| 1. |
|
|
| 2. |
- Horvath, I., et al.
(författare)
-
A European Respiratory Society technical standard: exhaled biomarkers in lung disease
- 2017
-
Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 49:4
-
Tidskriftsartikel (refereegranskat)abstract
- Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management. Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members. Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised. Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.
|
|
| 3. |
- Brorson, Håkan, et al.
(författare)
-
Circumferential suction-asssisted lipectomy is the only surgical procedure that can normalize large chronic fat-transformed lymphedemas
- 2018
-
Ingår i: European Book of Angiology/Vascular Medicine. - 9788825510522 ; , s. 1011-1012
-
Bokkapitel (refereegranskat)abstract
- 2.Brorson H. Circumferential suction-asssisted lipectomy is the only surgical procedure that can normalize large chronic fat-transformed lymphedemas. In: Catalano M, Pecsvarady Z, Olinic D, Wautrecht J-C, Gerotziafas G, Amann-Vesti B, Karetova D, Fagrell B, Diehm C, Kozak M, Edmonds M, editors, European Book of Angiology/Vascular Medicine. Milano, Italy: VAS, UNIMI-H Sacco; 2016. Pp XXX-XXX.
|
|
| 4. |
- Lopez-Posadas, R., et al.
(författare)
-
Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation
- 2016
-
Ingår i: Journal of Clinical Investigation. - : American Society for Clinical Investigation. - 0021-9738 .- 1558-8238. ; 126:2, s. 611-626
-
Tidskriftsartikel (refereegranskat)abstract
- Although defects in intestinal barrier function are a key pathogenic factor in patients with inflammatory bowel diseases (IBDs), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely unknown. Here, we addressed this issue by characterizing the transcriptome of IECs from IBD patients using a genome-wide approach. We observed disease-specific alterations in IECs with markedly impaired Rho-A signaling in active IBD patients. Localization of epithelial Rho-A was shifted to the cytosol in IBDs, and inflammation was associated with suppressed Rho-A activation due to reduced expression of the Rho-A prenylation enzyme geranylgeranyltransferase-I (GGTase-l). Functionally, we found that mice with conditional loss of Rhoa or the gene encoding GGTase-1, Pggtlb, in IECs exhibit spontaneous chronic intestinal inflammation with accumulation of granulocytes and CD4(+) T cells. This phenotype was associated with cytoskeleton rearrangement and aberrant cell shedding, ultimately leading to loss of epithelial integrity and subsequent inflammation. These findings uncover deficient prenylation of Rho-A as a key player in the pathogenesis of IBDs. As therapeutic triggering of Rho-A signaling suppressed intestinal inflammation in mice with GGTase-l-deficient IECs, our findings suggest new avenues for treatment of epithelial injury and mucosal inflammation in IBD patients.
|
|
| 5. |
- Schlueter, C., et al.
(författare)
-
New HAXPES Applications at PETRA III
- 2018
-
Ingår i: Synchrotron Radiation News. - : Informa UK Limited. - 0894-0886 .- 1931-7344. ; 31:4, s. 29-35
-
Tidskriftsartikel (refereegranskat)
|
|
| 6. |
- Schlueter, C., et al.
(författare)
-
The new dedicated HAXPES beamline P22 at PETRAIII
- 2019
-
Ingår i: 13th International Conference on Synchrotron Radiation Instrumentation (SRI2018). - : American Institute of Physics (AIP). - 9780735417823
-
Konferensbidrag (refereegranskat)abstract
- A new undulator beamline (P22) for hard X-ray photoelectron spectroscopy (HAXPES) was built at PETRA III (DESY, Hamburg) to meet the increasing demand for HAXPES-based techniques. It provides four special instruments for high-resolution studies of the electronic and chemical structure of functional nano-materials and catalytic interfaces, with a focus on measurements under operando and/or ambient conditions: (i) a versatile solid-state spectroscopy setup with optional wide-angle lens and in-situ electrical characterization, (ii) a HAXPEEM instrument for sub-µm spectro-microscopy applications, (iii) an ambient pressure system (> 1 bar) for operando studies of catalytic reactions and (iv) a time-of-flight spectrometer as a full-field k-microscope for measurements of the 4D spectral function ρ(EB,k). The X-ray optics were designed to deliver high brightness photon flux within the HAXPES energy range 2.4 – 15 keV. An LN2-cooled double-crystal monochromator with interchangeable pairs of Si(111) and (311) crystals is optionally combined with a double channel-cut post-monochromator to generate X-rays with variable energy bandpass adapted to the needs of the experiment. Additionally, the beam polarization can be varied using a diamond phase plate integrated into the beamline. Adaptive beam focusing is realized by Be compound refractive lenses and/or horizontally deflecting mirrors down to a spot size of ∼20x17 µm2 with a flux of up to 1.1x1013 ph/s (for Si(111) at 6 keV).
|
|
| 7. |
- Bogen, D., et al.
(författare)
-
The genetic tumor background is an important determinant for heterogeneous MYCN-amplified neuroblastoma
- 2016
-
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 139:1, s. 153-163
-
Tidskriftsartikel (refereegranskat)abstract
- Amplification of MYCN is the signature genetic aberration of 20-25% of neuroblastoma and a stratifying marker associated with aggressive tumor behavior. The detection of heterogeneous MYCN amplification (hetMNA) poses a diagnostic dilemma due to the uncertainty of its relevance to tumor behavior. Here, we aimed to shed light on the genomic background which permits hetMNA in neuroblastoma and tied the occurrence to other stratifying markers and disease outcome. We performed SNP analysis using Affymetrix Cytoscan HD arrays on 63 samples including constitutional DNA, tumor, bone marrow and relapse samples of 26 patients with confirmed hetMNA by MYCN-FISH. Tumors of patients 18m were mostly aneuploid with numeric chromosomal aberrations (NCAs), presented a prominent MNA subclone and carried none or a few segmental chromosomal aberrations (SCAs). In older patients, tumors were mostly di- or tetraploid, contained a lower number of MNA cells and displayed a multitude of SCAs including concomitant 11q deletions. These patients often suffered disease progression, tumor dissemination and relapse. Restricted to aneuploid tumors, we detected chromosomes with uniparental di- or trisomy (UPD/UPT) in almost every sample. UPD11 was exclusive to tumors of younger patients whereas older patients featured UPD14. In this study, the MNA subclone appears to be constraint by the tumor environment and thus less relevant for tumor behavior in aggressive tumors with a high genomic instability and many segmental aberrations. A more benign tumor background and lower tumor stage may favor an outgrowth of the MNA clone but tumors generally responded better to treatment. What's new?MYCN amplification (MNA) in neuroblastoma (NB) generally associates with an aggressive tumor behavior and detection of MNA leads to an automatic upstaging of the tumor in non-stage 1 tumors. But what if only a fraction of the tumor cells is MYCN-amplified? To investigate the diagnostic importance of heterogeneous MNA, the authors conducted a genetic analysis of samples from 26 NB patients with a particular focus on accompanying genetic aberrations. They concluded that tumor behavior is largely dependent on patient age and other chromosomal alterations in the genetic tumor background rather than the mere presence of the MNA clone.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
- Gottsäter, Anders, et al.
(författare)
-
Indications for carotid endarterectomy
- 2018
-
Ingår i: VAS european book on angiology/vascular medicine. - 9788825510522 - 9788825510522 ; , s. 461-469
-
Bokkapitel (refereegranskat)
|
|
| 11. |
- Yin, X., et al.
(författare)
-
Towards efficient 100 Gb/s serial rate optical interconnects : A duobinary way
- 2017
-
Ingår i: 6th IEEE Photonics Society Optical Interconnects Conference, OI 2017. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781509050154 ; , s. 33-34
-
Konferensbidrag (refereegranskat)abstract
- Recent advances in integrated opto-electronic devices and front end circuits have made it possible to efficiently transmit very high data rates over optical links for HPC/datacenter applications. This paper reviews our current progress towards serial 100-Gb/s optical interconnects, with emphasis on electrical duobinary (EDB) modulation.
|
|
| 12. |
- Zhang, Lu, et al.
(författare)
-
Nonlinearity Tolerant High-speed DMT Transmission with 1.5-μm Single-mode VCSEL and Multi-core Fibers for Optical Interconnects
- 2019
-
Ingår i: Journal of Lightwave Technology. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 0733-8724 .- 1558-2213. ; 37:2, s. 380-388
-
Tidskriftsartikel (refereegranskat)abstract
- We experimentally demonstrate the generation of 107-Gbit/s net-rate optical discrete multitone (DMT) signal using a 1.5-μm single-mode vertical cavity surface emitting laser (VCSEL) with modulation bandwidth of 22-GHz. Utilizing a nonlinearity-tolerant channel equalization algorithm for digital signal processing (DSP), total net-rates of 726.6-Gbit/s over 2.5-km dispersion-uncompensated 7-core fiber and 533.1-Gbit/s over 10-km dispersion-compensated 7-core fiber below 7% overhead hard-decision forward error correction (HD-FEC) limit have been experimentally achieved with a 1.5-μm VCSEL based intensity-modulation direct-detection (IM/DD) system. The features of the 1.5-μm single-mode VCSEL, 2.5-km/10km multi-core fibers and fan-in/fan-out modules are presented. Besides, the Volterra series based nonlinearity-tolerant channel equalization algorithm, which improves the signal-to-noise ratio (SNR) with more than 5-dB, is mathematically described and experimentally validated. The results have demonstrated that 1.5-μm single-mode VCSEL and multi-core fiber based transmission can be a promising candidate to solve the capacity challenges in short-reach optical interconnects.
|
|
