| 1. |
- Alvarez, E. M., et al.
(författare)
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The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet Oncology. - : Elsevier BV. - 1470-2045. ; 23:1, s. 27-52
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Tidskriftsartikel (refereegranskat)abstract
- Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
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| 2. |
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| 3. |
- Tran, K. B., et al.
(författare)
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The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet. - 0140-6736. ; 400:10352, s. 563-591
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Tidskriftsartikel (refereegranskat)abstract
- Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 4. |
- Bryazka, D., et al.
(författare)
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Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020
- 2022
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Ingår i: Lancet. - 0140-6736. ; 400:10347, s. 185-235
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Tidskriftsartikel (refereegranskat)abstract
- Background The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year. Methods For this analysis, we constructed burden-weighted dose-response relative risk curves across 22 health outcomes to estimate the theoretical minimum risk exposure level (TMREL) and non-drinker equivalence (NDE), the consumption level at which the health risk is equivalent to that of a non-drinker, using disease rates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020 for 21 regions, including 204 countries and territories, by 5-year age group, sex, and year for individuals aged 15-95 years and older from 1990 to 2020. Based on the NDE, we quantified the population consuming harmful amounts of alcohol. Findings The burden-weighted relative risk curves for alcohol use varied by region and age. Among individuals aged 15-39 years in 2020, the TMREL varied between 0 (95% uncertainty interval 0-0) and 0.603 (0.400-1.00) standard drinks per day, and the NDE varied between 0.002 (0-0) and 1.75 (0.698-4.30) standard drinks per day. Among individuals aged 40 years and older, the burden-weighted relative risk curve was J-shaped for all regions, with a 2020 TMREL that ranged from 0.114 (0-0.403) to 1.87 (0.500-3.30) standard drinks per day and an NDE that ranged between 0.193 (0-0.900) and 6.94 (3.40-8.30) standard drinks per day. Among individuals consuming harmful amounts of alcohol in 2020, 59.1% (54.3-65.4) were aged 15-39 years and 76.9% (7.0-81.3) were male. Interpretation There is strong evidence to support recommendations on alcohol consumption varying by age and location. Stronger interventions, particularly those tailored towards younger individuals, are needed to reduce the substantial global health loss attributable to alcohol. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd.
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| 5. |
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| 6. |
- Ikuta, K. S., et al.
(författare)
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Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet. - : Elsevier BV. - 0140-6736. ; 400:10369, s. 2221-2248
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Tidskriftsartikel (refereegranskat)abstract
- Background Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated the number of deaths associated with drug-resistant infections and sepsis and found that infections remain a leading cause of death globally. Understanding the global burden of common bacterial pathogens (both susceptible and resistant to antimicrobials) is essential to identify the greatest threats to public health. To our knowledge, this is the first study to present global comprehensive estimates of deaths associated with 33 bacterial pathogens across 11 major infectious syndromes. Methods We estimated deaths associated with 33 bacterial genera or species across 11 infectious syndromes in 2019 using methods from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, in addition to a subset of the input data described in the Global Burden of Antimicrobial Resistance 2019 study. This study included 343 million individual records or isolates covering 11 361 study-location-years. We used three modelling steps to estimate the number of deaths associated with each pathogen: deaths in which infection had a role, the fraction of deaths due to infection that are attributable to a given infectious syndrome, and the fraction of deaths due to an infectious syndrome that are attributable to a given pathogen. Estimates were produced for all ages and for males and females across 204 countries and territories in 2019. 95% uncertainty intervals (UIs) were calculated for final estimates of deaths and infections associated with the 33 bacterial pathogens following standard GBD methods by taking the 2.5th and 97.5th percentiles across 1000 posterior draws for each quantity of interest. Findings From an estimated 13.7 million (95% UI 10.9-17.1) infection-related deaths in 2019, there were 7.7 million deaths (5.7-10.2) associated with the 33 bacterial pathogens (both resistant and susceptible to antimicrobials) across the 11 infectious syndromes estimated in this study. We estimated deaths associated with the 33 bacterial pathogens to comprise 13.6% (10.2-18.1) of all global deaths and 56.2% (52.1-60.1) of all sepsis-related deaths in 2019. Five leading pathogens-Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa-were responsible for 54.9% (52.9-56.9) of deaths among the investigated bacteria. The deadliest infectious syndromes and pathogens varied by location and age. The age-standardised mortality rate associated with these bacterial pathogens was highest in the sub-Saharan Africa super-region, with 230 deaths (185-285) per 100 000 population, and lowest in the high-income super-region, with 52.2 deaths (37.4-71.5) per 100 000 population. S aureus was the leading bacterial cause of death in 135 countries and was also associated with the most deaths in individuals older than 15 years, globally. Among children younger than 5 years, S pneumoniae was the pathogen associated with the most deaths. In 2019, more than 6 million deaths occurred as a result of three bacterial infectious syndromes, with lower respiratory infections and bloodstream infections each causing more than 2 million deaths and peritoneal and intra-abdominal infections causing more than 1 million deaths. Interpretation The 33 bacterial pathogens that we investigated in this study are a substantial source of health loss globally, with considerable variation in their distribution across infectious syndromes and locations. Compared with GBD Level 3 underlying causes of death, deaths associated with these bacteria would rank as the second leading cause of death globally in 2019; hence, they should be considered an urgent priority for intervention within the global health community. Strategies to address the burden of bacterial infections include infection prevention, optimised use of antibiotics, improved capacity for microbiological analysis, vaccine development, and improved and more pervasive use of available vaccines. These estimates can be used to help set priorities for vaccine need, demand, and development. Copyright (c) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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| 7. |
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| 8. |
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| 9. |
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| 10. |
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| 11. |
- Sheena, B. S., et al.
(författare)
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Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- 2022
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Ingår i: Lancet Gastroenterology & Hepatology. - : Elsevier BV. - 2468-1253. ; 7:9, s. 796-829
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Tidskriftsartikel (refereegranskat)abstract
- Background Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-ofsample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. Findings In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4 center dot 1% (95% uncertainty interval [UI] 3 center dot 7 to 4 center dot 5), corresponding to 316 million (284 to 351) infected people. There was a 31 center dot 3% (29 center dot 0 to 33 center dot 9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76 center dot 8% (76 center dot 2 to 77 center dot 5) in prevalence in children younger than 5 years. HBV-related diseases resulted in 555 000 global deaths (487 000 to 630 000) in 2019. The number of HBV-related deaths increased between 1990 and 2019 (by 5 center dot 9% [-5 center dot 6 to 19 center dot 2]) and between 2015 and 2019 (by 2 center dot 9% [-5 center dot 9 to 11 center dot 3]). By contrast, all-age and age-standardised death rates due to HBV-related diseases decreased during these periods. We compared estimates for 2019 in 194 WHO locations to WHO-GHSS 2020 targets, and found that four countries achieved a 10% reduction in deaths, 15 countries achieved a 30% reduction in new cases, and 147 countries achieved a 1% prevalence in children younger than 5 years. As of 2019, 68 of 194 countries had already achieved the 2030 target proposed in WHO Interim Guidance of an all-age HBV-related death rate of four per 100 000. Interpretation The prevalence of chronic HBV infection declined over time, particularly in children younger than 5 years, since the introduction of hepatitis B vaccination. HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and cohort effects. By 2019, many countries had met the interim seroprevalence target for children younger than 5 years, but few countries had met the WHO-GHSS interim targets for deaths and new cases. Progress according to all indicators must be accelerated to meet 2030 targets, and there are marked disparities in burden and progress across the world. HBV interventions, such as vaccination, testing, and treatment, must be strategically supported and scaled up to achieve elimination.
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| 12. |
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| 13. |
- Abbafati, Cristiana, et al.
(författare)
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- 2020
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Tidskriftsartikel (refereegranskat)
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| 14. |
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| 15. |
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| 16. |
- Abbasi, Saeed, 1973-, et al.
(författare)
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A field investigation of the size, morphology and chemical composition of airborne particles in rail transport
- 2010
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Konferensbidrag (refereegranskat)abstract
- The health effects of inhalable airborne particles are well documented. In the European Union the European Council mandates that the level of airborne particles with a diameter smaller than 10 µm (PM10) must not exceed an annual average of 40 µg/m3. Examples of possible sources from rail transport are mechanical brakes, wheel rail contact, current collectors, ballast, sleepers and masonry structures. In this regard, a series of field tests have been conducted on a regular Swedish track using a regional train instrumented with: particle measurement devices, temperature sensors in brake pads and sensors to measure the magnitude of train speed and a GPS.Two sampling points for airborne particles were designated in the train under frame. One of the sampling points was near a pad to rotor disc brake contact and a second global sampling point was chosen under the frame, but not near a mechanical brake or the wheel-rail contact. The first one was highly influenced by brake pad wear debris and the other one was influenced by all of the brake pads, wheel and rail wear debris as well as re-suspension. In each sampling points, three tubes were linked to three particle measurement devices. Two sets of Ptrak, Dustrak and Grimm devices were used. The Ptrak 8525 was an optical particle measurement device which could measure particle diameter in the size interval of 20 nm up to 1 micrometer. The Dustrak was used to measure particle mass concentration. The Grimm 1.109 was an aerosol spectrometer which counted number of particles from 0.25 micrometer to 32 micrometer in 31 intervals. These two Grimm devices were equipped with Millipore filters in the devices outlets to capture particles for further studies on morphology and matter of particles.The total number and size distribution of the particles for these two sampling points were registered and evaluated in different situations such as activating and deactivating electrical brake or train curve negotiating.During braking, three peaks of 250 nm, 350 nm and 600 nm in diameter, with the 350 nm peak dominating were identified in the fine particle region. In the coarse particle region, a peak of around 3-6 µm in diameter was discovered. The brake pad temperature effects on particle size distribution were also investigated and the results showed that the peak around 250 nm increased. Furthermore, the activation of electrical braking significantly reduced the number of airborne particles.A SEM was used to capture the images from collected particles on filters. Furthermore, an ICP-Ms method was used to investigate the elemental contents of the particulates on the filter. In this case the main contribution belonged to Fe, Si, Al, Ca, Cu, Zn. The higher amount of some elements weights such as calcium, silicon, sodium and aluminum in the global sampling point filters revealed that ballast and concrete sleepers were the main sources for these particles although some of them originated from rail, wheel, brake disc and brake pad as well.
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| 17. |
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| 18. |
- Abbasi, Saeed, et al.
(författare)
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A pin-on-disc study of the rate of airborne wear particle emissions from railway braking materials
- 2012
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Ingår i: Wear. - UK : Elsevier. - 0043-1648 .- 1873-2577. ; 284, s. 18-29
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Tidskriftsartikel (refereegranskat)abstract
- The current study investigates the characteristics of particles generated from the wear of braking materials, and provides an applicable index for measuring and comparing wear particle emissions. A pin-on-disc tribometer equipped with particle measurement instruments was used. The number concentration, size, morphology, and mass concentration of generated particles were investigated and reported for particles 10 nm-32 mu m in diameter. The particles were also collected on filters and investigated using EDS and SEM. The effects of wear mechanisms on particle morphology and changes in particle concentration are discussed. A new index, the airborne wear particle emission rate (AWPER), is suggested that could be used in legislation to control non-exhaust emissions from transport modes, particularly rail transport.
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| 19. |
- Abbasi, Saeed, et al.
(författare)
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A study of airborne wear particles generated from organic railway brake pads and brake discs
- 2011
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Ingår i: Wear. - UK : Elsevier. - 0043-1648 .- 1873-2577. ; 273:1, s. 93-99
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Tidskriftsartikel (refereegranskat)abstract
- Brake pads on wheel-mounted disc brakes are often used in rail transport due to their good thermal properties and robustness. During braking, both the disc and the pads are worn. This wear process generates particles that may become airborne and thus affect human health. The long term purpose of ‘Airborne particles in Rail transport’ project is to gain knowledge on the wear mechanisms in order to find means of controlling the number and size distribution of airborne particles. In this regard, a series of full-scale field tests and laboratory tests with a pin-on-disc machine have been conducted. The morphology and the matter of particles, along with their size distribution and concentration, have been studied. The validity of results from the pin-on-disc simulation has been verified by the field test results. Results show an ultra-fine peak for particles with a diameter size around 100 nm in diameter, a dominant fine peak for particles with a size of around 350 nm in diameter, and a coarse peak with a size of 3-7 μm in diameter. Materials such as iron, copper, aluminium, chromium, cobalt, antimony, and zinc have been detected in the nano-sized particles.
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| 20. |
- Abbasi, Saeed, 1973-, et al.
(författare)
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A study of friction modifiers on airborne wear particles from wheel-rail contact
- 2012
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Konferensbidrag (refereegranskat)abstract
- Wheel-rail contact and its wear process are crucial issues in maintenance and operating of rolling stocks. During wheel-rail contact, materials in mating faces are worn off and some of them transferred to airborne particles. Eventhough the wear process in wheel-rail contact are well-known, few studies have been conducted on the airborne particles from wheel-rail contact.The purpose of this study is to investigate the effect of using different friction modifier on the amount of airbotne particles from wheel-rail contact in a laboratory simulation. In this regard, a series laboratory tests were used by using round head pin (R=25mm) and dead weight 40 N in a pin-on-disc machine. This set-up simulates a contact pressure around 750 MPa on the pin head.The amount of airborne particles and their characteristics were investigated in dry-contact, and non-dry contacts whereas a lubricant, Binol rail 510 and a friction modifier, tramsilence were used. According to the results, the effects of using Binol rail to reduce the amount of airborne particles were considerable.
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| 21. |
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| 22. |
- Abbasi, Saeed, 1973-, et al.
(författare)
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A field test study of airborne wear particles from a running regional train
- 2012
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Ingår i: IMechE, Part F: Journal of Rail and Rapid Transit. - UK : Sage Publications. - 0954-4097 .- 2041-3017. ; 226:1, s. 95-109
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Tidskriftsartikel (refereegranskat)abstract
- Inhalable airborne particles have inverse health affect. In railways, mechanical brakes, the wheel–rail contact, current collectors, ballast, sleepers, and masonry structures yield particulate matter. Field tests examined a Swedish track using a train instrumented with particle measurement devices, brake pad temperature sensors, and speed and brake sensors. The main objective of this field test was to study the characteristics of particles generated from disc brakes on a running train with an on-board measuring set-up.Two airborne particle sampling points were designated, one near a pad–rotor disc brake contact and a second under the frame, not near a mechanical brake or the wheel–rail contact; the numbers and size distributions of the particles detected were registered and evaluated under various conditions (e.g. activating/deactivating electrical brakes or negotiating curves). During braking, three speed/temperature-dependent particle peaks were identified in the fine region, representing particles 280 nm, 350 nm, and 600 nm in diameter. In the coarse region, a peak was discerned for particles 3–6 μm in diameter. Effects of brake pad temperature on particle size distribution were also investigated. Results indicate that the 280 nm peak increased with increasing temperature, and that electrical braking significantly reduced airborne particle numbers. FESEM images captured particles sizing down to 50 nm. The ICP-MS results indicated that Fe, Cu, Zn, Al, Ca, and Mg were the main elements constituting the particles.
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| 23. |
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| 24. |
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| 25. |
- Abbasi, Saeed
(författare)
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Characterisation of airborne particles from rail traffic
- 2011
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Since the investigation of wear particles in rail transport started in late-1910s, the high mass concentration of these particles has raised worries among researchers concerned with air quality. However, effective action has yet to be taken because of lack of relevant knowledge. This thesis provides applicable information for the airborne wear particles in rail transport. Some aspects of their characteristics such as diameter size, mass concentration, number concentration, and morphology of particles were investigated in field tests and laboratory tests.The effects on particle characterisations from different operational conditions in the field tests, and applying different braking materials, conducting tests in different applied loads or sliding velocities in the laboratory tests were studied. The main advantage of conducting laboratory tests was to focus on studying particles from one source. The possibility of repetition, using high sensitive instruments and conducting tests at low costs are the other advantages of laboratory studies. Paper A describes how a pin-on-disc machine was used to reproduce similar real operational conditions during mechanical braking in a train. The results were validated by comparing the field tests results with the laboratory studies. The particles morphology and size distribution were also studied.Paper B presents a summary of field tests results. The effects of curve negotiating and applying braking in different real conditions were investigated with an on-board measurement.The element composition of the particles and their potential sources were also investigated outside of the particles morphologies.Paper C presents comprehensive results from laboratory studies on airborne particles from different braking materials. The differences in the particle characteristics in similar test conditions were attributable to different material compositions and dominant wear mechanisms. A new index was introduced in this paper and is suggested to be used as a qualitative factor with regard to the airborne wear particle emission rate.Paper D is a review of the recent studies of exhaust emission and non-exhaust emission from rail vehicles. A summary of results, measurements, adverse health effects, and proposed or applied solutions are reviewed in this paper.
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| 26. |
- Abbasi, Saeed, et al.
(författare)
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Experiences of measuring airborne wear particles from braking materials and the wheel - Rail contact
- 2012
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Ingår i: 9th International Conference on Contact Mechanics and Wear of Rail/Wheel Systems, CM 2012. - : Southwest Jiaotong University. ; , s. 608-609
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Konferensbidrag (refereegranskat)abstract
- During braking both of the discs and pads of disc brakes are worn. Since disc brakes are not sealed, some of the generated wear particles can become airborne. The same condition also holds for block brakes utilized in rail vehicles. Furthermore, the wheel-rail contact is also subjected to wear processes during braking as well as during normal running. This contact also contributes to generation of airborne particles. Several studies have found an association between adverse health effects and the concentration of particles in the atmosphere, so it is of interest to improve our knowledge of the airborne wear particles. The present work includes results from full scale testing of rail vehicles. Particle size distribution, morphology and elemental contents are presented and discussed. Due to high back ground concentration levels in field tests, dedicated laboratory test set ups on a reduced scale were designed and utilized for airborne particle studies with zero background level. Promising correlation between field test and the lab set up is identified. Different ways of using this test set up for evaluating how the composition of the airborne particles is classified with respect to their health effects are discussed. Furthermore, different ways of using the proposed method to rank and to quantify airborne particle emission factors are presented.
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| 27. |
- Abbasi, Saeed, 1973-, et al.
(författare)
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Experiences of measuring airborne wear particles from braking materials and wheel-rail contact
- 2012
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Konferensbidrag (refereegranskat)abstract
- During braking both of the discs and pads of disc brakes are worn. Since disc brakes are not sealed, some of the generated wear particles can become airborne. Wheel-rail is also subjected to wear process during braking as well as normal running. They also contribute to generate airborne particles. Several studies have found an association between adverse health effects and the concentration of particles in the atmosphere, so it is of interest to improve our knowledge of the airborne wear particles generated by disc brakes.The present work includes results from full scale testing of rail vehicles. Particle size distribution, morphology and elemental contents are presented and discussed for different combinations of disc and pad materials. Due to high back ground concentration levels in field tests, dedicated laboratory test set ups on a reduced scale were designed and utilized for airborne particle studies with zero background level.Promising correlation between field test and the lab set up is identified. Different ways of using this test set up for evaluating how the composition of the airborne particles is classified with respect to their health effects are discussed. Furthermore, different ways of using the proposed method to rank and to quantify airborne particle emission factors are presented.
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| 28. |
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| 29. |
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| 30. |
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| 31. |
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| 32. |
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| 33. |
- Abbasi, Saeed, 1973-, et al.
(författare)
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Particle emission from rail vehicles : A literature review
- 2012
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Ingår i: Proceedings of the Institution of Mechanical Engineers, Part F. - Stirlingshire, UK : Sage Publications. ; 98
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Konferensbidrag (refereegranskat)abstract
- Emission of airborne particles is a side effect from rail transport. This work reviews recent research on particle emissions from rail vehicles. Both exhaust and non-exhaust particle emissions are characterized by size, morphology, composition, and size distribution. Current legislation, knowledge of adverse health effects, and available and proposed solutions for emission reductions are also treated. There has been much focus on exhaust emissions, but only a few limited studies have investigated non-exhaust particle emissions, which contain a significant amount of metallic materials. A new method for measuring the airborne wear particle emission rate (AWPER) is proposed as a first step to guide new legislations and to focus further research on non-exhaust airborne emission, i.e., research on the generation mechanisms for particle emissions and their adverse health effects.
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| 34. |
- Abbasi, Saeed, et al.
(författare)
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Particle emissions from rail traffic : a literature review
- 2013
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Ingår i: Critical reviews in environmental science and technology. - USA : Taylor & Francis. - 1064-3389 .- 1547-6537. ; 43:23, s. 2211-2244
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Forskningsöversikt (refereegranskat)abstract
- Particle emissions are a drawback of rail transport. This work is a comprehensive presentation of recent research into particle emissions from rail vehicles. Both exhaust and non-exhaust particle emissions are considered when examining particle characteristics such as PM10, and PM2.5 concentration levels, size, morphology, composition, as well as adverse health effects, current legislation, and available and proposed solutions for reducing such emissions. High concentration levels in enclosed rail traffic environments are reported and some toxic effects of the particles. We find that only a few limited studies have examined the adverse health effects of non-exhaust particle emissions and that no relevant legislation exists. Thus further research in this area is warranted.
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| 35. |
- Abbasi, Saeed, 1973-, et al.
(författare)
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Pin-on-disc study of the effects of railway friction modifiers on airborne wear particles from wheel-rail contact
- 2013
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Ingår i: Tribology International. - : Elsevier. - 0301-679X .- 1879-2464. ; 60, s. 136-139
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Tidskriftsartikel (refereegranskat)abstract
- Knowledge of wheel–rail interaction is crucial to wheel and rail maintenance. In this interaction, some of theworn-off material is transformed into airborne particles. Although such wear is well understood, few studiestreat the particles generated. We investigated friction modifiers' effects on airborne particles characteristicsgenerated in wheel-rail contacts in laboratory conditions. Pin-on-disc machine testing with a round-head pinloaded by a dead weight load 40 N simulated maximum contact pressure over 550 MPa. Airborne particlecharacteristics were investigated in dry contacts and in ones lubricated with biodegradable rail grease andwater- and oil-based friction modifiers. The number of particles declined with the grease; the number ofultrafine particles increased with the water-based friction modifier, mainly due to water vaporization.
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| 36. |
- Abbasi, Saeed, 1973-, et al.
(författare)
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Technical note: Experiences of studying airborne wear particles from road and rail transport
- 2013
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Ingår i: Aerosol and Air Quality Research. - : Taiwan Association for Aerosol Research. - 1680-8584 .- 2071-1409. ; 13:4, s. 1161-1169
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Tidskriftsartikel (refereegranskat)abstract
- Airborne particles and their adverse effects on air quality have been recognized by humans since ancient times. Current exhaust emission legislations increase the relative contribution of wear particles on the PM levels. Consequently, wearbased particle emissions from rail and road transport have raised concerns as ground transportation is developing quickly. Although scientific research on airborne wear-based particles started in 1909, there is almost no legislation that control the generation of wear-based particles. In addition, there is no accepted and approved standard measurement technique for monitoring and recording particle characteristics. The main objective of this study is to review recent experimental work in this field and to discuss their set-ups, the sampling methods, the results, and their limitations, and to propose measures for reducing these limitations.
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| 37. |
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| 38. |
- Abbasi, Saeed, 1973-, et al.
(författare)
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Temperature and Thermoelastic Instability at Tread Braking Using Cast Iron Friction Material
- 2013
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Ingår i: Wear. - : Elsevier BV. - 0043-1648 .- 1873-2577. ; 314:1–2, s. 171-180
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Tidskriftsartikel (refereegranskat)abstract
- Braking events in railway traffic often induce high frictional heating and thermoelastic instability (TEI) at the interfacing surfaces. In the present paper, two approaches are adopted to analyse the thermomechanical interaction in a pin-on-disc experimental study of railway braking materials. In a first part, the thermal problem is studied to find the heat partitioning between pin and disc motivated by the fact that wear mechanisms can be explained with a better understanding of the prevailing thermal conditions. The numerical model is calibrated using the experimental results. In a second part, the frictionally induced thermoelastic instabilities at the pin-disc contact are studied using a numerical method and comparing them with the phenomena observed in the experiments. The effects of temperature on material properties and on material wear are considered. It is found from the thermal analysis that the pin temperature and the heat flux to the pin increase with increasing disc temperatures up to a transition stage. This agrees with the behaviour found in the experiments. Furthermore, the thermoelastic analysis displays calculated pressure and the temperature distributions at the contact interface that are in agreement with the hot spot behaviour observed in the experiments.
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| 39. |
- Abbasi, Saeed, et al.
(författare)
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Temperature and thermoelastic instability of tread braking friction materials
- 2012
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Ingår i: Proceedings 9th International Conference on Contact Mechanics and Wear of Rail/Wheel Systems. ; , s. 606-607
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Konferensbidrag (refereegranskat)abstract
- Braking events in railway traffic often induce high frictional heating and thermoelastic instability (TEI) at the interfacing surfaces. In the present paper, two approaches are adopted to analyse the thermomechanical interaction in a pin-on-disc experimental study of railway braking materials. In a first part, the thermal problem is studied to find the heat partitioning between pin and disc motivated by the fact that wear mechanisms can be explained with a better understanding of the prevailing thermal conditions. The numerical model is calibrated using the experimental results. In a second part, the frictionally induced thermoelastic instabilities (TEI) at the pin-disc contact are studied using a numerical method and comparing them with the phenomena observed in the experiments. The effects of temperature on material properties and on material wear are considered. It is found from the thermal analysis that the pin temperature and the heat flux to the pin increase with increasing disc temperatures up to a transition stage. This agrees with the behaviour found in the experiments. Furthermore, the thermoelastic analysis displays calculated pressure and the temperature distributions at the contact interface that are in agreement with the hot spot behaviour observed in the experiments.
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| 40. |
- Abbasi, Saeed, 1973-
(författare)
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Towards elimination of airborne particles from rail traffic
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Since the investigation of wear particles from rail transport started in the late 1910s, the high mass concentrations of these particles have prompted concern among researchers interested in air quality. However, effective action has yet to be taken because relevant knowledge is still missing. This thesis provides knowledge of airborne wear particles originating from rail transport. Some aspects of their characteristic parameters, such as size, mass concentration, number concentration, and morphology, were investigated in the field and in laboratory tests. We also discuss means to mitigate non-exhaust emissions, as well as the advantages and disadvantages of various test set-ups in the seven appended journal papers:Paper A reviews recent studies of exhaust and non-exhaust emissions from rail vehicles. The results, measurements, adverse health effects, and proposed or applied solutions presented in this literature are summarized in this paper.Paper B summarizes the results of field tests we conducted. The effects of curve negotiation and braking under different real conditions were investigated in a field test in which on-board measurements were made. The elemental composition and morphology of the particles emitted and their potential sources were also investigated.Paper C describes how a pin-on-disc machine can be used to reproduce real operating conditions during mechanical train braking in a controlled laboratory setting. The results were validated by comparing the field test results with the results of laboratory studies.Paper D presents comprehensive results of laboratory studies of airborne particles from different braking materials. A new index is introduced in this paper, which can be used as a quantitative metric for assessing airborne wear particle emission rates.Paper E describes the effects of using various friction modifiers and lubricants on the characteristics of airborne particles from wheel–rail contact under lubricated and unlubricated conditions.Paper F reports work to simulate thermoelastic instability in the cast-iron braking material. We simulated the fluctuation of the flash temperature by considering the temperature dependency of the material properties and the transformation of the contact state due to thermomechanical phenomena and wear.Paper G reviews new full- and sub-scale measurements of non-exhaust emissions from ground transport. The advantages and disadvantages of on-board measurements, pin-on-disc tests, dynamometer tests, and test rig studies are discussed in this paper.
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| 41. |
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| 42. |
- Arab, Ghasem, et al.
(författare)
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Thermo-economic modeling of an atmospheric SOFC/CHP cycle : an exergy based approach
- 2014
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Ingår i: Mechanics and Industry. - : EDP Sciences. - 2257-7777 .- 2257-7750. ; 15:2, s. 113-121
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Tidskriftsartikel (refereegranskat)abstract
- Sustainability is one of the challenging issues in electricity production systems. Recently, solid oxide fuel cell (SOFC) has been suggested for use in combined heat and power (CHP) systems. This application is introduced as a promising environmentally-friendly system according to the thermodynamic and electrochemical models. In this paper, an atmospheric SOFC/CHP cycle was analysed based on integrating exergy concepts, energy and mass balance equations. In this regard, a zero-dimensional energy and mass balance model was developed in engineering equation solver (EES) software. Two dimensionless parameters (the exergetic performance coefficient (EPC) for investigating the whole cycle, and exergetic efficiency for investigating the exergy efficiency of the main component of this cycle) were applied. Results show that efficiencies of the system have been increased substantially. The electrical efficiency, total efficiency and EPC of this cycle were similar to 54%, similar to 79% and similar to 58% respectively. Moreover, the CO2 emission is 19% lower than when compared with a conventional combined power cycle fed by natural gas. In addition, a dynamic economic evaluation was performed to extract the most sensitive parameters affecting the outputs: electricity sales price (ESP), equipment purchase cost and fuel cost. Furthermore, an electricity production cost of similar to 125 $ MW.h(-1) was attributed to our model, resulting in yet further cost reduction for widespread applications of this cycle.
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| 43. |
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| 44. |
- Cha, Yingying, 1989-, et al.
(författare)
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Indoor and outdoor measurement of airborne particulates on a commuter train running partly in tunnels
- 2018
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Ingår i: Proceedings of the Institution of mechanical engineers. Part F, journal of rail and rapid transit. - : Sage Publications. - 0954-4097 .- 2041-3017. ; 232:1, s. 3-13
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Tidskriftsartikel (refereegranskat)abstract
- Wear processes from mechanical braking, rail/wheel contact, the railway electrification system and re-suspended materials due to the turbulence of passing trains in tunnels and stations have been suggested to be the main contributors to particulate matter levels inside trains. In this study, onboard monitoring was performed on a commuter train stopping at underground and aboveground stations. The concentration and size distribution of particulates were monitored for both indoor and outdoor levels. The results show that the levels of PM10 and PM2.5 inside the train were about one-fifth of the outdoor levels. Significant increases in indoor particulate number concentrations were observed in tunnel environments and there was a slight increase when the doors were open. Differences in the size distributions of micro- and nano-sized particulates could be identified for different tunnels.
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| 45. |
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| 46. |
- Feigin, Valery L., et al.
(författare)
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Global, regional, and national burden of stroke and its risk factors, 1990-2019 : a systematic analysis for the Global Burden of Disease Study 2019
- 2021
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 20:10, s. 795-820
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Tidskriftsartikel (refereegranskat)abstract
- Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12.2 million (95% UI 11.0-13.6) incident cases of stroke, 101 million (93.2-111) prevalent cases of stroke, 143 million (133-153) DALYs due to stroke, and 6.55 million (6.00-7.02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11.6% [10.8-12.2] of total deaths) and the third-leading cause of death and disability combined (5.7% [5.1-6.2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70.0% (67.0-73.0), prevalent strokes increased by 85.0% (83.0-88.0), deaths from stroke increased by 43.0% (31.0-55.0), and DALYs due to stroke increased by 32.0% (22.0-42.0). During the same period, age-standardised rates of stroke incidence decreased by 17.0% (15.0-18.0), mortality decreased by 36.0% (31.0-42.0), prevalence decreased by 6.0% (5.0-7.0), and DALYs decreased by 36.0% (31.0-42.0). However, among people younger than 70 years, prevalence rates increased by 22.0% (21.0-24.0) and incidence rates increased by 15.0% (12.0-18.0). In 2019, the age-standardised stroke-related mortality rate was 3.6 (3.5-3.8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3.7 (3.5-3.9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62.4% of all incident strokes in 2019 (7.63 million [6.57-8.96]), while intracerebral haemorrhage constituted 27.9% (3.41 million [2.97-3.91]) and subarachnoid haemorrhage constituted 9.7% (1.18 million [1.01-1.39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79.6 million [67.7-90.8] DALYs or 55.5% [48.2-62.0] of total stroke DALYs), high body-mass index (34.9 million [22.3-48.6] DALYs or 24.3% [15.7-33.2]), high fasting plasma glucose (28.9 million [19.8-41.5] DALYs or 20.2% [13.8-29.1]), ambient particulate matter pollution (28.7 million [23.4-33.4] DALYs or 20.1% [16.6-23.0]), and smoking (25.3 million [22.6-28.2] DALYs or 17.6% [16.4-19.0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
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| 47. |
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| 48. |
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| 49. |
- Gustafsson, Mats, 1966-, et al.
(författare)
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Particles in road and railroad tunnel air : sources, properties and abatement measures
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- High levels of air pollution are a common problem in both road and railroad tunnels. Sources and emission processes however differ significantly, as reflected by aerosols physical and chemical properties. As particle concentrations and properties affect exposure of and health effects for people on platforms and in vehicles, effective ways to reduce emissions and exposure are important. This study aims to improve the knowledge of the differences between PM10 in the rail and road tunnel environments, their sources and the possibilities to address problems with high particulate levels. Measurement campaigns were carried out at Arlanda Central, a railroad tunnel station below Arlanda airport and in Söderleden road tunnel, a road tunnel in central Stockholm.The results show large differences in concentration levels, size distributions and in composition of the particles. The railroad tunnel aerosol consisted of coarse particles with high iron content, while the properties of the coarse particles in the road tunnel were strongly influenced by whether the road surface was wet or dry. In wet conditions, concentrations were relatively low and iron and sulfur dominating elements, while silicon, potassium, calcium and iron from suspension and road wear dominated during dry conditions. The content of elemental carbon, most likely from the pantograph, were unexpectedly high in the railroad tunnel. An older type of train with a large proportion of mechanical brakes were suggested to be responsible to the main particle emissions in the railway tunnel. The report concludes with a discussion and proposals for action against particle sources in the various underground environments.
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| 50. |
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