| 1. |
- Abbafati, Cristiana, et al.
(författare)
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- 2020
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Micah, Angela E., et al.
(författare)
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Tracking development assistance for health and for COVID-19 : a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050
- 2021
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Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 398:10308, s. 1317-1343
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Forskningsöversikt (refereegranskat)abstract
- Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$ per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached $8. 8 trillion (95% uncertainty interval [UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total, $40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this, $13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and $1.4 billion was repurposed from existing health projects. $3.1 billion (22.4%) of the funds focused on country-level coordination and $2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7%) of COVID-19 development assistance for health went to Latin America, despite this region reporting 34.3% of total recorded COVID-19 deaths in low-income or middle-income countries in 2020. Spending on health is expected to rise to $1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
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| 3. |
- Feigin, Valery L., et al.
(författare)
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Global, regional, and national burden of stroke and its risk factors, 1990-2019 : a systematic analysis for the Global Burden of Disease Study 2019
- 2021
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 20:10, s. 795-820
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Tidskriftsartikel (refereegranskat)abstract
- Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12.2 million (95% UI 11.0-13.6) incident cases of stroke, 101 million (93.2-111) prevalent cases of stroke, 143 million (133-153) DALYs due to stroke, and 6.55 million (6.00-7.02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11.6% [10.8-12.2] of total deaths) and the third-leading cause of death and disability combined (5.7% [5.1-6.2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70.0% (67.0-73.0), prevalent strokes increased by 85.0% (83.0-88.0), deaths from stroke increased by 43.0% (31.0-55.0), and DALYs due to stroke increased by 32.0% (22.0-42.0). During the same period, age-standardised rates of stroke incidence decreased by 17.0% (15.0-18.0), mortality decreased by 36.0% (31.0-42.0), prevalence decreased by 6.0% (5.0-7.0), and DALYs decreased by 36.0% (31.0-42.0). However, among people younger than 70 years, prevalence rates increased by 22.0% (21.0-24.0) and incidence rates increased by 15.0% (12.0-18.0). In 2019, the age-standardised stroke-related mortality rate was 3.6 (3.5-3.8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3.7 (3.5-3.9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62.4% of all incident strokes in 2019 (7.63 million [6.57-8.96]), while intracerebral haemorrhage constituted 27.9% (3.41 million [2.97-3.91]) and subarachnoid haemorrhage constituted 9.7% (1.18 million [1.01-1.39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79.6 million [67.7-90.8] DALYs or 55.5% [48.2-62.0] of total stroke DALYs), high body-mass index (34.9 million [22.3-48.6] DALYs or 24.3% [15.7-33.2]), high fasting plasma glucose (28.9 million [19.8-41.5] DALYs or 20.2% [13.8-29.1]), ambient particulate matter pollution (28.7 million [23.4-33.4] DALYs or 20.1% [16.6-23.0]), and smoking (25.3 million [22.6-28.2] DALYs or 17.6% [16.4-19.0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
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| 4. |
- Sepanlou, Sadaf G., et al.
(författare)
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The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017 : a systematic analysis for the Global Burden of Disease Study 2017
- 2020
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Ingår i: The Lancet Gastroenterology & Hepatology. - 2468-1253. ; 5:3, s. 245-266
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Tidskriftsartikel (refereegranskat)abstract
- Background Cirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in this paper) are a major cause of morbidity and mortality globally, although the burden and underlying causes differ across locations and demographic groups. We report on results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 on the burden of cirrhosis and its trends since 1990, by cause, sex, and age, for 195 countries and territories. Methods We used data from vital registrations, vital registration samples, and verbal autopsies to estimate mortality. We modelled prevalence of total, compensated, and decompensated cirrhosis on the basis of hospital and claims data. Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost due to premature death and years lived with disability. Estimates are presented as numbers and age-standardised or age-specific rates per 100 000 population, with 95% uncertainty intervals (UIs). All estimates are presented for five causes of cirrhosis: hepatitis B, hepatitis C, alcohol-related liver disease, non-alcoholic steatohepatitis (NASH), and other causes. We compared mortality, prevalence, and DALY estimates with those expected according to the Socio-demographic Index (SDI) as a proxy for the development status of regions and countries. Findings In 2017, cirrhosis caused more than 1.32 million (95% UI 1.27-1.45) deaths (440000 [416 000-518 000; 33.3%] in females and 883 000 [838 000-967 000; 66.7%] in males) globally, compared with less than 899 000 (829 000-948 000) deaths in 1990. Deaths due to cirrhosis constituted 2.4% (2.3-2.6) of total deaths globally in 2017 compared with 1.9% (1.8-2.0) in 1990. Despite an increase in the number of deaths, the age-standardised death rate decreased from 21.0 (19.2-22.3) per 100 000 population in 1990 to 16.5 (15.8-18-1) per 100 000 population in 2017. Sub-Saharan Africa had the highest age-standardised death rate among GBD super-regions for all years of the study period (32.2 [25.8-38.6] deaths per 100 000 population in 2017), and the high-income super-region had the lowest (10.1 [9.8-10-5] deaths per 100 000 population in 2017). The age-standardised death rate decreased or remained constant from 1990 to 2017 in all GBD regions except eastern Europe and central Asia, where the age-standardised death rate increased, primarily due to increases in alcohol-related liver disease prevalence. At the national level, the age-standardised death rate of cirrhosis was lowest in Singapore in 2017 (3.7 [3.3-4.0] per 100 000 in 2017) and highest in Egypt in all years since 1990 (103.3 [64.4-133.4] per 100 000 in 2017). There were 10.6 million (10.3-10.9) prevalent cases of decompensated cirrhosis and 112 million (107-119) prevalent cases of compensated cirrhosis globally in 2017. There was a significant increase in age-standardised prevalence rate of decompensated cirrhosis between 1990 and 2017. Cirrhosis caused by NASH had a steady age-standardised death rate throughout the study period, whereas the other four causes showed declines in age-standardised death rate. The age-standardised prevalence of compensated and decompensated cirrhosis due to NASH increased more than for any other cause of cirrhosis (by 33.2% for compensated cirrhosis and 54.8% for decompensated cirrhosis) over the study period. From 1990 to 2017, the number of prevalent cases snore than doubled for compensated cirrhosis due to NASH and more than tripled for decompensated cirrhosis due to NASH. In 2017, age-standardised death and DALY rates were lower among countries and territories with higher SDI. Interpretation Cirrhosis imposes a substantial health burden on many countries and this burden has increased at the global level since 1990, partly due to population growth and ageing. Although the age-standardised death and DALY rates of cirrhosis decreased from 1990 to 2017, numbers of deaths and DALYs and the proportion of all global deaths due to cirrhosis increased. Despite the availability of effective interventions for the prevention and treatment of hepatitis B and C, they were still the main causes of cirrhosis burden worldwide, particularly in low-income countries. The impact of hepatitis B and C is expected to be attenuated and overtaken by that of NASH in the near future. Cost-effective interventions are required to continue the prevention and treatment of viral hepatitis, and to achieve early diagnosis and prevention of cirrhosis due to alcohol-related liver disease and NASH.
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| 5. |
- Ali, Kiran, et al.
(författare)
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Rapid Identification of Common Secondary Metabolites of Medicinal Herbs Using High-Performance Liquid Chromatography with Evaporative Light Scattering Detector in Extracts
- 2021
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Ingår i: Metabolites. - : MDPI AG. - 2218-1989 .- 2218-1989. ; 11:8
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Tidskriftsartikel (refereegranskat)abstract
- The discovery and identification of novel natural products of medicinal importance in the herbal medicine industry becomes a challenge. The complexity of this process can be reduced by dereplication strategies. The current study includes a method based on high-performance liquid chromatography (HPLC), using the evaporative light scattering detector (ELSD) to identify the 12 most common secondary metabolites in plant extracts. Twelve compounds including rutin, taxifolin, quercetin, apigenin, kaempferol, betulinic acid, oleanolic acid, betulin, lupeol, stigmasterol, and beta-sitosterol were analyzed simultaneously. The polarity of the compounds varied greatly from highly polar (flavonoids) to non-polar (triterpenes and sterols). This method was also tested for HPLC-DAD and HPLC-ESI-MS/MS analysis. Oleanolic acid and ursolic acid could not be separated in HPLC-ELSD analysis but were differentiated using LC-ESI-MS/MS analysis due to different fragment ions. The regression values (R-2 > 0.996) showed good linearity in the range of 50-1000 mu g/mL for all compounds. The range of LOD and LOQ values were 7.76-38.30 mu g/mL and 23.52-116.06 mu g/mL, respectively. %RSD and % trueness values of inter and intraday studies were mostly <10%. This method was applied on 10 species of medicinal plants. The dereplication strategy has the potential to facilitate and shorten the identification process of common secondary metabolites in complex plant extracts.
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| 6. |
- Kazmi, Bilal, et al.
(författare)
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Thermodynamic and economic assessment of cyano functionalized anion based ionic liquid for CO2 removal from natural gas integrated with, single mixed refrigerant liquefaction process for clean energy
- 2022
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Ingår i: Energy. - : Pergamon Press. - 0360-5442 .- 1873-6785. ; 239
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Tidskriftsartikel (refereegranskat)abstract
- The study proposes a novel integrated process in which ionic liquid is utilized to control carbon dioxide (CO2) emissions from the natural gas combined with a single mixed refrigerant-based liquefaction process to assist safe transportation over long distances providing a sustainable and cleaner energy. Commercially amines are utilized for CO2 sequestration, but amines entail energy-intensive regeneration with elevated process costs. The present study offers a solvent screening mechanism based on important parameters such as heat of dissolution, viscosity, selectivity, working capacity, vapor pressure, corrosivity, and toxicity. The selected solvents' performance is computed by sensitivity analysis suggesting imidazolium-based cation 1-hexyl-3-methylimidazolium[Hmim] functionalized with tricyanomethanide(tcm) as anion a potential natural gas sweetening solvent in comparison with commercially used solvent monoethanoloamine(MEA), conventional ILs 1-butyl-3-methylimidazolium hexa-fluorophosphate [Bmim][Pf(6)] and 1-butyl-3-methylimidazolium methyl sulfate [Bmim][MeSO4]. The obtained sweet gas is liquefied using a single mixed refrigerant-based process providing 0.99 mol fraction of liquefied CH4 with less overall specific compression power requirement of 0.41 kW/kg of natural gas. Moreover, an exergy analysis demonstrates that the [Hmim][tcm] based process has lower total exergy destruction of 7.49 x 10(3) kW and is found to utilize less overall specific energy consumption 0.49 kWh/kg of NG in contrast to other studied solvents. Furthermore, a detailed economic analysis establishes [Hmim][tcm]-based CO2 integrated with liquefaction technology offers 50.7%, 74.4%, and 85.8% of total annualized cost (TAC) savings compared with the MEA-amim][Pf(6)]-, and [Bmim][MeSO4], respectively. Hence, [Hmim][tcm] for CO2 removal and integration with liquefaction process will incur unit cost based on the total annualized cost to be $2.2 x 10(4)/kmol of purified NG.
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| 7. |
- Latif, Umar, et al.
(författare)
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In situ growth of nickel ammonium phosphate ribbons on nickel foam for supercapacitor applications
- 2023
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Ingår i: Journal of Energy Storage. - : Elsevier. - 2352-152X .- 2352-1538. ; 73:Part B
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Tidskriftsartikel (refereegranskat)abstract
- We report the in-situ growth of the nickel ammonium phosphate (NAP) ribbons on nickel (Ni) foam in a single step process using hydrothermal approach. The morphology, structure and elemental analysis of the NAP-ribbons grown on Ni foam were analyzed by scanning electron microscope (SEM), energy-dispersive x-ray analysis (EDX) and x-ray diffraction. The NAP-coated Ni foam sample was sonicated in ethanol and the obtained suspension was observed through AFM analysis to analyze the lateral dimensions of the NAP-ribbons. The obtained NAP ribbons powder was also characterized by x-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. Further, the NAP ribbons based electrodes were electrochemically characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and galvanostatic charge discharge analysis (GCD). NAP ribbons grown on Ni foam as electrodes achieved a specific capacitance (Csp) of 1196 Fg- 1 at 1 mVs- 1 and 1188 Fg- 1 at 1 Ag-1. The charge storage mechanism was identified and quantified by evaluating the CV data in 1-10 mVs- 1 scan rate range. It was established that at low scan rate the charge was dominantly stored by diffusion of electrolyte ions within the gaps of the NAP ribbons resulting in high energy density of 105.5 WhKg-1 at 1 Ag-1. NAP electrodes also demonstrated good cyclic stability by showing 92 % charge retention after 5000 cycles. A symmetric 2-elec-trode device comprised of NAP ribbons electrodes gave Csp of 309 Fg-1 at 1 mVs- 1 with energy density of 42.06 Wh/Kg and power density of 0.5 KW/Kg at 1 A/g current density, which is an exceptional for a symmetric supercapacitor device. The study confirms that NAP ribbons have a promising potential to be employed in the next-generation energy storage devices.
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| 8. |
- Minhaj, Syed Usama, et al.
(författare)
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How SIC-enabled LoRa Fares under Imperfect Orthogonality?
- 2021
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Ingår i: IWCMC 2021. - : IEEE. - 9781728186160 ; , s. 729-734
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Konferensbidrag (refereegranskat)abstract
- With the increase of connected Internet-of-things (IoT) devices, the need for low-power wide-area networks (LP-WANs) is imminent, and LoRaWAN is one such technology that offers an elegant solution to the problem of long-range communication and battery consumption. A parameter of special interest in LoRaWAN is the spreading factor (SF), and it is often assumed that communication between different SFs is independent of each other. However, this claim has been practically debunked by many works, proving that SFs have imperfect orthogonality. To maximize connectivity and throughput, several techniques have been introduced, such as non-orthogonal-multiple-access (NOMA) and dynamic resource allocation. NOMA is getting a lot of attention recently, especially for IoT networks, because it embraces interference and tries to obtain desired information packets from corrupted ones. Furthermore, NOMA can be easily implemented on the base-station side by using the principle of successive interference cancellation (SIC). In this paper, we investigate how SIC, under the assumption of imperfect orthogonality of SF channels, can be used to increase the performance of the system. We find the expressions for success and coverage probability considering various SF allocation schemes and found the most efficient scheme for different scenarios.
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| 9. |
- Minhaj, Syed Usama, et al.
(författare)
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Intelligent Resource Allocation in LoRaWAN Using Machine Learning Techniques
- 2023
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Ingår i: IEEE Access. - 2169-3536. ; 11, s. 10092-10106
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Tidskriftsartikel (refereegranskat)abstract
- With the ubiquitous growth of Internet-of-things (IoT) devices, current low-power wide-area network (LPWAN) technologies will inevitably face performance degradation due to congestion and interference. The rule-based approaches to assign and adapt the device parameters are insufficient in dynamic massive IoT scenarios. For example, the adaptive data rate (ADR) algorithm in LoRaWAN has been proven inefficient and outdated for large-scale IoT networks. Meanwhile, new solutions involving machine learning (ML) and reinforcement learning (RL) techniques are shown to be very effective in solving resource allocation in dense IoT networks. In this article, we propose a new concept of using two independent learning approaches for allocating spreading factor (SF) and transmission power to the devices using a combination of a decentralized and centralized approach. SF is allocated to the devices using RL for contextual bandit problem, while transmission power is assigned centrally by treating it as a supervised ML problem. We compare our approach with existing state-of-the-art algorithms, showing a significant improvement in both network level goodput and energy consumption, especially for large and highly congested networks.
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| 10. |
- Naqvi, Salman Raza, et al.
(författare)
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Agro-industrial residue gasification feasibility in captive power plants : A South-Asian case study
- 2021
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Ingår i: Energy. - : Elsevier. - 0360-5442 .- 1873-6785. ; 214
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study is to build knowledge on the potential of agro-industrial residue gasification (AIRG) for use in captive power generation through a comprehensive case study. In order to evaluate the economic viability, key performance indicators, such as net present value (NPV), levelized cost of electricity (LCOE), and operating costs etc. are studied. The major textile industry located in the Raiwind area of Punjab province of Pakistan has been selected. The effect and variations of the capacity factor has also been studied coupled with the levelized cost of electricity. The agricultural residue as feedstock to the gasifier is rice husk that is the abundantly available in South Asia. Furthermore, the impact of government subsidies on natural gas is also under the scope of the study. The agro-industrial residue gasification system is found to be a potential alternative to furnace oil (FO) or gas-based captive power plants (CPPs). The results of residue-based gasification system imply a large potential when comparing the cost of electricity with national grid electricity during the peak hours. Therefore, the proposed gasification system offers economic incentives when the textile industry potentially utilizes gasification-based electricity during peak hours and national grid electricity during off-peak hours. (C) 2020 Elsevier Ltd. All rights reserved.
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| 11. |
- Ali, Salamat, et al.
(författare)
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Experimental and Theoretical Aspects of MXenes-Based Energy Storage and Energy Conversion Devices
- 2023
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Ingår i: Journal of Chemistry and Environment. - : Science Research Publishers (SRP). - 2959-0132. ; 2:2, s. 54-81
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Forskningsöversikt (refereegranskat)abstract
- Transition metal carbides, nitrides, and carbonitrides (MXenes) have become an appealing framework for developing various energy applications. MXenes with van der Waals (vdW) interactions are facile, highly efficient, affordable, and self-assembled features that improve energy density. MXenes exhibit large surface area, high electric conductivity, and excellent electrochemical characteristics for various energy applications. This review summarizes and emphasizes the current developments in MXene with improved performance for energy storage or conversion devices, including supercapacitors (SCs), various types of rechargeable batteries (RBs), solar cells, and fuel cells. We discuss the crystal structures of MXenes properties of MXenes and briefly discuss them for different types of energy applications. Finally, the critical outlook and perspective for the MXene progress for applications in energy applications are also described.
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| 12. |
- Hameed, Zeeshan, et al.
(författare)
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A Comprehensive Review on Thermal Coconversion of Biomass, Sludge, Coal, and Their Blends Using Thermogravimetric Analysis
- 2020
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Ingår i: Journal of Chemistry. - : Hindawi Publishing Corporation. - 2090-9063 .- 2090-9071. ; 2020
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Forskningsöversikt (refereegranskat)abstract
- Lignocellulosic biomass is a vital resource for providing clean future energy with a sustainable environment. Besides lignocellulosic residues, nonlignocellulosic residues such as sewage sludge from industrial and municipal wastes are gained much attention due to its large quantities and ability to produce cheap and clean energy to potentially replace fossil fuels. These cheap and abundantly resources can reduce global warming owing to their less polluting nature. The low-quality biomass and high ash content of sewage sludge-based thermal conversion processes face several disadvantages towards its commercialization. Therefore, it is necessary to utilize these residues in combination with coal for improvement in energy conversion processes. As per author information, no concrete study is available to discuss the synergy and decomposition mechanism of residues blending. The objective of this study is to present the state-of-the-art review based on the thermal coconversion of biomass/sewage sludge, coal/biomass, and coal/sewage sludge blends through thermogravimetric analysis (TGA) to explore the synergistic effects of the composition, thermal conversion, and blending for bioenergy production. This paper will also contribute to detailing the operating conditions (heating rate, temperature, and residence time) of copyrolysis and cocombustion processes, properties, and chemical composition that may affect these processes and will provide a basis to improve the yield of biofuels from biomass/sewage sludge, coal/sewage sludge, and coal/biomass blends in thermal coconversion through thermogravimetric technique. Furthermore, the influencing factors and the possible decomposition mechanism are elaborated and discussed in detail. This study will provide recent development and future prospects for cothermal conversion of biomass, sewage, coal, and their blends.
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| 13. |
- Khan, Syed Ishtiaq, et al.
(författare)
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Mononuclear copper(i) complexes of triphenylphosphine and N,N′-disubstituted thioureas as potential DNA binding chemotherapeutics
- 2021
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Ingår i: New Journal of Chemistry. - : Royal Society of Chemistry. - 1144-0546 .- 1369-9261. ; 45:20, s. 8925-8935
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Tidskriftsartikel (refereegranskat)abstract
- In this work, nine new mixed-ligand complexes with the general formula [CuBr(TPP)2Tu1–9] were synthesized. The copper(I) complexes of triphenylphosphine (TPP) and different N,N′-disubstituted thioureas (Tu) were characterized via spectroscopic techniques including Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (1H, 13C, and 31P NMR), and single-crystal X-ray diffraction (SC-XRD). The complexes were synthesized via the direct reaction of bromo(tris(triphenylphosphine)copper(I)) [BrCu(PPh3)3] precursor and thiourea ligand solution under ambient conditions. Complexes 1, 2 and 3 crystallized in a triclinic system with the P space group. Each complex is mononuclear, and the copper atom is tetrahedrally attached to two TPP groups through the phosphorous atom, one thiourea molecule through the sulfur atom and one bromine atom. The synthesized compounds were docked with a DNA macromolecule to predict their binding site and it was found that all molecules showed favorable binding to the DNA minor grooves. The DNA interaction studies of the representative complexes demonstrated their efficient DNA binding affinities. Based on the docking and DNA interaction results, complex 7 was found to be the best binder with a docking affinity of 382.2 kJ mol−1 and binding constant of 3.96 × 104 M−1. This compound tends to interact with the minor groove through the bromine atom positioning the side triphenylphosphine rings along the X-axis of the groove while keeping the 1-(2-chlorobenzyl)-3-(3-(trifluoromethyl)phenyl)thiourea ring on the outside.
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| 14. |
- Raza, Mohsin Ali, et al.
(författare)
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Synthesis and characterization of zinc aluminate electrodes for supercapacitor applications
- 2024
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Ingår i: Electrochimica Acta. - : Elsevier. - 0013-4686 .- 1873-3859. ; 475
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Tidskriftsartikel (refereegranskat)abstract
- We report, for the first time, the thorough electrochemical characterization of zinc aluminate spinel. Four different stoichiometric composition of zinc aluminate (ZnAl1.5O3.25, ZnAl2O4, ZnAl2.87O5.30, and ZnAl4O7) were prepared by solution combustion method. The obtained powders after calcination at 1000 °C were characterized through scanning electron microscope (SEM), energy dispersive x-ray spectroscopy (EDX) and x-ray diffraction to analyze the morphology, elemental composition and structure, respectively, of the zinc aluminate compositions. The electrodes were prepared by coating slurry of zinc aluminate, carbon black and polyvinylidene fluoride on nickel foam in a ratio of 8:1:1. The electrochemical characterization was carried out by cyclic voltammetry (CV), galvanostatic charge discharge (GCD) and electrochemical impedance spectroscopy (EIS). ZnAl1.5O3.25 exhibited the highest specific capacity of 546 C/g at 1 mV/s and 336 C/g at 1 A/g, as appraised by CV and GCD analysis, respectively. EIS test revealed that ZnAl1.5O3.25 had the modest impedance value. The energy density value for ZnAl1.5O3.25 sample was 16.79 Wh/kg at 1 A/g with a power density of 179.9 W/kg. The as developed electrodes showed predominantly pseudo-capacitive charge storage mechanism.
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| 15. |
- Sartelli, Massimo, et al.
(författare)
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Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action
- 2023
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Ingår i: WORLD JOURNAL OF EMERGENCY SURGERY. - 1749-7922. ; 18:1
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Forskningsöversikt (refereegranskat)abstract
- Antibiotics are recognized widely for their benefits when used appropriately. However, they are often used inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component of universal healthcare, and it is a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive to develop new antibiotics due to scientific, regulatory, and financial barriers, further emphasizing the importance of appropriate antibiotic use. To address this issue, the Global Alliance for Infections in Surgery established an international multidisciplinary task force of 295 experts from 115 countries with different backgrounds. The task force developed a position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness of antimicrobial resistance and improving antibiotic prescribing practices worldwide. The statement outlined is 10 axioms, or "golden rules," for the appropriate use of antibiotics that all healthcare workers should consistently adhere in clinical practice.
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| 16. |
- Sumbal, Muhammad Saleem, et al.
(författare)
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A framework to retain the knowledge of departing knowledge workers in the manufacturing industry
- 2020
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Ingår i: VINE. - : Emerald Group Publishing Limited. - 2059-5891. ; 50:4, s. 631-661
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The purpose of this study is to develop a conceptual framework on knowledge loss in a manufacturing sector based on three aspects: likelihood of knowledge loss, critical areas of knowledge loss and relevance of each of these knowledge areas in terms of utilization and alignment with organizational goals and strategy. Such a conceptual framework can be helpful to the practicing managers in understanding the types of knowledge that is lost of a given departing employee and thus deciding on a measure to retain the critical employees or capture their knowledge before they leave. Design/methodology/approach: Using a case study approach, data has been collected from a multinational battery manufacturing company based in Hong Kong. Semi-structured interviews have been conducted and analyzed through CAQDAS ATLAS.ti to generate the themes which were then used to develop the conceptual framework. Findings: The findings revealed that the likelihood factors of knowledge loss in the manufacturing sector include layoffs, retirement, immigration and job change. The critical areas of knowledge loss comprise the knowledge of relationships and networks, especially with the customers and suppliers, the technical knowledge (battery and process technology) and knowledge of management, among others. The relevance of each of these knowledge areas needs to be determined through proper analysis whether these knowledge areas are needed in future projects, up to date and aligned with organizational goals and strategy along with other factors. Research limitations/implications: Using the developed conceptual framework, managers and executives can identify critical employees in the manufacturing sector and accordingly take some appropriate measures to retain their knowledge. Caution should be taken while applying the findings of this study in other industries and context. Originality/value: This paper is an attempt to reduce the dearth of empirical studies by exploring knowledge retention in the manufacturing sector, especially in the development of proper conceptual frameworks to assess the potential knowledge loss of employees.
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| 17. |
- Usman, Muhammad, et al.
(författare)
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Evaluation of the chronic intoxication of fluoride on human serum metabolome using untargeted metabolomics
- 2022
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Ingår i: Arabian Journal of Chemistry. - : Elsevier BV. - 1878-5352 .- 1878-5379. ; 15:7
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Tidskriftsartikel (refereegranskat)abstract
- Drinking water is the main source of fluoride intake for the human body and its regulated consumption helps in decreasing dental caries. However, excessive fluoride consumption over a prolonged time period causes fluorosis disease which adversely affects many tissues and organs of the body. This paper describes the evaluation of chronic intoxication of fluoride on human serum metabolome. The untargeted metabolomics approach using UPLC-QTOF-MS/MS is applied for metabolomic profiling, whereas the estimation of fluoride in serum samples was carried out using the ion-selective electrode (ISE). Fluoride concentration was found to be 0.16–1.25 mg/L in serum samples of 39 fluorosis patients and 0.008–0.045 mg/L in 20 healthy samples. A total of 47 metabolites were identified based on the high-resolution mass spectrometry analysis. A volcano plot was generated to discriminate features that are significantly different between the fluorosis and healthy groups at the probability of 0.05 and fold change ≥ 2. Among all identified metabolites, intensities of ten differential identified metabolites including inosine, α-linolenic acid, guanosine, octanoyl-L-carnitine, His-Trp, phytosphingosine, lauroyl-L-carnitine, hydrocortisone, deoxyinosine and dodecanedioic acid have been found altered in disease samples compared to healthy controls. Major pathways identified based on these metabolites include energy metabolism, fatty acid oxidation, purine degradation pathway, elevated protein degradation, and increased ω-6 fatty acid linoleate signatures were observed.
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| 18. |
- Ahmad, Naveed, et al.
(författare)
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The inter-relation of corporate social responsibility at employee level, servant leadership, and innovative work behavior in the time of crisis from the healthcare sector of pakistan
- 2021
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 18:9
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Tidskriftsartikel (refereegranskat)abstract
- Organizational crisis can serve as a base to provide an opportunity to an organization for enhancing individuals, organizations, and communities. The healthcare sector is one of those sectors that remains under continuous pressure to provide high-quality service delivery to the patients. Hence, the requirement of innovation for this sector is huge when compared to other sectors. The majority of the previous studies have investigated the phenomenon of CSR at the employee’s level (CSR-E) to influence employee behavior positively. However, the importance of CSR-E to enhance the innovative capability of the employees at the workplace is not well-explored in extant literature. Moreover, it is not clear from previous studies how the concept of servant leadership can explain the employee’s engagement towards innovative work behavior (EIB). Thus, the current survey aims to test the relationship of CSR-E and EIB in the healthcare sector of Pakistan with the mediating effect of servant leadership. The data of the current study were obtained through a self-administered (paper-pencil) survey and they were analyzed through the structural equation modeling (SEM) technique. The empirical results of SEM analysis revealed that CSR-E and EIB are positively related and servant leadership partially mediates this relationship. The findings of the current study will be helpful for policymakers to improve their understanding towards CSR-E to induce EIB in the time of crisis. At the same time, the current study also highlights the importance of servant leadership to the policymakers in encouraging the employees to display their innovative capability at the workplace to serve their organization during the time of crisis.
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| 19. |
- Ahsan, Ali, et al.
(författare)
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Formulation and evaluation of miconazole lipogel for enhanced drug permeation
- 2024
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Ingår i: Pakistan Journal of Pharmaceutical Sciences. - : UNIV KARACHI. - 1011-601X. ; 37:1, s. 95-105
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Tidskriftsartikel (refereegranskat)abstract
- Hydrophilic drugs could be incorporated into the skin surface by manes of Lipogel. This study aimed to prepare miconazole lipogel with natural ingredients to enhance drug permeability using dimethyl Sulfoxide (DMSO). The miconazole lipogels, A1 (without DMSO) and A2 (with DMSO) were formulated and evaluated for organoleptic evaluation, pH, viscosity, stability studies, freeze -thawing, drug release profile and drug permeation enhancement. Results had stated that prepared lipogel's pH falls within the acceptable range required for topical delivery (4 to 6) while both formulations show good results in organoleptic evaluation. The A2 formulation containing DMSO shows better permeation of miconazole (84.76%) on the artificial skin membrane as compared to A1 lipogel formulation (50.64%). In in -vitro drug release studies, A2 for-mulation showed 87.48% drug release while A1 showed just 60.1% drug release from lipogel. Stability studies were performed on model formulations under environmental conditions and both showed good spreadibility, stable pH, free of grittiness and good consistency in formulation. The results concluded that A2 formulation containing DMSO shows better results as compared to DMSO-free drug lipogel.
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| 20. |
- Ali Ahmad, Syed Ossama, et al.
(författare)
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Application of two-dimensional materials in perovskite solar cells: recent progress, challenges, and prospective solutions
- 2021
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Ingår i: Journal of Materials Chemistry C. - : ROYAL SOC CHEMISTRY. - 2050-7526 .- 2050-7534. ; 9:40, s. 14065-14092
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Forskningsöversikt (refereegranskat)abstract
- Perovskite solar cells (per-SCs) with high performance and cost-effective solution processing have been the center of interest for researchers in the past decade. Power conversion efficiencies (PCEs) have been gradually improved up to 25.2% with relatively improved stability, which is an unparalleled progress in all generations of solar cell (SC) technology. However, there are still some prevailing challenges regarding the stability and upscaling of these promising devices. Recently, 2D layered materials (LMs) have been extensively explored to overcome the prevailing challenges of poor stability (under moisture, light soaking and high temperature), halide segregation, hysteresis, involvement of toxic materials (i.e., lead), and upscaling of devices. A critical review addressing the recent developments in the use of 2D materials, especially transition metal dichalcogenides (TMDCs), is hence necessary. The development of novel synthesis and deposition techniques including liquid-metal synthesis and ultrasonic assisted spray pyrolysis has offered more efficient fabrication of 2D-LMs with controlled thickness and morphology. Effective functionalization approaches to increase the dispersability of 2D-LMs in non-polar solvents has boosted their potential application in solar cell technology as well. Moreover, compositing 2D TMDCs with suitable organic/inorganic compounds has enabled superior charge kinetics in all functional parts of per-SCs. In addition, newly developed materials such as graphyne and graphdyine along with 2D metal organic frameworks (MOFs) and covalent organic frameworks (COFs) have been employed in per-SCs to achieve PCEs up to 20%. This review summarizes the recent progress and challenges in the application of 2D-LMs in per-SCs and outlines the future pathways to further extend the PCE of per-SCs beyond 25%. This review particularly focuses on 2D-LMs as electrode materials and additives, the underlying charge (electron-hole) transport phenomenon in the functional layers, and their chemical and structural stability.
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| 21. |
- Anees, Hafiz Muhammad, et al.
(författare)
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A mathematical model-based approach for DC multi-microgrid performance evaluations considering intermittent distributed energy resources, energy storage, multiple load classes, and system components variations
- 2021
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Ingår i: Energy Science & Engineering. - : John Wiley & Sons. - 2050-0505. ; 9, s. 1919-1934
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Tidskriftsartikel (refereegranskat)abstract
- The efficiency of DC microgrid needs investigation from a smart grid perspective, since their spread has expected to prevail in comparison with AC counterparts. Furthermore, there is a need to address the limitations (majorly to cater the intermittency of distributed energy resources (DERs) as well as the time dependency of systematic parameters etc.) in previous model and propose a new mathematical model to evaluate system efficiency for given parameters and scenarios. The core focus of current study aims at formulation of an improved (composite) mathematical model, that is capable of bridging issues and serve as a tool to address requirements of future DC systems including microgrids (MGs) and multi-microgrids (MMGs). This research work offers such a mathematical model that consists of 3D matrices based on newly derived set of discrete time dependent equations, which evaluates the system efficiency of residential DC-MMGs. Each DC-MG is embedded with intermittent DERs, storage, components (with efficiency variations), and multi-class load (with discrete time dependency), for evaluation across worst, normal, and best scenarios. A comprehensive sensitivity analysis across various cases and respective scenarios are also presented to evaluate overall system performance. Also, the impacts of system parameters on various system variables, states, and overall system efficiency have presented in this paper.
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| 22. |
- Kazmi, Bilal, et al.
(författare)
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Process system analysis on oil processing facility and economic viability from oil well-to-tank
- 2021
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Ingår i: SN Applied Sciences. - : Springer Science and Business Media LLC. - 2523-3963 .- 2523-3971. ; 3:7
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Tidskriftsartikel (refereegranskat)abstract
- Hydrocarbon processing from extraction to the final product is an important aspect that needs an optimised technology for consumption-led market growth. This study investigated real data from the oil processing facility and analysed the simulation model for the entire crude oil processing unit based on the process system engineering aspect using Aspen HYSYS. The study mainly emphasises the process optimisation in processing the hydrocarbon for the maximum yield of the product with less energy consumption. The investigation also includes a thorough economic analysis of the processing facility. The datasets for oil properties are obtained from a modern petroleum refinery. The investigation comprises of varying transient conditions, such as well shutdowns using three oil reservoirs (low, intermediate, and heavy oil). The impact of various conditions, including process heating, well shutdown, oil combinations, presence of water on the production, is analysed. The results indicate that the factors involving crude oil processing are significantly affected by the process conditions, such as pressure, volume, and temperature. The vapour recovery unit is integrated with the oil processing model to recover the separator's gas. The optimisation analysis is performed to maximise the liquid recovery with Reid vapour pressure of 7 and minimum water content in oil around 0.5%. Economic analysis provided an overall capital cost of $ 9.7 x 10(6) and an operating cost of $2.1 x 10(6) for the process configuration. The model results further investigate the constraints that maximise the overall energy consumption of the process and reduce the operational cost.
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| 23. |
- Kumari, Sindhia, et al.
(författare)
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Metabolomics approach to understand the hepatitis C virus induced hepatocellular carcinoma using LC-ESI-MS/MS
- 2021
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Ingår i: Arabian Journal of Chemistry. - : Elsevier. - 1878-5352 .- 1878-5379. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Hepatocellular carcinoma (HCC) is a typical cancer that has region specified analysis with the incidence of hepatitis C virus (HCV) infection. This study was conducted to improve the understanding of metabolic alterations associated with HCV induced HCC which can open up new strategies to monitor the high risk of HCC. Samples of the subjects with HCV, HCV induced chronic liver disease (CLD), HCV induced HCC, and healthy controls (HS) were collected after complete blood count (CBC), hepatitis viral load, st-fetoprotein (AFP), liver function tests, and albumin. A total of 147 serum samples including HCC (n = 11), CLD (n = 24), HCV (n = 71), and HS (n = 41) were analyzed by LC-ESI-MS/MS. The 21 compounds were found to be responsible for group discrimination after the application of chemometric tools. Nfructosyl tyrosine and hydroxyindoleacetic acid showed an increase in level whereas L-aspartylL-phenylalanine and thyroxine showed a consistent decrease in the progression of HCV to HCC in comparison with HS indicating their importance for early detection. The biological pathways such as glycerophospholipid metabolism, phenylalanine, tyrosine, and tryptophan biosynthesis, phenylalanine metabolism and tryptophan metabolism showed alteration in some metabolites. The method was internally validated by ROC plot showing AUC value for HS, HCV, CLD, and HCC as 0.99, 1, 1, and 0.89, respectively; while 16 blind samples were also validated with 93% specificity. The untargeted metabolomics investigation of HCV, CLD, and HCC can help to understand the progression of HCV-induced HCC. It reveals significant differences in metabolites to predict prognostic and diagnostic markers. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
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| 24. |
- Qadri, Azam Mehmood, et al.
(författare)
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Heart failure survival prediction using novel transfer learning based probabilistic features
- 2024
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Ingår i: PeerJ Computer Science. - : PEERJ INC. - 2376-5992. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Heart failure is a complex cardiovascular condition characterized by the heart's inability to pump blood effectively, leading to a cascade of physiological changes. Predicting survival in heart failure patients is crucial for optimizing patient care and resource allocation. This research aims to develop a robust survival prediction model for heart failure patients using advanced machine learning techniques. We analyzed data from 299 hospitalized heart failure patients, addressing the issue of imbalanced data with the Synthetic Minority Oversampling (SMOTE) method. Additionally, we proposed a novel transfer learning-based feature engineering approach that generates a new probabilistic feature set from patient data using ensemble trees. Nine fine-tuned machine learning models are built and compared to evaluate performance in patient survival prediction. Our novel transfer learning mechanism applied to the random forest model outperformed other models and state-of-the-art studies, achieving a remarkable accuracy of 0.975. All models underwent evaluation using 10-fold crossvalidation and tuning through hyperparameter optimization. The findings of this study have the potential to advance the field of cardiovascular medicine by providing more accurate and personalized prognostic assessments for individuals with heart failure.
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| 25. |
- Tariq, Imran, et al.
(författare)
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Ameliorative delivery of docetaxel and curcumin using PEG decorated lipomers : A cutting-edge in-vitro/ in-vivo appraisal
- 2024
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Ingår i: Journal of Drug Delivery Science and Technology. - : Elsevier. - 1773-2247. ; 97
-
Tidskriftsartikel (refereegranskat)abstract
- The development of a PEG-decorated lipid-polymer hybrid system camouflaged with natural and synthetic chemotherapeutic moieties is an influential approach melding the biomimetic properties of long-circulating vesicles to utilize different mechanisms to dwindle the tumor growth. Therefore, a safe and efficient lipid-coated nano-particulate system (LCNPs) was proposed to investigate the in-vitro, ex-vivo and in-vivo demeanors of such amalgamation.Docetaxel loaded PLGA nanoparticles (DTX-NPs) were prepared by solvent evaporation while curcumin liposomes were mapped out using the film hydration method. Physicochemical characterizations were executed in terms of size, surface morphology, differential scanning calorimetry (DSC) and fourier-transform infrared spectroscopy (FTIR). In-vitro cytotoxicity was effectuated using MCF-7 cell line. Hemolysis, erythrocyte aggregation and acute in-vivo toxicity were carried out to establish the biocompatibility. The hydrodynamic diameters of samples were in the nano-range and corresponded to the findings of scanning electron microscopy (SEM) and atomic force microscopy (AFM). The absence of distinctive peaks of DTX-NPs in FTIR and DSC analysis of LCNPs depicts the shielding of the lipid bilayer over the nanoparticle. Cytotoxicity induced by the LCNPs represented the efficient delivery of cargo to the tumor cells. LCNPs also exhibited the least toxicity under ex-vivo and in-vivo circumstances compared to free drugs. Additionally, histological studies showed no evidence of substantial necrosis. Additionally, histological studies showed no evidence of notable necrosis.
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| 26. |
- Umer, Muhammad, et al.
(författare)
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Analysis of STAR-RIS Assisted Downlink CoMP-NOMA Multi-Cell Networks under Nakagami-m Fading
- 2024
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Ingår i: IEEE Communications Letters. - : IEEE. - 1089-7798 .- 1558-2558. ; 28:5, s. 1009-1013
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Tidskriftsartikel (refereegranskat)abstract
- In this letter, we conduct a thorough analytical assessment of a simultaneously transmitting and reflecting reconfigurable intelligent surface (STAR-RIS) assisted non-orthogonal multiple access (NOMA) enhanced coordinated multipoint (CoMP) multi-cell network under Nakagami-m fading. Using the central limit theorem (CLT) and moment-matching based Gamma approximation method, we derive the distributions of effective and cascaded channel gains. Subsequently, leveraging these results, we formulate tractable equations for ergodic rates and outage probabilities across all users in the network. Our analytical results correlate with the simulation results, affirming the efficacy of analytical methodology. Furthermore, the results demonstrate a significant performance improvement of STAR-RIS assisted CoMP-NOMA networks compared to conventional systems.
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| 27. |
- Abbas, Shahrukh, et al.
(författare)
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Impact Analysis of Large-Scale Wind Farms Integration in Weak Transmission Grid from Technical Perspectives
- 2020
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Ingår i: Energies. - : MDPI. - 1996-1073. ; 13:20
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Tidskriftsartikel (refereegranskat)abstract
- The integration of commercial onshore large-scale wind farms into a national grid comes with several technical issues that predominately ensure power quality in accordance with respective grid codes. The resulting impacts are complemented with the absorption of larger amounts of reactive power by wind generators. In addition, seasonal variations and inter-farm wake effects further deteriorate the overall system performance and restrict the optimal use of available wind resources. This paper presented an assessment framework to address the power quality issues that have arisen after integrating large-scale wind farms into weak transmission grids, especially considering inter-farm wake effect, seasonal variations, reactive power depletion, and compensation with a variety of voltage-ampere reactive (Var) devices. Herein, we also proposed a recovery of significant active power deficits caused by the wake effect via increasing hub height of wind turbines. For large-scale wind energy penetration, a real case study was considered for three wind farms with a cumulative capacity of 154.4 MW integrated at a Nooriabad Grid in Pakistan to analyze their overall impacts. An actual test system was modeled in MATLAB Simulink for a composite analysis. Simulations were performed for various scenarios to consider wind intermittency, seasonal variations across four seasons, and wake effect. The capacitor banks and various flexible alternating current transmission systems (FACTS) devices were employed for a comparative analysis with and without considering the inter-farm wake effect. The power system parameters along with active and reactive power deficits were considered for comprehensive analysis. Unified power flow controller (UPFC) was found to be the best compensation device through comparative analysis, as it maintained voltage at nearly 1.002 pu, suppressed frequency transient in a range of 49.88-50.17 Hz, and avoided any resonance while maintaining power factors in an allowable range. Moreover, it also enhanced the power handling capability of the power system. The 20 m increase in hub height assisted the recovery of the active power deficit to 48%, which thus minimized the influence of the wake effect.
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| 28. |
- Akhtar, Muhammad Waseem, et al.
(författare)
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Exploiting NOMA for Radio Resource Efficient Traffic Steering Use-case in O-RAN
- 2022
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Ingår i: 2022 IEEE Global Communications Conference, GLOBECOM 2022 - Proceedings. - : IEEE conference proceedings. - 9781665435406 ; , s. 5771-5776
-
Konferensbidrag (refereegranskat)abstract
- In this work, we consider the design of a radio resource management (RRM) solution for traffic steering (TS) use-case in the open radio access network (O-RAN). The O-RAN TS deals with the quality-of-service (QoS)-aware steering of the traffic by connectivity management (e.g., device-to-cell association, radio spectrum, and power allocation) for emerging heterogeneous networks (HetNets) in 5G-and-beyond systems. However, TS in HetNets is a complex problem in terms of efficiently assigning/utilizing the radio resources while satisfying the diverse QoS requirements of especially the cell-edge users due to their poor signal-to-interference-plus-noise ratio (SINR). In this respect, we propose an intelligent non-orthogonal multiple access (NOMA)-based RRM technique for a small cell base station (SBS) within a macro gNB. A Q-learning-assisted algorithm is designed to allocate the transmit power and frequency sub-bands at the O-RAN control layer such that interference from macro gNB to SBS devices is minimized while ensuring the QoS of the maximum number of devices. The numerical results show that the proposed method enhances the overall spectral efficiency of the NOMA-based TS use case without adding to the system's complexity or cost compared to traditional HetNet topologies such as co-channel deployments and dedicated channel deployments.
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| 29. |
- Aslam, Muhammad Shehryar, et al.
(författare)
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Exploring Multi-Hop LoRa for Green Smart Cities
- 2020
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Ingår i: IEEE Network. - : IEEE Communications Society. - 0890-8044 .- 1558-156X. ; 34:2, s. 225-231
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Tidskriftsartikel (refereegranskat)abstract
- With the growing popularity of Internet-of-Things (IoT)-based smart city applications, various long-range and low-power wireless connectivity solutions are under rigorous research. LoRa is one such solution that works in the sub-GHz unlicensed spectrum and promises to provide long-range communication with minimal energy consumption. However, the conventional LoRa networks are single-hop, with the end devices connected to a central gateway through a direct link, which may be subject to large path loss and hence render low connectivity and coverage. This article motivates the use of multi-hop LoRa topologies to enable energy-efficient connectivity in smart city applications. We present a case study that experimentally evaluates and compares single-hop and multi-hop LoRa topologies in terms of range extension and energy efficiency by evaluating packet reception ratio (PRR) for various source to destination distances, spreading factors (SFs), and transmission powers. The results highlight that a multi-hop LoRa network configuration can save significant energy and enhance coverage. For instance, it is shown that to achieve a 90% PRR, a two-hop network provides 50% energy savings as compared to a single-hop network while increasing 35% coverage at a particular SF. In the end, we discuss open challenges in multi-hop LoRa deployment and optimization.
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| 30. |
- Aziz, Nudrat, et al.
(författare)
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Erythroid induction activity of Aquilegia fragrans and Aquilegia pubiflora and identification of compounds using liquid chromatography-tandem mass spectrometry
- 2021
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Ingår i: JOURNAL OF KING SAUD UNIVERSITY SCIENCE. - : Elsevier. - 1018-3647 .- 2213-686X. ; 33:1
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Tidskriftsartikel (refereegranskat)abstract
- Aquilegia fragrans (AF) and Aquilegia pubiflora (AP) are the two medicinally important species of genus Aquilegia used for the treatment of various diseases and infections. This paper describes the potential of fetal hemoglobin induction activity of the methanolic extracts of AF and AP in K562 cell line. AF and AP have shown 27.147 +/- 1.376 and 32.786 +/- 1.048 percent erythroid induction, respectively at 15.625 (mg/mL) concentration which suggested that both plants can be the source of potential fetal hemoglobin inducers and may be used for the treatment of beta-thalassemia. Phytochemical analyses of both species were also evaluated by using high-resolution LC-ESI-QTOF-MS/MS techniques. A Total of thirty compounds were identified using positive and negative ionization modes. The identification was based on the matching of high-resolution masses, isotopic pattern, and MS/MS fragmentation. Several statistical analyses were performed to evaluate the distribution of compounds in both species. Identified compounds belong to various classes including flavonoids, steroids, lignans, terpenoids, benzofuran and coumarins. The established chemical fingerprints will be helpful in standardization and quality control of plant extracts.
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| 31. |
- Butun, Ismail, et al.
(författare)
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AI-Enabled Smart Sensing Technologies for Human-Centered Healthcare Applications
- 2022
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Ingår i: Sensors. - : MDPI Multidisciplinary Digital Publishing Institute. - 1424-8220. ; , s. 2
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Lead Guest Editor, Special Issue ‘AI-Enabled Smart Sensing Technologies for Human-Centered Healthcare Applications’, Sensors, MDPI, from Jan 2022 to Oct 2023, https://www.mdpi.com/journal/sensors/special_issues/AESSTHCHA
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| 32. |
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| 33. |
- Jiao, Yiping, et al.
(författare)
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LYSTO: The Lymphocyte Assessment Hackathon and Benchmark Dataset
- 2024
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Ingår i: IEEE journal of biomedical and health informatics. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 2168-2194 .- 2168-2208. ; 28:3, s. 1161-1172
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Tidskriftsartikel (refereegranskat)abstract
- We introduce LYSTO, the Lymphocyte Assessment Hackathon, which was held in conjunction with the MICCAI 2019 Conference in Shenzhen (China). The competition required participants to automatically assess the number of lymphocytes, in particular T-cells, in images of colon, breast, and prostate cancer stained with CD3 and CD8 immunohistochemistry. Differently from other challenges setup in medical image analysis, LYSTO participants were solely given a few hours to address this problem. In this paper, we describe the goal and the multi-phase organization of the hackathon; we describe the proposed methods and the on-site results. Additionally, we present post-competition results where we show how the presented methods perform on an independent set of lung cancer slides, which was not part of the initial competition, as well as a comparison on lymphocyte assessment between presented methods and a panel of pathologists. We show that some of the participants were capable to achieve pathologist-level performance at lymphocyte assessment. After the hackathon, LYSTO was left as a lightweight plug-and-play benchmark dataset on grand-challenge website, together with an automatic evaluation platform.
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| 34. |
- Khan, Sabih Ahmad, et al.
(författare)
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Investigation of the mechanical behavior of FDM processed CFRP/Al hybrid joint at elevated temperatures
- 2023
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Ingår i: Thin-walled structures. - : Elsevier BV. - 0263-8231 .- 1879-3223. ; 192
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Tidskriftsartikel (refereegranskat)abstract
- This research is focused on investigating the mechanical behavior of Fused Deposition Modeling (FDM) processed CFRP/Al hybrid riveted joints at elevated temperatures. A two-pronged approach was adopted entailing experimental and computational domains. In the experimental thrust, the developed joint was evaluated for its mechanical behavior by employing Digital Image Correlation, micro-XCT, and fractographic analysis. The tensile testing was performed at four different temperatures, i.e., Room Temperature (RT), 50°C, 75°C, and 100 °C. At RT, the joint experienced net-sectioning in the CFRP sheet along with minute secondary bending. Further, distinct failure modes were noticed for each ply orientation where the inherent porosity/voids appeared as the governing factor for the damage progression. Novel constitutive models were developed using accrued strain and change in energy dissipation to estimate the damage progression. The damage accumulation was found to be more uniform in the 0° layer as compared to 90°. Moreover, the 90° layer exhibited a more catastrophic damage pattern toward final failure. At elevated temperatures, a significant reduction in mechanical properties along with a non-uniform warping/bending of the plies was noticed due to viscoelastic behavior change. The computational analysis, having a hierarchical approach, was performed for the validation of the experimental results, and both were found to be in good agreement.
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| 35. |
- Mahnoor, Anjum, et al.
(författare)
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RSSI Fingerprinting-Based Localization Using Machine Learning in LoRa Networks
- 2020
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Ingår i: IEEE Internet of Things Magazine. - 2576-3180 .- 2576-3199. ; 3:4, s. 53-59
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Tidskriftsartikel (refereegranskat)abstract
- The scale of wireless technologies' penetration in our daily lives, primarily triggered by Internet of Things (IoT)-based smart cities, is beaconing the possibilities of novel localization and tracking techniques. Recently, low-power wide-area network (LPWAN) technologies have emerged as a solution to offer scalable wireless connectivity for smart city applications. LoRa is one such technology, which provides energy efficiency and wide-area coverage. This article explores the use of intelligent machine learning techniques, such as support vector machines, spline models, decision trees, and ensemble learning, for received signal strength indicator (RSSI)-based ranging in LoRa networks on a training dataset collected in two different environments: indoors and outdoors. The suitable ranging model is then used to experimentally evaluate the accuracy of localization and tracking using trilateration in the studied environments. Later, we present the accuracy of a LoRa-based positioning system (LPS) and compare it with the existing ZigBee, WiFi, and Bluetooth-based solutions. In the end, we discuss the challenges of satellite-independent tracking systems and propose future directions to improve accuracy and provide deployment feasibility.
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| 36. |
- Nawaz, Muhammad, et al.
(författare)
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Improved process monitoring using the CUSUM and EWMA-based multiscale PCA fault detection framework
- 2021
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Ingår i: Chinese Journal of Chemical Engineering. - : Elsevier. - 1004-9541 .- 2210-321X. ; 29:1, s. 253-265
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Tidskriftsartikel (refereegranskat)abstract
- Process monitoring techniques are of paramount importance in the chemical industry to improve both the product quality and plant safety. Small or incipient irregularities may lead to severe degradation in complex chemical processes, and the conventional process monitoring techniques cannot detect these irregularities. In this study to improve the performance of monitoring, an online multiscale fault detection approach is proposed by integrating multiscale principal component analysis (MSPCA) with cumulative sum (CUSUM) and exponentially weighted moving average (EWMA) control charts. The new Hotelling’s T2 and square prediction error (SPE) based fault detection indices are proposed to detect the incipient irregularities in the process data. The performance of the proposed fault detection methods was tested for simulated data obtained from the CSTR system and compared to that of conventional PCA and MSPCA based methods. The results demonstrate that the proposed EWMA based MSPCA fault detection method was successful in detecting the faults. Moreover, a comparative study shows that the SPE-EWMA monitoring index exhibits a better performance with lower values of missed detections ranging from 0 - 0.80% and false alarms ranging from 0 - 21.20%.
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| 37. |
- Shadab, Hamna, et al.
(författare)
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Cross-mixing study of a poisonous Cestrum species, Cestrum diurnum in herbal raw material by chemical fingerprinting using LC-ESI-QTOF-MS/MS
- 2020
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Ingår i: Arabian Journal of Chemistry. - : ELSEVIER. - 1878-5352 .- 1878-5379. ; 13:11, s. 7851-7859
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Tidskriftsartikel (refereegranskat)abstract
- Poisonous plants are widely distributed and may have risk of phytotoxicity upon mixing with medicinal plants. Several species of Cestrum genus are poisonous and linked with many serious health issues. In the present study, cross-mixing of a toxic plant, Cestrum diurnum with morphologically resembling medicinal plant, Adhatoda vasica was studied using chemical fingerprinting approach. LC-ESI-MS/MS tool was used to develop the chemical fingerprints of three toxic species of Cestrum, including, C. diurnum, C. nocturnum and C. parqui. Total forty-three compounds were identified using high-resolution LC-ESI-MS/MS data comparison. Chemometric analyses were done to compare the distribution of identified compounds present in these Cestrum species. One of the identified compounds, nornicotine (a toxic compound) was also quantified using LC-IT-MS/MS. Adulteration study was conducted by mixing toxic C. diurnum in A. vasica with various ratios (w/w) and five differentiable compounds were identified to detect the adulteration. The method was able to detect up to the limit of 5% mixing of toxic C. diurnum. Moreover, cytotoxicity of the methanolic extracts of these three species were also studied on normal human PBMC (peripheral blood mononuclear cells) and all found to be toxic, while the C. nocturnum showed the highest level of toxicity with the EC50 12.5 mu g/mL.
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| 38. |
- Taqvi, Syed Ali Ammar, et al.
(författare)
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Simultaneous fault diagnosis based on multiple kernel support vector machine in nonlinear dynamic distillation column
- 2022
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Ingår i: Energy Science & Engineering. - : John Wiley & Sons. - 2050-0505. ; , s. 1-26
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Tidskriftsartikel (refereegranskat)abstract
- Although numerous works have been done, most of the studies in fault diagnosis are limited to single fault type at a time. Majority of the works reported in the literature do not extend the diagnosis of the root cause of the fault for simultaneous faults specifically in the distillation column. However, an industrial system is susceptible to more than one fault at a time, which may or may not be interrelated. These faults not only reduce the diagnosis performance but also increase the computational complexity of the diagnosis algorithm. In this work, therefore, a multiple kernel support vector machine (MK-SVM) algorithm is proposed to diagnose simultaneous faults in the distillation column. In the developed MK-SVM algorithm, multilabel approach based on various kernel functions has been utilized for the classification of simultaneous faults. Dynamic simulation of a pilot-scale distillation column using Aspen Plus(R) is used for generating data in normal and faulty operation. Eight different fault types are considered, including valve sticking at reflux and reboiler, tray upsets, loss of feed flow, feed composition, and feed temperature changes. In the classification of simultaneous faults, a combination of two, three, and four faults is introduced for the performance evaluation of the proposed MK-SVM algorithm. The result showed that the proposed MK-SVM has a high fault detection rate (FDR) of 99.51% and a very low misclassification rate (MR) of 0.49%. The MK-SVM-based classification is better with the F1 score of >97% for all combinations of faults. Moreover, it is observed that the proposed MK-SVM shows better fault diagnosis for single, multiple, and simultaneous faults as compared to other established machine-learning algorithms.
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| 39. |
- Ul Haq, Sheikh Ehsan, et al.
(författare)
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Multistage carbon dioxide compressor efficiency enhancement using waste heat powered absorption chillers
- 2021
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Ingår i: Energy Science & Engineering. - : John Wiley & Sons. - 2050-0505. ; 9:9, s. 1373-1384
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Tidskriftsartikel (refereegranskat)abstract
- The performance of a multistage centrifugal compressor is highly influenced by the ambient conditions, especially during the summer seasons; their capacity shrinks and thus the power requirement for compression will increase. The prime cause of these constraints is the interstage cooling limitations. This study simulates various suction conditions of a multistage compressor on Aspen HYSYS (R) and suggests its debottlenecking by making the suction temperatures comparable to winter seasons. This is achieved by installing an additional exchanger at the downstream of each interstage cooler, cooling down the gas further by using absorption refrigeration chillers. These chillers are powered up by the waste heat recovered from the exhaust steam coming from the prime mover, steam turbine, of the same compressor. This modification will save a considerable amount of power (663 kW), net savings (Gross Savings - OPEX: 72 289 $/y), and reduce the carbon footprint (954 ton/y) of the overall process.
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| 40. |
- Zulfiqar, Waqas, et al.
(författare)
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Revisiting the structural, electronic and photocatalytic properties of Ti and Zr based perovskites with meta-GGA functionals of DFT
- 2021
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Ingår i: Journal of Materials Chemistry C. - UK : Royal Society of Chemistry. - 2050-7526 .- 2050-7534. ; 9:14, s. 4862-4876
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Tidskriftsartikel (refereegranskat)abstract
- The strongly constrained and appropriately normed (SCAN) functional of density functional theory (DFT) conforms to all possible exact constraints required of a meta-GGA functional and offers good approximations for structural and energetic properties of solids in comparison to experiments. However, SCAN is unable to fully overcome the underestimation of band gap for perovskite oxide materials suitable for photocatalysis. In the present work, we use a combination of meta-GGAs SCAN and modified Becke–Johnson local density approximation (mBJ-LDA) potential functional to accurately compute the structural, energetic, mechanical, vibrational and optoelectronic properties of Ti and Zr based ABO3 (A = Sr, Ba and B = Ti and Zr) perovskite oxides. In addition to evaluating their physical properties, the potential applications of these materials as photocatalyst operating in the UV region of the electromagnetic spectrum are also examined. We show that the structural, energetic, mechanical and vibrational properties calculated using SCAN are in better agreement with experimental data as compared to the commonly used semi-local functionals of DFT. However, the optoelectronic properties of the large band gap Ti and Zr based perovskite oxides are further improved if computed with the mBJ-LDA potential functional, whereby an even higher level of accuracy than with SCAN is achieved, with results that are comparable to the computationally expensive hybrid DFT functionals. On the whole, our DFT calculations indicate that a combination of SCAN and mBJ-LDA functionals for exploring the physical properties of large band gap perovskite oxides provide the means for identifying photocatalysts suitable for hydrogen production at low computational costs.
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