SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Ahlstrand E) srt2:(2015-2019)"

Sökning: WFRF:(Ahlstrand E) > (2015-2019)

  • Resultat 1-4 av 4
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  • Metcalfe, Daniel B., et al. (författare)
  • Patchy field sampling biases understanding of climate change impacts across the Arctic
  • 2018
  • Ingår i: Nature Ecology and Evolution. - : Springer Science and Business Media LLC. - 2397-334X. ; 2:9, s. 1443-1448
  • Tidskriftsartikel (refereegranskat)abstract
    • Effective societal responses to rapid climate change in the Arctic rely on an accurate representation of region-specific ecosystem properties and processes. However, this is limited by the scarcity and patchy distribution of field measurements. Here, we use a comprehensive, geo-referenced database of primary field measurements in 1,840 published studies across the Arctic to identify statistically significant spatial biases in field sampling and study citation across this globally important region. We find that 31% of all study citations are derived from sites located within 50 km of just two research sites: Toolik Lake in the USA and Abisko in Sweden. Furthermore, relatively colder, more rapidly warming and sparsely vegetated sites are under-sampled and under-recognized in terms of citations, particularly among microbiology-related studies. The poorly sampled and cited areas, mainly in the Canadian high-Arctic archipelago and the Arctic coastline of Russia, constitute a large fraction of the Arctic ice-free land area. Our results suggest that the current pattern of sampling and citation may bias the scientific consensuses that underpin attempts to accurately predict and effectively mitigate climate change in the region. Further work is required to increase both the quality and quantity of sampling, and incorporate existing literature from poorly cited areas to generate a more representative picture of Arctic climate change and its environmental impacts.
  •  
4.
  • Steinz, Maarten M, et al. (författare)
  • Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis
  • 2019
  • Ingår i: JCI Insight. - : American Society for Clinical Investigation (ASCI). - 2379-3708 .- 2324-7703 .- 2325-4556. ; 4:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Skeletal muscle weakness in patients suffering from rheumatoid arthritis (RA) adds to their impaired working abilities and reduced quality of life. However, little molecular insight is available on muscle weakness associated with RA. Oxidative stress has been implicated in the disease pathogenesis of RA. Here, we show that oxidative posttranslational modifications of the contractile machinery targeted to actin result in impaired actin polymerization and reduced force production. Using mass spectrometry, we identified the actin residues targeted by oxidative 3-nitrotyrosine (3-NT) or malondialdehyde (MDA) adduct modifications in weakened skeletal muscle from mice with arthritis and patients afflicted by RA. The residues were primarily located in 3 distinct regions positioned at matching surface areas of the skeletal muscle actin molecule from arthritic mice and patients with RA. Moreover, molecular dynamics simulations revealed that these areas, here coined "hotspots," are important for the stability of the actin molecule and its capacity to generate filaments and interact with myosin. Together, these data demonstrate how oxidative modifications on actin promote muscle weakness in RA patients and may provide novel leads for targeted therapeutic treatment to improve muscle function.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-4 av 4
Typ av publikation
tidskriftsartikel (3)
konferensbidrag (1)
Typ av innehåll
övrigt vetenskapligt/konstnärligt (2)
refereegranskat (2)
Författare/redaktör
Samuelsson, J (2)
Andreasson, B (2)
Ahlstrand, E (2)
Lindgren, M. (1)
Abdi, Abdulhakim M. (1)
Ejerblad, Elisabeth (1)
visa fler...
Rousk, Johannes (1)
Uddling, Johan, 1972 (1)
Wallin, Göran, 1955 (1)
Sandor, Katalin (1)
Svensson, Camilla, I (1)
Ajeganova, Sofia (1)
Friedman, Ran (1)
Ahlstrand, Emma (1)
Ahlström, Anders (1)
Metcalfe, Daniel B. (1)
Andersen, C (1)
Zhang, Wenxin (1)
Ahlstrand, Jenny (1)
Tenenbaum, David E. (1)
Berggren, Martin (1)
Persson, Malin, 1983 ... (1)
Gustafsson, Thomas (1)
Vestergaard, H. (1)
Jensen, M (1)
Mills, K (1)
Lee, Hanna (1)
Zweegman, S (1)
Harrison, C (1)
Hasselbalch, H (1)
Björk, Robert G., 19 ... (1)
Rullman, Eric (1)
Aresh, Bejan (1)
Fernandes, S. (1)
Hasselquist, Niles (1)
Tang, Jing (1)
Björkman, Mats P., 1 ... (1)
Kristensen, Jeppe A. (1)
Sundqvist, Maja K. (1)
Jonsson, Micael (1)
Sponseller, Ryan A. (1)
Lundberg, Tommy R. (1)
Linder, O (1)
Lanner, Johanna T (1)
Mayor, Jordan R (1)
Blok, Daan (1)
Classen, Aimée T. (1)
Yamada, Takashi (1)
Karlsson, Roger (1)
Tavi, Pasi (1)
visa färre...
Lärosäte
Karolinska Institutet (2)
Göteborgs universitet (1)
Umeå universitet (1)
Uppsala universitet (1)
Stockholms universitet (1)
Örebro universitet (1)
visa fler...
Lunds universitet (1)
Linnéuniversitetet (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (4)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)
Naturvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy