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Mast Cell Activatio...
Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome : A Clinical Association
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- Kohno, Ritsuko (författare)
- University of Minnesota
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- Cannom, David S (författare)
- PIH Health Good Samaritan Hospital,University of Southern California
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- Olshansky, Brian (författare)
- University of Iowa
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- Xi, Shijun Cindy (författare)
- University of Southern California
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- Krishnappa, Darshan (författare)
- University of Minnesota
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- Adkisson, Wayne O (författare)
- University of Minnesota
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- Norby, Faye L (författare)
- Cedars-Sinai Medical Center
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- Fedorowski, Artur (författare)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups,Karolinska University Hospital
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- Benditt, David G (författare)
- University of Minnesota
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(creator_code:org_t)
- 2021
- 2021
- Engelska.
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 10:17
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Recently there has been increased interest in a possible association between mast cell activation (MCA) disorder and postural orthostatic tachycardia syndrome (POTS). This study examined the frequency with which symptoms and laboratory findings suggesting MCA disorder occurred in patients diagnosed with POTS. Methods and Results Data were obtained from patients in whom symptoms and orthostatic testing were consistent with a POTS diagnosis. Individuals with <4 months symptom duration, evident ongoing inflammatory disease, suspected volume depletion, or declined consent were excluded. All patients had typical POTS symptoms; some, however, had additional nonorthostatic complaints not usually associated with POTS. The latter patients underwent additional testing for known MCA biochemical mediators including prostaglandins, histamine, methylhistamine, and plasma tryptase. The study comprised 69 patients who met POTS diagnostic criteria. In 44 patients (44/69, 64%) additional nonorthostatic symptoms included migraine, allergic complaints, skin rash, or gastrointestinal symptoms. Of these 44 patients, 29 (66%) exhibited at least 1 laboratory abnormality suggesting MCA disorder, and 11/29 patients had 2 or more such abnormalities. Elevated prostaglandins (n=16) or plasma histamine markers (n=23) were the most frequent findings. Thus, 42% (29/69) of patients initially diagnosed with POTS exhibited both additional symptoms and at least 1 elevated biochemical marker suggesting MCA disorder. Conclusions Laboratory findings suggesting MCA disorder were relatively common in patients diagnosed with POTS and who present with additional nonorthostatic gastrointestinal, cutaneous, and allergic symptoms. While solitary abnormal laboratory findings are not definitive, they favor MCA disorder being considered in such cases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- mast cell
- postural orthostatic tachycardia syndrome
- biochemical mediators
- histamine
- prostaglandins
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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