| 1. |
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| 2. |
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| 3. |
- Abdel-Motal, Ussama M., et al.
(författare)
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Major histocompatibility complex class I binding glycopeptides for the estimation of 'empty' class I molecules
- 1995
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Ingår i: Journal of Immunological Methods. - : Elsevier BV. - 0022-1759. ; 188:1, s. 21-31
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Tidskriftsartikel (refereegranskat)abstract
- Different forms of major histocompatibility complex (MHC) class I heavy chains are known to be expressed on the cell surface, including molecules which are functionally 'empty'. Direct peptide binding to cells is obvious during sensitization of target cells in vitro for cytotoxic T lymphocyte killing and 'empty' MHC-I molecules are comparatively abundant on TAP- 1 2 peptide transporter mutant cells. In the present work we have estimated the fraction of 'empty' MHC class I molecules using glycosylated peptides and cellular staining with carbohydrate specific monoclonal antibodies. Synthetic Db and Kb binding peptides were coupled at different positions with different di- or trisaccharides, using different spacing between the carbohydrate and the peptide backbone. Binding of sugar specific mAbs was compared in ELISA and cellular assays. An optimal Db binding glycopeptide was used for comparative staining with anti-Db and anti-carbohydrate monoclonal antibodies to estimate fractions of 'empty' molecules on different T lymphoid cells. On activated normal T cells, a large fraction of Db molecules were found to be 'empty'. The functional cole of such 'empty' MHC class I molecules on T cells is presently unclear. However, on antigen presenting cells they might participate in the antigen presentation process.
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| 4. |
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| 5. |
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| 6. |
- Aberg, Jan, et al.
(författare)
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Multialphabet coding with separate alphabet description
- 1997
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Ingår i: Proceedings. Compression and Complexity of SEQUENCES 1997. - 0818681322 ; , s. 56-65
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Konferensbidrag (refereegranskat)abstract
- For lossless universal source coding of memoryless sequences with an a priori unknown alphabet size (multialphabet coding), the alphabet of the sequence must be described as well as the sequence itself. Usually an efficient description of the alphabet can be made only by taking into account some additional information. We show that these descriptions can be separated in such a way that the encoding of the actual sequence can be performed independently of the alphabet description, and present sequential coding methods for such sequences. Such methods have applications in coding methods where the alphabet description is made available sequentially, such as PPM.
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| 7. |
- Aberg, J., et al.
(författare)
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Non-uniform PPM and context tree models
- 1998
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Ingår i: Proceedings DCC '98 Data Compression Conference. - 0818684062 ; , s. 279-288
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Konferensbidrag (refereegranskat)abstract
- The problem of optimizing PPM with the help of different choices of estimators and their parameters for different subsets of nodes in the context tree is considered. Methods of such optimization for Markov chain and context tree models for individual files and over given sets of files are presented, and it is demonstrated that the extension from Markov chain models to context tree models is necessary to receive significant improvements of the compression ratio.
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| 8. |
- Aberg, J., et al.
(författare)
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Towards understanding and improving escape probabilities in PPM
- 1997
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Ingår i: Proceedings DCC '97. Data Compression Conference. - 0818677619 ; , s. 22-31
-
Konferensbidrag (refereegranskat)abstract
- The choice of expressions for the coding probabilities in general, and the escape probability in particular, is of great importance in the family of PPM algorithms. We present a parameterized version of the escape probability estimator which, together with a 'compactness' criterion, provides guidelines for the estimator design given a 'representative' set of files. This parameterization also makes it possible to adapt the expression of the escape probability during one-pass coding. Finally, we present results for one such compression scheme that illustrates the usefulness of our approach.
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| 9. |
- Abkar, Ali
(författare)
-
Invariant Subspaces in Spaces of Analytic Functions
- 1999
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Let D be a finitely connected bounded domain with smooth boundary in the complex plane. We first study Banach spaces of analytic functions on D . The main result is a theorem which converts the study of hyperinvariant subspaces on multiply connected domains into the study of hyperinvariant subspaces on domains with fewer holes. The Banach spaces are defined by a natural set of axioms fulfilled by the familiar Hardy, Dirichlet, and Bergman spaces. Let D_1 be a bounded domain obtained from D by adding some of the connectivity components of the complement of D ; hence D_1 has fewer holes. Let B and B_1 be the Banach spaces of analytic functions on the domains D and D_1 , respectively. Assume that I is a hyperinvariant subspace of B_1 , and consider the smallest hyperinvariant subspace of B containing I ; this is Lambda (I) , the closure in B of the span of I cdot M(B) , where M(B) denotes the space of multipliers of B . Under reasonable assumptions, we prove that I mapsto Lambda (I) gives a one-to-one correspondence between a class of hyperinvariant subspaces of B_1 , and a class of hyperinvariant subspaces of B . The inverse mapping is given by J mapsto J cap B_1 . We then generalize the above result to the setting of the quasi-Banach spaces of analytic functions on D . In Chapter IV, we shall establish a Riesz-type representation formula for super-biharmonic functions satisfying certain growth conditions on the unit disk. This representation formula can be regarded as an analogue of the Poisson-Jensen representation formula for subharmonic functions. In Chapter V, this representation formula will be used to prove an approximation theorem in certain weighted Bergman spaces. More precisely, we consider those weighted Bergman spaces whose (non-radial) weights are super-biharmonic and fulfill a certain growth condition. We shall prove that the polynomials are dense in such weighted Bergman spaces.
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| 10. |
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| 11. |
- Abrahamson, Magnus
(författare)
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Cystatins
- 1994
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Ingår i: Methods in Enzymology. - : Elsevier. - 0076-6879. ; 244, s. 685-700
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Tidskriftsartikel (refereegranskat)
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| 12. |
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| 13. |
- Abrahamson, Magnus, et al.
(författare)
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Hereditary cystatin C amyloid angiopathy: Identification of the disease causing mutation and specific diagnosis by polymerase chain reaction based analysis
- 1992
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Ingår i: Human Genetics. - 1432-1203. ; 89:4, s. 377-380
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Tidskriftsartikel (refereegranskat)abstract
- Hereditary cystatin C amyloid angiopathy (HCCAA) is a dominantly inherited disease characterized by amyloidosis, dementia and fatal cerebral hemorrhage of young adults. A method for rapid and simple diagnosis of HCCAA is described. It is based upon oligonucleotide-directed enzymatic amplification of a 275-bp genomic DNA segment containing exon 2 of the cystatin C gene from a blood sample, followed by digestion of the amplification product with AluI. Loss of an AluI recognition site in the amplified DNA segment from HCCAA patients results in a deviating band-pattern at agarose gel electrophoresis, compared with that obtained from normal subjects or unaffected HCCAA family members. In a population of 9 patients with manifest HCCAA, 14 patients with other causes of brain hemorrhage and 16 healthy individuals, the diagnostic procedure displayed a sensitivity and specificity for HCCAA of 100%. Amplified DNA segments from 4 HCCAA patients of four different families were analyzed by nucleotide sequencing; the HCCAA-causing mutation in all families was found to be a single TrarrA substitution in the codon for amino acid residue 68 of cystatin C.
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| 14. |
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| 15. |
- Abrahamson, Magnus, et al.
(författare)
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Human cystatin C: Role of the N-terminal segment in the inhibition of human cysteine proteinases and in its inactivation by leucocyte elastase
- 1991
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Ingår i: Biochemical Journal. - 0264-6021. ; 273:3, s. 621-626
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Tidskriftsartikel (refereegranskat)abstract
- Leucocyte elastase in catalytic amounts was observed to rapidly cleave the Val-10-Gly-11 bond of the human cysteine-proteinase inhibitor cystatin C at neutral pH. The resulting modified inhibitor had size and amino acid composition consistent with a cystatin C molecule devoid of the N-terminal Ser-1-Val-10 decapeptide. Leucocyte-elastase-modified cystatin C had more than 240-fold lower affinity than native cystatin C for papain. Removal of the N-terminal decapeptide of human cystatin C also decreased inhibition of human cathepsins B and L by three orders of magnitude, but decreased inhibition of cathepsin H by only 5-fold. A tripeptidyldiazomethane analogue of of the N-terminal portion of cystatin C was a good inhibitor of cathepsins B and L but a poor inhibitor of cathepsin H. It therefore appears that amino acid side chains of the N-terminal segment of cystatin C bind in the substrate-binding pockets of cathepsins B and L but not in those of cathepsin H. It is argued that the N-terminal cystatin C interaction with cathepsin B is physiologically important and hence that leucocyte elastase could have a function as a regulator of extracellular cysteine-proteinase inhibitory activity at sites of inflammation.
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| 16. |
- Abrahamson, Magnus, et al.
(författare)
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Increased body temperature accelerates aggregation of the (Leu-68–>Gln) mutant cystatin C, the amyloid-forming protein in hereditary cystatin C amyloid angiopathy
- 1994
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Ingår i: Proceedings of the National Academy of Sciences. - 1091-6490. ; 91:4, s. 1416-1420
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Tidskriftsartikel (refereegranskat)abstract
- Hereditary cystatin C amyloid angiopathy is a dominantly inherited disorder, characterized by dementia, paralysis, and death from cerebral hemorrhage in early adult life. A variant of the cysteine proteinase inhibitor, cystatin C, is deposited as amyloid in the tissues of the patients and their spinal-fluid level of cystatin C is abnormally low. The disease-associated Leu-68-->Gln mutant (L68Q) cystatin C has been produced in an Escherichia coli expression system and isolated by use of denaturing buffers, immunosorption, and gel filtration. Parallel physicochemical and functional investigations of L68Q-cystatin C and wild-type cystatin C revealed that both proteins effectively inhibit the cysteine proteinase cathepsin B (equilibrium constants for dissociation, 0.4 and 0.5 nM, respectively) but differ considerably in their tendency to dimerize and form aggregates. While wild-type cystatin C is monomeric and functionally active even after prolonged storage at elevated temperatures, L68Q-cystatin C starts to dimerize and lose biological activity immediately after it is transferred to a nondenaturing buffer. The dimerization of L68Q-cystatin C is highly temperature-dependent, with a rise in incubation temperature from 37 to 40 degrees C resulting in a 150% increase in dimerization rate. The aggregation at physiological concentrations is likewise increased at 40 compared to 37 degrees C, by approximately 60%. These properties of L68Q-cystatin C have bearing upon our understanding of the pathophysiological process of hereditary cystatin C amyloid angiopathy. They might also be of clinical relevance, since medical intervention to abort febrile periods of carriers of the disease trait may reduce the in vivo formation of L68Q-cystatin C aggregates.
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| 17. |
- Abrahamson, Magnus, et al.
(författare)
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Modification of cystatin C activity by bacterial proteinases and neutrophil elastase in periodontitis
- 1997
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Ingår i: Molecular Pathology. - 1366-8714. ; 50:6, s. 291-297
-
Tidskriftsartikel (refereegranskat)abstract
- AIM: To study the interaction between the human cysteine proteinase inhibitor, cystatin C, and proteinases of periodontitis associated bacteria. METHODS: Gingival crevicular fluid samples were collected from discrete periodontitis sites and their cystatin C content was estimated by enzyme linked immunosorbent assay (ELISA). The interaction between cystatin C and proteolytic enzymes from cultured strains of the gingival bacteria Porphyromonas gingivalis, Prevotella intermedia, and Actinobacillus actinomycetemcomitans was studied by measuring inhibition of enzyme activity against peptidyl substrates, by detection of break down patterns of solid phase coupled and soluble cystatin C, and by N-terminal sequence analysis of cystatin C products resulting from the interactions. RESULTS: Gingival crevicular fluid contained cystatin C at a concentration of approximately 15 nM. Cystatin C did not inhibit the principal thiol stimulated proteinase activity of P gingivalis. Instead, strains of P gingivalis and P intermedia, but not A actinomycetemcomitans, released cystatin C modifying proteinases. Extracts of five P gingivalis and five P intermedia strains all hydrolysed bonds in the N-terminal region of cystatin C at physiological pH values. The modified cystatin C resulting from incubation with one P gingivalis strain was isolated and found to lack the eight most N-terminal residues. The affinity of the modified inhibitor for cathepsin B was 20-fold lower (Ki 5 nM) than that of full length cystatin C. A 50 kDa thiol stimulated proteinase, gingipain R, was isolated from P gingivalis and shown to be responsible for the Arg8-bond hydrolysis in cystatin C. The cathepsin B inhibitory activity of cystatin C incubated with gingival crevicular fluid was rapidly abolished after Val10-bond cleavage by elastase from exudate neutrophils, but cleavage at the gingipain specific Arg8-bond was also demonstrated. CONCLUSIONS: The physiological control of cathepsin B activity is impeded in periodontitis, owing to the release of proteinases from infecting P gingivalis and neutrophils, with a contribution to the tissue destruction seen in periodontitis as a probable consequence.
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| 18. |
- Abrahamson, Magnus
(författare)
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Molecular basis for amyloidosis related to hereditary brain hemorrhage
- 1996
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Ingår i: Scandinavian journal of clinical and laboratory investigation. Supplementum. - 0085-591X. ; 56:226, s. 47-56
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the project has been to elucidate molecular events leading to amyloidosis in Hereditary Cystatin C Amyloid Angiopathy (HCCAA) patients, to enable simple diagnosis of the disease and with the ultimate goal to understand the amyloid formation process in detail, in order to develop inhibitors to the process. At the DNA level, a point mutation segregating with HCCAA was identified in the cystatin C gene on chromosome 20, after basic characterization of cDNA and gene for the wildtype protein. The mutation results in the amino acid substitution Leu-68-Gin (L68Q) and abolishes a recognition site for Alu I. This information was used to design a PCR based assay for simple and rapid mutation detection in DNA from blood samples to allow routine diagnosis of HCCAA. Studies at the protein level, allowed through E. coli expression of wildtype and L68Q mutated cystatin C genes, revealed that both protein variants effectively inhibit the cysteine proteinase cathepsin B (equilibrium constants for dissociation: 0.4 and 0.3 nM, respectively), but differ considerably in their tendency to dimerize and form aggregates. The initial dimerization of L68Q-cystatin C results in complete loss of biological activity and is highly temperature-dependent, with a rise in incubation temperature from 37 to 40 degrees C resulting in a 150% increase in dimerization rate. This result might be of clinical relevance, since medical intervention to abort febrile periods of carriers of the disease trait may reduce the in vivo formation of L68Q-cystatin C aggregates. The three-dimensional structure of normal cystatin C, crystallized in a complex with cathepsin B, was elucidated by X-ray analysis and subsequent refinement of the structure to 3.0 A resolution. Besides pinpointing the cystatin C structures resulting in efficient target enzyme inhibition, the results demonstrated that the Leu-68 residue is buried in the hydrophobic core of the protein. Studies of the three-dimensional solution structure of wildtype cystatin C by NMR spectroscopy revealed that cystatin C dimers can be formed as a result of slight, localized structural changes under conditions preceding complete defolding and denaturation of the protein. Dimers of L68Q-cystatin C are likely similar but are formed at temperatures nearly 30 degrees C lower than needed for the wildtype protein, indicating that the Leu-68-Gln substitution lowers the transition temperature for unfolding. Thus, the results presented suggest that cystatin C provides a system where decreased stability of a mutant protein correlates with its amyloidogenic nature. The NMR results furthermore imply that the hydrophobic proteinase-binding region of cystatin C is directly involved in dimer formation and that compounds designed to interact with this region could serve as inhibitors to the dimerization, and likely also the subsequent amyloid formation process, of cystatin C in HCCAA patients.
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| 19. |
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| 20. |
- Abrahamson, Magnus, et al.
(författare)
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Structure and expression of the human cystatin C gene
- 1990
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Ingår i: Biochemical Journal. - 1470-8728. ; 268:2, s. 287-294
-
Tidskriftsartikel (refereegranskat)abstract
- The structural organization of the gene for the human cysteine-proteinase inhibitor cystatin C was studied. Restriction-endonuclease digests of human genomic DNA hybridized with human cystatin C cDNA and genomic probes produced patterns consistent with a single cystatin C gene and, also, the presence of six closely related sequences in the human genome. A 30 kb restriction map covering the genomic region of the cystatin C gene was constructed. The positions of three polymorphic restriction sites, found at examination of digests of genomic DNA from 79 subjects, were localized in the flanking regions of the gene. The gene was cloned and the nucleotide sequence of a 7.3 kb genomic segment was determined, containing the three exons of the cystatin C structural gene as well as 1.0 kb of 5'-flanking and 2.0 kb of 3'-flanking sequences. Northern-blot experiments revealed that the cystatin C gene is expressed in every human tissue examined, including kidney, liver, pancreas, intestine, stomach, antrum, lung and placenta. The highest cystatin C expression was seen in seminal vesicles. The apparently non-tissue-specific expression of this cysteine-proteinase inhibitor gene is discussed with respect to the structure of its 5'-flanking region, which shares several features with those of housekeeping genes.
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| 21. |
- Abrahamsson, K, et al.
(författare)
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Application of heat pump systems for energy conservation in paper drying
- 1997
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Ingår i: International Journal of Energy Research. - 0363-907X. ; 21:7, s. 631-642
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Tidskriftsartikel (refereegranskat)abstract
- Drying is one of the most energy intensive and common operations in the chemical and process industries. Scope for energy recovery is substantial, particularly from the latent heat of the exhaust moist air. Using real operating data from a major Swedish mill, optimal energy conservation strategies were investigated using different heat pump systems in paper drying. Simulation results are compared for compressor-driven and absorption heat pump systems. An absorption heat transformer was also investigated. A CH3OH-LiBr double-lift cycle would have a low COP value due to the low temperature of the moist air stream and the restricted temperature of the cooling water available. A total of 30 MW thermal equivalent is currently needed in the mill at a temperature of 75 degrees C for mixing-pits, district heating and a log store. Exhaust humid air at a temperature of 54 degrees C from only three of the paper machines was used in this study. SHPUMP simulations revealed that installing a mechanical heat pump unit using HFC 134a would result in a recovery of 22 MW due to the temperature level of this application. On the other hand, 12 MW can be recovered with an absorption heat pump. To optimize the operating conditions, H2O-NaOH was selected as the best of three based on exergy index criteria. Assuming a steam cost of 22 $/MW h and an electricity cost of 32 $/MW h, the pay-off periods would be 3.3 and 2.9 years for compressor-driven and absorption heat pump alternatives, respectively. (C) 1997 by John Wiley & Sons, Ltd.
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| 22. |
- Abrahamsson, Mats, et al.
(författare)
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Distribution Channel Reengineering - Organisational Separation of Distribution and Sales Functions in the European Market
- 1998
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Ingår i: Transport Logistics. ; 1:4, s. 237-249
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Tidskriftsartikel (refereegranskat)abstract
- In this article, the concept of distribution channel re-engineering stands for a restructuring of distribution activities where the physical distribution and sales functions are organizationally separated from each other. The objective of the re-engineering process is primarily to reach dramatic improvements in operational efficiency. Our study indicates improvements in the distribution process in terms of: (1) economies of scale; (2) specialization and increased expertise; and (3) coordination and control. Altogether, the competitive outcomes of distribution channel re-engineering can be dramatic improvements both in cost efficiency and customer services. Modern information technology is the necessary vehicle both for a successful organizational separation of functions, including an efficient coordination between functions, and at the same time a closer integration within each function. Distribution channel re-engineering is probably the most important key to a successful restructuring of distribution channels of standardized products on the European market. In a case study of a multinational tool manufacturer, the improvements in terms of decreased costs and increased customer services have been remarkable. Traditional distribution structures, building chains of warehouses from factories through central warehouses to national warehouses at the sales company level, have been replaced with distribution structures of centralized warehousing to one single distribution centre and also of centralized administration from sales companies to one single administrative centre covering the European market.
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| 23. |
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| 24. |
- Abrahamsson, P. A., et al.
(författare)
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Molecular forms of serum prostate-specific antigen : The clinical value of percent free prostate-specific antigen
- 1997
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Ingår i: Urologic Clinics of North America. - 0094-0143. ; 24:2, s. 353-365
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Tidskriftsartikel (refereegranskat)abstract
- The concept of measuring the proportions of various forms of PSA in serum, particularly the proportion of free to total PSA, represents a new and exciting method of detecting early curable prostate cancers and avoiding unnecessary prostate biopsies in men who have BPH only. Compared with other methods of improving diagnostic specificity, it does not require transrectal ultrasound for determination of prostate volume, as does the use of PSA density, and it does not require multiple blood sampling over a sufficiently long period, as does PSA velocity. Recent findings suggest determination of the proportion of free to total PSA, rather than that of complexed to total PSA, to be the optimal discriminator between patients with prostate cancer and those with BPH in the PSA reflex range of 2.5 or 3 ng/mL to 10 ng/mL, and to improve the clinical accuracy of the PSA test substantially. If the total PSA value is normal, percent free PSA improves the sensitivity (increases cancer detection) of the PSA test; if the total PSA value is slightly elevated, percent free PSA enhances the specificity (eliminates unnecessary negative prostate biopsies) of the PSA test. Both of these outcomes are clinically desirable in attempting to diagnose early, curable prostate cancers in a cost-effective manner among men who also have varying degrees of BPH. Figure 5 contains a diagnostic algorithm for the detection of clinically significant prostate cancers at a curable stage, employing the concept of percent free PSA. As more is learned about percent free PSA, however, it may be necessary to make modifications in how this concept is used clinically.
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| 25. |
- Abrahamsson, P. ‐A, et al.
(författare)
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Three predominant prostatic proteins : Drei vorherrschende Prostataproteine
- 1990
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Ingår i: Andrologia. - : Hindawi Limited. - 0303-4569 .- 1439-0272. ; 22:1 S, s. 122-131
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Tidskriftsartikel (refereegranskat)abstract
- Summary Prostatic acid phosphatase (PAP), prostate‐specific antigen (PSA; or γ‐seminoprotein), and β‐microseminoprotein (β‐MSP; PSP94 or β‐inhibin) are the three predominant proteins secreted by the normal human prostate gland. In the epithelium of normal and hyperplastic prostatic acini and ducts PAP, PSA and β‐MSP have an identical immunohistochemical localization. Highly differentiated (grade I) carcinomas contain an almost equal number of PAP‐, PSA‐ and β‐MSP‐immunoreactive cells; the incidence of these cells is lower and they display a greater staining variability in the moderately and poorly (grade II‐III) differentiated tumours. Especially in poorly differentiated tumours PSA seems to be a more sensitive immunohistochemical marker than PAP or prostatic carcinomas. Moreover, the use of PAP as a marker for prostatic carcinomas is complicated by the reported structural similarities between the prostatic secreted acid phosphatase and lysosomal acid phosphatase occurring in all tissues. The use of β‐MSP as a marker for prostatic carcinomas may be limited by indications of non‐prostatic production of this protein.
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| 26. |
- Abrahamsson, Sven Olof, et al.
(författare)
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Dehydration inhibits matrix synthesis and cell proliferation : An in vitro study of rabbit flexor tendons
- 1991
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Ingår i: Acta Orthopaedica. - : Medical Journals Sweden AB. - 1745-3674 .- 0001-6470. ; 62:2, s. 159-162
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Tidskriftsartikel (refereegranskat)abstract
- Segments of the deep flexor tendon of the rabbit were exposed to air; the effects of dehydration on in vitro synthesis of proteoglycan, collagen, non-collagenous protein, and cell proliferation were compared with tendon segments that were kept moist with physiologic saline. After 20 min of expo-sure to air, the tendons lost half and after 40 min all of their ability to synthesize matrix components and to proliferate, whereas irrigated tendons remained viable during the entire experiment.
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| 27. |
- Abrahamsson, Sven Olof, et al.
(författare)
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Variations in cellular proliferation and matrix synthesis in intrasynovial and extrasynovial tendons : An in vitro study in dogs
- 1994
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Ingår i: The Journal of Hand Surgery. - : Elsevier BV. - 0363-5023. ; 19:2, s. 259-265
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Tidskriftsartikel (refereegranskat)abstract
- Intrasynovial and extrasynovial flexor tendon grafts recently have been shown to have dissimilar patterns of cellular survival and host integration within the digital sheath. In an effort to determine if fundamental differences exist between these two types of tendons, we investigated the biochemical composition and cellular activity of intrasynovial and extrasynovial tendon segments of 12 adult mongrel dogs in short-term explant culture in MCDB 105 and in DMEM media. Proteoglycan, collagen and noncollagen protein synthesis and content and DNA synthesis were determined following culture in both media. Intrasynovial tendon segments cultured in MCDB 105 medium synthesized significantly less collagen, noncollagen protein, and DNA and had similar amounts of proteoglycans compared to extrasynovial tendons. Comparison of intrasynovial and extrasynovial tendon segment responses in DMEM medium showed that intrasynovial tendons synthesized more proteoglycan, protein, and DNA than they did in MCDB 105. Extrasynovial tendons had similar rates of matrix component and DNA synthesis in both media. Findings that the synthesis of matrix components and DNA between intrasynovial flexor and extrasynovial peroneal tendon segments differ significantly indicate that intrasynovial flexor tendons may be specially adapted to the nutritional milieu provided by an intrasynovial environment. These data are supported by the selective successful stimulation of fibrocartilaginous segments within intrasynovial flexor tendons in media favored for the culture of cartilaginous tissue.
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| 28. |
- Abramowicz, H., et al.
(författare)
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The Physics case for a forward detector upgrade
- 1995
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Ingår i: Future physics at HERA. Proceedings, Workshop, Hamburg, Germany, September 25, 1995-May 31, 1996. Vol. 1, 2.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 29. |
- Accomando, E., et al.
(författare)
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Physics with e + e - linear colliders
- 1998
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Ingår i: Physics Reports. - 0370-1573. ; 299:1, s. 1-78
-
Tidskriftsartikel (refereegranskat)abstract
- The physics potential of e + e - linear colliders is summarized in this report. These machines are planned to operate in the first phase at a center-of-mass energy of 500 GeV, before being scaled up to about 1 TeV. In the second phase of the operation, a final energy of about 2 TeV is expected. The machines will allow us to perform precision tests of the heavy particles in the Standard Model, the top quark and the electroweak bosons. They are ideal facilities for exploring the properties of Higgs particles, in particular in the intermediate mass range. New vector bosons and novel matter particles in extended gauge theories can be searched for and studied thoroughly. The machines provide unique opportunities for the discovery of particles in supersymmetric extensions of the Standard Model, the spectrum of Higgs particles, the supersymmetric partners of the electroweak gauge and Higgs bosons, and of the matter particles. High precision analyses of their properties and interactions will allow for extrapolations to energy scales close to the Planck scale where gravity becomes significant. In alternative scenarios, i.e. compositeness models, novel matter particles and interactions can be discovered and investigated in the energy range above the existing colliders up to the TeV scale. Whatever scenario is realized in Nature, the discovery potential of e + e - linear colliders and the high precision with which the properties of particles and their interactions can be analyzed, define an exciting physics program complementary to hadron machines.
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| 30. |
- Ackelid, U, et al.
(författare)
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Kinetics of ethylene oxidation on plane Pt/SiO2 catalysts in the viscous pressure regime: Evidence of support activity
- 1996
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Ingår i: Catalysis Letters. - 1011-372X. ; 39:1-2, s. 129-139
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Tidskriftsartikel (refereegranskat)abstract
- C2H4 oxidation on plane Pt/SiO2 model catalysts with various Pt loadings was studied at T = 373-473 K and in the pressure ranges 10-6-102 Torr C2H4 and 0.3-1500 Torr O2 (1 Torr = 133.3 Pa). Mass spectrometry combined with spatially resolved gas sampling enabled kinetic data to be collected far into the viscous pressure regime. Reaction orders and activation energies were similar to those of a macroscopic Pt surface. However, under fuel-lean conditions the global reaction rate decreases faster than the decrease in metal area. On the other hand, the global rate was independent of Pt loading and metal surface area in fuel-rich gas mixtures. This is interpreted in terms of a spillover effect.
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| 31. |
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| 32. |
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| 36. |
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| 37. |
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| 38. |
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| 39. |
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| 40. |
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| 41. |
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| 42. |
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| 43. |
- Adalberth, Karin
(författare)
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Bygga - Bruka - Riva : Energianvändning i småhus ur ett kretsloppsperspektiv
- 1995
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This report deals with single-unit dwellings built in 1991 and 1992 in a city called Orebro, Sweden.The houses are prefabricated and the frameworks are made of wood. The aim of the essay is to present the total use of energy during the life-cycle of single-unit dwellings, taking their mode of construction into account. The life-cycle of a house is divided into the following periods: production (manufacturing of the building materials, transportation of the materials and erection of the single-unit dwellings);· management (occupation and renovation); and, finally, destruction (demolition and removal of debris). The management period is assumed to be 50 years.
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| 44. |
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| 45. |
- Adalberth, Karin
(författare)
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Energi för att bygga bruka riva småhus, Bo92 : Den nya trästaden
- 1994
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I denna rapport redovisas energiberäkningar för tre småhus på Bo 92 i Örebro. Syftet med rapporten är att beräkna och analysera det totala energibehovet och mängd byggnadsmaterial från 'vaggan till graven' för småhus. Med det totala energibehovet menas summan av energibehovet under produktion (materialtillverkning, materialtransporter och uppförande av byggnaden), förvaltning (brukande av byggnaden) samt destruktion (rivning och borttransport).
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| 46. |
- Adalberth, Karin
(författare)
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Energianvändning i småhus, Bo92. D. 1, Beräkningar : Den nya trästaden
- 1994
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I denna rapport redovisas teoretiska beräkningar av energibehov till uppvärmning, tappvarmvatten och hushållselektricitet, energitransporter genom småhusens grunder och energiflöden genom köldbryggor. Beräkningarna omfattar 26 småhus på Bo 92 i Örebro med olika typer av grundläggning, värmeisolering, fönster, värme- och ventilationssystem. Beräkningarna har utförts med datorprogrammen ENORM, CRAWL, SLAB och HConP.
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| 47. |
- Adalberth, Karin
(författare)
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Energy Use in Multi-Family Dwellings during their Life Cycle
- 1999
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this study is to analyse the total use of energy in four multi-family houses during their life cycles, and to compare the use of energy during the different periods in the life cycle. The aim is also to investigate how energy use during the life cycle changes with different construction parts, e g if the thermal insulation thickness or the framework is changed. Results show that the energy used to manufacture building and installation materials during the production phase is approx. 800-1,200 kWh m2 usable floor area. This corresponds to 10-15 per cent of the total energy use during the life cycle. A majority of the energy is used during the period of occupancy for e g space heating, ventilation, domestic hot water production, household electricity and lighting. During this period 5,000-7,500 kWh/m2 usable floor area is used (the life span of the occupancy is assumed to be 50 years). The energy use during this period equals 80-85 per cent of the total use during the life cycle. Results also show a small difference between buildings with different kinds of framework. The difference is very small. It is thus impossible to conclude that one framework is more energy- efficient than another. Instead, the best way to design an energy-efficient building would be to install a heat recovery system in the exhaust air and use windows with a low U value. These solutions may decrease the total energy use during the whole life cycle for one of the studied houses, by 13 and 6 per cent respectively.
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| 48. |
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| 49. |
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| 50. |
- Adamovich, M.I., et al.
(författare)
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Charged particle multiplicity and pseudorapidity density distributions in 16O-, 28Si- and 197Au-induced nuclear interactions at 14.6 and 11.6A GeV/c
- 1995
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Ingår i: Nuclear Physics, Section A. - : Elsevier BV. - 0375-9474. ; 593:4, s. 535-549
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Tidskriftsartikel (refereegranskat)abstract
- Pseudorapidity density and multiplicity distributions of charged particles produced in heavy-ion collisions at the BNL AGS have been studied. The multiplicity distributions and pseudorapidity distributions of shower particles in Au-induced interactions are presented and compared with model predictions from RQMD, FRITIOF and VENUS. It is shown that the widths of the pseudorapidity distributions of produced particles in central collisions are independent of the interacting system. The results from EMU01 have been compared, and found to agree, with the results from two other heavy-ion experiments, E802 and E814.
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