| 1. |
- Albrecht, Martin, et al.
(författare)
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Electrification of vehicles – policy drivers and impacts in two scenarios.
- 2013
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Ingår i: Grid Integration of Electric Vehicles in Open Electricity Markets. - Oxford, UK : John Wiley & Sons. - 9781118446072
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Bokkapitel (refereegranskat)abstract
- This chapter examines current policy drivers of battery electric vehicles (EVs) and plug-in hybrid EVs, the current and anticipated impacts on carbon emissions, as well as what potential role policy can play in enhancing the innovation system and market development around such vehicles in the future. We start with a policy review of key targets in the Nordic countries and the EU, up to 2030, and discuss to what extent they are consistent with industry and expert estimates of how the systems can grow. On the basis of this, the second part elaborates two simple scenarios of EV development in the EU: one breakthrough expansion scenario and one incremental expansion scenario. Building on that is an analysis of the climate impacts of the two scenarios, given different assumptions relating to, for example, electricity production as well as EV penetration in the fleet. The third part examines what policy drivers might be needed to enable the breakthrough scenario, using a technological innovation systems perspective to describe the needed processes, drivers and developments.
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| 2. |
- Albrecht, Martin, et al.
(författare)
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Nordic power road map 2050:Strategic choices towards carbon neutrality. D4.2.R Policy and Institutional Review Electric Vehicles (EV).
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This report examines policy drivers of electric vehicles (EVs), and what potential role policy can play in enhancing the innovation and market development of EVs. We start with a policy review of key targets in the Nordic countries and the EU, up to 2030, and discuss to what extent they are consistent with industry, government and expert estimates of how the EV innovation systems can grow. On the basis of this, the second part examines what policy drivers might be needed to enable a breakthrough scenario, using a technological innovation systems (TIS) perspective to describe the needed processes, drivers and developments in policy and technology.
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| 3. |
- Carneiro, Ana, et al.
(författare)
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Ezrin expression predicts local recurrence and development of metastases in soft tissue sarcomas.
- 2011
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Ingår i: Journal of Clinical Pathology. - : BMJ. - 1472-4146 .- 0021-9746. ; 64, s. 689-694
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Tidskriftsartikel (refereegranskat)abstract
- Background Ezrin is a cytoskeletal protein involved in tumour growth and invasion. Ezrin expression has been suggested to play a role in metastasis in paediatricosteosarcoma and rhabdomyosarcoma. Aim To evaluate the prognostic role of ezrin in a large series of soft tissue sarcoma of the extremities and trunk wall. Methods Ezrin expression was evaluated by immunohistochemistry on tissue microarrays from a mixed series of 256 soft tissue sarcomas. The expression patterns were correlated to local recurrence and metastasis as well as to established prognostic factors in soft tissue sarcoma. Results Increased ezrin expression predicted development of metastasis (HR=1.8, 95% CI 1.1 to 2.8; p=0.007) and local recurrence, also after adjustment for surgical margin (HR=2.4, 95% CI 1.4 to 4.3; p=0.02). Correlations to established prognostic factors showed strong associations between ezrin and necrosis (OR=3.9, p<0.0001) and ezrin and growth pattern (OR=3.1, p=0.03). Conclusions Ezrin independently predicts development of local recurrences and metastases in soft tissue sarcomas. The possibility of preoperative evaluation makes ezrin a potential marker for identification of high-risk sarcoma patients who would benefit from neoadjuvant therapy.
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| 4. |
- Seinen, Jojanneke M, et al.
(författare)
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Prognostic value of proliferation in pleomorphic soft tissue sarcomas: a new look at an old measure.
- 2012
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Ingår i: Human Pathology. - : Elsevier BV. - 1532-8392 .- 0046-8177.
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Tidskriftsartikel (refereegranskat)abstract
- Though proliferation has repeatedly shown a prognostic role in sarcomas, it has not reached clinical application. We performed a comprehensive evaluation of the prognostic role of 5 proliferation measures in a large series of soft tissue sarcomas of the extremities and the trunk wall. One hundred ninety-six primary soft tissue sarcomas of the extremities and the trunk wall were subjected to DNA flow cytometry for quantification of S-phase fraction and to immunohistochemical evaluation of Ki-67, Top2a, p21, and p27Kip1. In univariate analysis, positive expression of Ki-67 (hazard ratio = 4.5, CI = 1.6-12.1), Top2a (hazard ratio = 2.2, CI = 1.2-3.5) and high S-phase fraction (hazard ratio = 1.8, CI = 1.2-3.7) significantly correlated with risk for metastasis. When combined with currently used prognostic factors, Ki-67, S-phase fraction and Top2a fraction contributed to refined identification of prognostic risk groups. Proliferation, as assessed by expression of Ki-67 and Top2a and evaluation of S-phase fraction and applied to statistical decision-tree models, provides prognostic information in soft tissue sarcomas of the extremity and trunk wall. Though proliferation contributes independently to currently applied prognosticators, its role is particularly strong when few other factors are available, which suggests a role in preoperative decision-making related to identification of high-risk individuals who would benefit from neoadjuvant therapy.
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| 5. |
- Åkerman, Måns, et al.
(författare)
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Bone metastases.
- 2010
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 19, s. 75-80
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Tidskriftsartikel (refereegranskat)
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| 12. |
- Åkerman, Måns, et al.
(författare)
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Epidemiology of bone tumours.
- 2010
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 19:Sep 23, s. 1-2
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Tidskriftsartikel (refereegranskat)
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| 14. |
- Åkerman, Måns, et al.
(författare)
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Inflammatory lesions.
- 2010
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 19, s. 73-74
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Tidskriftsartikel (refereegranskat)
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| 15. |
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| 16. |
- Åkerman, Måns, et al.
(författare)
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Morphological diagnosis of bone tumours.
- 2010
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 19, s. 7-12
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Tidskriftsartikel (refereegranskat)
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