dissolved in an acidic solution, but the following dense layer could be kept even after soaking in an acid solution. In conclusion, Sr-substituted calcium phosphate spheres could be a good candidate for at-home treatment of dental hypersensitivity.
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