| 1. |
- Anderson, D., et al.
(författare)
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The optimal journey from A to B
- 2008
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Ingår i: American Journal of Physics. - : American Association of Physics Teachers. - 0002-9505 .- 1943-2909. ; 76:9, s. 863-866
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Tidskriftsartikel (refereegranskat)abstract
- How fast can you comfortably travel between two points A and B? This question is formulated as a minimization problem of a functional where the discomfort is quantified in terms of the integral of the square of the acceleration between A and B. The problem is solved in terms of the corresponding Euler-Lagrange equation and approximately using a direct variational approach based on trial functions and Ritz optimization. The main purpose of the analysis is to introduce undergraduate students to variational calculus in an interesting and pedagogical way.
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| 2. |
- Anderson, Henrik, et al.
(författare)
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Quartz crystal microbalance sensor design : I. Experimental study of sensor response and performance
- 2007
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Ingår i: Sensors and actuators. B, Chemical. - : Elsevier BV. - 0925-4005 .- 1873-3077. ; 123:1, s. 27-34
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Tidskriftsartikel (refereegranskat)abstract
- This paper investigates a novel quartz crystal microbalance (QCM) biosensor with a small and rectangular flow cell along with a correspondingly shaped crystal electrode. The sensor was evaluated with impedance analysis and compared to standard circular sensor crystals and sensor crystals with small circular electrodes. Comparative QCM measurements on an antibody–antigen interaction system were carried out on the rectangular and standard circular sensor systems. Impedance analysis and subsequent data extraction of the three different sensor crystals showed that the smaller sensors had significantly higher Q-values in air, but that liquid load on the electrodes lowered the Q-values radically for all crystals. Under liquid load, Q-values for the standard circular and the rectangular sensors were similar whereas the Q-value for the small circular sensor was 50% higher. QCM experiments showed that the QCM system with rectangular crystal electrodes was fully functional in a liquid environment. The rectangular system showed higher and more rapid responses for series of antibody injections, albeit at a higher noise level than the standard system. The study elucidates a significant potential for improvement of sensor performance by optimising the sensor electrode size and shape together with the flow cell geometry.
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| 3. |
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| 4. |
- Desaix, Mats, et al.
(författare)
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Nonlinear Schrödinger Solitons with non-zero velocities emerging from real symmetric initial conditions
- 2009
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Konferensbidrag (refereegranskat)abstract
- Solutions of the nonlinear Schrodinger equation for initial conditions in the form of two separated sech-shaped in-phase pulsed,; are analyzed. It is found that; this initial condition, with appropriate amplitude, may give rise to, not; only stationary solitons, but also to symmetrically separating solitons, if the initial distance of separation is large enough. The condition for the generation of a separating soliton pair is derived from the Zakharov-Shabat eigenvalue problem using a variational approach.
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| 5. |
- Grahn, Maria, 1963, et al.
(författare)
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Fuel and Vehicle Technology Choices for Passenger Vehicles in Achieving Stringent CO2 Targets: Connections between Transportation and Other Energy Sectors
- 2009
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Ingår i: Environmental Science and Technology. - 1382-3124. ; 43:9, s. 3365-3371
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Tidskriftsartikel (refereegranskat)abstract
- The regionalized Global Energy Transition (GET-R 6.0) modelhas been modified to include a detailed description of light-duty vehicle options and used to investigate the potential impact of carbon capture and storage (CCS) and concentrating solar power (CSP) on cost-effective fuel/vehicle technologies in a carbon-constrained world. Total CO2 emissions were constrained to achieve stabilization at 400-550 ppm, by 2100, at lowest total system cost. The dominant fuel/vehicle technologies varied significantly depending on CO2 constraint, future cost of vehicle technologies, and availability of CCS and CSP. For many cases, no one technology dominated on a global scale. CCS provides relatively inexpensive low-CO2 electricity and heat which prolongs the use of traditional ICEVs. CSP displaces fossil fuel derived electricity, prolongs the use of traditional ICEVs, and promotes electrification of passenger vehicles. In all cases considered, CCS and CSP availability had a major impact on the lowest cost fuel/vehicle technologies, and alternative fuels are needed in response to expected dwindling oil and natural gas supply potential by the end of the century.
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| 6. |
- Grahn, Maria, 1963, et al.
(författare)
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The role of ICEVs, HEVs, PHEVs, BEVs and FCVs in achieving stringent CO2 targets: results from global energy systems modeling
- 2009
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Ingår i: World Electric Vehicle Journal. - : MDPI AG. - 2032-6653. ; 3:1, s. 519-530, s. 1645-1655
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Tidskriftsartikel (refereegranskat)abstract
- A modified GET model version was used to investigate long-term, cost-effective fuel and vehicle technologies for global passenger transport. The aim was to quantify the potential impact of carbon capture and storage (CCS) technology and low CO2 intensity electricity from renewable sources, such as concentrating solar power (CSP), on cost-effective passenger vehicle fuel and technology options necessary to achieve stabilization of atmospheric CO2 at 450 ppm. In addition, the model was used to assess the sensitivity of future vehicle cost assumptions. For all cases investigated, there is no single technology and fuel that dominates throughout the century; instead a variety of fuels and vehicle technologies are important. The availability of CCS and CSP have a substantial impact on cost-effective fuel and technology choices, in general: (i) the introduction of CCS increases the use of coal in the energy system and conventional vehicle technology, (ii) the introduction of CSP reduces the relative cost of electricity in relation to hydrogen and tends to increase the use of electricity for transport, and (iii) the introduction of both CCS and CSP reduces the economic incentives to shift to more advanced vehicle technologies. Varying cost estimates for future vehicle technologies results in large differences in the cost-effective fuel and vehicle technology solutions. For instance, for low battery costs ($150/kWh), electrified powertrains dominate and for higher battery costs ($450/kWh), hydrogen-fueled vehicles dominate, regardless of CCS and CSP availability. The results highlight the importance of a multi-sector approach and the importance of pursuing research and development of multiple fuel and vehicle technologies.
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| 7. |
- Gunnlaugsson, Adalsteinn, et al.
(författare)
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Multicentre phase II trial of capecitabine and oxaliplatin in combination with radiotherapy for unresectable colorectal cancer : The CORGI-L study
- 2009
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 45:5, s. 807-813
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: This study assessed radiotherapy combined with capecitabine and oxaliplatin in patients with primary, inextirpable colorectal adenocarcinoma. PATIENTS AND METHODS: Forty-nine patients entered the trial. Two cycles of XELOX (capecitabine 1000mg/m(2) bid d1-14+oxaliplatin 130mg/m(2) d1, q3w) were followed by radiotherapy (50.4Gy), combined with capecitabine 825mg/m(2) bid every radiotherapy day and oxaliplatin 60mg/m(2) once weekly. The primary end-point was objective response. RESULTS: Forty-seven patients were evaluable. Twenty-nine (62% [95% CI: 46-75%]) achieved complete or partial response. Thirty-eight (81%) went through surgery of whom 37 (97%) had an R0 resection and five (13%) had a pathological complete response. Seventy-eight percent were alive and estimated local progression rate was 11% at 2 years. The most common grade 3+ toxicity during chemoradiotherapy was diarrhoea (24%). CONCLUSIONS: XELOX-RT was feasible and showed promising efficacy when treating patients with primary inextirpable colorectal cancer, establishing high local control rate.
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| 8. |
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| 9. |
- Jönsson, Mats, et al.
(författare)
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Quartz crystal microbalance biosensor design: II. Simulation of sample transport
- 2007
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Ingår i: Sensors and actuators. B, Chemical. - : Elsevier BV. - 0925-4005 .- 1873-3077. ; 123:1, s. 21-26
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Tidskriftsartikel (refereegranskat)abstract
- The influence of flow cell geometry on sample dispersion in a quartz crystal microbalance (QCM) biosensor system was investigated. A circular and a rectangular flow cell and corresponding sensor electrodes were studied experimentally and modelled using a coupled Navier-Stokes and convection-diffusion model. Finite element simulations showed that dispersion phenomena in a flow cell can be significantly reduced with the rectangular flow cell compared to a circular system. Experimental results from measurement of the time-dependent viscosity change of a model sample indicate that the sample delivery system has a predominant effect on the dispersion of the whole sensor system. Consequently, improvement of the sensor flow cell should be accompanied with improvement of the sample delivery system. With reference to kinetic studies of biological interactions, the current dispersion should have little effect on the results for studies of interaction pairs with relatively slow to normal binding rates such as antibody-antigen interactions. Incentive for further development of the flow cell and sample delivery system exists primarily for applications with high reaction rates such as for certain receptor ligand interactions.
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| 10. |
- Liedberg, Fredrik, et al.
(författare)
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Prospective study of transitional cell carcinoma in the prostatic urethra, and prostate in cystoprostatectomy specimen
- 2007
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Ingår i: Scandinavian Journal of Urology and Nephrology. - : Informa UK Limited. - 0036-5599 .- 1651-2065. ; 41:4, s. 290-296
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Tidskriftsartikel (refereegranskat)abstract
- Objectives. To prospectively evaluate the incidence of transitional cell carcinoma (TCC) in the prostatic urethra and prostate in the cystoprostatectomy specimen, investigate characteristics of bladder tumours in relation to the risk of involvement of the prostatic urethra and prostate and examine the sensitivity of preoperative loop biopsies from the prostatic urethra. Material and methods. Preoperatively, patients were investigated with cold cup biopsies from the bladder and transurethral loop biopsies from the bladder neck to the verumontanum. The prostate and bladder neck were submitted to sagittal whole-mount pathological analysis. Results. The incidence of TCC in the prostatic urethra and prostate in the cystoprostatectomy specimen was 29% (50/175 patients). Age, previous bacillus Calmette-Gueacuterin treatment, carcinoma in situ (Cis) in the cold cup mapping biopsies and tumour grade were not associated with the risk of TCC in the prostatic urethra/prostate. Cis, multifocal Cis (≥2 locations) and tumour location in the trigone were significantly more common in cystectomy specimens with TCC in the prostatic urethra and prostate: 21/50 (42%) vs 32/125 (26%), p=0.045; 20/50 (40%) vs 27/125 (22%), p=0.023; and 20/50 (40%) vs 26/125 (21%), p=0.01, respectively. Preoperative resectional biopsies from the prostatic urethra in the 154 patients analysed identified 31/47 (66%) of patients with TCC in the prostatic urethra/prostate, with a specificity of 89%. The detection of stromal-invasive and non-stromal involvement was similar: 66% and 65%, respectively. Conclusions. The incidence of TCC in the prostatic urethra and prostate was 29% (50/175) in the cystoprostatectomy specimen. Preoperative biopsies from the prostatic urethra identified 66% of patients with such tumour growth. Our findings suggest that preoperative cold cup mapping biopsies of the bladder for detection of Cis add little extra information with regard to the risk of TCC in the prostatic urethra and prostate.
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| 11. |
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| 12. |
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| 13. |
- Rosenberg, C.-J., et al.
(författare)
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Diffusion of super-Gaussian profiles
- 2007
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Ingår i: European journal of physics. - : Institute of Physics Publishing, Bristol, BS1 6BE, United Kingdom. - 0143-0807 .- 1361-6404. ; 28, s. 45-50
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Tidskriftsartikel (refereegranskat)
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| 14. |
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