SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Andrén Oliver) srt2:(2020)"

Sökning: WFRF:(Andrén Oliver) > (2020)

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Garcia Gallego, Sandra, et al. (författare)
  • Accelerated Chemoselective Reactions to Sequence-Controlled Heterolayered Dendrimers
  • 2020
  • Ingår i: Journal of the American Chemical Society. - : American Chemical Society. - 0002-7863 .- 1520-5126.
  • Tidskriftsartikel (refereegranskat)abstract
    • Chemoselective reactions are a highly desirable approach to generate well-defined functional macromolecules. Their extraordinary efficiency and selectivity enable the development of flawless structures, such as dendrimers, with unprecedented structure-to-property capacity but with typically tedious synthetic protocols. Here we demonstrate the potency of chemoselective reactions to accomplish sequence-controlled heterolayered dendrimers. An accurate accelerated design of bis-MPA monomers with orthogonally complementary moieties and a wisely selected chemical toolbox generated highly complex monodisperse dendrimers through simplified protocols. The versatility of the strategy was proved by obtaining different dendritic families with different properties after altering the order of addition of the monomers. Moreover, we evaluated the feasibility of the one-pot approach toward these heterolayered dendrimers as proof-of-concept.
  •  
2.
  • Zhang, Yuning, et al. (författare)
  • Degradable High Molecular Weight Monodisperse Dendritic Poly(ethylene glycols)
  • 2020
  • Ingår i: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 21:10, s. 4294-4301
  • Tidskriftsartikel (refereegranskat)abstract
    • Poly(ethylene glycols) (PEGs) are extensively explored by the pharma industry as foundations for new therapeutic products. PEGs are typically used for their conjugation to active drugs, peptides, and proteins and the likeliness to increase the half-life and enhance the therapeutic outcome. Considering the necessity of batch-to-batch consistency for clinical products, monodisperse PEGs are highly attractive but are generally limited to 5 kDa as an upper molecular weight (Mw) and with an oligomer purity of 95%. By amalgamating short, monodisperse PEGs with dendritic frameworks based on 2,2-bis(methylol)propionic acid polyesters, we showcase a robust synthetic approach to monodisperse PEGs with Mw ranging from 2 to 65 kDa. The latter is, to our knowledge, the highest Mw structure of its kind ever reported. Importantly, the dendritic multifunctional connector facilitated degradability at pH 7.4 at 37 °C, which is an important feature for the delivery of therapeutic agents.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Malkoch, Michael, 19 ... (2)
Andrén, Oliver C. J. (2)
Zhang, Yuning (1)
García-Gallego, Sand ... (1)
Mesa-Antunez, Pablo (1)
Fortuin, Lisa (1)
Lärosäte
Kungliga Tekniska Högskolan (2)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (1)
Teknik (1)
År
2020 (2)Ta bort avgränsningen

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy