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- Rönnblom, Anders, et al.
(författare)
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Gastric emptying in myotonic dystrophy
- 2002
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Ingår i: European Journal of Clinical Investigation. - : Wiley. - 0014-2972 .- 1365-2362. ; 32:8, s. 570-4
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Gastrointestinal symptoms are common and important for the quality of life in patients with myotonic dystrophy (MD). Gastric emptying was studied in patients with MD who suffered from symptoms suggesting slow gastric emptying and the effect of prokinetic treatment was evaluated. METHODS: Gastric emptying was studied in 10 patients with MD who were suffering from nausea, early satiety, bloating, regurgitation, vomiting, or abdominal pain using a (99)Tc-labelled test meal, and was compared with gastric emptying in a group of healthy controls. The patients were subsequently treated with erythromycin and their gastrointestinal symptoms were recorded and the gastric emptying test was repeated. RESULTS: Patients with MD had a significantly longer gastric lag phase (46.1 +/- 4.3 vs. 31.9 +/- 4.0 min, P = 0.03), a slower emptying phase (7.1 +/- 0.9 vs. 10.2 +/- 0.9 kJ min(-1), P = 0.02) and a longer half-emptying time, T50 (141.7 +/- 10.5 vs. 98.6 +/- 8.7 min, P = 0.01) than a matched control group. Erythromycin did not stimulate the gastric emptying rate. The effect on gastrointestinal symptoms was modest, except for a reduction of diarrhoea. CONCLUSIONS: Patients with MD suffering from nausea, vomiting and early satiety, displayed a slow gastric emptying. Treatment with erythromycin had only moderate effect on gastric emptying or gastric symptoms, but reduced diarrhoea in a majority of the patients.
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- Samsoe, E, et al.
(författare)
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Improvement of spatial and temporal coherence of a broad area laser diode using an external-cavity design with double grating feedback
- 2004
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Ingår i: Optics Express. - 1094-4087. ; 12:4, s. 609-616
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate a novel technique for narrow bandwidth and highly improved lateral mode operation of a high-power broad area laser diode. The system uses simultaneous feedback from the first diffracted order and the zeroth reflected order of a diffraction grating. The two feedback paths lead to simultaneously improvement of the spectral and spatial properties of the laser diode. The laser system operates in the well-known asymmetric double-lobed far field pattern with the larger lobe being extracted as the output. The bandwidth of the output beam is measured to 0.07 nm, which corresponds to an improvement of a factor of 17 compared to the bandwidth of the freely running laser. The output from the system contains 54% of the energy reaching the grating, or 75% of the power reflected into the zeroth order. The improvements in both the spatial and temporal coherence opens the possibility of using this laser system in applications such as frequency doubling and pumping of optical parametric oscillators. (C) 2004 Optical Society of America.
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- Samsöe Andersen, Eva, et al.
(författare)
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A novel diode laser system for photodynamic therapy
- 2001
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Ingår i: LASER-TISSUE INTERACTIONS, THERAPEUTIC APPLICATIONS, AND PHOTODYNAMIC THERAPY. - : SPIE. - 0277-786X .- 1996-756X. - 0819441473 ; 4433:33, s. 134-139
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Konferensbidrag (refereegranskat)abstract
- In this paper a novel diode laser system for photodynamic therapy is demonstrated. The system is based on linear spatial filtering and optical phase conjugate feedback from a photorefractive BaTiO3 crystal. The spatial coherence properties of the diode laser are significantly improved. The system provides an almost diffraction limited output which is efficiently coupled into a 50 mum core diameter fiber. The optical power transmitted through the fiber is increased by a factor of six when the feedback is applied to the diode laser. 85 percent of the power from the freely running laser diode is extracted in a high-quality beam and 80 percent of the output power is extracted through the fiber. The power transmitted through tile fiber scales linearly with the power of the laser diode. which means that a laser diode emitting 1.7 W multi-mode radiation would provide 1 W of optical power through a 50 mum core diameter fiber. The system is compact, portable, stable, and easy to operate.
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| 10. |
- Samsöe Andersen, Eva, et al.
(författare)
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Improvement of brightness and output power of high-power laser diodes in the visible spectral region
- 2003
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Ingår i: Optics Communications. - 0030-4018. ; 219:1-6, s. 369-375
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Tidskriftsartikel (refereegranskat)abstract
- This paper reports on a novel design for a high-brightness quantum-well AlGaInP laser-diode system operating at 635 nm. The spatial coherence of two broad area laser diodes is improved using spatial filtering and optical feedback from a narrow mirror stripe on each laser. To increase power, the outputs from the two systems are passively combined using a polarizing beam splitter. The result is a compact system providing a high-brightness beam. The beam-quality parameter is improved in one direction from M-2 = 12 and M-2 = 16 for the two lasers, to M-2 = 2.1 for the combined beam. The other direction of the beam is left unchanged due to its natural high quality with an M-2 value around 1.5. A procedure for efficient coupling of the two lasers into a small core-diameter optical fiber is given. This capability facilitates a wide range of applications including interstitial medical therapies, where delivery of the treatment light through thin optical fibers is essential. (C) 2003 Elsevier Science B.V. All rights reserved.
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