| 1. |
- Andersson, Roland, et al.
(författare)
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Akut buk
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 102-102
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Andersson, Roland, et al.
(författare)
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Appendicit
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 144-144
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Andersson, Roland, et al.
(författare)
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Bråck
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 156-156
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Andersson, Roland, et al.
(författare)
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Bukhålan - peritonit, abscess och ileus
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 107-107
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Andersson, Roland, et al.
(författare)
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Gallvägssjukdomar
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 119-119
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Andersson, Roland, et al.
(författare)
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Inflammation
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 29-29
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Andersson, Roland, et al.
(författare)
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Interventionell radiologi
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 78-78
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Andersson, Roland, et al.
(författare)
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Kirurgisk intensivvård
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 415-415
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Andersson, Roland, et al.
(författare)
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Komplikationer hos kirurgiska patienter
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 408-408
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Andersson, Roland, et al.
(författare)
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Pankreas
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 130-130
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 11. |
- Andersson, Roland, et al.
(författare)
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Perioperativ vård
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 82-82
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 12. |
- Andersson, Roland, et al.
(författare)
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Tunntarmssjukdomar
- 2004
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Ingår i: Kirurgiska sjukdomar: patofysiologi, behandling, specifik omvårdnad. - 9144024185 ; , s. 139-139
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 13. |
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| 14. |
- Jönsson, Christina, et al.
(författare)
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Immobilized oxazoline-containing ligands in asymmetric catalysis - A review
- 2002
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Ingår i: Bioorganic & Medicinal Chemistry Letters. - 0960-894X .- 1464-3405. ; 12:14, s. 1857-1861
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Forskningsöversikt (refereegranskat)abstract
- Metal complexes of chiral oxazoline derivatives immobilized on soluble as well as insoluble supports serve as versatile asymmetric catalysts in a variety of applications. In a few cases recovery and reuse of the chiral ligands have been achieved.
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| 15. |
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| 16. |
- Lundgren, Stina, et al.
(författare)
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Micro reactors for the optimisation of reaction conditions in asymmetric metal catalysis
- 2005
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Ingår i: Micro Total Analysis Systems 2004. - 0854046437 ; , s. 445-447
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Konferensbidrag (refereegranskat)abstract
- Two types of micro reactors were employed for enantioselective metal catalysed reactions. In the first type of reactor, an electroosmotic flow was used, whereas the second type of reactor used a pressure driven flow. The purpose of the study is to develop tools for rapid and efficient optimization of reactions, utilising minimum amounts of reagents.
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| 17. |
- Söderström, A, et al.
(författare)
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A large Escherichia coli O157 outbreak in Sweden associated with locally produced lettuce.
- 2008
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Ingår i: Foodborne pathogens and disease. - : Mary Ann Liebert Inc. - 1556-7125 .- 1535-3141. ; 5:3, s. 339-49
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Tidskriftsartikel (refereegranskat)abstract
- In 2005 a large outbreak of verotoxin-producing Escherichia coli (VTEC) occurred in Sweden. Cases were interviewed and cohort and case-control studies were conducted. Microbiological investigations were performed using polymerase chain reaction (PCR) to detect the Shiga-like toxin (Stx) genes followed by cultivation and pulsed-field gel electrophoresis. A total of 135 cases were recorded, including 11 cases of hemolytic uremic syndrome. The epidemiological investigations implicated lettuce as the most likely source of the outbreak, with an OR of 13.0 (CI 2.94-57.5) in the case-control study. The lettuce was irrigated by water from a small stream, and water samples were positive for Stx 2 by PCR. The identical VTEC O157 Stx 2 positive strain was isolated from the cases and in cattle at a farm upstream from the irrigation point. An active surveillance and reporting system was crucial and cooperation between all involved parties was essential for quickly identifying the cause of this outbreak. Handling of fresh greens from farm to table must be improved to minimize the risk of contamination.
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| 18. |
- Aalberg, Laura, et al.
(författare)
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Development of a harmonised method for the profiling of amphetamines : I. Synthesis of standards and compilation of analytical data
- 2005
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Ingår i: Forensic Science International. - : Elsevier BV. - 0379-0738 .- 1872-6283. ; 149:2-3, s. 219-229
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Tidskriftsartikel (refereegranskat)abstract
- Reference material was synthesised for 21 substances that are frequently present as synthetic impurities, i.e. by-products, in illicitly produced amphetamine. Each of these substances is a typical by-product for at least one of the three approaches most often used to synthesise amphetamine, namely, the Leuckart, the reductive amination of benzyl methyl ketone, and the nitrostyrene routes. A large body of data on the substances was recorded, including the following: mass spectra, ultraviolet spectra, Fourier transform infrared spectra, infrared spectra in gas phase, and 1H NMR and 13C NMR spectra. © 2004 Elsevier Ireland Ltd. All rights reserved.
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| 19. |
- Adolfsson, Päivi, et al.
(författare)
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Observed dietary intake in adults with intellectual disability living in the community
- 2008
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Ingår i: Food & Nutrition Research. - : Co-Action Publishing. - 1654-6628 .- 1654-661X. ; 52
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Tidskriftsartikel (refereegranskat)abstract
- Background: Knowledge is lacking about dietary habits among people with intellectual disability (ID) living in community residences under new living conditions.Objective: To describe the dietary habits of individuals with ID living in community residences, focusing on intake of food, energy and nutrients as well as meal patterns.Design: Assisted food records and physical activity records over a 3-day observation period for 32 subjects.Results: Great variation was observed in daily energy intake (4.9-14 MJ) dispersed across several meals, with on average 26% of the energy coming from in-between-meal consumption. Main energy sources were milk products, bread, meat products, buns and cakes. The daily intake of fruit and vegetables (320_221 g) as well as dietary fiber (21_99.6 g) was generally low. For four vitamins and two minerals, 19-34% of subjects showed an intake below average requirement (AR). The physical activity level (PAL) was low for all individuals (1.4_0.1).Conclusion: A regular meal pattern with a relatively high proportion of energy from in-between-meal eating occasions and a low intake of especially fruits were typical of this group of people with ID. However, the total intake of energy and other food items varied a great deal between individuals. Thus, every adult with ID has to be treated as an individual with specific needs. A need for more knowledge about food in general and particularly how fruit and vegetables could be included in cooking as well as encouraged to be eaten as inbetween-meals seems imperative in the new living conditions for adults with ID.
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| 20. |
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| 21. |
- Andersson, Agneta, et al.
(författare)
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Alcohol use among university students in Sweden measured by an electronic screening instrument
- 2009
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Ingår i: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 9:229
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Tidskriftsartikel (refereegranskat)abstract
- Background: Electronic-based alcohol screening and brief interventions for university students with problem drinking behaviours forms an important means by which to identify risky drinkers. Methods: In this study an e-SBI project was implemented to assess drinking patterns, and to provide personalised feedback about alcohol consumption and related health problems, to students in a Swedish university. In this study, third semester university students (n = 2858) from all faculties (colleges) at the University were invited to participate in e-SBI screenings. This study employed a randomised controlled trial, with respondents having a equal chance of being assigned to a limited, or full-feedback response. Results: The study shows that high risk drinkers tend to underestimate their own consumption compared to others, and that these high risk drinkers experience more negative consequences after alcohol intake, than other respondents. There was a strong belief, for both high-and low-risk drinkers, that alcohol helped celebrations be more festive. This study also confirms findings from other study locations that while males drank more than females in our study population; females reached the same peak alcohol blood concentrations as males. Conclusion: Obtaining clear and current information on drinking patterns demonstrated by university students can help public health officials, university administration, and local health care providers develop appropriate prevention and treatment strategies.
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| 22. |
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| 23. |
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| 24. |
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| 25. |
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| 26. |
- Andersson, Björn, 1939, et al.
(författare)
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Att förstå naturen - från vardagsbegrepp till kemi, sex "workshops"
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Rapporten behandlar hur elever förstår centrala aspekter av kemin. Först kommer tre workshops om materiens bevarande, byggnad respektive faser. Därefter tas blandning, lösning och vattnets kretslopp upp. Som avslutning kommer två workshops om ämnen respektive kemiska reaktioner.
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| 27. |
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| 28. |
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| 29. |
- Andersson, Christina, 1955, et al.
(författare)
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Användning av benzodiazepiner
- 2007
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Ingår i: Svenska Föreningen för Alkohol- och Drogforskning, forskarmöte 20071025-26.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 30. |
- Andersson, Christina, 1955, et al.
(författare)
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Dryckeskontextens betydelse för unga kvinnors alkoholkonsumtion. En klusteranalys av 20- och 25-åriga kvinnor åren 1995 och 2000.
- 2008
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Ingår i: Läkarstämman, Göteborg 2008.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Dryckeskontextens betydelse för unga kvinnors alkoholkonsumtion. En klusteranalys av 20- och 25-åriga kvinnor åren 1995 och 2000. Bakgrund Under de senaste åren har framför allt en del internationell drogforskning fokuserat på fenomen som dryckeskontext och egna motiv till att dricka samt dessas samband med alkoholkonsumtion. Dryckeskontext har i nämnda studier definierats på något olika sätt, några mer teoretiskt förankrade, gemensamt kan sägas att man försökt besvara frågor om var, med vem och varför man druckit alkohol I den aktuella studien har vi analyserat sambandet mellan dryckeskontext och alkoholkonsumtion bland 20- och 25-åriga kvinnor i Göteborg. Syftet var att undersöka om det fanns specifika dryckesmönster, med hänsyftning på kontextuella variabler, om dessa dryckesmönster skiljde sig åt mellan undersökningsåren och om vissa dryckesmönster visade starkare samband med olika grader av alkoholkonsumtion. Metod Data från en befolkningsundersökning, ”Kvinnor och alkohol i Göteborg”: I studien ingick 897 unga kvinnor intervjuade under åren 1995 och 2000. Då dryckeskontext kan ses som ett multifaktoriellt fenomen valde vi att använda klusteranalys (”Two-step clustering”) för att identifiera grupper med olika dryckesmönster. Vi använde Pearson Chi-square för att undersöka skillnader i alkoholkonsumtion mellan de olika grupperna. Alkoholkonsumtion fördelades som Alkoholmissbruk/beroende - ABM, Intensivkonsumtion (60g etanol/tillfälle) - IK, Intensivkonsumtion/12 mån. – IK12 och Hög alkoholkonsumtion (20g etanol/dag senaste månaden) - HAK. Resultat Med hjälp av klusteranalys identifierades tre grupper med olika dryckesmönster för varje undersökningsår. 1995 syntes en grupp måttlighetsdrickare, en grupp som drack ofta både i sociala sammanhang och i ensamhet samt en grupp som bejakade mest upplevda effekter av sitt drickande. 2000 fann vi åter gruppen måttlighetsdrickare, därtill en grupp där man bejakade sociala effekter av alkohol och en annan grupp som uppgav mer fysiska och kognitiva effekter. 1995 visade gruppen som drack i ofta i sociala sammanhang signifikanta samband med ABM, IK12 och HAK. År 2000 sågs signifikanta samband med alla konsumtionsvariablerna hos de båda grupper som bejakande olika upplevda effekter av alkoholanvändning. Sammanfattning Klusteranalys var en god metod för att identifiera grupper med olika dryckesmönster som underlag för analys av skillnader i alkoholkonsumtion. Analysen understryker vikten av att ta hänsyn till upplevda effekter av och egna anledningar till drickande när man vill medverka till en minskad alkoholkonsumtion i befolkningen.
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| 31. |
- Andersson, Christina
(författare)
-
Physical capacity in individuals with cerebral palsy : problems, needs and resources, with special emphasis on locomotion
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Many individuals with cerebral palsy (CP) have difficulties in walking independently because of impaired postural control, abnormal tone and pathological muscular coordination. Walkers are often a prerequisite and are often prescribed for assisting and providing the stability necessary for ambulation. There are not many studies published concerning adults with CP and their physical capacity, problems, needs, and resources, especially regarding walking ability, walking aids, effects of training and reliable assessment tools. Aims: The aims of these studies were to survey physical capacity in individuals with CP and their problems, needs, and resources, with special emphasis on locomotion, and to study the effects of walking with different kinds of walking aids (Study I and II). The aims were alsoto study the effects of training and to determine the reliability of the SixMinute Walk Test (6MWT). Study I: A questionnaire was constructed. It consisted of 33 questions. The questionnaire was mailed to 363 adults with CP living in the County of Stockholm. Two hundred and twenty-one individuals answered the questionnaire. 84 % lived in own apartments, alone or together with partner and/or children, 24 % worked full-time, 64 % were able to walk with or without walking aids, 35 % reported decreased walking ability, 27 % had never been able to walk, and 9 % had stopped walking. Study II: Ten children with CP participated in a study comparing two different kinds of walkers (anterior and posterior). Oxygen cost was measured by an argon gas method. Spasticity was estimated according to the modified Ashworth scale. Perceived exertion was expressed by pointing to a five-point face scale. The results showed no differences in the measured variables when walking with the two walkers. Most children preferred the posterior walker, which was recommended as it contributed to a more upright posture. Study III: Ten adults with CP represented a training group and eight a control group in a progressive strength training programme during 10 weeks. Isokinetic and isometric muscle strength was measured by KIN-COM 500 H dynamometer, and isometric muscle strength with a hand-held dynamometer (Nicholas). Range of motion was measured with a goniometer and spasticity was estimated according to the modified Ashworth scale. Walking ability was assessed with Gross Motor Function Measure (GMFM), Timed Up and Go (TUG) and 6MWT. Perceived exertion was estimated according to the Borg scale (RPE 6-20). Significant increase of muscle strength, range of motion, and walking ability was only seen in the training group. No increase in spasticity was noted. Study IV: Twenty-five adults with CP participated in a study with the aim to determine reliability on the Six-Minute Walk Test (6MWT). The individuals were in four tests instructed to walk as far as possible for six minutes. The distance walked, heart rate and perceived exertion were assessed. The walked metre averaged 316 (range 74-579), 336 (range 65621), 341 (range 83-626) and 345 (range 88-640) m. 6MWT showed high reliability, with ICC 0.99 and with a repeatability (clinical measurement error) of 40 m. One practice walk was recommended as the walking distance in the first test was significantly shorter (p<0.01) compare to the other tests.
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| 32. |
- Andersson, Christina, 1955, et al.
(författare)
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Prevalence of drug use in three cohorts of young Swedish women
- 2005
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Ingår i: Kettil Bruun Society, Annual Meeting Riverside CA, USA, 20050530-03.
-
Konferensbidrag (refereegranskat)abstract
- The study presents prevalence of drug use among 1123 women aged 20 and 25 years in Göteborg, Sweden. The aim of the study was to measure prevalence of illegal and legal drug use in three cross-sectional cohorts interviewed in 1990, 1995 and 2000 as well as to describe the development of drug use within the same period. Prevalence was calculated for illicit and licit drug use in total and for three different patterns of drug use; narcotics only, medications only or a combination of the use of these substances. Also presented is the frequency of drug use. Further was analysed trends in changes of the use of nine specified drugs. Results: Both life-time and 12-months use of illicit drugs was significantly higher for 20-year-old women in 2000 (from 20.2% to 33.4% and from 9.5% to 22.3% respectively). The use of licit drugs was highest (but not significant) among 25-year-old women in 1990. Cannabis was the most prevalent drug used with a significant increase in life-time use for 20-year-old women from 17,4% to 28,8%. Both age-groups reported significant increases in the use of heroin, 25-year-old women in use of psychedelica and 20-year-old women in use of other drugs. Conclusions: The prevalence rates found were higher than compared to contemporary studies in Sweden. Further was found a significant trend for using both illegal and legal drugs among the youngest cohort, and a tendency for more regular use of drugs in both age-groups in 2000.
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| 33. |
- Andersson, Christina, 1955, et al.
(författare)
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Prevalens av användning/missbruk av legala och illegala droger i tre kohorter unga, svenska kvinnor
- 2004
-
Ingår i: Riksstämman, Göteborg 2004.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Bakgrund: Efter en minskning under 1980-talet visar ett flertal studier både inom och utanför Europa på en ökning av droganvändandet från 1990-talet och framåt. Detta gäller framför allt bland yngre personer och cannabis är den mest förekommande drog i alla rapporteringar. Totalt för Sverige svarade 16% bland ungdomar (19-24 år) år 2000 att man prövat narkotika. Metod: Data från en longitudinell befolkningsundersökning, “Kvinnor och alkohol i Göteborg”. Denna presentation avser tvärsnittsstudier av droganvändande hos tre kohorter 20 och 25 åriga unga kvinnor intervjuade mellan 1990 och 2000. Resultatet redovisas både som prevalenstal i jämförelse mellan de tre intervjuomgångarna och som trendanalys av förändringen i användandet av enskilda drogtyper. Resultat: Andelen 20-åriga kvinnor som enbart använt illegala droger ökade från 14,7 till 17,7% mellan åren 1995 och 2000. Vad gäller gruppen som använde både illegala droger och beroendeframkallande mediciner (BM) ökade denna bland 20-åriga kvinnor från 5,5 1995 till 15,7% 2000. Däremot var gruppen som enbart använde BM högst hos 25-åringar år 1990, därefter sågs sjunkande siffror 1995 och 2000. Livstidsprevalensen för cannabis ökade hos 20-åringar från 17,4 till 28,8%. Övriga specifika illegala droger gav prevalenstal mellan 0,5 och 5,4% med en signifikant ökning för heroin i båda åldersgrupperna år 2000. Sammanfattning: Användandet av illegala droger ökade under 90-talet, framförallt hos 20-åriga kvinnor. Det syntes en svag tendens till att även 25-åringar år 2000 fortsatte använda droger i högre grad än tidigare. Likaså syntes en tendens till att användandet blivit mer frekvent i båda åldersgrupperna år 2000. Gruppen av 20-åriga kvinnor som enbart använde BM minskade i omfattning år 2000 medan en signifikant ökning syntes för gruppen som använde både illegala droger och BM.
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| 34. |
- Andersson, Christina, 1955, et al.
(författare)
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The association between patterns of women’s daily occupations and alcohol consumption; a cluster analytic approach.
- 2009
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Ingår i: 35th Annual Alcohol Epidemiology Symposium of the Kettil Bruun Society, Köpenhamn, DK 2009601-05.
-
Konferensbidrag (refereegranskat)abstract
- Earlier studies on women's health and women's drinking and contemporary associated risk factors have highlighted the need for more complex approaches in understanding the pathways into women's problem drinking. Research from both social science and occupational therapy theory have underlined the importance of deconstructing the often dichotomised way of investigating women's daily lives (such as in paid and unpaid work or in work and leisure) when discussing factors from the daily life environment and their impact on health issues. The aim of this study is to explore the relationship between patterns of women's daily occupation and alcohol consumption using the broader concept of occupation from occupational therapy theory. Method: A cross-sectional study with data from the latest wave (2000) of a population-based project, Women and Alcohol in Göteborg (WAG). The study group consists of in total 871 women, aged 20-55 years. For identifying different groups of occupational patterns we are using an individual oriented method; Two-step clustering. Further we aim to use analyses of variance to analyse if there are specific occupational patterns related to problematic alcohol consumption. The specific variables constituting the patterns of daily occupations in this study are employment status, leisure, distribution of household/maintenance work, time for free disposal and the satisfaction with each of these four domains. Preliminary results will be presented.
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| 35. |
- Andersson, Christina, 1955, et al.
(författare)
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Young women´s drinking contexts. A cluster analysis of 20- and 25-year old women.
- 2007
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Ingår i: 33rd Annual Alcohol Epidemiology Symposium of the Kettil Bruun Society, Budapest 20070604-08.
-
Konferensbidrag (refereegranskat)abstract
- During the last years some international research on young adult drinking have focused on drinking contexts and drinking motives and the association with alcohol consumption. In this study we have analysed the association between drinking context and alcohol consumption in 20- and 25-year old women in Sweden. The aim was to find if drinking patterns, with respect to drinking context, varied between 1995 and 2000 and if specific drinking patterns related to specific consumption variables. Method: A total of 897 respondents were interviewed in 1995 and 2000. Looking at drinking context as a multi-dimensional phenomenon we chose two-step clustering as a method for identifying the drinking patterns. We used Pearson Chi-square to test for differences between the cluster groups with respect to problematic alcohol consumption. Results: Three clusters of drinking patterns in 1995 and 2000 respectively were defined. In 1995 the clusters were characterised as moderate drinking, partying and solitary drinking and drinking effects. In 2000 the three cluster groups were moderate drinking, social effects-drinking and individual effects and solitary drinking. Association with alcohol consumption showed significant differences: in 1995 the cluster party and solitary drinking was related to alcohol use disorders, binge drinking and high alcohol consumption, in 2000 the two clusters including drinking effects showed associations with all consumption variables.
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| 36. |
- Andersson, Ellinor, et al.
(författare)
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High-resolution genomic profiling reveals gain of chromosome 14 as a predictor of poor outcome in ileal carcinoids.
- 2009
-
Ingår i: Endocrine-related cancer. - 1479-6821. ; 16:3, s. 953-66
-
Tidskriftsartikel (refereegranskat)abstract
- Ileal carcinoids are malignant neuroendocrine tumours of the small intestine. The aim of this study was to obtain a high-resolution genomic profile of ileal carcinoids in order to define genetic changes important for tumour initiation, progression and survival. Forty-three patients with ileal carcinoids were investigated by high-resolution array-based comparative genomic hybridization. The average number of copy number alterations (CNAs) per tumour was 7.1 (range 1-22), with losses being more common than gains (ratio 1.4). The most frequent CNA was loss of chromosome 18 (74%). Other frequent CNAs were gain of chromosome 4, 5, 14 and 20, and loss of 11q22.1-q22.2, 11q22.3-q23.1 and 11q23.3, and loss of 16q12.2-q22.1 and 16q23.2-qter. Two distinct patterns of CNAs were found; the majority of tumours was characterized by loss of chromosome 18 while a subgroup of tumours had intact chromosome 18, but gain of chromosome 14. Survival analysis, using a series of Poisson regressions including recurrent CNAs, demonstrated that gain of chromosome 14 was a strong predictor of poor survival. In conclusion, high-resolution profiling demonstrated two separate patterns of CNAs in ileal carcinoids. The majority of tumours showed loss of chromosome 18, which most likely represents a primary event in the development and pathogenesis of tumours. A different genetic pathway is operative in a subgroup of tumours; this is characterized by gain of chromosome 14 and is strongly associated with poor prognosis. Predictive fluorescence in situ hybridization analysis of chromosome 14 status in patients with ileal carcinoids is suggested.
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| 37. |
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| 38. |
- Andersson, Helene, et al.
(författare)
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Consecutive microcontact printing - ligands for asymmetric catalysis in silicon channels
- 2001
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Ingår i: Sensors and actuators. B, Chemical. - 0925-4005 .- 1873-3077. ; 79:1, s. 78-84
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Tidskriftsartikel (refereegranskat)abstract
- Consecutive microcontact printing ( mu CP) has been developed to enable multiple functionalization of silicon surfaces, such as the immobilization of chiral ligands. The technique involves two subsequent printing steps using unstructured poly(methylsiloxane) stamps. The pattern is already defined on the substrate, consisting of etched channels. Hence, no precise alignment is needed between the two printing steps. A carboxylic acid group containing reagent was initially printed onto the silicon oxide surface and transformed to an anhydride. hi the second printing step an ester bond was formed with the hydroxy-functionalized ligand. The formed molecular layers were evaluated by contact angle measurements, scanning electron microscopy (SEM) and electron spectroscopy for chemical analysis (ESCA), indicating that the consecutive mu CP was successful. Initially, printing was performed on planar silicon surfaces but to realize a flow-through microfluidic device for high throughput screening a mu CP technique was developed for etched channels. To verify the technique, hydrophobic valves consisting of octadecyltrichlorosilane were formed using mu CP in deep reactive ion etched channels (50 mum wide and 50 mum deep). The printed hydrophobic patches were visualized by SEM and functioned well. Finally, the consecutive mu CP technique was applied to immobilize the ligand in the channels. The channels were then sealed with a low-temperature bonding technique using an adhesive PDMS film, which does not destroy the printed ligand. In this study mu CP is used in a novel manner. It enables a convenient method for performing complex surface modification of etched structures, which is a frequently appearing problem in biochemical microfluidic systems.
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| 39. |
- Andersson, Helene, et al.
(författare)
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Patterned self-assembled beads in silicon channels
- 2001
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Ingår i: Electrophoresis. - 0173-0835 .- 1522-2683. ; 22:18, s. 3876-3882
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Tidskriftsartikel (refereegranskat)abstract
- A novel technique enabling selective bead trapping in microfluidic devices without the use of physical barriers is presented in this paper. It is a fast, convenient and simple method, involving microcontact printing and self-assembly, that can be applied to silicon, quartz or plastic substrates. In the first step, channels are etched in the substrate. The surface chemistry of the internal walls of the channels is then modified by microcontact printing. The chip is submerged in a bead slurry where beads self-assemble based on surface chemistry and immobilize on the internal walls of the channels. Silicon channels (100 mum wide and 50 mum deep) have been covered with monolayers of streptavidin-, amino- and hydroxy-functionalized microspheres and resulted in good surface coverage of beads on the channel walls. A high-resolution pattern of lines of self-assembled streptavidin beads, as narrow as 5 mum, has also been generated on the bottom of a 500 mum wide and 50 mum deep channel. Flow tests were performed in sealed channels with the different immobilized beads to confirm that the immobilized beads could withstand the forces generated by water flowing in the channels. The presented results indicate that single beads can be precisely positioned within microfluidic devices based on self-assembly which is useful as screening and analysis tools within the field of biochemistry and organic chemistry.
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| 40. |
- Andersson, Helene, et al.
(författare)
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Self-assembled and self-sorted array of chemically active beads for analytical and biochemical screening
- 2002
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Ingår i: Talanta. - 0039-9140 .- 1873-3573. ; 56:2, s. 301-308
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Tidskriftsartikel (refereegranskat)abstract
- A technique for generating a general screening platform consisting of dots of immobilized beads on silicon has been developed via self-sorting and -assembly of different kinds of beads. The dots are defined by a teflon-like film, which due to its hydrophobic characteristics also prevents cross-contamination of liquid from different dots. To enable functionalization of individual dots with different target molecules simultaneously a new way of microcontact printing has been explored where different target solutions are printed in parallel using one stamp. In order to show that this platform can be designed for both biochemical assays and organic chemistry, streptavidin-, amino- and hydroxy-functionalized beads have been self-sorted and -assembled both on separate and common platforms. The self-sorting and -arrangement are based on surface chemistry only, which has not previously been reported. Beads of different sizes and material have successfully been immobilized in line patterns as narrow as 5 mum. Besides silicon, quartz and polyethylene have also been used as substrates.
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| 41. |
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| 42. |
- Andersson, Jonas, 1977-, et al.
(författare)
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C-reactive protein is a determinant of first-ever stroke: prospective nested case-referent study.
- 2009
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Ingår i: Cerebrovascular diseases (Basel, Switzerland). - : S. Karger AG. - 1421-9786 .- 1015-9770. ; 27:6, s. 544-51
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND PURPOSE: C-reactive protein (CRP) is a determinant of stroke, but there are no prospective studies on CRP and first ischemic stroke divided into etiologic subtypes. Our primary aim was to study CRP as a determinant of ischemic stroke, classified according to Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria, and intracerebral hemorrhage (ICH) in a prospective study. A secondary aim was to study the relationship between the 1444C>T polymorphism, plasma levels of CRP and stroke. METHODS: The study was a prospective population-based case-referent study nested within the Northern Sweden Cohorts. We defined 308 cases of ischemic stroke and 61 ICH. Two controls for each case were defined from the same cohort. RESULTS: The OR for the highest (>3 mg/l) versus lowest group (<1 mg/l) of CRP was 2.58 (95% CI 1.74-3.84) for ischemic stroke and 1.63 (95% CI 0.67-3.93) for ICH. In a multivariate model including traditional risk factors, CRP remained associated with ischemic stroke (OR 2.06; 95% CI 1.29-3.29). Small-vessel disease was associated with CRP in the multivariate model (OR 3.88; 95% CI 1.10-13.7). The CRP 1444 (CC/CT vs. TT) polymorphism was associated with plasma levels of CRP but neither with ischemic stroke nor with ICH. CONCLUSIONS: This prospective population-based study shows that CRP is significantly associated with the risk of having a first ischemic stroke, especially for small-vessel disease. No significant associations were found between the CRP 1444C>T polymorphism and any stroke subtype.
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| 43. |
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| 44. |
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| 45. |
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| 46. |
- Andersson, Kristina, 1962-, et al.
(författare)
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Gender Theory as a Tool for Analysing Science Teaching
- 2009
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Ingår i: Teaching and Teacher Education. - : Elsevier BV. - 0742-051X .- 1879-2480. ; 25:2, s. 336-343
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Tidskriftsartikel (refereegranskat)abstract
- This study examines to what extent experienced teachers are aware of gender issues in the science classroom. It also explores how an introduction to gender theory might alter this awareness. Teachers wrote their reflections about a real classroom situation. They were then asked to analyse the same situation after having read texts that discussed gender theory concepts. The fourteen teachers' understanding about gender and society were challenged. Some teachers were able to analyse the case differently by applying gender theory, others discussed the case on a more general level, while one teacher showed signs of resistance regarding gender theory.
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| 47. |
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| 48. |
- Andersson, Lars-Göran, et al.
(författare)
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Thallium-201 Myocardial Imaging at Rest in Male Orienteers and Other Endurance Athletes
- 2001
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Ingår i: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 106:1, s. 59-66
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Tidskriftsartikel (refereegranskat)abstract
- During the period 1979 to 1992, 16 sudden unexpected cardiac deaths were known to have occurred in young Swedish orienteers. Autopsy indicated myocarditis to be the most frequent finding, most often combined with extensive myocardial fibrosis. The aim of the present investigation was to explore whether young male orienteers show a higher frequency than other young elite endurance athletes (controls) in the occurrence of Thallium-201 myocardial perfusion defects at rest, suggestive of fibrosis evoked by myocarditis. Thallium-201 perfusion abnormalities at rest were more frequently found in the controls than in the orienteers (26% vs. 12%, p=0.03). Uneven Tl-201 perfusion was associated with left ventricular mass (r=0.32, r=0.24, p<0.01, p=0.02) and body weight (r=0.30, r=0.31, p<0.01, p=0.03) in orienteers and controls, respectively. Echocardiographic left ventricular wall motion abnormalities were found in 11 athletes (9 orienteers and 2 controls) but only two displayed an abnormal Thallium-201 perfusion scan at rest. Perfusion abnormalities at rest did not occur more frequently in the orienteers but were commonly found in both groups of apparently healthy athletes making it futile to discern abnormals from normals. Thallium-201 perfusion aberrations were not associated with left ventricular wall motion abnormalities obtained by echocardiography.
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| 49. |
- Andersson, Malin E, 1978, et al.
(författare)
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Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease.
- 2007
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Ingår i: International journal of molecular medicine. - 1107-3756 .- 1791-244X. ; 20:2, s. 233-9
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Tidskriftsartikel (refereegranskat)abstract
- Kinesin is a microtubule-associated motor protein that transports Alzheimer-associated amyloid precursor protein (APP) in neurons. In animal models, impaired kinesin-mediated APP transport seems to enhance formation of the neurotoxic 42 amino acid fragment of beta-amyloid (A beta 42). In man, one study suggests that a polymorphism (rs8702, 56,836G>C) in the kinesin light chain 1 gene (KNS2) may affect the risk of Alzheimer's disease (AD). To further assess KNS2 as a susceptibility gene for AD we analyzed 802 patients with sporadic AD and 286 controls, 134 longitudinally followed patients with mild cognitive impairment (MCI) and 39 cognitively stable controls for the rs8702 polymorphism. The rs8702 polymorphism did not influence risk of AD (p=0.46). However, rs8702 interacted with APOE epsilon 4 carrier status in AD (p=0.006) and influenced cerebrospinal fluid levels of hyperphosphorylated tau in MCI patients who converted to AD during follow-up (p=0.018). These findings support earlier indications that genetic variability in the KNS2 gene may play a role during early stages of AD pathogenesis.
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| 50. |
- Andersson, Roger, et al.
(författare)
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Large Housing Estates in Stockholm and Jönköping, Sweden : Opinions of residents on recent developments
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- RESTATE is the acronyme for Restructuring Large-scale Housing Estates in European Cities: Good Practices and New Visions for Sustainable Neighbourhoods and Cities. All the participants in this project share the basic underlying conviction: if the problems of these large-scale housing estates are not resolved, they will increasingly hinder the good economic functioning of cities. The study draws on estates in ten European countries: France, Germany, Hungury, Italy, the Netherlands, Poland, Slovenia, Spain, Sweden and the United Kingdom. Most results in this report are based on a survey carried out in the estates. The opinions and experiences of the inhabitants of the estates stand to the fore in this survey. This report is concerned with two Swedish cities, Stockholm and Jönköping; the same kind of information for estates in other countries in the RESTATE project can be found in parallel reports.
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