| 1. |
- Adolfsson, Jan, et al.
(författare)
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Clinical characteristics and primary treatment of prostate cancer in Sweden between 1996 and 2005 : Data from the national prostate cancer register in Sweden
- 2007
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Ingår i: Scandinavian Journal of Urology and Nephrology. - Stockholm : Taylor & Francis. - 0036-5599 .- 1651-2065. ; 41:6, s. 456-477
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Tidskriftsartikel (refereegranskat)abstract
- Objective. The incidence of prostate cancer is rising rapidly in Sweden and there is a need to better understand the pattern of diagnosis, tumor characteristics and treatment. Material and methods. Between 1996 and 2005, all new cases of adenocarcinoma of the prostate gland were intended to be registered in the National Prostate Cancer Register (NPCR). This register contains information on diagnosing unit, date of diagnosis, cause of diagnosis, tumor grade, tumor stage according to the TNM classification in force, serum prostate-specific antigen (PSA) levels at diagnosis and primary treatment given within the first 6 months after diagnosis. Results. In total, 72 028 patients were registered, comprising >97% of all pertinent incident cases of prostate cancer in the Swedish Cancer Register (SCR). During the study period there was a considerable decrease in median age at the time of diagnosis, a stage migration towards smaller tumors, a decrease in median serum PSA values at diagnosis, a decrease in the age-standardized incidence rate of men diagnosed with distant metastases or with a PSA level of >100 ng/ml at diagnosis and an increase in the proportion of tumors with Gleason score ≤6. Relatively large geographical differences in the median age at diagnosis and the age-standardized incidence of cases with category T1c tumors were observed. Treatment with curative intent increased dramatically and treatment patterns varied according to geographical region. In men with localized tumors and a PSA level of <20 ng/ml at diagnosis, expectant treatment was more commonly used in those aged ≥75 years than in those aged <75 years. Also, the pattern of endocrine treatment varied in different parts of Sweden. Conclusions. All changes in the register seen over time are consistent with increased diagnostic activity, especially PSA testing, resulting in an increased number of cases with early disease, predominantly tumors in category T1c. The patterns of diagnosis and treatment of prostate cancer vary considerably in different parts of Sweden. The NPCR continues to be an important source for research, epidemiological surveillance of the incidence, diagnosis and treatment of prostate cancer
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| 2. |
- Adolfsson, Jan, et al.
(författare)
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Clinical characteristics and primary treatment of prostate cancer in Sweden between 1996 and 2005
- 2007
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Ingår i: Scandinavian Journal of Urology and Nephrology. - : Informa UK Limited. - 0036-5599 .- 1651-2065. ; 41:6, s. 456-477
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: The incidence of prostate cancer is rising rapidly in Sweden and there is a need to better understand the pattern of diagnosis, tumor characteristics and treatment. MATERIAL AND METHODS: Between 1996 and 2005, all new cases of adenocarcinoma of the prostate gland were intended to be registered in the National Prostate Cancer Register (NPCR). This register contains information on diagnosing unit, date of diagnosis, cause of diagnosis, tumor grade, tumor stage according to the TNM classification in force, serum prostate-specific antigen (PSA) levels at diagnosis and primary treatment given within the first 6 months after diagnosis. RESULTS: In total, 72,028 patients were registered, comprising >97% of all pertinent incident cases of prostate cancer in the Swedish Cancer Register (SCR). During the study period there was a considerable decrease in median age at the time of diagnosis, a stage migration towards smaller tumors, a decrease in median serum PSA values at diagnosis, a decrease in the age-standardized incidence rate of men diagnosed with distant metastases or with a PSA level of > 100 ng/ml at diagnosis and an increase in the proportion of tumors with Gleason score <6. Relatively large geographical differences in the median age at diagnosis and the age-standardized incidence of cases with category T1c tumors were observed. Treatment with curative intent increased dramatically and treatment patterns varied according to geographical region. In men with localized tumors and a PSA level of <20 ng/ml at diagnosis, expectant treatment was more commonly used in those aged > or =75 years than in those aged <75 years. Also, the pattern of endocrine treatment varied in different parts of Sweden. CONCLUSIONS: All changes in the register seen over time are consistent with increased diagnostic activity, especially PSA testing, resulting in an increased number of cases with early disease, predominantly tumors in category T1c. The patterns of diagnosis and treatment of prostate cancer vary considerably in different parts of Sweden. The NPCR continues to be an important source for research, epidemiological surveillance of the incidence, diagnosis and treatment of prostate cancer.
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| 3. |
- Cinthio, Magnus, et al.
(författare)
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A NEW NON-INVASIVE ULTRASONIC METHOD FOR MEASUREMENTS OF LONGITUDINAL LENGTH ALTERATION OF THE ARTERIAL WALL - FIRST IN VIVO TRIAL
- 2008
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Ingår i: Acoustical Imaging. - 0270-5117. ; 29, s. 39-43
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Konferensbidrag (refereegranskat)abstract
- We have recently shown that there is a previous unknown longitudinal movement present in the arterial wall. We aim now to investigate whether the longitudinal movement causes length alteration of the arterial wall. The objective of this paper was to describe a new non-invasive ultrasonic technique that measures the length alteration of arteries in human in-vivo. Results indicate that a significant length alteration is present in the common carotid artery.
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| 4. |
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| 5. |
- Cinthio, Magnus, et al.
(författare)
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Longitudinal movements and resulting shear strain of the arterial wall
- 2006
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Ingår i: American Journal of Physiology: Heart and Circulatory Physiology. - : American Physiological Society. - 1522-1539 .- 0363-6135. ; 291:1, s. 394-402
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Tidskriftsartikel (refereegranskat)abstract
- There has been little interest in the longitudinal movement of the arterial wall. It has been assumed that this movement is negligible compared with the diameter change. Using a new high-resolution noninvasive ultrasonic method, we measured longitudinal movements and diameter change of the common carotid artery of 10 healthy humans. During the cardiac cycle, a distinct bidirectional longitudinal movement of the intima-media complex could be observed in all the subjects. An antegrade longitudinal movement, i.e., in the direction of blood flow, in early systole [ 0.39 mm ( SD 0.26)] was followed by a retrograde longitudinal movement, i.e., in the direction opposite blood flow [ -0.52 mm ( SD 0.27)], later in systole and a second antegrade longitudinal movement [ 0.41 mm ( SD 0.33)] in diastole. The corresponding diameter change was 0.65 mm ( SD 0.19). The adventitial region showed the same basic pattern of longitudinal movement; however, the magnitude of the movements was smaller than that of the intimamedia complex, thereby introducing shear strain and, thus, shear stress within the wall [ maximum shear strain between the intima-media complex and the adventitial region was 0.36 rad ( SD 0.26). These phenomena have not previously been described. Measurements were also performed on the abdominal aorta ( n = 3) and brachial ( n = 3) and popliteal ( n = 3) arteries. Our new information seems to be of fundamental importance for further study and evaluation of vascular biology and hemodynamics and, thus, for study of atherosclerosis and vascular diseases.
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| 6. |
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| 7. |
- Cinthio, Magnus, et al.
(författare)
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New Approaches in Arterial Characterisation
- 2008
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Ingår i: Proceedings of 11th International Symposium on Advanced Biomedical Ultrasound (Invited). ; , s. 3-8
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- —The aim of this paper is to briefly present the historyand the status of the arterial characterization of today as wellas summarize our work on two new approaches in arterialcharacterization – measurements of the longitudinal movementand the minute roughness of the arterial wall.
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| 8. |
- Cinthio, Magnus, et al.
(författare)
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New improved and modified method for measurements of arterial wall movements in longitudinal and radial directions
- 2005
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Ingår i: Medical physics : proceedings of the jointly held congresses ICMP 2005, 14th International Conference of the Medical Physics of the International Organization for Medical Physics (IOMP), the European Federation of Organisations in Medical Physics (EFOMP) and the German Society of Medical Physics (DGMP) [and] BMT 2005, 39th annual congress of the German Society for Biomedical Engineering (DGBMT) ; 14th - 17th September 2005, Nuremberg, Germany. ; 50, s. 869-870
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Cinthio, Magnus, et al.
(författare)
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New improved method for 2D arterial wall movement measurements
- 2005
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Ingår i: Proceedings of the International Federation for Medical & Biomedical Engineering. 13th Nordic Baltic Conference on Biomedical Engineering and Medical Physics. - 9173059102 ; , s. 117-118
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Konferensbidrag (refereegranskat)abstract
- We have recently reported that the inner layers of the arteries, the intima-media complex, of common carotid artery, move as much in the longitudinal direction as in the radial direction, during the cardiac cycle. In order to study this phenomenon we have developed a high-resolution ultrasonic method that can simultaneously record both the longitudinal and the radial movements of the arterial wall non-invasively in vivo. However, in young individuals with large movements and with thin intima-media complex it happens sometimes that the echoes from the adventitia region interfere. To be able to minimise the size of the region-of-interest in the radial direction, we suggest that the radial movement of the arterial vessel is first measured and that the radial movement is used as a priori information when the longitudinal movement is measured. The mean difference between the two methods is 8 and 2 standard deviation is 24 μm
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| 10. |
- Cinthio, Magnus, et al.
(författare)
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New non-invasive method for intima-media thickness and intima-media compression measurements
- 2005
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Ingår i: Proceedings - IEEE Ultrasonics Symposium. - 1051-0117. - 0780393821 ; 1, s. 389-392
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Konferensbidrag (refereegranskat)abstract
- Intim a-media thickness (IMT) is considered as a valuable marker of early atherosclerosis. We suggest a new algorithm for simultaneous measurements of absolute diameter at diastole, distension (diameter change), IMT at diastole and the intima-media compression (IMC) with a new fast, robust, high-resolution, and automatic algorithm utilizing the ultrasonic gray-scale information. The new algorithm is evaluated in a limited in vivo study on the common carotid artery of 5 healthy volunteers. The standard deviation within an investigation was (8 ± 4 μm; range 4-14 μm) during IMC measurements, (8 ± 5 μm; range 4-16 μm) during the measurements of the IMT at diastole, (30 ±36 μm; range 6-92 μm) during the distension measurements and (48 ±49 μm; range 15-134 μm) during the measurements of the lumen diameter at diastole. The evaluation shows that the algorithm is fast and that the reproducibility and resolution are more than sufficient for in vivo studies. © 2005 IEEE.
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| 11. |
- Cinthio, Magnus, et al.
(författare)
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Non-invasive measurements of longitudinal strain of the arterial wall
- 2007
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Ingår i: Ultrasonics Symposium, 2007. IEEE, vols 1-6. - 1051-0117. - 9781424413843 ; , s. 570-572
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Konferensbidrag (refereegranskat)abstract
- We have recently shown that there is a previous unknown longitudinal movement present in the arterial wall. The aim is now to investigate whether the longitudinal movement is associated with longitudinal strain of the arterial wall. The objective of this paper was to describe a new non-invasive ultrasonic technique that measures the longitudinal strain of arteries in human in-vivo. Results indicate that a longitudinal strain is present in the common carotid artery.
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| 12. |
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| 13. |
- Mogensen, Hannes, et al.
(författare)
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Non-Invasive Ultrasonic Measurement of the Relative Volume Change of the Arterial Wall - First in vivo trial
- 2008
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Ingår i: 2008 IEEE Ultrasonics symposium, vols 1-4 and appendix. - 1051-0117. ; , s. 856-858
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Konferensbidrag (refereegranskat)abstract
- The objective of this study was to show a method that combine non-invasive measurements of the relative diameter change, the radial and the longitudinal strain of the intima-media complex of arterial walls, respectively, to obtain total change in arterial wall volume for a segment of the common carotid artery. The method was evaluated in a limited trial in vivo, comprising five normotensive subjects. Compared to the volume at end-diastole, the average maximum increase in arterial wall volume during each cardiac cycle was 3.2 % (SD 1.8). The aver-age maximum decrease of the arterial wall volume was -5.7 % (SD 3.5). This provides a new way of examining and quantifying the elastic properties of arterial walls.
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| 14. |
- Nahi, Hareth, et al.
(författare)
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An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia : a multi-center study of 381 patients
- 2008
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Ingår i: Haematologica. - Pavia : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 93:11, s. 8-1734
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Tidskriftsartikel (refereegranskat)abstract
- In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia.
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| 15. |
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| 16. |
- Rydén Ahlgren, Åsa, et al.
(författare)
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Effects of adrenaline on longitudinal arterial wall movements and resulting intramural shear strain: a first report.
- 2009
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Ingår i: Clinical Physiology and Functional Imaging. - 1475-0961. ; 29, s. 353-359
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Tidskriftsartikel (refereegranskat)abstract
- Using ultrasound we recently demonstrated that in central elastic arteries as well as in large muscular arteries in humans there is a distinct longitudinal displacement of the arterial wall during the cardiac cycle. Further, for the first time, we also demonstrated that the inner parts of the vessel wall, the intima-media complex, in these vessels exhibit a larger longitudinal displacement than the outer part of the vessel wall, the adventitial region, introducing the presence of substantial shear strain, and thus shear stress within the vessel wall. The role of these unexplored phenomena is unknown. Here, in a first study on the longitudinal movements of the porcine common carotid artery, we show that administration of adrenaline (epinephrine) might have pronounced effects on the longitudinal displacement of the intima-media complex. In this experiment the longitudinal displacement of the intima-media complex increased >200% at the highest blood pressure levels as compared to baseline. Further, shear strain within the wall increased >250%; the longitudinal displacement of the adventitial region being smaller than that of the intima-media complex. Thus, our results indicate that adrenaline can markedly influence the longitudinal displacement of the arterial wall and the resulting shear strain, and thus shear stress, within the arterial wall. This opens up a new field within cardiovascular research, revealing a previously unknown mechanism in the circulatory system. Further studies on larger materials are needed to confirm our findings and to elucidate the underlying mechanisms and the physiological, pathophysiological and clinical implications of this phenomenon.
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| 17. |
- Villman, Kenneth, et al.
(författare)
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A phase II study of epirubicin, cisplatin and capecitabine as neoadjuvant chemotherapy in locally advanced or inflammatory breast cancer
- 2007
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 43:7, s. 1153-1160
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To assess the efficacy and safety of epirubicin, capecitabine and cisplatin (EXC) combination therapy in locally advanced breast cancer (LABC) and investigate the predictive value of selected biomarkers. Methods: Newly diagnosed LABC patients received four 3-weekly cycles of neoadjuvant EXC (epirubicin 60 mg/m2 day 1; capecitabine 1000 mg/m2 bid, days 1-14; cisplatin 60 mg/m2day 1) and two cycles of post-operative EXC. Results: Eight (17%) of 48 patients had inflammatory breast cancer. Overall response rate was 74% (95% CI: 59-86%), including complete responses in 13% (95% CI: 5-26%). Nine (22%; 95% CI: 11-38%) of 41 patients undergoing surgery achieved pathologic complete response (pCR), giving a pCR rate of 19% (95% CI: 9-33%) in the intent-to-treat population. Haematological toxicity was manageable. The most problematic toxicities were chemotherapy-induced nausea/vomiting and hypercoagulative disorders. None of the biomarkers investigated, including HER2, predicted response. Conclusion: EXC showed high efficacy in LABC, with high clinical response and pCR rate. Nausea and vomiting were unexpectedly frequent, and more aggressive prophylaxis and management of these side effects is recommended in future studies of this combination.
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