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Sökning: WFRF:(Andersson Andreas) > (2005-2009)

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1.
  • Alin, David, 1984, et al. (författare)
  • Reducing the EPEI-Time Using Discrete Event Simulation
  • 2009
  • Ingår i: Proceedings of the 2009 Swedish Production Symposium. ; :2, s. 295-301
  • Konferensbidrag (refereegranskat)abstract
    • One of the cornerstones in LEAN production is ‘make to order’, which requires small batch sizes and, thus, short Every Part Every Interval (EPEI) times. EPEI-time is defined as the time it takes to produce all product variants, before the first variant in the cycle returns in the schedule. However, many companies are reluctant to reduce their EPEI-times due to the increased number of set-ups. This skepticism is also supported by parts of existing theory, while other research contributions mean that companies often can reduce batch-sizes without affecting productivity. This paper presents a case study which uses discrete event simulation (DES) to evaluate the relation between EPEI-time and productivity. The results show that it is possible to reduce the EPEI-time and still maintain productivity and service levels to customers, without any investments. Increased variation in the production schedule evened out the load among the machines and, hence, the time lost in set-ups was gained in more parallel work.
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  • Andersson, Thomas, et al. (författare)
  • Competence Development for Growth : International Outlook and Analysis
  • 2007
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • The focus of this report is on the growing importance of skills upgrading in SMEs, coupled with the search for a comprehensive policy approach to meet the new needs and opportunities in this area. Emphasis is placed on the diversity of SMEs, ranging from the vast community of relatively stable and mature firms to the more limited group of high-tech and/or potentially fast-growing categories of firms which we may know as gazelles or similar names. The report argues that it is time to apply a specific double-edged approach to strengthen these firms’ competencies and the preconditions for regional and societal growth in increasingly knowledge-based societies. SMEs are more vulnerable than large firms; they invest less in R&D and their processes for skills upgrading are often problematic. Public funding is commonly provided to educational or public research institutions, earmarked for promoting courses adapted to the needs, for instance, of traditional or “blue-collar” sectors. There is an inadequate interface between traditional educational institutions and the specific knowledge and competency needs of SMEs and entrepreneurs. This situation, which is due to fundamental incentive problems, leads to frustrating outcomes. The report highlights the presence of: partly contradictory interests between owners/managers and workers; lack of information, skills and/or time at management level; and differences in bridging the highly specialised demands for skills development at business level and the more general supply of skills by education providers such as universities. Against this backdrop, the report examines a new way forward – an approach that aims to address the upgrading of core skills at SMEs and to increase the supply of adequate external, professional services while also trying to augment potential positive synergies between these two levels. Examining the policies pursued by a set of selected countries, however, permits identification of only a few serious attempts to foster a coherent approach to encompass direct training of SMEs and measures to bolster complementary service providers. Most programmes remain piecemeal and have various limitations. Weaknesses commonly relate to the dominant influence of supply-side perspectives in training programmes. There is also generally a lack of effective identification of and adaptation to SME needs. Still, the report identifies a few cases of clear-cut synergies between measures at the two levels, notably in Belgium and Ireland.
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4.
  • Markljung, Ellen, et al. (författare)
  • ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth
  • 2009
  • Ingår i: PLoS biology. - : Public Library of Science (PLoS). - 1544-9173 .- 1545-7885. ; 7:12, s. e1000256-
  • Tidskriftsartikel (refereegranskat)abstract
    • A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold up-regulation of IGF2 in skeletal muscle. The mutation has major effects on muscle growth, size of the heart, and fat deposition. Here, we have identified the repressor and find that the protein, named ZBED6, is previously unknown, specific for placental mammals, and derived from an exapted DNA transposon. Silencing of Zbed6 in mouse C2C12 myoblasts affected Igf2 expression, cell proliferation, wound healing, and myotube formation. Chromatin immunoprecipitation (ChIP) sequencing using C2C12 cells identified about 2,500 ZBED6 binding sites in the genome, and the deduced consensus motif gave a perfect match with the established binding site in Igf2. Genes associated with ZBED6 binding sites showed a highly significant enrichment for certain Gene Ontology classifications, including development and transcriptional regulation. The phenotypic effects in mutant pigs and ZBED6-silenced C2C12 myoblasts, the extreme sequence conservation, its nucleolar localization, the broad tissue distribution, and the many target genes with essential biological functions suggest that ZBED6 is an important transcription factor in placental mammals, affecting development, cell proliferation, and growth.
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5.
  • Ahn, Song-ee, 1972-, et al. (författare)
  • Kunskap – synlig, standardiserad och jämförbar?
  • 2009. - 1
  • Ingår i: Lärande på vuxnas vis. - Lund : Studentlitteratur. - 9789144042763 - 9144042760 ; , s. 123-142
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • Denna bok belyser och jämför flera gemensamma brännpunkter i kommunal vuxenutbildning, folkhögskola och högskola: till vilka utbildningarna riktas, hur de utformas didaktiskt, hur de studerande betygssätts och bedöms. Författarna använder konkreta exempel när de diskuterar bland annat utbildares och studerandes perspektiv på dessa områden. Boken riktar sig till blivande och verksamma personalvetare, yrkes- och studievägledare samt pedagoger.
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6.
  • Andersson, Andreas, 1980-, et al. (författare)
  • Evaluating cable forces in cable supported bridges using ambient vibration method
  • 2006
  • Ingår i: The International Conference on Bridge Engineering – Challenges in the 21st Century , November 1-3, 2006, Hong Kong. - Hong Kong.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • This paper deals with the assessment of cable forces in existing cable supported bridges using the ambient vibration method. A case study of the Älvsborg suspension bridge in Sweden is presented. Dynamic measurements of the backstays and hangers as well as on each strand in one of the splay chambers have been carried out. The measured frequencies are evaluated and calculations of corresponding axial force in the cable structures are performed taking into account the cable sag, boundary conditions and flexural rigidity. Modal analyses have been used to study the shape of vibration and for comparison with finite element models.
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7.
  • Andersson, Andreas, et al. (författare)
  • Forecasting Real Exchange Rate Trends Using Age Structure Data – The Case of Sweden
  • 2005
  • Ingår i: Applied Economics Letters. - : Informa UK Limited. - 1466-4291 .- 1350-4851. ; 12:5, s. 267-272
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • Theory predicts that life cycle saving and consumption behaviour could cause real exchange rate variations as the age structure varies. Time series regressions show that the Swedish demographic structure has significant explanatory power on the real exchange rate during 1960 to 2002. A model using age shares as regressors is used for medium-term out-of-sample forecasts, which perform well both compared to na ve forecasts and forecasts based on an autoregressive model.  
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  • Andersson, Andreas, 1980- (författare)
  • Utmattningsanalys av järnvägsbroar : En fallstudie av stålbroarna mellan Stockholm Central och Söder Mälarstrand, baserat på teoretiska analyser och töjningsmätningar
  • 2009
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Föreliggande avhandling omfattar en fallstudie av utmattningsrisken för järnvägsbroarna mellan Stockholm Central och Söder Mälarstrand. Ett stort antal utmattningssprickor i broarna över Söderström och Söder Mälarstrand har sedan länge varit kända. I samband med en bärighetsutredning av sträckan har ett stort antal anslutningspunkter i samtliga broar identifierats som kritiska avseende utmattningsrisk. Sträckan är den mest trafikerade i Sverige och de förenklade beräkningsmetoder som anges i Banverkets föreskrift för bärighetsberäkningar är i vissa fall inte tillämpliga. De formella bärighetsberäkningarna har visat på flerfaldiga överskridanden i utnyttjandegrad gällande utmattning. I de punkter som beräkningarna visar störst risk för utmattning har inga sprickor påträffats, trots omfattande förbandsbesiktningar. Beräkningarna baseras på typiserade spänningskollektiv och givet antal spännings­växlingar, oberoende av den aktuella trafikmängden. Enligt bärighetsnormen ges möjlighet att beakta den verkliga trafikmängden baserat på historiskt bruttotonnage och typiserade trafiklaster. Dessa beräkningar har utförts och visar på ännu större risk för utmattning, jämfört med den förenklade metoden. I syfte att på ett ännu mer nyanserat sätt uppskatta utmattningsrisken har en metod använts, baserat på uppskattning av den faktiska trafikmängden och dess fördelningar. Beräkningarna baseras på trafikdata tillgänglig från Banverket. Metoden är tillämplig på andra järnvägsbroar på andra sträckor. Utöver teoretiska beräkningar har töjningsmätningar utförts. Under 2006 utförde dåvarande Carl Bro AB töjningsmätningar på bro över Söder Mälarstrand och viadukt söder om Söder Mälarstrand, avseende några enskilda tågöverfarter. Under 2008 utförde KTH Brobyggnad omfattande töjningsmätningar på bro över Söderström, avseende all trafik under en månads tid.
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16.
  • Andersson, Andreas, 1980-, et al. (författare)
  • Utvärdering av krafter i Älvsborgsbron genom dynamisk mätning och analys
  • 2006
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Föreliggande rapport behandlar mätning och analys av krafter i Älvsborgsbron i Göteborgsom underlag för klassningsberäkning. Den metod som används för bestämning av krafternaär den s.k. vibrationsmetoden där konstruktionselement sätts i svängning och dessas egenfrekvenserbestäms med hjälp av accelerometrar. Med kända egenfrekvenser för t.ex. kablaroch hängare kan krafterna i dessa analyseras fram. Eftersom flera av de aktuella elementenhar egenskaper som inte är enkla att beskriva med hjälp av faktorer som geometriska mått,massa, styvhet och inspänningsförhållanden, har möda lagts ner på att använda så noggrannametoder som möjligt för att kunna bestämma krafter och kraftfördelning. Metoderna beskrivsi rapporten och resultat och noggrannhet diskuteras och bedöms.De resultat som presenteras beträffande krafter bedöms ha en så god noggrannhet som det f.n.går att analysera fram med idag kända någorlunda enkla metoder.
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  • Andersson, Julia, et al. (författare)
  • Protonation and hydrogen bonding of Ca2+ site residues in the E2P phosphoenzyme intermediate of sarcoplasmic reticulum Ca2+-ATPase studied by a combination of infrared spectroscopy and electrostatic calculations.
  • 2008
  • Ingår i: Biophys J. - 1542-0086. ; 94:2, s. 600-11
  • Tidskriftsartikel (refereegranskat)abstract
    • Protonation of the Ca(2+) ligands of the SR Ca(2+)-ATPase (SERCA1a) was studied by a combination of rapid scan FTIR spectroscopy and electrostatic calculations. With FTIR spectroscopy, we investigated the pH dependence of C=O bands of the Ca(2+)-free phosphoenzyme (E2P) and obtained direct experimental evidence for the protonation of carboxyl groups upon Ca(2+) release. At least three of the infrared signals from protonated carboxyl groups of E2P are pH dependent with pK(a) values near 8.3: a band at 1758 cm(-1) characteristic of nonhydrogen-bonded carbonyl groups, a shoulder at 1720 cm(-1), and part of a band at 1710 cm(-1), both characteristic of hydrogen-bonded carbonyl groups. The bands are thus assigned to H(+) binding residues, some of which are involved in H(+) countertransport. At pH 9, bands at 1743 and 1710 cm(-1) remain which we do not attribute to Ca(2+)/H(+) exchange. We also obtained evidence for a pH-dependent conformational change in beta-sheet or turn structures of the ATPase. With MCCE on the E2P analog E2(TG+MgF(4)(2-)), we assigned infrared bands to specific residues and analyzed whether or not the carbonyl groups of the acidic Ca(2+) ligands are hydrogen bonded. The carbonyl groups of Glu(771), Asp(800), and Glu(908) were found to be hydrogen bonded and will thus contribute to the lower wave number bands. The carbonyl group of some side-chain conformations of Asp(800) is left without a hydrogen-bonding partner; they will therefore contribute to the higher wave number band.
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21.
  • Andersson, Jeanette, et al. (författare)
  • Results from the Swedish National Screening programme 2005. Sub report 1 Antibiotics, Anti-inflammatory substances and Hormones
  • 2006
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Measurements of pharmaceuticals were performed in 179 samples of water, sludge, manure, sediment and biota at background sites, municipal STPs, landfills, hospital effluents and recipient water from STPs. Bioassays of hormone activity were performed for a selected number of water samples. The NSAIDs were the most frequently detected pharmaceuticals and occurred in the highest concentrations. There were large differences in concentrations both between substances and between sampling sites. A regional trend in the STP effluent water could be observed for the NSAIDs and for some antibiotics with increased concentrations in samples originating from the north. No pattern could be seen for the hormones. Estrogenic effects were detected in STP outlets to the aquatic environment while values obtained for androgenicity were in most samples close to or below the detection limit. Based on the risk asessment (MEC/PNEC) risk quotients >1 was obtained for estradiol, estriol, ethinylestradiol and ibuprofen.
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22.
  • Andersson, Kristofer, et al. (författare)
  • Evenemang med spinn! : En utvärdering av Uddeholm Swedish Rally 2005
  • 2005
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Uddeholm Swedish Rally är ett anrikt rally som utvecklats till att bli ett stort evenemang och del av en internationell rallytävling med hög status. Tävlingen lockar stora skaror svenska och utländska besökare vilket har ekonomisk betydelse för regionen. Genom högre kunskap om tävlingen och dess effekter finns förutsättningar för ett i framtiden än bättre evenemang och fortsatt viktig roll för turismnäringen. Studiens syfte löd enligt följande:Det huvudsakliga syftet med utvärderingen av Uddeholm Swedish Rally 2005 är att kartlägga de ekonomiska effekter som evenemanget genererat i Värmlands län. Vidare kommer mediebevakningen av evenemanget beskrivas.Ett underordnat syfte är att redogöra för deltagarnas, publikens och medierepresentanternas synpunkter på Uddeholm Swedish Rally. Vad anser dessa grupper om miljöarbetet, säkerheten, servicen och inte minst upplevelsen vid evenemanget?Jämförelser kommer att göras med resultatet från utvärderingar av två andra WRC-rallyn samt Uddeholm Swedish Rally 2003.Flera olika metoder användes för att samla in det empiriska materialet. Under evenemanget befann sig grupper om fyra personer ute vid specialsträckorna och genomförde kortare intervjuer med besökarna. De besökare som gav sitt medgivande har i ett senare skede kunnat lämna ytterligare information vid enkätutskick och telefonintervjuer. Medierepresentanter, ansvariga för de tävlande teamen, personer från regionens näringsliv, intresse- samt turismorganisationer har kontaktats och bidragit med information.Studien visar att antalet besökare minskat lite jämfört ned 2003. Det styrks även genom uppgifter från turismnäringen som uppger en minskad efterfrågan på antalet bäddar. En förklaring kan vara en oro för att rallyt skulle ställas in på grund av det milda vädret. Uddeholm Swedish Rally lockar en internationell publik och majoriteten av de utländska besökarna utgörs av norrmän. Beräkningar visar att besökarna lokalbefolkningen borträknad har utgifter på cirka 28 miljoner kronor i samband med evenemanget. Motsvarande siffror för media samt deltagarna uppskattas till ungefär 2,5 respektive 8 miljoner kronor. Summan visar att evenemanget utgör viktig ekonomisk faktor för regionen men en stor del av inkomsterna lämnar regionen och hamnar på riksnivå. De utländska besökarnas ekonomiska utlägg kan läggas till svensk turismexport. Inkomsterna har stor betydelse för näringslivet i regionen i en tid då det annars är få turister i området. Evenemangets ekonomiska betydelse är störst i området kring Hagfors medan den är mer begränsad i Karlstad, hotell och restaurangbranschen undantagen. Medias växande intresse för evenemanget på plats men även i tv-sändningar globalt, vilka har betydelse inte bara för varumärket Uddeholm Swedish Rally utan även för marknadsföringen av Sverige i stort.Uddeholm Swedish Rally anses som evenemang hålla en hög nivå. Arbetet för att höja säkerheten och förbättra miljöarrangemanget har enligt respondenterna gett resultat även om det finns vissa saker att arbeta vidare med. Rallyupplevelsen och den totala upplevelsen av evenemanget är enligt besökarna stor även vid en jämförelse med andra WRC. Evenemangets svaghet är det som erbjuds besökarna utöver själva rallyt. Ett större utbud av logi, restauranger, nöjen och kringaktiviteter efterfrågas. Organisationen kring evenemanget uppskattas och får beröm. Överlag är både deltagare och media belåtna med arbetsförhållandena även om främst den senare gruppen har förslag på förändringar. 
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  • Andersson, Lars-Erik, 1942-, et al. (författare)
  • Existence theorems for noncoercive incremental contact problems with Coulomb friction
  • 2006
  • Ingår i: Analysis and Simulation of Contact Problems. - Berlin/Heidelberg : Springer Berlin/Heidelberg. - 9783540317609 - 9783540317616 - 3540317600 ; , s. 121-128
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • For static or incremental contact problems with Coulomb friction there are satisfactory and well known existence results for the coercive case, i.e., when the elastic body is anchored so that rigid body motions are not possible, see [3, 1, 6, 7, 2]. The articles by Jaruusek and Cocu, [7, 2] indeed contain results for the noncoercive case, i.e., when rigid body motions are possible. However, the compatibility conditions which are used to ensure the existence of a solution, are the same that guarantee that the corresponding contact problem without friction has a solution. The condition is essentially that the applied force field should push the elastic body towards the obstacle. One of few previous articles containing friction-dependent compatibility conditions is.
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  • Andersson, Martin, et al. (författare)
  • A Reconfigurable Pipelined ADC in 0.18 um CMOS
  • 2005
  • Ingår i: 2005 Symposium on VLSI Circuits, Digest of Technical Papers. - 490078401X ; , s. 326-329
  • Konferensbidrag (refereegranskat)abstract
    • A reconfigurable pipelined A/D converter has been implemented in a 0.18 mu m RF-CMOS process. The ADC has eight configurations with a top performance of 10 bits resolution at 80 MSPS consuming 94mW. The reconfigurability is achieved by combining the cyclic and pipelined ADC architectures giving it a low level of complexity. In the conventional pipeline mode, the measured SFDR is 69 dBFS and the SNDR is 56.5 dBc for a 1.54 MHz single sinusoid tone input.
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  • Andersson, Martin, et al. (författare)
  • Teaching Top Down Design of Analog/Mixed Signal ICs Through Design Projects
  • 2007
  • Ingår i: FIE 2007: 37th annual Frontiers in education conference - global engineering: knowledge without borders, opportunities without passports, Proceedings. - 0190-5848. ; , s. 40-43
  • Konferensbidrag (refereegranskat)abstract
    • This paper describes a project course that focuses on the design of analog and mixed signal circuits through a systematic top down design flow. In the project, the student will be involved in the planning, modeling, circuit level design, physical level implementation and measurement verification of for example a successive approximation (SA) ADC or a class-D audio amplifier. Throughout the project, the project members will improve their design skills and create an understanding for the importance of a systematic top-down design methodology at the different levels of the design flow.
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  • Andersson, Olof, et al. (författare)
  • Gradient Hydrogel Matrix for Microarray and Biosensor Applications : An Imaging SPR Study
  • 2009
  • Ingår i: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 10:1, s. 142-148
  • Tidskriftsartikel (refereegranskat)abstract
    • A biosensor matrix based on UV-initiated graft copolymerized poly(ethylene glycol) methacrylate and 2-hydroxyethyl methacrylate has been studied using imaging surface plasmon resonance (iSPR). By using a photo mask and a programmable shutter to vary the exposure time laterally, a gradient of matrix spots with physical thicknesses ranging from a few to tens of nanometers was generated. To maximize the dynamic range, imaging SPR was employed in wavelength interrogation mode. By finding the minimum in the reflectance spectra from each pixel of an image, SPR wavelength maps were constructed. The shift in SPR wavelength upon biospecific interaction was then measured both as a function of matrix thickness and composition. The performance of the matrix was evaluated in terms of immobilization of human serum albumin, biomolecular interaction with its antibody, and nonspecific binding of human fibrinogen. In addition, a low molecular weight interaction pair based on a synthetic polypeptide and calmodulin was also studied to explore the size selectivity of the hydrogel matrix. Our results show that the gradient matrix exhibits excellent properties for quick evaluation and screening of optimal hydrogel performance. The mixed hydrogel matrices display very low levels of nonspecific binding. It is also evident that the low molecular weight calmodulin is capable of freely diffusing and interacting throughout the entire hydrogel matrix, whereas the much larger albumin and its corresponding antibody, in particular, are partly/completely hindered from penetrating the interior of the matrix. This size-selectivity is attributed to a significant UV-initiated cross-linking or branching of the matrix during fabrication and/or protein mediated multipoint attachment during immobilization.
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  • Andersson, Per-Johan, et al. (författare)
  • Power mapping and noise reduction for financial correlations
  • 2005
  • Ingår i: Acta Physica Polonica, Series B. - 0587-4254. ; 36:9, s. 2611-2619
  • Konferensbidrag (refereegranskat)abstract
    • The spectral properties of financial correlation matrices can show features known from completely random matrices. A major reason is noise originating from the finite lengths of the financial time series used to compute the correlation matrix elements. In recent years, various methods have been proposed to reduce this noise, i.e. to clean the correlation matrices. This is of direct practical relevance for risk management in portfolio optimization. In this contribution, we discuss in detail the power mapping, a new shrinkage method. We show that the relevant parameter is, to a certain extent, self-determined. Due to the "chirality" and the normalization of the correlation matrix, the optimal shrinkage parameter is fixed. We apply the power mapping and the well-known filtering method, to market data and compare them by optimizing stock portfolios. We address the rle of constraints by excluding short selling in the optimization.
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  • Andersson, Per, 1964-, et al. (författare)
  • Kunskapers värde : validering i teori och praktik
  • 2005. - 1
  • Bok (övrigt vetenskapligt/konstnärligt)abstract
    • Denna bok handlar om validering av kunskap och kompetens, närmare bestämt den ambition som finns i vårt samhälle att värdera och ge erkännande åt vad människor lärt sig oavsett var, när och hur detta skett. Ambitionen att validera sätts in i sitt sammanhang genom att relateras dels till hur vuxnas lärande har organiserats i olika former, dels till hur valideringstanken gestaltat sig på olika sätt. Författarna problematiserar validering i relation till olika teorier om kunskap och lärande samt till den kunskapsbedömning som är en central del av en validering. Några olika modeller för hur validering kan organiseras och genomföras i praktiken diskuteras, liksom de olika roller som finns i en valideringsprocess.
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  • Andersson, Per Ola, et al. (författare)
  • A novel ATR-FTIR method for functionalised surface characterisation
  • 2008
  • Ingår i: Surface and Interface Analysis. - : Wiley. - 0142-2421 .- 1096-9918. ; 40:3-4, s. 623-626
  • Tidskriftsartikel (refereegranskat)abstract
    • We demonstrate a novel method to analyse ex situ prepared chips by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), which circumvents tedious functionalisation steps of internal reflection elements (IREs), and simultaneously allows for complementary measurements by other analytical techniques. This concept is proved by utilising immobilised metal affinity capture (IMAC) chips containing about 10 gm thick films of copolymers coated with nitrilotriacetic acid (NTA) groups. With this so-called 'upside-down' ATR-FTIR technique, each chemical modification step can be followed and optimised with respect to concentration, buffer, pH, ionic strength, and so on, and there are no limitations in variations or numbers of functionalised surfaces that can be generated. We have demonstrated the feasibility of this approach to determine the molecular structure of ligand bonded to immobilised polypeptide, directly observed in the raw ATR-FTIR spectrum. Peptide adsorption in a thick NTA-copolymer matrix yields a high peptide concentration as determined by the analysis of the Langmuir adsorption isotherm. Combined with the 'upside-down' ATR-FTIR approach which samples the outermost region of the exposed NTA-copolymer film, this generates well-resolved amide I and II absorption bands that reduce the necessity of using D2O based buffers, which otherwise is common in mid-IR spectroscopy of proteins. We believe that this new optical surface characterisation method has a great potential as a stand-alone or complementary analytical tool. We emphasise further that with this approach no chemical treatment of IREs is needed; the chips can be regenerated and reused, and analysed by complementary analytical techniques such as mass spectrometry.
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  • Andersson, Per, et al. (författare)
  • Recognition of prior learning as a technique for fabricating the adult learner : a genealogical analysis on Swedish adult education policy
  • 2005
  • Ingår i: Journal of education policy. - : Informa UK Limited. - 0268-0939 .- 1464-5106. ; 20:5, s. 595-613
  • Tidskriftsartikel (refereegranskat)abstract
    • This article focuses on the recognition of prior learning and the figure of thought it represents in Swedish policy on adult education. It can be seen as a technique for governing the adult learner and a way of fabricating the subject. We are tracing this thought back in time to see how it has changed and what it consists of. The material analysed consists of Swedish official documents published between 1948 and 2004. We draw on two concepts from the Foucauldian toolbox: genealogy and governmentality. The result shows that this technique for governing and fabricating the adult subject is not new. It has been present during all periods analysed. However, there is a difference in how the ideas of competence and knowledge are stressed. Today the focus is on the subject's specific experience, which means competence. You are constructed as an adult with experiences that are to be evaluated. During the 1960s and 1970s the focus was rather on general experience. There was also discussion concerning the subject's ability to study. During the 1950s this figure of thought focused on ability was dominant. Those with the talent/ability to study were to be accepted for adult education.
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  • Axén, Andreas, et al. (författare)
  • Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor
  • 2007
  • Ingår i: Journal of Peptide Science. - : Wiley. - 1075-2617 .- 1099-1387. ; 13:7, s. 434-444
  • Tidskriftsartikel (refereegranskat)abstract
    • Angiotensin IV analogs encompassing aromatic scaffolds replacing parts of the backbone of angiotensin IV have been synthesized and evaluated in biological assays. Several of the ligands displayed high affinities to the insulin-regulated aminopeptidase (IRAP)/AT4 receptor. Displacement of the C-terminal of angiotensin IV with an o-substituted aryl acetic acid derivative delivered the ligand 4, which exhibited the highest binding affinity (Ki = 1.9 nM). The high affinity of this ligand provides support to the hypothesis that angiotensin IV adopts a -turn in the C-terminal of its bioactive conformation.Ligand (4) inhibits both human IRAP and aminopeptidase N-activity and induces proliferation of adult neural stem cells at low concentrations. Furthermore, ligand 4 is degraded considerably more slowly in membrane preparations than angiotensin IV. Hence, it might constitute a suitable research tool for biological studies of the (IRAP)/AT4 receptor.
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37.
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38.
  • Bergh, Andreas, et al. (författare)
  • Korruption i svenska kommuner: Lärdomar från evolutionär spelteori och experimentell ekonomi
  • 2008
  • Ingår i: Uppsats presenterad vid NOPSA i Tromsö, 6-9 augusti 2008..
  • Konferensbidrag (refereegranskat)abstract
    • I internationell jämförelse är Sverige ett av de länder världen som har den minst korrupta förvaltningsbyråkratin. Samtidigt har en rad uppmärksammade skandaler på senare tid visat att inte heller Sverige är helt fritt från problem i detta avseende. Detta gäller i synnerhet när korruption tolkas som att tillskansa sig själv eller sina närmaste fördelar på samhällets bekostnad. I artikeln analysera kommunal korruption med hjälp av lärdomar från ny forskning inom spelteori och experimentell ekonomi. Vi visar att det inom dessa fält finns både teori och empiri som hjälper oss att förstå under vilka omständigheter korruption kan förväntas förekomma.
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39.
  • Bergström, Jan, 1976-, et al. (författare)
  • An open study of the effectiveness of Internet treatment for panic disorder delivered in a psychiatric setting
  • 2009
  • Ingår i: Nordic Journal of Psychiatry. - : Informa UK Limited. - 0803-9488 .- 1502-4725. ; 63:1, s. 44-50
  • Tidskriftsartikel (refereegranskat)abstract
    • Panic Disorder with or without or without agoraphobia (PD/A) is common and can be treated effectively with SSRI medication or cognitive behavior therapy (CBT). There is however a great lack of access to CBT services, which has motivated the development of self-help approaches requiring less therapist contact. A novel treatment modality in this field, showing efficacy in several randomised trials but until now not evaluated within the context of regular psychiatric care, is Internet-based treatment. The present study evaluated the effectiveness of Internet-based CBT for 20 consecutively referred PD patients in a psychiatric setting. At post-treatment, 94% of patients no longer met DSM-IV criteria for PD (82% at 6-month follow up). The within-group effect sizes (for the main outcome PDSS; Panic Disorder Severity Scale) were Cohens d=2.5 (pre- to posttreatment) and 2.8 (pre-treatment to follow up) respectively. The proportion of responders on the PDSS was 75% at posttreatment and 70% at 6-month follow up. These results indicate that Internet-based CBT can be both an effective, feasible and potentially cost-effective alternative within regular psychiatric care for patients with PD.
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40.
  • Bergström, Sara K., et al. (författare)
  • A simplified multidimensional approach for analysis of complex biological samples : on-line LC-CE-MS
  • 2006
  • Ingår i: The Analyst. - : Royal Society of Chemistry (RSC). - 0003-2654 .- 1364-5528. ; 131:7, s. 791-798
  • Tidskriftsartikel (refereegranskat)abstract
    • Information on protein expression, disease biomarkers or surrogate markers and genetic disorders can nowadays be achieved from analysis of complex biological samples by liquid separation coupled to mass spectrometric (MS) detection. This paper describes fast multidimensional separation by on-line liquid chromatography (LC) and capillary electrophoresis (CE), followed by electrospray ionization (ESI) Fourier transform ion cyclotron resonance (FTICR) MS detection. This detector provides ultrahigh resolution of the detected ions, mass accuracy at the ppm-level and high sensitivity. Most of the challenge of this system lies in the development of a new interface for the on-line coupling of LC to CE. The interface developed in poly(dimethylsiloxane) provides a RSD for injection repeatability of <3.5% and surface control for unspecific binding by deactivation with a cationic polymer, PolyE-323. We have evaluated the interface, as well as the overall system, with respect to robustness and deconvolution ability. Sequence coverage for bovine serum albumin (BSA) of 93% showed a high recovery of sample in the different transfer steps through the system. The detection limit for identification is 277 ng mL−1 (or 280 nM) on average for peptides. In the future, we expect LC-CE-MS to be a novel strategy for elucidating the chemistry of biological matrices.
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41.
  • Berntsson, Andreas, 1978, et al. (författare)
  • A LIF-study of OH in the Negative Valve Overlap of a Spark-assisted HCCI Combustion Engine
  • 2008
  • Ingår i: SAE Technical Papers. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191 .- 2688-3627.
  • Tidskriftsartikel (refereegranskat)abstract
    • Future requirements for emission reduction from combustionengines in ground vehicles might be met byusing the HCCI combustion concept. In this study,negative valve overlap (NVO) and low lift, short duration,camshaft profiles, were used to initiate HCCIcombustion by increasing the internal exhaust gas recirculation(EGR) and thus retaining sufficient thermalenergy for chemical reactions to occur when a pilot injectionwas introduced prior to TDC, during the NVO.One of the crucial parameters to control in HCCI combustionis the combustion phasing and one way of doingthis is to vary the relative ratio of fuel injected inpilot and main injections. The combustion phasing isalso influenced by the total amount of fuel supplied tothe engine, the combustion phasing is thus affectedwhen the load is changed. This study focuses on thereactions that occur in the highly diluted environmentduring the NVO when load and pilot to main ratio arechanged.To monitor these reactions, planar laser-induced fluorescence(PLIF) from OH radicals was analyzed ina series of experiments with an optical single-cylinderengine, since these radicals are known to be associatedwith high temperature reactions. A series of experimentswas also performed using a multi-cylinderengine with varied NVO timings, which showed thatthe combustion phasing was influenced by both theratio between the pilot and main injection amountsand the total amount of fuel. Data acquired from correspondingoptical analysis showed the occurrenceof OH radicals (and thus high temperature reactions)during the NVO in all tested operating conditions. Theresults also indicate that the extent of the high temperaturereactions was influenced by both varied parameters,since decreasing the relative amount of the pilotinjection and/or increasing the total amount of fuel ledto larger amounts of OH radicals.
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42.
  • Berntsson, Andreas, 1978, et al. (författare)
  • LIF imaging of OH during the Negative Valve Overlap of a HCCI Combustion Engine
  • 2007
  • Ingår i: The Spark Ignition Engine of the Future Conference, Strasbourg - INSA 28/11 - 29/11 2007. ; :Code: R-2007-01-22, s. (9)-
  • Konferensbidrag (refereegranskat)abstract
    • Future requirements for emission reduction from combustion engines in ground vehicles might be met by using the HCCI combustion concept. In this concept a more or less homogenous air fuel mixture is compressed to auto-ignition. This gives a good fuel economy compared to a normal SI engine and it has a positive impact on exhaust emissions. In the study presented here negative valve overlap (NVO) was used to initiate HCCI combustion by increasing the exhaust gas recirculation (EGR) and thus retaining sufficient thermal energy to reach auto-ignition temperatures, and raising the temperature during the NVO sufficiently to allow reactions to occur when a pilot injection was made prior to the NVO. The focus of the investigation was on the resulting high temperature reactions.Since OH radicals are associated with high temperature reactions, the reactions were followed by monitoring planar laser-induced fluorescence (PLIF) of OH, using a dye laser and an intensified LaVision Dynamight camera. The presence of OH radicals detected during the negative valve overlap indicates that high temperature reactions do occur in the highly diluted environment of the trapped exhaust gases during the NVO. Reactions were identified from 20 CAD prior to TDC (during the NVO) and to around 60 CAD after TDC, with the intensity peak at about TDC.
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43.
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44.
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45.
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46.
  • Börjesson, Andreas, et al. (författare)
  • Survival of an islet allograft deficient in iNOS after implantation into diabetic NOD mice
  • 2006
  • Ingår i: Cell Transplantation. - 0963-6897 .- 1555-3892. ; 15:8-9, s. 769-775
  • Tidskriftsartikel (refereegranskat)abstract
    • Proinflammatory cytokines play a major role in rejection of pancreatic islet allografts and in type 1 diabetes (T1D). In rodent islets, exposure to IL-1β alone or combined with IFN-γ induces expression of inducible nitric oxide synthase (iNOS). Inhibition of iNOS or a deletion of the iNOS gene has been shown to be protective in animal models of T1D. In the present study we tested the hypothesis that transplantation of pancreatic islets deficient in iNOS (iNOS-/-) would permit increased graft survival. Pancreatic islets isolated from wild-type (wt) mice and iNOS-/- mice were allogeneically transplanted beneath the kidney capsule of spontaneously diabetic NOD mice. When blood glucose increased above 12.0 mM after preceding normalization of hyperglycemia, animals were sacrificed. Histological examinations of grafts were performed and graft gene expression was analyzed by real-time PCR. Transplantations of the two types of islets could reverse hyperglycemia and the grafts functioned for on average 1 week posttransplantation. Morphological examination of both types of islet grafts showed immune cell infiltration around and within the grafts. Remaining endocrine cells could be observed in wt and iNOS-/- islet grafts. In the removed grafts iNOS-/- islet tissue contained higher mRNA levels of insulin, proinsulin convertases (PC-1 and PC-2), and IL-1β compared to transplanted wt islets. The assessments of insulin, PC-1 and PC-2 mRNAs of the grafts suggest that the iNOS-/- islets may be more resistant to destruction in the transplantation model used; however, this was not sufficient to prolong the period of normoglycemia posttransplantation.
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47.
  • da Silva, Zacarias, et al. (författare)
  • Decline in human T-cell lymphotropic virus-1 prevalence in urban areas of Bissau, Guinea-Bissau: exploring the association with HIV infections.
  • 2009
  • Ingår i: AIDS. - 1473-5571. ; 23, s. 637-639
  • Tidskriftsartikel (refereegranskat)abstract
    • In 2006, a cross-sectional survey of 384 randomly selected houses within a community-based follow-up study was conducted to assess the human T-cell lymphotropic virus (HTLV) prevalence in Bissau. Changes in prevalence and incidence rates were assessed based on a similar survey carried out 10 years earlier. The prevalence of HTLV-1 declined significantly from 3.5% in 1996 to 2.3% in 2006. The incidence between 1996 and 2006 was only 0.9/1000 person-years and tended to be higher for women than for men.
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48.
  • da Silva, Zacarias J., et al. (författare)
  • Changes in prevalence and incidence of HIV-1, HIV-2 and dual infections in urban areas of Bissau, Guinea-Bissau : is HIV-2 disappearing?
  • 2008
  • Ingår i: AIDS. - London : Gower Academic Journals. - 0269-9370 .- 1473-5571. ; 22:10, s. 1195-1202
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Objectives: To assess the changes in HIV prevalence and incidence between 1996 and 2006 in urban areas of Bissau.Design: A cross-sectional survey of 384 randomly selected houses within a community-based follow-up study of HIV-1 and HIV-2.Methods: A total of 3242 individuals aged at least 15 years were eligible for inclusion. Participants were interviewed about behavioral and socio-economic factors and had a blood sample drawn. A total of 2548 individuals were tested for antibodies to HIV-1 and HIV-2, of whom 649 had taken part in a similar survey in 1996.Results: With 0.5% HIV dual reactions included, the overall HIV-1 prevalence was 4.6% (118 out of 2548) and the HIV-2 prevalence was 4.4% (112 out of 2548). The prevalence of HIV-1 increased more for women than men especially in the 25-34-year age group. HIV-2 prevalence decreased below 45 years of age but not for individuals more than 45 years old. The incidence rate between 1996 and 2006 was 0.5 per 100 person-years for HIV-1 and 0.24 per 100 person-years for HIV-2. Compared with a previous period from 1987 to 1996, the incidence of HIV-2 is declining whereas no significant increase in the incidence of HIV-1 was observed.Conclusions: The present study shows an increasing prevalence of HIV-1 and a decreasing prevalence of HIV-2 in Guinea-Bissau. HIV is generally a bigger problem for women. Despite the general decline in prevalence, HIV-2 may continue as an infection in older people, especially women.
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49.
  • Dahl, Daniel, 1982, et al. (författare)
  • Reducing pressure fluctuations at high loads by means of charge stratification in HCCI combustion with negative valve overlap
  • 2009
  • Ingår i: SAE Technical Papers. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191 .- 2688-3627. ; 2009
  • Tidskriftsartikel (refereegranskat)abstract
    • Future demands for improvements in the fuel economy of gasoline passenger car engines will require the development and implementation of advanced combustion strategies, to replace, or combine with the conventional spark ignition strategy. One possible strategy is homogeneous charge compression ignition (HCCI) achieved using negative valve overlap (NVO). However, several issues need to be addressed before this combustion strategy can be fully implemented in a production vehicle, one being to increase the upper load limit. One constraint at high loads is the combustion becoming too rapid, leading to excessive pressure-rise rates and large pressure fluctuations (ringing), causing noise. In this work, efforts were made to reduce these pressure fluctuations by using a late injection during the later part of the compression. A more appropriate acronym than HCCI for such combustion is SCCI (Stratified Charge Compression Ignition). The approach was evaluated in tests with a single-cylinder metal research engine and a single-cylinder optical engine. The latter was used to characterize the combustion in laser-based analyses including laser-induced florescence (LIF) determinations of fuel tracer, OH and CH 2O (formaldehyde) distributions. A high speed camera was also used for direct imaging of chemiluminescence. The effects of two main parameters were studied: the proportion of fuel injected late to create a stratified charge and the timing of the late injection. In addition, two fuels were used: a certification gasoline fuel and a blend of n-heptane, iso-octane and 3-pentanone. Both fuels were used in the metal engine for comparison. Use of a stratified charge allowed the maximum pressure-rise rates and ringing intensity to be reduced at the expense of increases in NOx and CO emissions, regardless of fuel type. Optical results indicated that both the fuel distribution and combustion were not homogenous.
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50.
  • Erlingsson, Gissur, et al. (författare)
  • Hur korrupt är en icke-korrupt stat? Teoretiska förväntningar och lokala eliters subjektiva bedömningar.
  • 2008
  • Ingår i: Uppsats presenterad vid NOPSA i Tromsö, 6-9 augusti 2008.
  • Konferensbidrag (refereegranskat)abstract
    • Sweden has traditionally been regarded as a country free from corruption. But since the 1990s several corruption scandals and critique of weak institutional control mechanisms have somewhat challenged this picture. The purpose of the paper is to: i) build a theoretical ground for the argument that corruption has increased in Swedish municipalities, and ii) explore if corruption is regarded as a substantial problem by senior members and officers in Swedish municipalities and if there is reason to believe that corruption has increased over time. The paper establishes that changes in the public sector, among else New Public Management reforms, have contributed to altered incentives for corruption, and indeed increased possibilities, for members and officers in municipalities. Empirical results from our survey of senior officers and members in all Swedish municipalities carried out in 2008 show that respondents do not consider corruption as widespread, which is true no matter whether respondents are asked about the situation in Swedish municipalities in general, activities and operations in the own municipality or own experiences of bribe attempts. But despite this respondents do perceive corruption as a substantial problem and judged from respondents’ own experiences one in 20 did experience corrupt offers. Finally, although it is not possible to establish conclusively, the paper discusses based on empirical findings whether corruption really is a widespread phenomenon and has increased over time.
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