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- Allamani, A, et al.
(författare)
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Pourquoi la France ne devrait pas changer la loi Evin
- 2004
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Ingår i: Le Monde. - 0395-2037. ; , s. 11-11
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Abstract in French Pendant des décennies, la France a détenu le record mondial de la consommation d'alcool, et cela au prix de milliers de cirrhoses et de cancers du foie, d'accidents vasculaires cardiaques et cérébraux, de dépendances sévères avec leur cortège de conséquences dans les familles et dans la société : violence, accidents... Mais la France est aussi le pays où, pendant quarante ans, la consommation moyenne d'alcool a continûment décru, ce qui lui a fait perdre cette première place. Le rôle des politiques publiques et des actions de prévention est difficile à évaluer, mais il y a des preuves scientifiques de l'efficacité de décisions politiques comme la taxation et la réduction des publicités. La loi Evin a servi de modèle aux politiques européennes de diminution de l’incitation à consommer de l’alcool. La changer aujourd’hui sous la pression des lobbies alcooliers serait un recul pour la santé publique en France mais aussi pour toute l’Europe.
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| 2. |
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| 3. |
- Jerkeman, Mats, et al.
(författare)
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Assessment of biological prognostic factors provides clinically relevant information in patients with diffuse large B-cell lymphoma-a Nordic Lymphoma Group study.
- 2004
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Ingår i: Annals of Hematology. - : Springer Science and Business Media LLC. - 1432-0584 .- 0939-5555. ; 83:7, s. 414-419
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to investigate the prognostic effects of four biological markers, BCL2, TP53, Ki-67, and P-glycoprotein, and their possible clinical relevance in addition to the international prognostic index (IPI) in diffuse large B-cell lymphoma (DLBCL). A total of 405 patients with aggressive lymphoma, stage II-IV, between 18 and 67 years, were randomized in a trial comparing CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin). Of these, 267 cases were classified as DLBCL, with adequate paraffin blocks available in 207 cases, enabling immunohistochemical assessment of the expression of BCL2, TP53, P-glycoprotein, and Ki-67. In a multivariate analysis, stratified for IPI, high BCL2 expression (>10%) low (<60%) expression of Ki-67, and high TP53 protein expression (>75%) were shown to provide additional prognostic information with regard to overall or failure-free survival. We found no association between expression of P-glycoprotein and outcome. Assessment of BCL2 positivity might be introduced as part of the routine investigation in patients with DLBCL, but further studies are necessary to confirm the clinical relevance of Ki-67 and TP53 expression.
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| 4. |
- Malmquist, Carola, et al.
(författare)
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Time Trends of Selected Persistent Organic Pollutants in Lake Sediments from Greenland
- 2003
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 37:19, s. 4319-24
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Tidskriftsartikel (refereegranskat)abstract
- Sediments from seven lakes in West Greenland were used as natural archives to study past and present levels of PCBs (polychlorinated biphenyls, tri- to decachlorinated), tetra-BDE #47 (2,2',4,4'-bromodiphenyl ether), chlordane (cis- and trans-octachlordane) and HxCBz (hexachlorobenzene). The concentrations found are lower than or comparable to concentrations found in sediments from other Arctic regions and one to 2 orders of magnitude lower than concentrations typically found in sediments at lower latitudes. The observed temporal trends (direct and indirect dating) show a decreasing total PCB concentration. Even though local contamination sources exist, the POP deposition in the studied area is most likely a result from long-range transport. The hypothesis about "cold condensation" suggests a latitudinal fractionation to occur between different volatile compounds during the transport toward the pole. In this study a time delay in the deposition for the low-chlorinated PCBs (tri- and tetrachlorinated), compared to their emission histories and compared to higher chlorinated PCBs, was indicated. Although very low tetra-BDE #47 concentrations are observed in this study, there are indications for an increasing concentration in recent sediment layers that may reflect increasing environmental concentrations at lower latitudes. The investigated pesticides are still in use at lower latitudes, however neither chlordane nor HxCBz show any distinct temporal trend of increasing or decreasing concentration toward the sediment surface.
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